Aliases for FAM178B Gene
Aliases for FAM178B Gene
External Ids for FAM178B Gene
- HGNC: 28036
- Entrez Gene: 51252
- Ensembl: ENSG00000168754
- UniProtKB: Q8IXR5
Previous GeneCards Identifiers for FAM178B Gene
- GC02M097541
- GC02M091501
Summaries for FAM178B Gene
GeneCards Summary for FAM178B Gene
FAM178B (Family With Sequence Similarity 178 Member B) is a Protein Coding gene. An important paralog of this gene is SLF2.
Additional gene information for FAM178B Gene
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM178B Gene
Genomics for FAM178B Gene
GeneHancer (GH) Regulatory Elements for FAM178B Gene
Promoters and enhancers for FAM178B Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH02I096898 | Promoter/Enhancer | 0.7 | EPDnew dbSUPER | 550.2 | +88.4 | 88422 | 0.1 | FAM178B LOC101927053 SEMA4C | ||
GH02I096986 | Promoter | 0.6 | EPDnew | 550.8 | +0.0 | 1 | 0.1 | ZBTB33 | FAM178B RNA5SP101 | |
GH02I096905 | Enhancer | 1.1 | Ensembl ENCODE dbSUPER | 18.6 | +79.4 | 79381 | 2.5 | KLF1 USF1 NFIB SIN3A ZIC2 ZFHX2 GLIS2 SCRT2 EGR2 SP3 | FAM178B SEMA4C ANKRD23 ANKRD39 SNRNP200 LOC101927053 | |
GH02I096894 | Enhancer | 1.6 | FANTOM5 Ensembl ENCODE dbSUPER | 12.3 | +90.7 | 90663 | 2 | HDGF ARNT TCF12 GATA2 E2F8 FOS NCOA1 ZNF592 SNIP1 MBD2 | SNRNP200 KANSL3 CIAO1 FAM178B CNNM3 STARD7-AS1 ANKRD36B FAHD2B ACTR1B LOC101927053 | |
GH02I097094 | Promoter/Enhancer | 1.6 | EPDnew Ensembl ENCODE | 12.1 | -108.2 | -108223 | 1.6 | MEIS2 PKNOX1 ATF1 L3MBTL2 ZBTB8A ATF2 ZNF335 POLR2A CREB1 ATF7 | FAHD2B ENSG00000279791 LOC100506123 FAM178B SNRNP200 GC02M097053 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around FAM178B on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for FAM178B Gene
Genomic Locations for FAM178B Gene
- chr2:96,875,882-96,986,601
- (GRCh38/hg38)
- Size:
- 110,720 bases
- Orientation:
- Minus strand
- chr2:97,541,619-97,684,175
- (GRCh37/hg19)
Genomic View for FAM178B Gene
Genes around FAM178B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q11.2 by Ensembl
- 2q11.2 by Entrez Gene
- 2q11.2 by HGNC
FAM178B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)


RefSeq DNA sequence for FAM178B Gene
Proteins for FAM178B Gene
-
Protein details for FAM178B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8IXR5-F178B_HUMAN
- Recommended name:
- Protein FAM178B
- Protein Accession:
- Q8IXR5
- A8MXN2
- E9PD86
- Q8IUY0
- Q9P0P4
Protein attributes for FAM178B Gene
- Size:
- 827 amino acids
- Molecular mass:
- 93514 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAF36154.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=AAF36154.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};
Post-translational modifications for FAM178B Gene
No Post-translational modifications
Other Protein References for FAM178B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for FAM178B
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Protein Products
-
OriGene Purified Proteins for FAM178B
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- Search GeneTex for Proteins for FAM178B
Assay Products
No data available for DME Specific Peptides for FAM178B Gene
Domains & Families for FAM178B Gene
Gene Families for FAM178B Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for FAM178B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8IXR5- Family:
-
- Belongs to the FAM178 family.
