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Aliases for FAM179B Gene

Aliases for FAM179B Gene

  • Family With Sequence Similarity 179, Member B 2 3
  • KIAA0423 2 3 4
  • Protein FAM179B 3

External Ids for FAM179B Gene

Previous HGNC Symbols for FAM179B Gene

  • KIAA0423

Previous GeneCards Identifiers for FAM179B Gene

  • GC14P044502
  • GC14P045431
  • GC14P025542

Summaries for FAM179B Gene

GeneCards Summary for FAM179B Gene

FAM179B (Family With Sequence Similarity 179, Member B) is a Protein Coding gene. An important paralog of this gene is FAM179A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM179B Gene

Genomics for FAM179B Gene

Regulatory Elements for FAM179B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM179B Gene

44,962,208 bp from pter
45,074,431 bp from pter
112,224 bases
Plus strand

Genomic View for FAM179B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM179B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM179B Gene

Proteins for FAM179B Gene

  • Protein details for FAM179B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM179B
    Protein Accession:
    Secondary Accessions:
    • Q68D66
    • Q6PG27

    Protein attributes for FAM179B Gene

    1720 amino acids
    Molecular mass:
    189360 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA24853.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAH18354.1; Type=Frameshift; Positions=1069, 1506; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM179B Gene


neXtProt entry for FAM179B Gene

Proteomics data for FAM179B Gene at MOPED

Post-translational modifications for FAM179B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM179B Gene

No data available for DME Specific Peptides for FAM179B Gene

Domains for FAM179B Gene

Protein Domains for FAM179B Gene


Suggested Antigen Peptide Sequences for FAM179B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9Y4F4
  • Belongs to the FAM179 family.
  • Contains 6 HEAT repeats.
genes like me logo Genes that share domains with FAM179B: view

No data available for Gene Families for FAM179B Gene

Function for FAM179B Gene

Gene Ontology (GO) - Molecular Function for FAM179B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
genes like me logo Genes that share ontologies with FAM179B: view

Phenotypes for FAM179B Gene

GenomeRNAi human phenotypes for FAM179B:
genes like me logo Genes that share phenotypes with FAM179B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM179B

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FAM179B Gene

Localization for FAM179B Gene

Subcellular locations from

Jensen Localization Image for FAM179B Gene COMPARTMENTS Subcellular localization image for FAM179B gene
Compartment Confidence
endoplasmic reticulum 2
nucleus 2
cytosol 1
extracellular 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM179B Gene

Pathways for FAM179B Gene

SuperPathways for FAM179B Gene

No Data Available

Interacting Proteins for FAM179B Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000355045 Q9Y4F4-F179B_HUMAN for FAM179B Gene via STRING I2D

Gene Ontology (GO) - Biological Process for FAM179B Gene


No data available for Pathways by source for FAM179B Gene

Transcripts for FAM179B Gene

Unigene Clusters for FAM179B Gene

Family with sequence similarity 179, member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM179B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM179B Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1: - -
SP2: - - -
SP5: -

Relevant External Links for FAM179B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM179B Gene

mRNA expression in normal human tissues for FAM179B Gene

Protein differential expression in normal tissues for FAM179B Gene

This gene is overexpressed in Urinary Bladder (19.4), Heart (17.2), Urine (13.3), and Ovary (11.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FAM179B Gene

SOURCE GeneReport for Unigene cluster for FAM179B Gene Hs.371078

genes like me logo Genes that share expressions with FAM179B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for FAM179B Gene

Orthologs for FAM179B Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM179B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM179B 35
  • 90.52 (n)
  • 90.23 (a)
FAM179B 36
  • 87 (a)
(Canis familiaris)
Mammalia FAM179B 35
  • 91.17 (n)
  • 91.17 (a)
FAM179B 36
  • 85 (a)
(Mus musculus)
Mammalia Fam179b 35
  • 86.32 (n)
  • 87.09 (a)
Fam179b 16
Fam179b 36
  • 84 (a)
(Pan troglodytes)
Mammalia FAM179B 35
  • 99.59 (n)
  • 99.24 (a)
FAM179B 36
  • 96 (a)
(Rattus norvegicus)
Mammalia Fam179b 35
  • 87.19 (n)
  • 88.09 (a)
(Monodelphis domestica)
Mammalia FAM179B 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia FAM179B 36
  • 68 (a)
(Gallus gallus)
Aves FAM179B 35
  • 67.68 (n)
  • 66.07 (a)
(Anolis carolinensis)
Reptilia FAM179B 36
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495084 35
  • 56.62 (n)
  • 50.95 (a)
(Danio rerio)
Actinopterygii FAM179B 36
  • 30 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG42399 36
  • 10 (a)
(Caenorhabditis elegans)
Secernentea che-12 36
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
Species with no ortholog for FAM179B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM179B Gene

Gene Tree for FAM179B (if available)
Gene Tree for FAM179B (if available)

Paralogs for FAM179B Gene

Paralogs for FAM179B Gene

Selected SIMAP similar genes for FAM179B Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with FAM179B: view

Variants for FAM179B Gene

Sequence variations from dbSNP and Humsavar for FAM179B Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs3510 -- 45,015,814(-) ATAAA(C/G)AGCTC intron-variant
rs226975 -- 45,069,229(+) ctggg(C/T)gtggt intron-variant
rs961194 -- 44,973,788(+) ctaaa(C/T)tgatg intron-variant
rs1053665 -- 45,027,374(+) GGATA(C/T)ATTTT reference, missense, nc-transcript-variant
rs1053667 -- 45,073,835(+) GCTCA(C/T)TTGCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FAM179B Gene

Variant ID Type Subtype PubMed ID
nsv901841 CNV Loss 21882294
nsv1259 CNV Loss 18451855
nsv1260 CNV Loss 18451855
esv2505295 CNV Deletion 19546169
nsv901842 CNV Loss 21882294
nsv901843 CNV Gain 21882294
esv2748675 CNV Deletion 23290073
nsv832785 CNV Loss 17160897

Relevant External Links for FAM179B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM179B Gene

Disorders for FAM179B Gene

Relevant External Links for FAM179B

Genetic Association Database (GAD)

No disorders were found for FAM179B Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for FAM179B Gene

Publications for FAM179B Gene

  1. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K. … Ohara O. (DNA Res. 1997) 3 4
  2. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Detection of hypothetical proteins in human fetal perireticular nucleus. (PMID: 16335990) Hepner F. … Lubec G. (J. Proteome Res. 2005) 3 4
  5. Broad spectrum identification of SUMO substrates in melanoma cells. (PMID: 17549794) Ganesan A.K. … White M.A. (Proteomics 2007) 3

Products for FAM179B Gene

Sources for FAM179B Gene

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