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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FAM178B Gene

protein-coding GIFtS: 41
GCID: GC02M097541

Family With Sequence Similarity 178, Member B

Search for FAM178B
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Family With Sequence Similarity 178, Member B¹ ²
Protein FAM178B²

External Ids:	HGNC: 28036¹	Entrez Gene: 51252²	Ensembl: ENSG00000168754⁷	UniProtKB: Q8IXR5³

Export aliases for FAM178B gene to outside databases

Previous GC identifers: GC02M096906 GC02M091501

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FAM178B Gene:

FAM178B (family with sequence similarity 178, member B) is a protein-coding gene. An important paralog of this gene is FAM178A.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NT_022171.15 NC_018913.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FAM178B gene promoter:
HFH-3 E2F-4 E2F-3a E2F-5 ATF-2 E2F-2 FOXI1 E2F E2F-1 FOXC1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FAM178B promoter sequence

Search SABiosciences Chromatin IP Primers for FAM178B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM178B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11.2 Ensembl cytogenetic band: 2q11.2 HGNC cytogenetic band: 2q11.2

FAM178B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM178B gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M097541: view genomic region (about GC identifiers)

Start:	97,541,619 bp from pter	End:	97,684,175 bp from pter
Size:	142,557 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: F178B_HUMAN, Q8IXR5 (See protein sequence)

Recommended Name: Protein FAM178B

Size: 827 amino acids; 93514 Da

Sequence caution: Sequence=AAF36154.1; Type=Erroneous translation; Note=Wrong choice of frame;

Sequence=AAF36154.1; Type=Frameshift; Positions=Several;

Secondary accessions: A8MXN2 E9PD86 Q8IUY0 Q9P0P4

Alternative splicing: 3 isoforms: Q8IXR5-1 Q8IXR5-2 Q8IXR5-3 (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for FAM178B: NX_Q8IXR5

Explore proteomics data for FAM178B at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q8IXR5

FAM178B Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins (3 alternative transcripts):

NP_001116118.2 NP_001166138.1 NP_057574.2

ENSEMBL proteins:

ENSP00000377160 ENSP00000429896 ENSP00000413245 ENSP00000333553

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

1 InterPro protein domain:

IPR026161 FAM178

Graphical View of Domain Structure for InterPro Entry Q8IXR5

ProtoNet protein and cluster: Q8IXR5

UniProtKB/Swiss-Prot: F178B_HUMAN, Q8IXR5

Similarity: Belongs to the FAM178 family

FAM178B for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Phenotypes:
4 GenomeRNAi human phenotypes for FAM178B:

Decreased homologous recombina

Increased G2M DNA content

Increased cell number in G2M,

Synthetic lethal with Ras

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for FAM178B

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FAM178B

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genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FAM178B

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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for FAM178B

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

2 Interacting proteins for FAM178B (Q8IXR5^{2, 3} ENSP00000333553⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
LRSAM1	Q6UWE0²^,³, ENSP00000300417⁴	MINT-64688 I2D: score=5 STRING: ENSP00000300417
ZNF598	Q86UK7³	I2D: score=2

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FAM178B (F178B)

Search CenterWatch for drugs/clinical trials and news about FAM178B / F178B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FAM178B gene (3 alternative transcripts):

NM_001122646.2 NM_001172667.1 NM_016490.4

Unigene Cluster for FAM178B:

Family with sequence similarity 178, member B

Hs.107922 [show with all ESTs]

Unigene Representative Sequence: NM_001122646

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000393526(uc002sxj.4) ENST00000490605 ENST00000470789 ENST00000494172

ENST00000478671 ENST00000520074 ENST00000417561 ENST00000327896(uc002sxi.4 uc002sxk.4 uc002sxl.4)

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		3 QIAGEN miScript miRNA Assays for microRNAs that regulate FAM178B:
		hsa-miR-542-3p hsa-miR-3176 hsa-miR-3922-3p
		SwitchGear 3'UTR luciferase reporter plasmid: FAM178B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM178B

Additional mRNA sequence:

AF151068.1 AK122705.1 AK308698.1 BC038583.1 BC039488.1 BC051379.1

6 DOTS entries:

DT.99932631 DT.99935651 DT.403333 DT.99961327 DT.103122 DT.95190733

24/25 AceView cDNA sequences (see all 25):

NM_016490 BC038583 BX103404 AI148629 AK122705 N55428 AA448091 BC039488

AA447592 AI087961 BC051379 BU628905 BM007607 BI834707 N76801 N55496

H67099 BM471664 N68280 H80588 N76984 BF240113 AF151068 N80976

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FAM178B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CTGACCAGCC

About this image

See FAM178B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM178B

SOURCE GeneReport for Unigene cluster: Hs.107922

SABiosciences Custom PCR Arrays for FAM178B

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM178B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for FAM178B gene from 4/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Fam178b^{1 , 5}	family with sequence similarity 178, member B^{1, 5}	77.95(n)¹ 72.47(a)¹		1 (15.33 cM)⁵ 381337¹ NM_001126046.1¹ NP_001119518.1¹ 36562696⁵
chicken (Gallus gallus)	Aves	LOC425134¹	protein FAM178B-like	55.35(n) 40.83(a)		425134 XM_422925.3 XP_422925.3
lizard (Anolis carolinensis)	Reptilia	FAM178B⁶	family with sequence similarity 178, member B	41(a)	1 ↔ 1	GL343484.1(165510-317497)
zebrafish (Danio rerio)	Actinopterygii	fam178a⁶	family with sequence similarity 178, member A	12(a)	1 → many	13(8982107-9021722)

