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FAM178B Gene

protein-coding   GIFtS: 40
GCID: GC02M097541

Family With Sequence Similarity 178, Member B

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 178, Member B1 2
Protein FAM178B2

External Ids:    HGNC: 280361   Entrez Gene: 512522   Ensembl: ENSG000001687547   UniProtKB: Q8IXR53   

Export aliases for FAM178B gene to outside databases

Previous GC identifers: GC02M096906 GC02M091501


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM178B Gene:
FAM178B (family with sequence similarity 178, member B) is a protein-coding gene. An important paralog of this gene is FAM178A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAM178B gene promoter:
         HFH-3   E2F-4   E2F-3a   E2F-5   ATF-2   E2F-2   FOXI1   E2F   E2F-1   FOXC1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM178B promoter sequence
   Search Chromatin IP Primers for FAM178B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM178B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11.2   Ensembl cytogenetic band:  2q11.2   HGNC cytogenetic band: 2q11.2

FAM178B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM178B gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M097541:  view genomic region     (about GC identifiers)

Start:
97,541,619 bp from pter      End:
97,684,175 bp from pter
Size:
142,557 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: F178B_HUMAN, Q8IXR5 (See protein sequence)
Recommended Name: Protein FAM178B  
Size: 827 amino acids; 93514 Da
Sequence caution: Sequence=AAF36154.1; Type=Erroneous translation; Note=Wrong choice of frame;
Sequence=AAF36154.1; Type=Frameshift; Positions=Several;
Secondary accessions: A8MXN2 E9PD86 Q8IUY0 Q9P0P4
Alternative splicing: 3 isoforms:  Q8IXR5-1   Q8IXR5-2   Q8IXR5-3   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for FAM178B: NX_Q8IXR5

Explore proteomics data for FAM178B at MOPED


See FAM178B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (3 alternative transcripts): 
NP_001116118.2  NP_001166138.1  NP_057574.2  

ENSEMBL proteins: 
 ENSP00000377160   ENSP00000429896   ENSP00000413245   ENSP00000333553  

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antibodies-online antibodies for FAM178B (2 products) 

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antibodies-online kits for FAM178B (4 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR026161 FAM178

Graphical View of Domain Structure for InterPro Entry Q8IXR5

ProtoNet protein and cluster: Q8IXR5

UniProtKB/Swiss-Prot: F178B_HUMAN, Q8IXR5
Similarity: Belongs to the FAM178 family


Find genes that share domains with FAM178B           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Phenotypes:
     4 GenomeRNAi human phenotypes for FAM178B:
 Decreased homologous recombina  Increased G2M DNA content  Increased cell number in G2M,   Synthetic lethal with Ras 

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for FAM178B

miRNA
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3 qRT-PCR Assays for microRNAs that regulate FAM178B:
hsa-miR-542-3p hsa-miR-3176 hsa-miR-3922-3p
SwitchGear 3'UTR luciferase reporter plasmidFAM178B 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat FAM178B

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM178B


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol1
endoplasmic reticulum1
extracellular1
mitochondrion1
peroxisome1
plasma membrane1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM178B
Interactions:

    Search GeneGlobe Interaction Network for FAM178B

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

2 Interacting proteins for FAM178B (Q8IXR52, 3 ENSP000003335534) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
LRSAM1Q6UWE02, 3, ENSP000003004174MINT-64688 I2D: score=5 STRING: ENSP00000300417
ZNF598Q86UK73I2D: score=2 
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for FAM178B (F178B)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for FAM178B gene (3 alternative transcripts): 
NM_001122646.2  NM_001172667.1  NM_016490.4  

Unigene Cluster for FAM178B:

Family with sequence similarity 178, member B
Hs.107922  [show with all ESTs]
Unigene Representative Sequence: NM_001122646
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000393526(uc002sxj.4) ENST00000490605 ENST00000470789 ENST00000494172
ENST00000478671 ENST00000520074 ENST00000417561 ENST00000327896(uc002sxi.4 uc002sxk.4 uc002sxl.4)

miRNA
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3 qRT-PCR Assays for microRNAs that regulate FAM178B:
hsa-miR-542-3p hsa-miR-3176 hsa-miR-3922-3p
SwitchGear 3'UTR luciferase reporter plasmidFAM178B 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for FAM178B
Predesigned siRNA for gene silencing in human, mouse, rat FAM178B
Clone
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Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FAM178B
Primer
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Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FAM178B
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  QuantiFast Probe-based Assays in human, mouse, rat FAM178B

