FAM179B Gene
protein-coding GIFtS: 46
GCID: GC14P045431
|
|
family with sequence similarity 179, member B(Previous name: KIAA0423 )
(Previous symbol: KIAA0423)
| |
Aliases
for FAM179B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Family With Sequence Similarity 179, Member B1 2 | | KIAA04231 2 3 | | Protein FAM179B2 |
Export aliases for FAM179B gene to outside databasesPrevious GC identifers: GC14P044502 GC14P025542 |
Summaries
for FAM179B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FAM179B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FAM179B gene promoter:
Nkx3-1 E2F-4 E2F-3a E2F-5 Nkx3-1 v4 Nkx3-1 v1 E2F-2 Nkx3-1 v2 E2F E2F-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM179B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM179B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q21.2 Ensembl cytogenetic band: 14q21.2 HGNC cytogenetic band: 14q21.3FAM179B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14P045431: view genomic region
(about GC identifiers)
Start:
|
45,431,411 bp from pter |
End:
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45,543,634 bp from pter |
Size:
|
112,224 bases |
Orientation:
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plus strand |
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Proteins
for FAM179B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: F179B_HUMAN, Q9Y4F4 (See
protein sequence)Recommended Name: Protein FAM179B Size: 1720 amino acids; 189360 Da
Sequence caution: Sequence=BAA24853.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;Sequence=CAH18354.1; Type=Frameshift; Positions=1069, 1506;
Secondary accessions: Q68D66 Q6PG27Alternative splicing: 3 isoforms: Q9Y4F4-1 Q9Y4F4-2 Q9Y4F4-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for FAM179B: NX_Q9Y4F4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y4F4
FAM179B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055906.2
ENSEMBL proteins: ENSP00000355045 ENSP00000451829 ENSP00000354917 ENSP00000451141 ENSP00000451013 ENSP00000450465 ENSP00000371668
Human Recombinant Protein Products:
FAM179B Antibody Products:
Assay Products for FAM179B: |
Protein
Domains /
Families
for FAM179B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FAM179B for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y4F4ProtoNet protein and cluster: Q9Y4F4 1 Blocks protein family: IPB000357 HEAT repeat
UniProtKB/Swiss-Prot: F179B_HUMAN, Q9Y4F4Similarity: Belongs to the FAM179 familySimilarity: Contains 6 HEAT repeats |
Function
for FAM179B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM179B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM179B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FAM179B (NM_015091) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM179B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM179B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM179B |
1 GenomeRNAi human phenotype for FAM179B:
|
Pathways & Interactions
for FAM179B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM179B
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
5 Interacting proteins for FAM179B (Q9Y4F43 ENSP000003550454) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for FAM179B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM179B
Search CenterWatch for drugs/clinical trials and news about FAM179B / F179B
|
Transcripts
for FAM179B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAM179B gene: NM_015091.2 Unigene Cluster for FAM179B: Family with sequence similarity 179, member B Hs.371078 [show with all ESTs]Unigene Representative Sequence: BX64872311 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000361577(uc001wvv.3) ENST00000557423(uc010anc.3) ENST00000555607(uc001wvu.3)
ENST00000555945(uc010anb.1) ENST00000361462(uc001wvw.3) ENST00000555874
ENST00000557250 ENST00000556105 ENST00000555586 ENST00000556823 ENST00000382233
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM179B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM179B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FAM179B (NM_015091) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM179B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM179B |
Additional cDNA sequence: AB007883.2 AK096934.1 AK295185.1 AK307722.1 AK311034.1 BC057255.2 BC065234.1 BX648723.1 CR749557.1 7 DOTS entries: DT.101975955 DT.75182774 DT.99999500 DT.414851 DT.86836837 DT.414853 DT.99938489 24/81 AceView cDNA sequences (see all 81): BM683780 AK096934 NM_015091 AI952685 BM987009 BM930287 N92639 AI905969 BE465650 BX956213 AA059102 BC065234 BM683757 R58737 AB007883 CA417450 AI864646 BX648723 BM930313 BC057255 AI608660 AA405700 AA257077 BU158432
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for FAM179B About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 |
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| SP1: | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FAM179B
|
Expression
for FAM179B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAM179B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCTTACAAG
About this image
See FAM179B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM179B
SOURCE GeneReport for Unigene cluster: Hs.371078
SABiosciences Custom PCR Arrays for FAM179B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM179B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FAM179B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM179B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM179B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM179B |
Orthologs
for FAM179B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FAM179B gene from 6/18 species (see all 18) About this table
ENSEMBL Gene Tree for FAM179B (if available)
TreeFam Gene Tree for FAM179B (if available) |
Paralogs
for FAM179B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAM179B gene
- FAM179A2
1 SIMAP similar gene for FAM179B using alignment to 7 protein entries: F179B_HUMAN (see all proteins):FAM179A
FAM179B for paralogs About GeneDecksing
|
Genomic Variants
for FAM179B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM179B (45431411 - 45543634 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FAM179B
1 CNV: 101943 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM179B |
|
Disorders
/ Diseases
for FAM179B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FAM179B for disorders About GeneDecksing
1  disease for FAM179B: About MalaCardsneuronitis
Export disorders for FAM179B gene to outside databases
|
Publications
for FAM179B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM179B gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM179B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Detection of hypothetical proteins in human fetal perireticular nucleus. (PubMed id 16335990)1, 2 Hepner F.... Lubec G. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
- Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9455477)1, 2 Ishikawa K....Ohara O. (1997)
- Broad spectrum identification of SUMO substrates in m elanoma cells. (PubMed id 17549794)1 Ganesan A.K....White M.A. (2007)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)2 Heilig R.... Weissenbach J. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for FAM179B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FAM179B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM179B gene
(According to HUGE)
About This Section
| |
Specialized Databases showing FAM179B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAM179B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FAM179B gene:
Search GeneIP for patents involving FAM179B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM179B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FAM179B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM179B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM179B | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FAM179B | | OriGene 3'-UTR Clone for FAM179B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM179B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM179B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FAM179B | | OriGene Custom Protein Services for FAM179B | | | OriGene Custom Immunoassay Development | | |
| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM179B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM179B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM179B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM179B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM179B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM179B |
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| | | | Search Tocris compounds for FAM179B |
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 | | | FAM179B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM179B |
|  |  |  | | | | Search ThermoFisher Antibodies for FAM179B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM179B |
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