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Aliases for FAM177B Gene

Aliases for FAM177B Gene

  • Family With Sequence Similarity 177 Member B 2 3 5
  • Family With Sequence Similarity 177, Member B 2

External Ids for FAM177B Gene

Previous GeneCards Identifiers for FAM177B Gene

  • GC01P220978
  • GC01P222910
  • GC01P193584

Summaries for FAM177B Gene

GeneCards Summary for FAM177B Gene

FAM177B (Family With Sequence Similarity 177 Member B) is a Protein Coding gene. An important paralog of this gene is FAM177A1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM177B Gene

Genomics for FAM177B Gene

Regulatory Elements for FAM177B Gene

Genomic Location for FAM177B Gene

222,737,207 bp from pter
222,753,727 bp from pter
16,521 bases
Plus strand

Genomic View for FAM177B Gene

Genes around FAM177B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM177B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM177B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM177B Gene

Proteins for FAM177B Gene

  • Protein details for FAM177B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM177B
    Protein Accession:
    Secondary Accessions:
    • Q6ZUN8

    Protein attributes for FAM177B Gene

    158 amino acids
    Molecular mass:
    18145 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM177B Gene


neXtProt entry for FAM177B Gene

Proteomics data for FAM177B Gene at MOPED

Post-translational modifications for FAM177B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM177B Gene

No data available for DME Specific Peptides for FAM177B Gene

Domains & Families for FAM177B Gene

Protein Domains for FAM177B Gene


Suggested Antigen Peptide Sequences for FAM177B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM177 family.
  • Belongs to the FAM177 family.
genes like me logo Genes that share domains with FAM177B: view

No data available for Gene Families for FAM177B Gene

Function for FAM177B Gene

genes like me logo Genes that share phenotypes with FAM177B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM177B Gene

Localization for FAM177B Gene

Subcellular locations from

Jensen Localization Image for FAM177B Gene COMPARTMENTS Subcellular localization image for FAM177B gene
Compartment Confidence
cytosol 3
extracellular 1
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM177B Gene

Pathways & Interactions for FAM177B Gene

SuperPathways for FAM177B Gene

No Data Available

Interacting Proteins for FAM177B Gene

Gene Ontology (GO) - Biological Process for FAM177B Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM177B Gene

Drugs & Compounds for FAM177B Gene

No Compound Related Data Available

Transcripts for FAM177B Gene

mRNA/cDNA for FAM177B Gene

(4) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM177B Gene

Family with sequence similarity 177, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM177B Gene

No ASD Table

Relevant External Links for FAM177B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM177B Gene

mRNA expression in normal human tissues for FAM177B Gene

mRNA differential expression in normal tissues according to GTEx for FAM177B Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x14.6), Stomach (x12.2), Minor Salivary Gland (x4.4), and Colon - Transverse (x4.2).

Protein differential expression in normal tissues from HIPED for FAM177B Gene

This gene is overexpressed in Stomach (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM177B Gene

SOURCE GeneReport for Unigene cluster for FAM177B Gene Hs.697608

genes like me logo Genes that share expression patterns with FAM177B: view

Protein tissue co-expression partners for FAM177B Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FAM177B Gene

Orthologs for FAM177B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM177B Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia FAM177B 35
  • 84.6 (n)
  • 76.58 (a)
FAM177B 36
  • 68 (a)
(Pan troglodytes)
Mammalia FAM177B 35
  • 98.31 (n)
  • 96.84 (a)
FAM177B 36
  • 97 (a)
(Monodelphis domestica)
Mammalia FAM177B 36
  • 58 (a)
(Ornithorhynchus anatinus)
Mammalia FAM177B 36
  • 48 (a)
(Anolis carolinensis)
Reptilia FAM177B 36
  • 40 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam177b 35
  • 58.93 (n)
  • 52.8 (a)
(Danio rerio)
Actinopterygii FAM177B 36
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4574 36
  • 31 (a)
Species with no ortholog for FAM177B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM177B Gene

Gene Tree for FAM177B (if available)
Gene Tree for FAM177B (if available)

Paralogs for FAM177B Gene

Paralogs for FAM177B Gene

(1) SIMAP similar genes for FAM177B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FAM177B: view

Variants for FAM177B Gene

Sequence variations from dbSNP and Humsavar for FAM177B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2378607 - 222,746,553(+) GGAGA(G/T)TGACG reference, missense
rs6683071 - 222,750,009(+) GGTCC(A/G)AGAGT intron-variant, reference, missense
rs2068814 -- 222,749,659(+) TGGTC(A/G)TATGT intron-variant, downstream-variant-500B
rs2378606 -- 222,746,406(+) TTTGA(A/G)GAATC intron-variant
rs2378608 -- 222,750,497(+) TCAGG(A/G)TTTGA intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FAM177B Gene

Variant ID Type Subtype PubMed ID
nsv873205 CNV Loss 21882294

Variation tolerance for FAM177B Gene

Residual Variation Intolerance Score: 77.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.60; 12.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM177B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM177B Gene

Disorders for FAM177B Gene

Relevant External Links for FAM177B

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM177B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM177B Gene

Publications for FAM177B Gene

  1. A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. (PMID: 19734545) Need A.C. … Goldstein D.B. (Hum. Mol. Genet. 2009) 3 48 67

Products for FAM177B Gene

Sources for FAM177B Gene

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