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FAM179A Gene

protein-coding   GIFtS: 43
GCID: GC02P029179

Family With Sequence Similarity 179, Member A

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 179, Member A1 2
Protein FAM179A2

External Ids:    HGNC: 337151   Entrez Gene: 1651862   Ensembl: ENSG000001893507   UniProtKB: Q6ZUX33   

Export aliases for FAM179A gene to outside databases

Previous GC identifer: GC02P029032


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM179A Gene:
FAM179A (family with sequence similarity 179, member A) is a protein-coding gene. An important paralog of this gene is FAM179B.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAM179A gene promoter:
         GR   Pbx1a   p53   GR-beta   AREB6   FOXO1a   GR-alpha   Pax-4a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM179A promoter sequence
   Search Chromatin IP Primers for FAM179A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM179A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23.2   Ensembl cytogenetic band:  2p23.2   HGNC cytogenetic band: 2p23.2

FAM179A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM179A gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P029179:  view genomic region     (about GC identifiers)

Start:
29,179,477 bp from pter      End:
29,284,239 bp from pter
Size:
104,763 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: F179A_HUMAN, Q6ZUX3 (See protein sequence)
Recommended Name: Protein FAM179A  
Size: 1019 amino acids; 111153 Da
Secondary accessions: Q6ZUF5
Alternative splicing: 3 isoforms:  Q6ZUX3-1   Q6ZUX3-2   Q6ZUX3-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FAM179A: NX_Q6ZUX3

Explore proteomics data for FAM179A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FAM179A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_954974.2  
    ENSEMBL proteins: 
     ENSP00000384897   ENSP00000402415   ENSP00000368876   ENSP00000396739   ENSP00000384699  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR011989 ARM-like
     IPR028401 FAM179
     IPR024395 CLASP_N_dom
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q6ZUX3

    ProtoNet protein and cluster: Q6ZUX3

    1 Blocks protein domain: IPB000357 HEAT repeat

    UniProtKB/Swiss-Prot: F179A_HUMAN, Q6ZUX3
    Similarity: Belongs to the FAM179 family


    Find genes that share domains with FAM179A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
         
    Find genes that share ontologies with FAM179A           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for FAM179A:
     Increased HPV18 LCR reporter a 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAM179A
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    miRTarBase miRNAs that target FAM179A:
    hsa-mir-335-5p (MIRT017561)

    Block miRNA regulation of human, mouse, rat FAM179A using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate FAM179A:
    hsa-miR-138-1*
    SwitchGear 3'UTR luciferase reporter plasmidFAM179A 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FAM179A

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    extracellular1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM179A
    Interactions:

        Search GeneGlobe Interaction Network for FAM179A

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM179A (F179A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FAM179A gene: 
    NM_199280.2  

    Unigene Cluster for FAM179A:

    Family with sequence similarity 179, member A
    Hs.525977  [show with all ESTs]
    Unigene Representative Sequence: NM_199280
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000401723 ENST00000420297 ENST00000379558(uc010ezl.3 uc010ymm.2 uc002rmr.4)
    ENST00000465300 ENST00000440012 ENST00000460951 ENST00000475900(uc002rms.1)
    ENST00000403861
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate FAM179A:
    hsa-miR-138-1*
    SwitchGear 3'UTR luciferase reporter plasmidFAM179A 3' UTR sequence
    Inhib. RNA
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    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FAM179A
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat FAM179A
      QuantiFast Probe-based Assays in human, mouse, rat FAM179A

    Additional mRNA sequence: 

    AK125239.1 AK296977.1 

    5 DOTS entries:

    DT.100016081  DT.101976405  DT.121035204  DT.91963696  DT.95086536 

    18 AceView cDNA sequences:

    BQ772038 AK125239 AK125744 NM_199280 BG656432 AI799168 BU101516 AW002821 
    AI632621 AI657079 BU687028 BI828991 BG656126 BM686358 AI860547 N53431 
    BE159786 BE159784 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM179A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTATATTTTG
    FAM179A Expression
    About this image

