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Aliases for FAM177B Gene

Aliases for FAM177B Gene

  • Family With Sequence Similarity 177 Member B 2 3 5
  • Family With Sequence Similarity 177, Member B 2

External Ids for FAM177B Gene

Previous GeneCards Identifiers for FAM177B Gene

  • GC01P220978
  • GC01P222910
  • GC01P193584

Summaries for FAM177B Gene

GeneCards Summary for FAM177B Gene

FAM177B (Family With Sequence Similarity 177 Member B) is a Protein Coding gene. An important paralog of this gene is FAM177A1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM177B Gene

Genomics for FAM177B Gene

Regulatory Elements for FAM177B Gene

Enhancers for FAM177B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F222771 1 Ensembl ENCODE 13.3 +35.4 35395 2.4 ZNF202 PKNOX1 MTA2 HLF MAX EBF1 RAD51 SMARCA4 POLR2A EED BROX CICP13 ENSG00000272750 FAM177B DISP1 LOC102724017 LOC105372984
GH01F222738 0.9 Ensembl ENCODE 10 +2.1 2067 1.9 ZNF263 CTCF ZNF654 CEBPB REST RAD21 NR2F2 TARDBP SMC3 ZBTB20 ENSG00000272750 FAM177B LOC105372984
GH01F222710 1.2 ENCODE 7.5 -24.7 -24715 3.9 PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 CICP13 BROX ENSG00000272750 LOC102724017 FAM177B GC01M222708
GH01F222736 0.9 Ensembl ENCODE 0.8 0.0 -17 2.0 HLF TEAD4 ZNF140 FEZF1 JUND FOXP2 FOS MAFK BROX ENSG00000272750 CICP13 HHIPL2 GC01P222732 FAM177B
GH01F222733 0.9 Ensembl 0.8 -3.9 -3907 0.6 HDGF ATF1 PTRF ZNF766 KLF13 ZBTB11 USF2 HDAC8 CREB3 TFDP1 GC01P222732 FAM177B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM177B on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM177B Gene

Chromosome:
1
Start:
222,737,207 bp from pter
End:
222,753,727 bp from pter
Size:
16,521 bases
Orientation:
Plus strand

Genomic View for FAM177B Gene

Genes around FAM177B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM177B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM177B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM177B Gene

Proteins for FAM177B Gene

  • Protein details for FAM177B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6PVY3-F177B_HUMAN
    Recommended name:
    Protein FAM177B
    Protein Accession:
    A6PVY3
    Secondary Accessions:
    • Q6ZUN8

    Protein attributes for FAM177B Gene

    Size:
    158 amino acids
    Molecular mass:
    18145 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM177B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM177B Gene

Post-translational modifications for FAM177B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM177B Gene

Domains & Families for FAM177B Gene

Protein Domains for FAM177B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM177B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6PVY3

UniProtKB/Swiss-Prot:

F177B_HUMAN :
  • Belongs to the FAM177 family.
Family:
  • Belongs to the FAM177 family.
genes like me logo Genes that share domains with FAM177B: view

No data available for Gene Families for FAM177B Gene

Function for FAM177B Gene

genes like me logo Genes that share phenotypes with FAM177B: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM177B Gene

Localization for FAM177B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM177B gene
Compartment Confidence
cytosol 3
extracellular 1
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM177B Gene

Pathways & Interactions for FAM177B Gene

SuperPathways for FAM177B Gene

No Data Available

Interacting Proteins for FAM177B Gene

Gene Ontology (GO) - Biological Process for FAM177B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM177B Gene

Transcripts for FAM177B Gene

mRNA/cDNA for FAM177B Gene

(9) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(5) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM177B Gene

Family with sequence similarity 177, member B:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM177B Gene

No ASD Table

Relevant External Links for FAM177B Gene

GeneLoc Exon Structure for
FAM177B
ECgene alternative splicing isoforms for
FAM177B

Expression for FAM177B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM177B Gene

mRNA differential expression in normal tissues according to GTEx for FAM177B Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x14.6), Stomach (x12.2), Minor Salivary Gland (x4.4), and Colon - Transverse (x4.2).

Protein differential expression in normal tissues from HIPED for FAM177B Gene

This gene is overexpressed in Stomach (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM177B Gene



Protein tissue co-expression partners for FAM177B Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM177B Gene:

FAM177B

SOURCE GeneReport for Unigene cluster for FAM177B Gene:

Hs.697608
genes like me logo Genes that share expression patterns with FAM177B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FAM177B Gene

Orthologs for FAM177B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM177B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM177B 34 35
  • 98.31 (n)
dog
(Canis familiaris)
Mammalia FAM177B 34 35
  • 84.6 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM177B 35
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM177B 35
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM177B 35
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam177b 34
  • 58.93 (n)
zebrafish
(Danio rerio)
Actinopterygii FAM177B 35
  • 21 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4574 35
  • 31 (a)
OneToMany
Species where no ortholog for FAM177B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM177B Gene

ENSEMBL:
Gene Tree for FAM177B (if available)
TreeFam:
Gene Tree for FAM177B (if available)

Paralogs for FAM177B Gene

Paralogs for FAM177B Gene

(1) SIMAP similar genes for FAM177B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FAM177B: view

Variants for FAM177B Gene

Sequence variations from dbSNP and Humsavar for FAM177B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10596119 -- 222,772,266(+) GGGGG(-/GG)CGGTG intron-variant, downstream-variant-500B
rs10687018 -- 222,760,691(+) TTCAT(-/TCAA)TCAGT intron-variant
rs111507751 -- 222,737,233(+) GAACA(G/T)AACAG nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs111579941 -- 222,766,282(+) GACAG(A/C)GTCTT intron-variant
rs111682421 -- 222,746,513(+) GTGCC(-/CT)GTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM177B Gene

Variant ID Type Subtype PubMed ID
esv3368539 CNV insertion 20981092

Variation tolerance for FAM177B Gene

Residual Variation Intolerance Score: 77.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.60; 12.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM177B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM177B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM177B Gene

Disorders for FAM177B Gene

Relevant External Links for FAM177B

Genetic Association Database (GAD)
FAM177B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM177B

No disorders were found for FAM177B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM177B Gene

Publications for FAM177B Gene

  1. A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. (PMID: 19734545) Need A.C. … Goldstein D.B. (Hum. Mol. Genet. 2009) 3 46 64
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64

Products for FAM177B Gene

Sources for FAM177B Gene

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