FAM178B Gene
protein-coding GIFtS: 41
GCID: GC02M097541
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Family With Sequence Similarity 178, Member B
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Aliases
for FAM178B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
About This Section
|
| Aliases |
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| Family With Sequence Similarity 178, Member B1 2 | | Protein FAM178B2 |
Export aliases for FAM178B gene to outside databasesPrevious GC identifers: GC02M096906 GC02M091501 |
Summaries
for FAM178B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
GeneCards Summary for FAM178B Gene: 
FAM178B (family with sequence similarity 178, member B) is a protein-coding gene. An important paralog of this gene is FAM178A.
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Genomic Views
for FAM178B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 73),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NT_022171.15 NC_018913.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FAM178B gene promoter:
HFH-3 E2F-4 E2F-3a E2F-5 ATF-2 E2F-2 FOXI1 E2F E2F-1 FOXC1
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM178B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM178B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q11.2 Ensembl cytogenetic band: 2q11.2 HGNC cytogenetic band: 2q11.2FAM178B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M097541: view genomic region
(about GC identifiers)
Start:
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97,541,619 bp from pter |
End:
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97,684,175 bp from pter |
Size:
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142,557 bases |
Orientation:
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minus strand |
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Proteins
for FAM178B gene
(According to
UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MAXQB
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Ontologies according to Gene
Ontology Consortium 01 Oct 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
About This Section
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UniProtKB/Swiss-Prot: F178B_HUMAN, Q8IXR5 (See
protein sequence)Recommended Name: Protein FAM178B Size: 827 amino acids; 93514 Da
Sequence caution: Sequence=AAF36154.1; Type=Erroneous translation; Note=Wrong choice of frame; Sequence=AAF36154.1;Type=Frameshift; Positions=Several;
Secondary accessions: A8MXN2 E9PD86 Q8IUY0 Q9P0P4Alternative splicing: 3 isoforms: Q8IXR5-1 Q8IXR5-2 Q8IXR5-3 (Gene prediction based on EST data)Explore the universe of human proteins at neXtProt for FAM178B: NX_Q8IXR5
Explore proteomics data for FAM178B at MOPED
Post-translational modifications:
View modification sites using PhosphoSitePlusView neXtProt modification sites for NX_Q8IXR5
FAM178B Protein expression data from MOPED1, PaxDb2 and
MAXQB3 : About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001116118.2 NP_001166138.1 NP_057574.2
ENSEMBL proteins: ENSP00000377160 ENSP00000429896 ENSP00000413245 ENSP00000333553
Human Recombinant Protein Products for FAM178B:
FAM178B Antibody Products:
Assay Products for FAM178B: |
Protein
Domains /
Families
for FAM178B gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| 1 InterPro protein domain:Graphical View of Domain Structure for InterPro Entry Q8IXR5 ProtoNet protein and cluster: Q8IXR5 UniProtKB/Swiss-Prot: F178B_HUMAN, Q8IXR5Similarity: Belongs to the FAM178 family
FAM178B for domains About GeneDecksing
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Function
for FAM178B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene.)
About This Section
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Phenotypes:
4 GenomeRNAi human phenotypes for FAM178B:
Animal Models:
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM178B |
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Pathways & Interactions
for FAM178B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM178B
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
2 Interacting proteins for FAM178B (Q8IXR52, 3 ENSP000003335534) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for FAM178B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
IUPHAR,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM178B (F178B)
Search CenterWatch for drugs/clinical trials and news about FAM178B / F178B
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Transcripts
for FAM178B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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REFSEQ mRNAs for FAM178B gene (3 alternative transcripts): NM_001122646.2 NM_001172667.1 NM_016490.4 Unigene Cluster for FAM178B: Family with sequence similarity 178, member B Hs.107922 [show with all ESTs]Unigene Representative Sequence: NM_0011226468 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000393526(uc002sxj.4) ENST00000490605 ENST00000470789 ENST00000494172
ENST00000478671 ENST00000520074 ENST00000417561 ENST00000327896(uc002sxi.4 uc002sxk.4 uc002sxl.4)
Primer
Products: |  | OriGene qSTAR qPCR primer pairs in human, mouse for FAM178B
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FAM178B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM178B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM178B |
Additional mRNA sequence: AF151068.1 AK122705.1 AK308698.1 BC038583.1 BC039488.1 BC051379.1 6 DOTS entries: DT.99932631 DT.99935651 DT.403333 DT.99961327 DT.103122 DT.95190733 24/25 AceView cDNA sequences (see all 25): NM_016490 BC038583 BX103404 AI148629 AK122705 N55428 AA448091 BC039488 AA447592 AI087961 BC051379 BU628905 BM007607 BI834707 N76801 N55496 H67099 BM471664 N68280 H80588 N76984 BF240113 AF151068 N80976
GeneLoc Exon Structure
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Expression
for FAM178B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAM178B expression in normal human tissues
(normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CTGACCAGCC
About this image
See FAM178B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM178B
SOURCE GeneReport for Unigene cluster: Hs.107922
SABiosciences Custom PCR Arrays for FAM178B
Primer
Products: | | OriGene qSTAR qPCR primer pairs in human, mouse for FAM178B
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FAM178B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM178B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM178B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM178B |
Orthologs
for FAM178B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of chordates.
Orthologs for FAM178B gene from 4/10 species (see all 10) About this table
ENSEMBL Gene Tree for FAM178B (if available)
TreeFam Gene Tree for FAM178B (if available) |
Paralogs
for FAM178B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAM178B gene
- FAM178A2
FAM178B for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for FAM178B
PGOHUM00000240205 PGOHUM00000240797
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Genomic Variants
for FAM178B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for FAM178B (97541619 - 97684175 bp)
Structural Variations
Database of Genomic Variants (DGV) 10 variations for FAM178B: About this table
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM178B |
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Disorders
/ Diseases
for FAM178B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 FAM178B for disorders About MalaCards
FAM178B for disorders About GeneDecksing
Genetic Association Database (GAD): FAM178B
Export disorders for FAM178B gene to outside databases
|
Publications
for FAM178B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM178B gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM178B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (2000)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for FAM178B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing FAM178B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM178B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FAM178B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAM178B | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for FAM178B gene:
Search GeneIP for patents involving FAM178B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM178B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM178B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM178B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM178B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM178B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM178B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM178B |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM178B |
|  |  |  |  | | | | Search ThermoFisher Antibodies for FAM178B |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FAM178B |
| |  |  | | | | LSBio Antibodies in human, mouse, rat for FAM178B |
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