Additional mRNA sequence: 

AF151068.1 AK122705.1 AK308698.1 BC038583.1 BC039488.1 BC051379.1 

6 DOTS entries:

DT.99932631  DT.99935651  DT.403333  DT.99961327  DT.103122  DT.95190733 

Selected AceView cDNA sequences (see all 25):

AI148629 AK122705 BC038583 NM_016490 BX103404 BU628905 BM007607 N55428 
BC051379 AA447592 AA448091 AI087961 BI834707 BC039488 H67099 N55496 
N76801 BM471664 N68280 H80588 BF240113 N76984 AF151068 BF746694 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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FAM178B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CTGACCAGCC
FAM178B Expression
About this image

FAM178B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

FAM178B Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.107922
    Custom PCR Arrays for FAM178B
Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for FAM178B
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QuantiFast Probe-based Assays in human, mouse, rat FAM178B
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM178B

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for FAM178B gene from Selected species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Fam178b1 , 5 family with sequence similarity 178, member B1, 5 77.95(n)1
72.47(a)1
  1 (15.33 cM)5
3813371  NM_001126046.11  NP_001119518.11 
 365626965 
chicken
(Gallus gallus)
Aves FAM178B1 family with sequence similarity 178, member B 54.41(n)
40.48(a)
  425134  XM_422925.4  XP_422925.4 
lizard
(Anolis carolinensis)
Reptilia FAM178B6
family with sequence similarity 178, member B
40(a)
1 ↔ 1
GL343484.1(165510-317497)


ENSEMBL Gene Tree for FAM178B (if available)
TreeFam Gene Tree for FAM178B (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for FAM178B gene
FAM178A2  

Find genes that share paralogs with FAM178B           About GenesLikeMe


2 Pseudogenes.org Pseudogenes for FAM178B
PGOHUM00000240205 PGOHUM00000240797


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for FAM178B (see all 2168)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 2 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs788745981,2
C,F--97541180(+) ATGAAC/TTCATC 3 -- int12Minor allele frequency- T:0.03WA NA 238
rs75817641,2
C,F,A,H--97541238(+) TGAACC/TGCCCC 3 -- int125Minor allele frequency- T:0.34NS EA NA WA CSA 2348
rs1916561161,2
--97541239(+) GAACTA/GCCCCC 3 -- int10--------
rs1390179371,2
--97541297(+) TTAAGA/TGTAAT 3 -- int10--------
rs1406958791,2
--97541333(+) TGTGCA/GTCCTC 3 -- int10--------
rs1841992321,2
--97541335(+) TGCGTC/TCTCCT 3 -- int10--------
rs2018356821,2
--97541452(+) CCCCT-/CCCCGG 3 -- int10--------
rs1880951561,2
--97541580(+) CATGAA/GCCCTC 3 -- int10--------
rs1810512961,2
C--97541601(+) CTGAAA/GGAAGT 3 -- int10--------
rs1412202641,2
--97541602(+) TGAAGG/TAAGTG 3 -- int10--------

HapMap Linkage Disequilibrium report for FAM178B (97541619 - 97684175 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10 variations for FAM178B:    About this table    
Variant IDTypeSubtypePubMed ID
dgv650e201CNV Deletion23290073
nsv512773CNV Insertion21212237
dgv4249n71CNV Loss21882294
nsv874680CNV Loss21882294
nsv526313CNV Loss19592680
nsv874677CNV Loss21882294
esv32727CNV Gain+Loss17666407
esv718CNV CNV17122850
essv10696CNV CNV17122850
esv5003CNV Complex18987735

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing FAM178B
DNA2.0 Custom Variant and Variant Library Synthesis for FAM178B

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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Find genes that share disorders with FAM178B           About GenesLikeMe

Genetic Association Database (GAD): FAM178B

Export disorders for FAM178B gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for FAM178B gene integrated from 10 sources:
(articles sorted by number of sources associating them with FAM178B)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
  2. Genome-scale RNAi screen for host factors required for HIV replication. (PubMed id 18976975)1 Zhou H....Espeseth A.S. (amp 2008)
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  4. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 51252 HGNC: 28036 AceView: LOC51252 Ensembl:ENSG00000168754 euGenes: HUgn51252
ECgene: FAM178B H-InvDB: FAM178B

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for FAM178B Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for FAM178B gene:
Search GeneIP for patents involving FAM178B

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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