ENSEMBL Gene Tree for FAM178B (if available)
TreeFam Gene Tree for FAM178B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FAM178B gene

FAM178A²

FAM178B for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for FAM178B
PGOHUM00000240205 PGOHUM00000240797

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs78874598^1,2	C,F	--	97541180(+)	`ATGAAC/TTCATC`	3	--	int¹		2		WA NA	238
rs7581764^1,2	C,F,A,H	--	97541238(+)	`TGAACC/TGCCCC`	3	--	int¹		25		NS EA NA WA CSA	2348
rs191656116^1,2		--	97541239(+)	`GAACTA/GCCCCC`	3	--	int¹		0	--	--	--	--
rs139017937^1,2		--	97541297(+)	`TTAAGA/TGTAAT`	3	--	int¹		0	--	--	--	--
rs140695879^1,2		--	97541333(+)	`TGTGCA/GTCCTC`	3	--	int¹		0	--	--	--	--
rs184199232^1,2		--	97541335(+)	`TGCGTC/TCTCCT`	3	--	int¹		0	--	--	--	--
rs201835682^1,2		--	97541452(+)	`CCCCT-/CCCCGG`	3	--	int¹		0	--	--	--	--
rs188095156^1,2		--	97541580(+)	`CATGAA/GCCCTC`	3	--	int¹		0	--	--	--	--
rs181051296^1,2	C	--	97541601(+)	`CTGAAA/GGAAGT`	3	--	int¹		0	--	--	--	--
rs141220264^1,2		--	97541602(+)	`TGAAGG/TAAGTG`	3	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for FAM178B (97541619 - 97684175 bp)

Structural Variations
Database of Genomic Variants (DGV) 10 variations for FAM178B: About this table

Variant ID	Type	Subtype	PubMed ID
dgv650e201	CNV	Deletion	23290073
nsv512773	CNV	Insertion	21212237
dgv4249n71	CNV	Loss	21882294
nsv874680	CNV	Loss	21882294
nsv526313	CNV	Loss	19592680
nsv874677	CNV	Loss	21882294
esv32727	CNV	Gain+Loss	17666407
esv718	CNV	CNV	17122850
essv10696	CNV	CNV	17122850
esv5003	CNV	Complex	18987735

SABiosciences Cancer Mutation PCR Assays

SeqTarget long-range PCR primers for resequencing FAM178B

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FAM178B for disorders About MalaCards

FAM178B for disorders About GeneDecksing

Genetic Association Database (GAD): FAM178B

Export disorders for FAM178B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FAM178B gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM178B)

Utopia: connect your pdf to the dynamic
world of online information

Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)^{1, 2, 3} Zhang Q.-H.... Chen Z. (2000)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)¹ Stelzl U.... Wanker E.E. (2005)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)² Hillier L.W....Wilson R.K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 51252	HGNC: 28036	AceView: LOC51252	Ensembl:ENSG00000168754	euGenes: HUgn51252
ECgene: FAM178B	H-InvDB: FAM178B

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FAM178B	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FAM178B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for FAM178B gene:
Search GeneIP for patents involving FAM178B

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section


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Search Tocris compounds for FAM178B (F178B)

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	inGenious Targeting Laboratory - Custom generated mouse model solutions for FAM178B
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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FAM178B Gene

Family With Sequence Similarity 178, Member B

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for FAM178B gene

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for FAM178B gene

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for FAM178B gene

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for FAM178B gene

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Export list of displayed genes

FAM178B Gene

Family With Sequence Similarity 178, Member B

Aliasesfor FAM178B gene

Summariesfor FAM178B gene

Genomic Viewsfor FAM178B gene

Proteinsfor FAM178B gene

Protein Domains /Familiesfor FAM178B gene

Functionfor FAM178B gene

Pathways & Interactionsfor FAM178B gene

Drugs & Compoundsfor FAM178B gene

Transcriptsfor FAM178B gene

Expression for FAM178B gene

Orthologsfor FAM178B gene

Paralogsfor FAM178B gene

Genomic Variantsfor FAM178B gene

Disorders / Diseasesfor FAM178B gene

Publicationsfor FAM178B gene

External Searches for FAM178B gene

Genome Databases showing FAM178B gene

Other Databases showing FAM178B gene

Specialized Databases showing FAM178B gene

Intellectual Propertyfor FAM178B gene

Productsfor FAM178B gene

View Random Gene

Aliases
for FAM178B gene

Summaries
for FAM178B gene

Genomic Views
for FAM178B gene

Proteins
for FAM178B gene

Protein Domains /
Families
for FAM178B gene

Function
for FAM178B gene

Pathways & Interactions
for FAM178B gene

Drugs & Compounds
for FAM178B gene

Transcripts
for FAM178B gene

Expression
for FAM178B gene

Orthologs
for FAM178B gene

Paralogs
for FAM178B gene

Genomic Variants
for FAM178B gene

Disorders / Diseases
for FAM178B gene

Publications
for FAM178B gene

Intellectual Property
for FAM178B gene

Products
for FAM178B gene