    FAM179A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM179A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.525977
        Custom PCR Arrays for FAM179A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM179A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FAM179A gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam179a1 , 5 family with sequence similarity 179, member A1, 5 78.74(n)1
    72.82(a)1
      17 (42.06 cM)5
    3201591  NM_177087.41  NP_796061.21 
     716732615 
    chicken
    (Gallus gallus)
    Aves FAM179A1 family with sequence similarity 179, member A 61.12(n)
    51.63(a)
      421296  NM_001277797.1  NP_001264726.1 
    lizard
    (Anolis carolinensis)
    Reptilia FAM179A6
    family with sequence similarity 179, member A
    57(a)
    1 ↔ 1
    1(248474139-248491764)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fam179a1 family with sequence similarity 179, member A 54.11(n)
    43.35(a)
      100495375  XM_004914816.1  XP_004914873.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG423996
    --
    7(a)
    1 → many
    2L(144231-153288)
    worm
    (Caenorhabditis elegans)
    Secernentea che-126
    Protein CHE-12, isoform a
    10(a)
    1 → many
    V(10299473-10307354) WBGene00000491


    ENSEMBL Gene Tree for FAM179A (if available)
    TreeFam Gene Tree for FAM179A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM179A gene
    FAM179B2  
    1 SIMAP similar gene for FAM179A using alignment to 5 protein entries:     F179A_HUMAN (see all proteins):
    FAM179B

    Find genes that share paralogs with FAM179A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM179A (see all 1906)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs677441621,2
    C--28973907(+) AGCAG-/GTGT  
            
    GTGTG
    1 -- int10--------
    rs75716861,2
    C,F,A,H--29202192(+) CTGGCG/AGGCAC 1 -- us2k113Minor allele frequency- A:0.22NS EA NA WA 788
    rs1150269001,2
    C,F--29202312(+) CTGGGA/GTCAGA 1 -- us2k11Minor allele frequency- G:0.01NA 120
    rs65479001,2
    C,F,A,H--29202386(+) CCTCCT/CTTATT 1 -- us2k128Minor allele frequency- C:0.22NS EA NA WA CSA 2778
    rs1425397251,2
    --29202396(+) TGCAGC/GTAACA 1 -- us2k10--------
    rs1160542151,2
    C,F--29202436(+) GCCTCT/CCTCCA 1 -- us2k11Minor allele frequency- C:0.01WA 118
    rs758937991,2
    F--29202456(+) TCCTGA/GGGGCA 1 -- us2k11Minor allele frequency- G:0.04WA 118
    rs1851520611,2
    --29202503(+) AGAGCA/GTGGCC 1 -- us2k10--------
    rs1911216581,2
    --29202531(+) CATAAC/TGCTCG 1 -- us2k10--------
    rs728574161,2
    C,F--29202580(+) TGAAGG/AAGGAT 1 -- us2k17Minor allele frequency- A:0.18WA NA CSA EA 365

    HapMap Linkage Disequilibrium report for FAM179A (29179477 - 29284239 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FAM179A (see all 24):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv687e199CNV Deletion23128226
    esv2162111CNV Deletion18987734
    esv2719845CNV Deletion23290073
    dgv633e201CNV Deletion23290073
    esv2670234CNV Deletion23128226
    esv2719849CNV Deletion23290073
    esv4275CNV Deletion18987735
    esv2719855CNV Deletion23290073
    dgv686e199CNV Deletion23128226
    esv2719852CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FAM179A
    DNA2.0 Custom Variant and Variant Library Synthesis for FAM179A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with FAM179A           About GenesLikeMe

    Genetic Association Database (GAD): FAM179A

    Export disorders for FAM179A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM179A gene integrated from 10 sources:
    (articles sorted by number of sources associating them with FAM179A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association study of recurrent early-onset major depressive disorder. (PubMed id 20125088)1, 4 Shi J....Levinson D.F. (Mol. Psychiatry 2011)
    2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1, 3 Kimura K.... Sugano S. (Genome Res. 2006)
    3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 165186 HGNC: 33715 AceView: LOC165186 Ensembl:ENSG00000189350 euGenes: HUgn165186
    ECgene: FAM179A H-InvDB: FAM179A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM179A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM179A gene:
    Search GeneIP for patents involving FAM179A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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