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Aliases for FAM178A Gene

Aliases for FAM178A Gene

  • Family With Sequence Similarity 178, Member A 2 3
  • C10orf6 3 4 6
  • Chromosome 10 Open Reading Frame 6 2
  • Protein FAM178A 3

External Ids for FAM178A Gene

Previous HGNC Symbols for FAM178A Gene

  • C10orf6

Previous GeneCards Identifiers for FAM178A Gene

  • GC10P102663
  • GC10P096300

Summaries for FAM178A Gene

GeneCards Summary for FAM178A Gene

FAM178A (Family With Sequence Similarity 178, Member A) is a Protein Coding gene. An important paralog of this gene is FAM178B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM178A Gene

Genomics for FAM178A Gene

Regulatory Elements for FAM178A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM178A Gene

Start:
100,912,569 bp from pter
End:
100,965,136 bp from pter
Size:
52,568 bases
Orientation:
Plus strand

Genomic View for FAM178A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM178A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM178A Gene

Proteins for FAM178A Gene

  • Protein details for FAM178A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IX21-F178A_HUMAN
    Recommended name:
    Protein FAM178A
    Protein Accession:
    Q8IX21
    Secondary Accessions:
    • A8K950
    • B1AL17
    • Q5W0L8
    • Q6GMU6
    • Q9NPE8

    Protein attributes for FAM178A Gene

    Size:
    1173 amino acids
    Molecular mass:
    131873 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Localized in the locus associated with inherited infantile onset spinocerebellar ataxia (IOSCA). No mutation were found associated with IOSCA compared to control subjects. The expression level in the brain was not different between the 2 populations
    SequenceCaution:
    • Sequence=BAA91657.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM178A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM178A Gene

Proteomics data for FAM178A Gene at MOPED

Post-translational modifications for FAM178A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM178A Gene

No data available for DME Specific Peptides for FAM178A Gene

Domains for FAM178A Gene

Protein Domains for FAM178A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM178A Gene

Graphical View of Domain Structure for InterPro Entry

Q8IX21

UniProtKB/Swiss-Prot:

F178A_HUMAN :
  • Q8IX21
Family:
  • Belongs to the FAM178 family.
genes like me logo Genes that share domains with FAM178A: view

No data available for Gene Families for FAM178A Gene

Function for FAM178A Gene

Animal Model Products

CRISPR Products

miRNA for FAM178A Gene

miRTarBase miRNAs that target FAM178A

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM178A

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FAM178A Gene

Localization for FAM178A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM178A Gene

Nucleus. Note=Mainly localizes to nucleus: colocalizes with PCNA on replication sites.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM178A Gene COMPARTMENTS Subcellular localization image for FAM178A gene
Compartment Confidence
nucleus 3
cytosol 2
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FAM178A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IDA 24561620
GO:0005615 extracellular space IDA 22664934
GO:0005634 nucleus IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with FAM178A: view

Pathways for FAM178A Gene

SuperPathways for FAM178A Gene

No Data Available

Interacting Proteins for FAM178A Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000359292%0d%0a9606.ENSP00000385269%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: Q8IX21-F178A_HUMAN ENSP00000359292 for FAM178A Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for FAM178A Gene

None

No data available for Pathways by source for FAM178A Gene

Transcripts for FAM178A Gene

Unigene Clusters for FAM178A Gene

Family with sequence similarity 178, member A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM178A

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for FAM178A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM178A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^
SP1: - - - -
SP2: - - - -
SP3: -
SP4: - -
SP5:
SP6:
SP7:
SP8:

ExUns: 21a · 21b · 21c ^ 22a · 22b · 22c
SP1: - -
SP2: -
SP3:
SP4:
SP5: - -
SP6:
SP7:
SP8: -

Relevant External Links for FAM178A Gene

GeneLoc Exon Structure for
FAM178A
ECgene alternative splicing isoforms for
FAM178A

Expression for FAM178A Gene

mRNA expression in normal human tissues for FAM178A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FAM178A Gene

SOURCE GeneReport for Unigene cluster for FAM178A Gene Hs.447458

mRNA Expression by UniProt/SwissProt for FAM178A Gene

Q8IX21-F178A_HUMAN
Tissue specificity: Widely expressed. Expressed at higher level in skeletal muscle and at slightly lower level in brain, liver and heart, than in lung, kidney, spleen and thymus.
genes like me logo Genes that share expressions with FAM178A: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for FAM178A Gene

Orthologs for FAM178A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM178A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM178A 35
  • 99.6 (n)
  • 99.06 (a)
FAM178A 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C26H10ORF6 36
  • 88 (a)
OneToOne
FAM178A 35
  • 90.56 (n)
  • 88.21 (a)
dog
(Canis familiaris)
Mammalia FAM178A 35
  • 92.18 (n)
  • 90.75 (a)
FAM178A 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam178a 35
  • 88 (n)
  • 85.7 (a)
Fam178a 16
Fam178a 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM178A 36
  • 52 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam178a 35
  • 87.29 (n)
  • 85.09 (a)
chicken
(Gallus gallus)
Aves C10ORF6 35
  • 66.11 (n)
  • 57.34 (a)
FAM178A 36
  • 33 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM178A 36
  • 31 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.32297 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7374 35
zebrafish
(Danio rerio)
Actinopterygii fam178a 36
  • 22 (a)
OneToOne
Species with no ortholog for FAM178A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM178A Gene

ENSEMBL:
Gene Tree for FAM178A (if available)
TreeFam:
Gene Tree for FAM178A (if available)

Paralogs for FAM178A Gene

Paralogs for FAM178A Gene

genes like me logo Genes that share paralogs with FAM178A: view

Variants for FAM178A Gene

Sequence variations from dbSNP and Humsavar for FAM178A Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs12308 -- 100,964,799(-) TTAAT(G/T)GGCTA utr-variant-3-prime
rs927302 -- 100,963,159(-) CCCCC(C/G)ACAAC utr-variant-3-prime
rs1052017 -- 100,965,000(+) AATCC(A/C)CCAGC utr-variant-3-prime
rs1056295 -- 100,955,426(+) TATAA(C/T)ACATT intron-variant
rs1063665 -- 100,965,039(+) TTTCC(C/T)TTTTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FAM178A Gene

Variant ID Type Subtype PubMed ID
nsv831965 CNV Loss 17160897
nsv515627 CNV Gain+Loss 19592680
nsv467443 CNV Loss 19166990

Relevant External Links for FAM178A Gene

HapMap Linkage Disequilibrium report
FAM178A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM178A Gene

Disorders for FAM178A Gene

Relevant External Links for FAM178A

Genetic Association Database (GAD)
FAM178A
Human Genome Epidemiology (HuGE) Navigator
FAM178A
genes like me logo Genes that share disorders with FAM178A: view

No data available for UniProtKB/Swiss-Prot for FAM178A Gene

Publications for FAM178A Gene

  1. cDNA cloning, expression profile and genomic structure of a novel human transcript on chromosome 10q24, and its analyses as a candidate gene for infantile onset spinocerebellar ataxia. (PMID: 12459258) Nikali K. … Peltonen L. (Gene 2002) 2 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 48
  5. Nascent chromatin capture proteomics determines chromatin dynamics during DNA replication and identifies unknown fork components. (PMID: 24561620) Alabert C. … Groth A. (Nat. Cell Biol. 2014) 3 4

Products for FAM178A Gene

Sources for FAM178A Gene

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