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Aliases for FAM179A Gene

Aliases for FAM179A Gene

  • Family With Sequence Similarity 179 Member A 2 3 5
  • Family With Sequence Similarity 179, Member A 2

External Ids for FAM179A Gene

Previous GeneCards Identifiers for FAM179A Gene

  • GC02P029179

Summaries for FAM179A Gene

GeneCards Summary for FAM179A Gene

FAM179A (Family With Sequence Similarity 179 Member A) is a Protein Coding gene. GO annotations related to this gene include binding. An important paralog of this gene is FAM179B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM179A Gene

Genomics for FAM179A Gene

Regulatory Elements for FAM179A Gene

Promoters for FAM179A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAM179A on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM179A Gene

Chromosome:
2
Start:
28,956,611 bp from pter
End:
29,061,373 bp from pter
Size:
104,763 bases
Orientation:
Plus strand

Genomic View for FAM179A Gene

Genes around FAM179A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM179A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM179A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM179A Gene

Proteins for FAM179A Gene

  • Protein details for FAM179A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZUX3-F179A_HUMAN
    Recommended name:
    Protein FAM179A
    Protein Accession:
    Q6ZUX3
    Secondary Accessions:
    • Q6ZUF5

    Protein attributes for FAM179A Gene

    Size:
    1019 amino acids
    Molecular mass:
    111153 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM179A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM179A Gene

Proteomics data for FAM179A Gene at MOPED

Post-translational modifications for FAM179A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM179A Gene

No data available for DME Specific Peptides for FAM179A Gene

Domains & Families for FAM179A Gene

Protein Domains for FAM179A Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM179A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZUX3

UniProtKB/Swiss-Prot:

F179A_HUMAN :
  • Belongs to the FAM179 family.
Family:
  • Belongs to the FAM179 family.
genes like me logo Genes that share domains with FAM179A: view

No data available for Gene Families for FAM179A Gene

Function for FAM179A Gene

Phenotypes for FAM179A Gene

genes like me logo Genes that share phenotypes with FAM179A: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM179A Gene

Localization for FAM179A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM179A Gene COMPARTMENTS Subcellular localization image for FAM179A gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM179A Gene

Pathways & Interactions for FAM179A Gene

SuperPathways for FAM179A Gene

No Data Available

Interacting Proteins for FAM179A Gene

Gene Ontology (GO) - Biological Process for FAM179A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM179A Gene

Drugs & Compounds for FAM179A Gene

No Compound Related Data Available

Transcripts for FAM179A Gene

Unigene Clusters for FAM179A Gene

Family with sequence similarity 179, member A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM179A Gene

No ASD Table

Relevant External Links for FAM179A Gene

GeneLoc Exon Structure for
FAM179A
ECgene alternative splicing isoforms for
FAM179A

Expression for FAM179A Gene

mRNA expression in normal human tissues for FAM179A Gene

mRNA differential expression in normal tissues according to GTEx for FAM179A Gene

This gene is overexpressed in Muscle - Skeletal (x7.5) and Heart - Left Ventricle (x4.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM179A Gene



SOURCE GeneReport for Unigene cluster for FAM179A Gene Hs.525977

genes like me logo Genes that share expression patterns with FAM179A: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FAM179A Gene

Orthologs for FAM179A Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM179A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAM179A 35
  • 83.19 (n)
  • 78.82 (a)
FAM179A 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM179A 35
  • 83.06 (n)
  • 77.13 (a)
FAM179A 36
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam179a 35
  • 78.74 (n)
  • 72.82 (a)
Fam179a 16
Fam179a 36
  • 69 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM179A 35
  • 98.66 (n)
  • 96.86 (a)
FAM179A 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam179a 35
  • 78.92 (n)
  • 73.44 (a)
oppossum
(Monodelphis domestica)
Mammalia FAM179A 36
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM179A 36
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM179A 35
  • 61.12 (n)
  • 51.63 (a)
FAM179A 36
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM179A 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam179a 35
  • 54.11 (n)
  • 43.35 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG42399 36
  • 7 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea che-12 36
  • 10 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
OneToMany
Species with no ortholog for FAM179A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for FAM179A Gene

ENSEMBL:
Gene Tree for FAM179A (if available)
TreeFam:
Gene Tree for FAM179A (if available)

Paralogs for FAM179A Gene

Paralogs for FAM179A Gene

(1) SIMAP similar genes for FAM179A Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FAM179A: view

Variants for FAM179A Gene

Sequence variations from dbSNP and Humsavar for FAM179A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs13009279 - 28,999,204(+) CAAGA(A/G)CCCTG nc-transcript-variant, reference, missense
rs12623297 - 29,003,646(+) AGGCC(A/G)GGGAG nc-transcript-variant, reference, missense
rs11127202 - 29,017,194(+) GATGC(A/G)GCTGA intron-variant, nc-transcript-variant, reference, missense
rs1109758 - 29,017,917(-) GCTGA(C/G/T)GGGGA intron-variant, nc-transcript-variant, reference, missense
rs6721861 - 29,023,178(+) CTTGG(C/T)GGTGA nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for FAM179A Gene

Variant ID Type Subtype PubMed ID
dgv1163e1 CNV Complex 17122850
esv34904 CNV Gain 17911159
dgv686e199 CNV Deletion 23128226
dgv213n21 CNV Loss 19592680
esv2719845 CNV Deletion 23290073
esv2719846 CNV Deletion 23290073
esv2719847 CNV Deletion 23290073
esv4275 CNV Deletion 18987735
dgv687e199 CNV Deletion 23128226
esv2660458 CNV Deletion 23128226
dgv633e201 CNV Deletion 23290073
esv2719849 CNV Deletion 23290073
dgv688e199 CNV Deletion 23128226
esv2162111 CNV Deletion 18987734
esv2719852 CNV Deletion 23290073
esv7077 CNV Loss 19470904
esv2719853 CNV Deletion 23290073
esv2719854 CNV Deletion 23290073
esv1152713 CNV Deletion 17803354
esv2670234 CNV Deletion 23128226
esv2719855 CNV Deletion 23290073
nsv525642 CNV Gain 19592680
nsv528652 CNV Gain 19592680
nsv2657 CNV Loss 18451855

Variation tolerance for FAM179A Gene

Residual Variation Intolerance Score: 99.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 21.30; 99.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM179A Gene

HapMap Linkage Disequilibrium report
FAM179A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM179A Gene

Disorders for FAM179A Gene

Relevant External Links for FAM179A

Genetic Association Database (GAD)
FAM179A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM179A

No disorders were found for FAM179A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM179A Gene

Publications for FAM179A Gene

  1. Genome-wide association study of recurrent early-onset major depressive disorder. (PMID: 20125088) Shi J. … Levinson D.F. (Mol. Psychiatry 2011) 3 48 67
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 2 3
  3. Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9. (PMID: 24376456) Simino J. … Rao D.C. (Front Genet 2013) 3

Products for FAM179A Gene

Sources for FAM179A Gene

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