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Aliases for FAM179A Gene

Aliases for FAM179A Gene

  • Family With Sequence Similarity 179 Member A 2 3 5
  • Family With Sequence Similarity 179, Member A 2
  • Protein FAM179A 3
  • Crescerin-2 3

External Ids for FAM179A Gene

Previous GeneCards Identifiers for FAM179A Gene

  • GC02P029179

Summaries for FAM179A Gene

GeneCards Summary for FAM179A Gene

FAM179A (Family With Sequence Similarity 179 Member A) is a Protein Coding gene. GO annotations related to this gene include binding. An important paralog of this gene is FAM179B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM179A Gene

Genomics for FAM179A Gene

Regulatory Elements for FAM179A Gene

Enhancers for FAM179A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F028893 1.1 ENCODE 30.8 -61.0 -61036 3.3 PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF207 FAM179A WDR43 TRMT61B GC02P028913
GH02F029008 1.1 Ensembl ENCODE 28.2 +57.0 56974 9.8 CTCF MAX EBF1 ZIC2 THRB RAD21 ZBTB40 ZKSCAN1 ZFHX2 CTBP1 FAM179A C2orf71 PPP1CB TRMT61B ENSG00000200283 LOC105374385
GH02F028950 1.5 FANTOM5 Ensembl ENCODE 19.9 -4.6 -4613 3.2 DMAP1 RAD21 RARA YY1 THAP11 MXD4 CEBPB MIER2 REST NR2F2 FAM179A TRMT61B WDR43 PPP1CB ENSG00000265706
GH02F028747 1.5 FANTOM5 ENCODE 18.8 -204.6 -204604 9.0 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 YY1 SP5 NFYC TRMT61B FAM179A PPP1CB SPDYA ENSG00000230730 WDR43 FOSL2 LOC100505774
GH02F028868 1.1 ENCODE 21.9 -86.5 -86512 2.2 PKNOX1 CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 TRMT61B FAM179A FOSL2 FLJ31356 ENSG00000273233
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM179A on UCSC Golden Path with GeneCards custom track

Promoters for FAM179A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001821080 189 800 ELF3 CTCF USF1 SAP130 TEAD4 RAD21 TEAD3 GATA3 SMC3 GATAD2A

Genomic Location for FAM179A Gene

28,956,611 bp from pter
29,061,373 bp from pter
104,763 bases
Plus strand

Genomic View for FAM179A Gene

Genes around FAM179A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM179A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM179A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM179A Gene

Proteins for FAM179A Gene

  • Protein details for FAM179A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q6ZUF5

    Protein attributes for FAM179A Gene

    1019 amino acids
    Molecular mass:
    111153 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM179A Gene


neXtProt entry for FAM179A Gene

Post-translational modifications for FAM179A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM179A Gene

Domains & Families for FAM179A Gene

Protein Domains for FAM179A Gene

Suggested Antigen Peptide Sequences for FAM179A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Crescerin family.
  • Belongs to the Crescerin family.
genes like me logo Genes that share domains with FAM179A: view

No data available for Gene Families for FAM179A Gene

Function for FAM179A Gene

Phenotypes for FAM179A Gene

genes like me logo Genes that share phenotypes with FAM179A: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM179A Gene

Localization for FAM179A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM179A gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM179A Gene

Pathways & Interactions for FAM179A Gene

SuperPathways for FAM179A Gene

No Data Available

Interacting Proteins for FAM179A Gene

Gene Ontology (GO) - Biological Process for FAM179A Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM179A Gene

Transcripts for FAM179A Gene

Unigene Clusters for FAM179A Gene

Family with sequence similarity 179, member A:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM179A Gene

No ASD Table

Relevant External Links for FAM179A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM179A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM179A Gene

mRNA differential expression in normal tissues according to GTEx for FAM179A Gene

This gene is overexpressed in Muscle - Skeletal (x7.5) and Heart - Left Ventricle (x4.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM179A Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM179A Gene:


SOURCE GeneReport for Unigene cluster for FAM179A Gene:

genes like me logo Genes that share expression patterns with FAM179A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for FAM179A Gene