Function for FAM178B Gene
Phenotypes From GWAS Catalog for FAM178B Gene
Phenotypes for FAM178B Gene
- GenomeRNAi human phenotypes for FAM178B:
-
- Increased vaccinia virus (VACV) infection
- Decreased viability
- Synthetic lethal with Ras
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased NF-kappaB reporter expression
- Increased G1 DNA content
- Decreased IL-8 secretion
- Decreased homologous recombination repair frequency
- Increased cell number in S
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for FAM178B
-
-
ViGene Biosciences lentiviral particle packaged cDNA for FAM178B gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FAM178B gene
- Search ViGene Biosciences for FAM178B
CRISPR Products
-
OriGene CRISPR knockouts for FAM178B
- genomics-online: gRNA clones - Search results for 103 available FAM178B gene related products
- Overview of 103 available FAM178B gene related products
- Applied Biological Materials CRISPR for FAM178B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for FAM178B
- GenScript: Design CRISPR guide RNA sequences for FAM178B
miRNA Products
- Search ViGene Biosciences for FAM178B
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for FAM178B
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- genomics-online: shRNA clones - Search results for 103 available FAM178B gene related products
- Overview of 103 available FAM178B gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for FAM178B gene
Clone Products
-
OriGene ORF clones in human for FAM178B
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for FAM178B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for FAM178B
-
ViGene Biosciences adenoviral particle packaged cDNA for FAM178B gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FAM178B gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FAM178B gene
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM178B Gene
Localization for FAM178B Gene
- Golgi apparatus (1)
- Nuclear speckles (1)
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM178B Gene
Transcripts for FAM178B Gene
mRNA/cDNA for FAM178B Gene
- (11) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (25) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FAM178B Gene
- Family with sequence similarity 178, member B:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for FAM178B
- genomics-online: gRNA clones - Search results for 103 available FAM178B gene related products
- Overview of 103 available FAM178B gene related products
- Applied Biological Materials CRISPR for FAM178B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for FAM178B
- GenScript: Design CRISPR guide RNA sequences for FAM178B
miRNA Products
- Search ViGene Biosciences for FAM178B
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for FAM178B
- Browse OriGene Inhibitory RNA Products For FAM178B
- genomics-online: shRNA clones - Search results for 103 available FAM178B gene related products
- Overview of 103 available FAM178B gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for FAM178B gene
Clone Products
-
OriGene ORF clones in human for FAM178B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- VectorBuilder custom plasmid, inducible vectors for FAM178B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FAM178B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for FAM178B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for FAM178B Gene
mRNA differential expression in normal tissues according to GTEx for FAM178B Gene
This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x7.0), Testis (x5.2), and Nerve - Tibial (x4.0).
NURSA nuclear receptor signaling pathways regulating expression of FAM178B Gene:
FAM178BSOURCE GeneReport for Unigene cluster for FAM178B Gene:
Hs.107922Primer Products
-
OriGene qPCR primer pairs for FAM178B
- genomics-online: primer clones - Search results for 103 available FAM178B gene related products
- Overview of 103 available FAM178B gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM178B Gene
Orthologs for FAM178B Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | FAM178B 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | FAM178B 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | FAM178B 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Fam178b 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Fam178b 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | FAM178B 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | FAM178B 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | FAM178B 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | FAM178B 34 |
|
OneToOne |
- Species where no ortholog for FAM178B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for FAM178B Gene
Variants for FAM178B Gene
SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000061295 | -- | 96,956,929(-) | C/A | genic_upstream_transcript_variant, intron_variant | |
rs1000077926 | -- | 96,914,127(-) | G/A | genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant | |
rs1000131322 | -- | 96,913,962(-) | A/C | genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant | |
rs1000153589 | -- | 96,950,476(-) | G/A | genic_upstream_transcript_variant, intron_variant | |
rs1000188183 | -- | 96,932,416(-) | A/G | genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv607e201 | CNV | deletion | 23290073 |
esv2759077 | CNV | gain+loss | 17122850 |
esv32727 | CNV | gain+loss | 17666407 |
esv3425717 | CNV | duplication | 20981092 |
esv5003 | OTHER | complex | 18987735 |
nsv1072425 | CNV | deletion | 25765185 |
nsv1135873 | CNV | deletion | 24896259 |
nsv512773 | CNV | insertion | 21212237 |
nsv526313 | CNV | loss | 19592680 |
nsv582497 | CNV | loss | 21841781 |
nsv582498 | CNV | loss | 21841781 |
Gene Damage Index Score:
6.11;
75.48% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FAM178B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FAM178B
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM178B Gene
Disorders for FAM178B Gene
Additional Disease Information for FAM178B
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for FAM178B Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM178B Gene
Publications for FAM178B Gene
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4 58
- Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H … Espeseth AS (Cell host & microbe 2008) 3 58
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
- A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U … Wanker EE (Cell 2005) 3 58
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 4 58
Products for FAM178B Gene
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- Invitrogen Antibodies for FAM178B
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- VectorBuilder custom plasmid, inducible vectors for FAM178B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FAM178B
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- GeneTex FAM178B antibody for FAM178B
- Search GeneTex for Proteins for FAM178B
- ViGene Biosciences adenoviral particle packaged cDNA for FAM178B gene
- ViGene Biosciences lentiviral particle packaged cDNA for FAM178B gene
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- genomics-online: cdna clones - Search results for 103 available FAM178B gene related products
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- Overview of 103 available FAM178B gene related products
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- Overview of 103 available FAM178B gene related products
Sources for FAM178B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew