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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAM178B Gene

protein-coding   GIFtS: 41
GCID: GC02M097541

Family With Sequence Similarity 178, Member B

  Search for FAM178B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Family With Sequence Similarity 178, Member B1 2
Protein FAM178B2

External Ids:    HGNC: 280361   Entrez Gene: 512522   Ensembl: ENSG000001687547   UniProtKB: Q8IXR53   

Export aliases for FAM178B gene to outside databases

Previous GC identifers: GC02M096906 GC02M091501


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FAM178B Gene: 
FAM178B (family with sequence similarity 178, member B) is a protein-coding gene. An important paralog of this gene is FAM178A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022171.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FAM178B gene promoter:
         HFH-3   E2F-4   E2F-3a   E2F-5   ATF-2   E2F-2   FOXI1   E2F   E2F-1   FOXC1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM178B promoter sequence
   Search SABiosciences Chromatin IP Primers for FAM178B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM178B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11.2   Ensembl cytogenetic band:  2q11.2   HGNC cytogenetic band: 2q11.2

FAM178B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM178B gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M097541:  view genomic region     (about GC identifiers)

Start:
97,541,619 bp from pter      End:
97,684,175 bp from pter
Size:
142,557 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: F178B_HUMAN, Q8IXR5 (See protein sequence)
Recommended Name: Protein FAM178B  
Size: 827 amino acids; 93514 Da
Sequence caution: Sequence=AAF36154.1; Type=Erroneous translation; Note=Wrong choice of frame;
Sequence=AAF36154.1; Type=Frameshift; Positions=Several;
Secondary accessions: A8MXN2 E9PD86 Q8IUY0 Q9P0P4
Alternative splicing: 3 isoforms:  Q8IXR5-1   Q8IXR5-2   Q8IXR5-3   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for FAM178B: NX_Q8IXR5

Explore proteomics data for FAM178B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IXR5

  • FAM178B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FAM178B Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001116118.2  NP_001166138.1  NP_057574.2  

    ENSEMBL proteins: 
     ENSP00000377160   ENSP00000429896   ENSP00000413245   ENSP00000333553  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR026161 FAM178

    Graphical View of Domain Structure for InterPro Entry Q8IXR5

    ProtoNet protein and cluster: Q8IXR5

    UniProtKB/Swiss-Prot: F178B_HUMAN, Q8IXR5
    Similarity: Belongs to the FAM178 family


    FAM178B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         4 GenomeRNAi human phenotypes for FAM178B:
     Decreased homologous recombina  Increased G2M DNA content  Increased cell number in G2M,   Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FAM178B 
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    SwitchGear 3'UTR luciferase reporter plasmidFAM178B 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM178B


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM178B

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for FAM178B (Q8IXR52, 3 ENSP000003335534) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LRSAM1Q6UWE02, 3, ENSP000003004174MINT-64688 I2D: score=5 STRING: ENSP00000300417
    ZNF598Q86UK73I2D: score=2 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FAM178B (F178B)

    Search CenterWatch for drugs/clinical trials and news about FAM178B / F178B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FAM178B gene (3 alternative transcripts): 
    NM_001122646.2  NM_001172667.1  NM_016490.4  

    Unigene Cluster for FAM178B:

    Family with sequence similarity 178, member B
    Hs.107922  [show with all ESTs]
    Unigene Representative Sequence: NM_001122646
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393526(uc002sxj.4) ENST00000490605 ENST00000470789 ENST00000494172
    ENST00000478671 ENST00000520074 ENST00000417561 ENST00000327896(uc002sxi.4 uc002sxk.4 uc002sxl.4)

    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate FAM178B:
    hsa-miR-542-3p hsa-miR-3176 hsa-miR-3922-3p
    SwitchGear 3'UTR luciferase reporter plasmidFAM178B 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FAM178B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM178B
    Clone
    Products:
         
    OriGene clones in human, mouse for FAM178B (see all 12)
    OriGene ORF clones in mouse, rat for FAM178B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): FAM178B (NM_001172667)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM178B
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FAM178B
    Sirion Biotech Customized lentivirus for stable overexpression of FAM178B 
                         Customized lentivirus expression plasmids for stable overexpression of FAM178B 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for FAM178B
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FAM178B
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM178B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM178B

    Additional mRNA sequence: 