Orthologs for FAM179A Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM179A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM179A 34 35
  • 98.66 (n)
(Bos Taurus)
Mammalia FAM179A 34 35
  • 83.19 (n)
(Canis familiaris)
Mammalia FAM179A 34 35
  • 83.06 (n)
(Rattus norvegicus)
Mammalia Fam179a 34
  • 78.92 (n)
(Mus musculus)
Mammalia Fam179a 34 16 35
  • 78.74 (n)
(Monodelphis domestica)
Mammalia FAM179A 35
  • 55 (a)
(Ornithorhynchus anatinus)
Mammalia FAM179A 35
  • 50 (a)
(Gallus gallus)
Aves FAM179A 34 35
  • 61.12 (n)
(Anolis carolinensis)
Reptilia FAM179A 35
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam179a 34
  • 54.11 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG42399 35
  • 7 (a)
(Caenorhabditis elegans)
Secernentea che-12 35
  • 10 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 22 (a)
Species where no ortholog for FAM179A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for FAM179A Gene

Gene Tree for FAM179A (if available)
Gene Tree for FAM179A (if available)

Paralogs for FAM179A Gene

Paralogs for FAM179A Gene

(1) SIMAP similar genes for FAM179A Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FAM179A: view

Variants for FAM179A Gene

Sequence variations from dbSNP and Humsavar for FAM179A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10176016 -- 28,982,933(+) TAATT(C/T)TTCCT intron-variant
rs10181032 -- 28,988,696(+) TCCAA(C/T)CTCTC intron-variant
rs10196050 -- 28,988,966(+) TAGGG(C/T)CTCCC intron-variant
rs10208411 -- 29,043,034(+) GGTGA(C/T)GGAGG intron-variant
rs1026044 -- 29,043,593(+) CACCT(A/G)CCCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM179A Gene

Variant ID Type Subtype PubMed ID
dgv2088e59 CNV duplication 20981092
dgv213n21 CNV loss 19592680
dgv592e201 CNV deletion 23290073
dgv686e199 CNV deletion 23128226
dgv687e199 CNV deletion 23128226
dgv688e199 CNV deletion 23128226
esv1152713 CNV deletion 17803354
esv2162111 CNV deletion 18987734
esv2660458 CNV deletion 23128226
esv2670234 CNV deletion 23128226
esv2719845 CNV deletion 23290073
esv2719846 CNV deletion 23290073
esv2719847 CNV deletion 23290073
esv2719849 CNV deletion 23290073
esv2719852 CNV deletion 23290073
esv2719853 CNV deletion 23290073
esv2719854 CNV deletion 23290073
esv2719855 CNV deletion 23290073
esv2759035 CNV gain 17122850
esv2762437 CNV loss 21179565
esv34904 CNV gain 17911159
esv3583692 CNV loss 25503493
esv3583695 CNV loss 25503493
esv3583696 CNV loss 25503493
esv3590167 CNV gain 21293372
esv3590168 CNV loss 21293372
esv4275 CNV loss 18987735
esv7077 CNV loss 19470904
nsv1008490 CNV gain 25217958
nsv1072401 CNV deletion 25765185
nsv1134845 CNV deletion 24896259
nsv1138761 CNV deletion 24896259
nsv1151130 CNV duplication 26484159
nsv2657 CNV deletion 18451855
nsv525642 CNV gain 19592680
nsv528652 CNV gain 19592680
nsv581247 CNV loss 21841781

Variation tolerance for FAM179A Gene

Residual Variation Intolerance Score: 99.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 21.30; 99.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM179A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM179A Gene

Disorders for FAM179A Gene

Relevant External Links for FAM179A

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM179A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM179A Gene

Publications for FAM179A Gene

  1. Genome-wide association study of recurrent early-onset major depressive disorder. (PMID: 20125088) Shi J. … Levinson D.F. (Mol. Psychiatry 2011) 3 46 64
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 2 3 64
  3. Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9. (PMID: 24376456) Simino J. … Rao D.C. (Front Genet 2013) 3 64
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64

Products for FAM179A Gene

Sources for FAM179A Gene

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