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Aliases for FAM178B Gene

Aliases for FAM178B Gene

  • Family With Sequence Similarity 178, Member B 2 3

External Ids for FAM178B Gene

Previous GeneCards Identifiers for FAM178B Gene

  • GC02M097541
  • GC02M091501

Summaries for FAM178B Gene

GeneCards Summary for FAM178B Gene

FAM178B (Family With Sequence Similarity 178, Member B) is a Protein Coding gene. An important paralog of this gene is SLF2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM178B Gene

Genomics for FAM178B Gene

Regulatory Elements for FAM178B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM178B Gene

96,875,882 bp from pter
97,018,438 bp from pter
142,557 bases
Minus strand

Genomic View for FAM178B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM178B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM178B Gene

Proteins for FAM178B Gene

  • Protein details for FAM178B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM178B
    Protein Accession:
    Secondary Accessions:
    • A8MXN2
    • E9PD86
    • Q8IUY0
    • Q9P0P4

    Protein attributes for FAM178B Gene

    827 amino acids
    Molecular mass:
    93514 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF36154.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=AAF36154.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM178B Gene


neXtProt entry for FAM178B Gene

Proteomics data for FAM178B Gene at MOPED

Post-translational modifications for FAM178B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM178B Gene

No data available for DME Specific Peptides for FAM178B Gene

Domains & Families for FAM178B Gene

Protein Domains for FAM178B Gene


Suggested Antigen Peptide Sequences for FAM178B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM178 family.
  • Belongs to the FAM178 family.
genes like me logo Genes that share domains with FAM178B: view

No data available for Gene Families for FAM178B Gene

Function for FAM178B Gene

genes like me logo Genes that share phenotypes with FAM178B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM178B Gene

Localization for FAM178B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for FAM178B Gene

Pathways & Interactions for FAM178B Gene

SuperPathways for FAM178B Gene

No Data Available

Interacting Proteins for FAM178B Gene

Selected Interacting proteins: Q8IXR5-F178B_HUMAN for FAM178B Gene via MINT I2D

Gene Ontology (GO) - Biological Process for FAM178B Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM178B Gene

Drugs & Compounds for FAM178B Gene

No Compound Related Data Available

Transcripts for FAM178B Gene

Unigene Clusters for FAM178B Gene

Family with sequence similarity 178, member B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM178B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM178B Gene

No ASD Table

Relevant External Links for FAM178B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM178B Gene

mRNA expression in normal human tissues for FAM178B Gene

mRNA differential expression in normal tissues according to GTEx for FAM178B Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x7.0), Testis (x5.2), and Nerve - Tibial (x4.0).

SOURCE GeneReport for Unigene cluster for FAM178B Gene Hs.107922

genes like me logo Genes that share expression patterns with FAM178B: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FAM178B Gene

Orthologs for FAM178B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM178B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM178B 35
  • 78.99 (n)
  • 68.17 (a)
FAM178B 36
  • 66 (a)
(Canis familiaris)
Mammalia FAM178B 35
  • 79.88 (n)
  • 73.47 (a)
FAM178B 36
  • 69 (a)
(Mus musculus)
Mammalia Fam178b 35
  • 77.95 (n)
  • 72.47 (a)
Fam178b 16
Fam178b 36
  • 70 (a)
(Pan troglodytes)
Mammalia FAM178B 35
  • 98.83 (n)
  • 98.62 (a)
FAM178B 36
  • 78 (a)
(Rattus norvegicus)
Mammalia Fam178b 35
  • 72.3 (n)
  • 66.9 (a)
(Monodelphis domestica)
Mammalia FAM178B 36
  • 40 (a)
(Ornithorhynchus anatinus)
Mammalia FAM178B 36
  • 10 (a)
(Gallus gallus)
Aves FAM178B 35
  • 54.41 (n)
  • 40.48 (a)
FAM178B 36
  • 25 (a)
(Anolis carolinensis)
Reptilia FAM178B 36
  • 40 (a)
Species with no ortholog for FAM178B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM178B Gene

Gene Tree for FAM178B (if available)
Gene Tree for FAM178B (if available)

Paralogs for FAM178B Gene

Paralogs for FAM178B Gene Pseudogenes for FAM178B Gene

genes like me logo Genes that share paralogs with FAM178B: view

Variants for FAM178B Gene

Sequence variations from dbSNP and Humsavar for FAM178B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1257007 -- 96,969,577(-) CTTGT(C/T)GGTGT intron-variant
rs1257008 -- 96,968,935(-) CCGGT(C/T)AGGAC intron-variant
rs1257009 -- 96,968,469(-) GAGGG(A/G)CCAGA intron-variant
rs1257010 -- 96,968,077(-) AATCC(G/T)AGTGC intron-variant
rs1257011 -- 96,968,035(-) GAAAT(C/T)GCTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM178B Gene

Variant ID Type Subtype PubMed ID
dgv650e201 CNV Deletion 23290073
esv5003 CNV Complex 18987735
nsv874677 CNV Loss 21882294
nsv874680 CNV Loss 21882294
nsv526313 CNV Loss 19592680
dgv4249n71 CNV Loss 21882294
essv10696 CNV CNV 17122850
esv718 CNV CNV 17122850
nsv512773 CNV Insertion 21212237
esv32727 CNV Gain+Loss 17666407

Variation tolerance for FAM178B Gene

Gene Damage Index Score: 6.11; 75.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM178B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM178B Gene

Disorders for FAM178B Gene

Relevant External Links for FAM178B

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FAM178B: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM178B Gene

Publications for FAM178B Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 67
  2. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H. … Espeseth A.S. (Cell Host Microbe 2008) 67
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 67
  4. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 67
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 67

Products for FAM178B Gene

Sources for FAM178B Gene

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