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Aliases for FAM179B Gene

Aliases for FAM179B Gene

  • Family With Sequence Similarity 179, Member B 2 3
  • KIAA0423 2 3 4
  • Protein FAM179B 3

External Ids for FAM179B Gene

Previous Symbols for FAM179B Gene

  • KIAA0423

Summaries for FAM179B Gene

GeneCards Summary for FAM179B Gene

FAM179B (Family With Sequence Similarity 179, Member B) is a Protein Coding gene. An important paralog of this gene is FAM179A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM179B Gene

Genomics for FAM179B Gene

Genomic Location for FAM179B Gene

Start:
44,962,208 bp from pter
End:
45,074,431 bp from pter
Size:
112,224 bases
Orientation:
Plus strand

Genomic View for FAM179B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM179B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM179B Gene

Regulatory Elements for FAM179B Gene

Proteins for FAM179B Gene

  • Protein details for FAM179B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4F4-F179B_HUMAN
    Recommended name:
    Protein FAM179B
    Protein Accession:
    Q9Y4F4
    Secondary Accessions:
    • Q68D66
    • Q6PG27

    Protein attributes for FAM179B Gene

    Size:
    1720 amino acids
    Molecular mass:
    189360 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA24853.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAH18354.1; Type=Frameshift; Positions=1069, 1506; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM179B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM179B Gene

Proteomics data for FAM179B Gene at MOPED

Post-translational modifications for FAM179B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM179B Gene

No data available for DME Specific Peptides for FAM179B Gene

Domains for FAM179B Gene

Protein Domains for FAM179B Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

F179B_HUMAN
Family:
  • Belongs to the FAM179 family.:
    • Q9Y4F4
Similarity:
  • Contains 6 HEAT repeats.:
    • Q9Y4F4
genes like me logo Genes that share domains with FAM179B: view

No data available for Gene Families for FAM179B Gene

Function for FAM179B Gene

Gene Ontology (GO) - Molecular Function for FAM179B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
genes like me logo Genes that share ontologies with FAM179B: view

Phenotypes for FAM179B Gene

GenomeRNAi human phenotypes for FAM179B:
genes like me logo Genes that share phenotypes with FAM179B: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FAM179B Gene

Localization for FAM179B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM179B Gene COMPARTMENTS Subcellular localization image for FAM179B gene
Compartment Confidence
endoplasmic reticulum 2
nucleus 2
cytosol 1
extracellular 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for FAM179B Gene

Pathways for FAM179B Gene

SuperPathways for FAM179B Gene

No Data Available

Interacting Proteins for FAM179B Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000355045%0d%0a9606.ENSP00000376076%0d%0a9606.ENSP00000347184%0d%0a
Selected Interacting proteins: ENSP00000355045 Q9Y4F4-F179B_HUMAN for FAM179B Gene via STRING I2D

Gene Ontology (GO) - Biological Process for FAM179B Gene

None

No data available for Pathways by source for FAM179B Gene

Transcripts for FAM179B Gene

Unigene Clusters for FAM179B Gene

Family with sequence similarity 179, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM179B Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1: - -
SP2: - - -
SP3:
SP4:
SP5: -

Relevant External Links for FAM179B Gene

GeneLoc Exon Structure for
FAM179B
ECgene alternative splicing isoforms for
FAM179B

Expression for FAM179B Gene

mRNA expression in normal human tissues for FAM179B Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FAM179B Gene

SOURCE GeneReport for Unigene cluster for FAM179B Gene Hs.371078

genes like me logo Genes that share expressions with FAM179B: view

Orthologs for FAM179B Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM179B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM179B 36
  • 99.59 (n)
  • 99.24 (a)
FAM179B 37
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM179B 36
  • 90.52 (n)
  • 90.23 (a)
FAM179B 37
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM179B 36
  • 91.17 (n)
  • 91.17 (a)
FAM179B 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam179b 36
  • 86.32 (n)
  • 87.09 (a)
Fam179b 16
Fam179b 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM179B 37
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM179B 37
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam179b 36
  • 87.19 (n)
  • 88.09 (a)
chicken
(Gallus gallus)
Aves FAM179B 36
  • 67.68 (n)
  • 66.07 (a)
lizard
(Anolis carolinensis)
Reptilia FAM179B 37
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495084 36
  • 56.62 (n)
  • 50.95 (a)
zebrafish
(Danio rerio)
Actinopterygii FAM179B 37
  • 30 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG42399 37
  • 10 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea che-12 37
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 27 (a)
OneToMany
Species with no ortholog for FAM179B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM179B Gene

ENSEMBL:
Gene Tree for FAM179B (if available)
TreeFam:
Gene Tree for FAM179B (if available)

Paralogs for FAM179B Gene

Paralogs for FAM179B Gene

Selected SIMAP similar genes for FAM179B Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with FAM179B: view

Variants for FAM179B Gene

Sequence variations from dbSNP and Humsavar for FAM179B Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs3510 -- 45,015,814(-) ATAAA(C/G)AGCTC intron-variant
rs226975 -- 45,069,229(+) ctggg(C/T)gtggt intron-variant
rs961194 -- 44,973,788(+) ctaaa(C/T)tgatg intron-variant
rs1053665 -- 45,027,374(+) GGATA(C/T)ATTTT reference, missense, nc-transcript-variant
rs1053667 -- 45,073,835(+) GCTCA(C/T)TTGCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FAM179B Gene

Variant ID Type Subtype PubMed ID
nsv901841 CNV Loss 21882294
nsv1259 CNV Loss 18451855
nsv1260 CNV Loss 18451855
esv2505295 CNV Deletion 19546169
nsv901842 CNV Loss 21882294
nsv901843 CNV Gain 21882294
esv2748675 CNV Deletion 23290073
nsv832785 CNV Loss 17160897

Relevant External Links for FAM179B Gene

HapMap Linkage Disequilibrium report
FAM179B

Disorders for FAM179B Gene

Relevant External Links for FAM179B

Genetic Association Database (GAD)
FAM179B
genes like me logo Genes that share disorders with FAM179B: view

No data available for UniProtKB/Swiss-Prot for FAM179B Gene

Publications for FAM179B Gene

  1. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K. … Ohara O. (DNA Res. 1997) 3 4
  2. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Detection of hypothetical proteins in human fetal perireticular nucleus. (PMID: 16335990) Hepner F. … Lubec G. (J. Proteome Res. 2005) 3 4
  5. Broad spectrum identification of SUMO substrates in melanoma cells. (PMID: 17549794) Ganesan A.K. … White M.A. (Proteomics 2007) 3

Products for FAM179B Gene

Sources for FAM179B Gene

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