    AF151068.1 AK122705.1 AK308698.1 BC038583.1 BC039488.1 BC051379.1 

    6 DOTS entries:

    DT.99932631  DT.99935651  DT.403333  DT.99961327  DT.103122  DT.95190733 

    24/25 AceView cDNA sequences (see all 25):

    NM_016490 BC038583 BX103404 AI148629 AK122705 N55428 AA448091 BC039488 
    AA447592 AI087961 BC051379 BU628905 BM007607 BI834707 N76801 N55496 
    H67099 BM471664 N68280 H80588 N76984 BF240113 AF151068 N80976 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FAM178B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGACCAGCC
    FAM178B Expression
    About this image


    See FAM178B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FAM178B

    SOURCE GeneReport for Unigene cluster: Hs.107922
        SABiosciences Custom PCR Arrays for FAM178B
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for FAM178B
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    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM178B
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM178B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM178B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FAM178B gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam178b1 , 5 family with sequence similarity 178, member B1, 5 77.95(n)1
    72.47(a)1
      1 (15.33 cM)5
    3813371  NM_001126046.11  NP_001119518.11 
     365626965 
    chicken
    (Gallus gallus)
    Aves LOC4251341 protein FAM178B-like 55.35(n)
    40.83(a)
      425134  XM_422925.3  XP_422925.3 
    lizard
    (Anolis carolinensis)
    Reptilia FAM178B6
    family with sequence similarity 178, member B
    41(a)
    1 ↔ 1
    GL343484.1(165510-317497)
    zebrafish
    (Danio rerio)
    Actinopterygii fam178a6
    family with sequence similarity 178, member A
    12(a)
    1 → many
    13(8982107-9021722)


    ENSEMBL Gene Tree for FAM178B (if available)
    TreeFam Gene Tree for FAM178B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FAM178B gene
    FAM178A2  

    FAM178B for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for FAM178B
    PGOHUM00000240205 PGOHUM00000240797


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2168 SNPs in FAM178B are shown (see all 2168)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs788745981,2
    C,F--97541180(+) ATGAAC/TTCATC 3 -- int12Minor allele frequency- T:0.03WA NA 238
    rs75817641,2
    C,F,A,H--97541238(+) TGAACC/TGCCCC 3 -- int125Minor allele frequency- T:0.34NS EA NA WA CSA 2348
    rs1916561161,2
    --97541239(+) GAACTA/GCCCCC 3 -- int10--------
    rs1390179371,2
    --97541297(+) TTAAGA/TGTAAT 3 -- int10--------
    rs1406958791,2
    --97541333(+) TGTGCA/GTCCTC 3 -- int10--------
    rs1841992321,2
    --97541335(+) TGCGTC/TCTCCT 3 -- int10--------
    rs2018356821,2
    --97541452(+) CCCCT-/CCCCGG 3 -- int10--------
    rs1880951561,2
    --97541580(+) CATGAA/GCCCTC 3 -- int10--------
    rs1810512961,2
    C--97541601(+) CTGAAA/GGAAGT 3 -- int10--------
    rs1412202641,2
    --97541602(+) TGAAGG/TAAGTG 3 -- int10--------

    HapMap Linkage Disequilibrium report for FAM178B (97541619 - 97684175 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for FAM178B:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv650e201CNV Deletion23290073
    nsv512773CNV Insertion21212237
    dgv4249n71CNV Loss21882294
    nsv874680CNV Loss21882294
    nsv526313CNV Loss19592680
    nsv874677CNV Loss21882294
    esv32727CNV Gain+Loss17666407
    esv718CNV CNV17122850
    essv10696CNV CNV17122850
    esv5003CNV Complex18987735

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing FAM178B
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    FAM178B for disorders           About MalaCards

    FAM178B for disorders           About GeneDecksing

    Genetic Association Database (GAD): FAM178B

    Export disorders for FAM178B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FAM178B gene integrated from 9 sources:
    (articles sorted by number of sources associating them with FAM178B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (2000)
    2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    3. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51252 HGNC: 28036 AceView: LOC51252 Ensembl:ENSG00000168754 euGenes: HUgn51252
    ECgene: FAM178B H-InvDB: FAM178B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FAM178B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FAM178B gene:
    Search GeneIP for patents involving FAM178B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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