FAM178A Gene
protein-coding GIFtS: 46
GCID: GC10P102663
|
|
family with sequence similarity 178, member A(Previous name: chromosome 10 open reading frame 6 )
(Previous symbol: C10orf6)
| |
Aliases
for FAM178A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Family With Sequence Similarity 178, Member A1 2 | | C10orf61 2 3 5 | | FLJ105121 | | FLJ250121 | | Chromosome 10 Open Reading Frame 61 | | Protein FAM178A2 |
Export aliases for FAM178A gene to outside databasesPrevious GC identifer: GC10P096300 |
Summaries
for FAM178A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FAM178A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FAM178A gene promoter:
Sp1 FOXO3 Nkx5-1 FOXO3b Egr-2 CREB deltaCREB FOXO3a ZIC2/Zic2 ATF
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM178A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM178A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q24.31 Ensembl cytogenetic band: 10q24.31 HGNC cytogenetic band: 10q24.31FAM178A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P102663: view genomic region
(about GC identifiers)
Start:
|
102,672,326 bp from pter |
End:
|
102,724,893 bp from pter |
Size:
|
52,568 bases |
Orientation:
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plus strand |
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Proteins
for FAM178A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: F178A_HUMAN, Q8IX21 (See
protein sequence)Recommended Name: Protein FAM178A Size: 1173 amino acids; 131873 Da
Miscellaneous: Localized in the locus associated with inherited infantile onset spinocerebellar ataxia (IOSCA). Nomutation were found associated with IOSCA compared to control subjects. The expression level in the brain was notdifferent between the 2 populations
Sequence caution: Sequence=BAA91657.1; Type=Erroneous initiation;
Secondary accessions: A8K950 B1AL17 Q5W0L8 Q9NPE8Alternative splicing: 2 isoforms: Q8IX21-1 Q8IX21-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for FAM178A: NX_Q8IX21
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IX21
FAM178A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001129595.1 NP_001230699.1 NP_060591.3
ENSEMBL proteins: ENSP00000238961 ENSP00000359294 ENSP00000359292
Human Recombinant Protein Products:
FAM178A Antibody Products:
Assay Products for FAM178A: |
Protein
Domains /
Families
for FAM178A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FAM178A for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8IX21ProtoNet protein and cluster: Q8IX21 UniProtKB/Swiss-Prot: F178A_HUMAN, Q8IX21Similarity: Belongs to the FAM178 family |
Function
for FAM178A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM178A (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM178A (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): FAM178A (NM_018121) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM178A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM178A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM178A |
|
Pathways & Interactions
for FAM178A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM178A
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
5/7 Interacting proteins for FAM178A (Q8IX212, 3 ENSP000003592924) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
|
Drugs & Compounds
for FAM178A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM178A
Search CenterWatch for drugs/clinical trials and news about FAM178A / F178A
|
Transcripts
for FAM178A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAM178A gene (4 alternative transcripts): NM_144592.1 NM_001136123.1 NM_001243770.1 NM_018121.3 Unigene Cluster for FAM178A: Family with sequence similarity 178, member A Hs.447458 [show with all ESTs]Unigene Representative Sequence: NM_0181214 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000238961(uc001krt.4) ENST00000370271(uc001krr.1 uc001kru.1)
ENST00000370269(uc001krs.3) ENST00000481654
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM178A (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM178A (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): FAM178A (NM_018121) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM178A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM178A |
Additional cDNA sequence: AF460991.1 AF460992.1 AK001374.1 AK024283.1 AK292565.1 AL832343.1 AL832383.1 AL833126.1 BC015131.1 BC020915.1 BC030565.1 BC047715.1 BC064526.1 BC073832.1 13 DOTS entries: DT.447779 DT.100024753 DT.403630 DT.428704 DT.121266513 DT.121266531 DT.91816894 DT.92067167 DT.100669050 DT.121266456 DT.121266517 DT.100644001 DT.95176762 24/203 AceView cDNA sequences (see all 203): AI435576 CR614509 AW016229 AA295307 BM666132 H38792 AA737563 AI218321 CA390090 AI951781 AA327526 AF460991 AK057741 AI681455 AU132172 BQ007456 AU153757 BC020915 AA279837 BU177051 AA343965 AK001374 CA406897 W87420
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for FAM178A (see all 8) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20a | · | 20b | ^ |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | - | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | - | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 21a | · | 21b | · | 21c | ^ | 22a | · | 22b | · | 22c |
|---|
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| SP1: | - | | | | - | | | | | | | | |
| SP2: | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | |
| SP5: | - | | | | - | | | | | | | |
ECgene alternative splicing isoforms for FAM178A
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Expression
for FAM178A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAM178A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACAGTGTCG
About this image
See FAM178A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM178A
SOURCE GeneReport for Unigene cluster: Hs.447458
UniProtKB/Swiss-Prot: F178A_HUMAN, Q8IX21Tissue specificity: Widely expressed. Expressed at higher level in skeletal muscle and at slightly lower level inbrain, liver and heart, than in lung, kidney, spleen and thymus
SABiosciences Custom PCR Arrays for FAM178A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM178A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FAM178A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM178A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM178A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM178A |
Orthologs
for FAM178A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for FAM178A gene from 5/12 species (see all 12) About this table
ENSEMBL Gene Tree for FAM178A (if available)
TreeFam Gene Tree for FAM178A (if available) |
Paralogs
for FAM178A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAM178A gene
- FAM178B2
FAM178A for paralogs About GeneDecksing
|
Genomic Variants
for FAM178A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM178A (102672326 - 102724893 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for FAM178A
4 CNVs: 48396 48394 48395 4711 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM178A |
|
Disorders
/ Diseases
for FAM178A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FAM178A for disorders About GeneDecksing
OMIM gene information: 610348
OMIM disorders: --
4  diseases for FAM178A: About MalaCardsinfantile onset spinocerebellar ataxia spinocerebellar ataxia ataxia alzheimer's disease
Human Genome Epidemiology (HuGE) Navigator: FAM178A (1 document)
Export disorders for FAM178A gene to outside databases
|
Publications
for FAM178A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM178A gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with FAM178A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- cDNA cloning, expression profile and genomic structure of a novel human transcript on chromosome 10q24, and its analyses as a candidate gene for infantile onset spinocerebellar ataxia. (PubMed id 12459258)1, 2, 3, 9 Nikali K.... Peltonen L. (2002)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1 Olsen J.V....Mann M. (2006)
- A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1 Grupe A....Goate A. (2006)
- Scanning the human proteome for calmodulin-binding pr oteins. (PubMed id 15840729)1 Shen X....Liu R. (2005)
|
External Searches for FAM178A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FAM178A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM178A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FAM178A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAM178A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FAM178A gene:
Search GeneIP for patents involving FAM178A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM178A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FAM178A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM178A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM178A | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for FAM178A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM178A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM178A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FAM178A | | OriGene Custom Protein Services for FAM178A | | | OriGene Custom Immunoassay Development | | |
| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM178A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM178A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM178A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM178A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM178A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM178A |
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| | | | Search Tocris compounds for FAM178A |
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 | | | FAM178A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM178A |
|  |  |  | | | | Search ThermoFisher Antibodies for FAM178A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM178A |
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