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FAM177B Gene

protein-coding   GIFtS: 32
GCID: GC01P222910

Family With Sequence Similarity 177, Member B

  Search for FAM177B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 177, Member B1 2
RP11-452F19.22
Protein FAM177B2

External Ids:    HGNC: 343951   Entrez Gene: 4008232   Ensembl: ENSG000001975207   UniProtKB: A6PVY33   

Export aliases for FAM177B gene to outside databases

Previous GC identifers: GC01P220978 GC01P193584


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM177B Gene:
FAM177B (family with sequence similarity 177, member B) is a protein-coding gene. An important paralog of this gene is FAM177A1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the FAM177B gene promoter:
         HOXA9B   HOXA9   RP58   Pax-6   HNF-3beta   Meis-1b   AREB6   POU2F1   POU2F1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM177B promoter sequence
   Search Chromatin IP Primers for FAM177B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM177B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q41   Ensembl cytogenetic band:  1q41   HGNC cytogenetic band: 1q41

FAM177B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM177B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P222910:  view genomic region     (about GC identifiers)

Start:
222,910,549 bp from pter      End:
222,924,147 bp from pter
Size:
13,599 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: F177B_HUMAN, A6PVY3 (See protein sequence)
Recommended Name: Protein FAM177B  
Size: 158 amino acids; 18145 Da
Secondary accessions: Q6ZUN8
Alternative splicing: 2 isoforms:  A6PVY3-1   A6PVY3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FAM177B: NX_A6PVY3

Explore proteomics data for FAM177B at MOPED


See FAM177B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_997351.2  
ENSEMBL proteins: 
 ENSP00000391615   ENSP00000375752   ENSP00000354070   ENSP00000400233   ENSP00000414451  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR028260 FAM177

Graphical View of Domain Structure for InterPro Entry A6PVY3

ProtoNet protein and cluster: A6PVY3

UniProtKB/Swiss-Prot: F177B_HUMAN, A6PVY3
Similarity: Belongs to the FAM177 family


FAM177B for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Phenotypes:
     1 GenomeRNAi human phenotype for FAM177B:
 Increased gamma-H2AX phosphory 

Animal Models:
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hsa-miR-19b hsa-miR-539 hsa-miR-19a hsa-miR-4308
SwitchGear 3'UTR luciferase reporter plasmidFAM177B 3' UTR sequence
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM177B


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol3
extracellular1
mitochondrion1
nucleus1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM177B
Interactions:

    Search GeneGlobe Interaction Network for FAM177B

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for FAM177B (F177B)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for FAM177B gene: 
NM_207468.2  

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000434700 ENST00000391880(uc009xeb.3) ENST00000360827 ENST00000460763
ENST00000456298 ENST00000445590(uc001hnt.3)
miRNA
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hsa-miR-19b hsa-miR-539 hsa-miR-19a hsa-miR-4308
SwitchGear 3'UTR luciferase reporter plasmidFAM177B 3' UTR sequence
Inhib. RNA
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Primer
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  QuantiFast Probe-based Assays in human, mouse, rat FAM177B

5 AceView cDNA sequences:

AK125494 NM_207468 AI814075 CD688648 CD703544 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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FAM177B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGACGAGGGT
FAM177B Expression
About this image

FAM177B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

FAM177B Protein Expression
    Custom PCR Arrays for FAM177B
Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM177B

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for FAM177B gene from Selected species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia FAM177B1 family with sequence similarity 177, member B 84.6(n)
76.58(a)
  478995  XM_536150.4  XP_536150.1 
lizard
(Anolis carolinensis)
Reptilia FAM177B6
family with sequence similarity 177, member B
40(a)
1 ↔ 1
1(244532502-244543742)
tropical clawed frog
(Xenopus tropicalis)
Amphibia fam177b1 family with sequence similarity 177, member B 58.93(n)
52.8(a)
  100145772  NM_001127139.1  NP_001120611.1 
zebrafish
(Danio rerio)
Actinopterygii FAM177B6
family with sequence similarity 177, member B
21(a)
1 ↔ 1
20(51998315-52009956) ENSDARG00000086748


ENSEMBL Gene Tree for FAM177B (if available)
TreeFam Gene Tree for FAM177B (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for FAM177B gene
FAM177A12  
1 SIMAP similar gene for FAM177B using alignment to 3 protein entries:     F177B_HUMAN (see all proteins):
FAM177A1

FAM177B for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for FAM177B (see all 281)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1895717691,2
--222908735(+) GACAAC/TGTGGT 1 -- us2k10--------
rs1155783621,2
F--222908738(+) AACGTG/AGTGAA 1 -- us2k11Minor allele frequency- A:0.13WA 118
rs790598621,2
C,F--222908874(+) CAAACA/GTTTGC 1 -- us2k11Minor allele frequency- G:0.02EA 120
rs174739361,2
C,F,H--222908921(+) TCAACG/ACTCCT 1 -- us2k112Minor allele frequency- A:0.04NA NS 1206
rs1487805441,2
C--222908924(+) CGCTC-/CTTGA 
        
CTTGT
1 -- us2k10--------
rs1880860981,2
--222909052(+) TACGCC/TAAGCT 1 -- us2k10--------
rs1179199831,2
C,F--222909065(+) AGAGTG/TTATCA 1 -- us2k11Minor allele frequency- T:0.02EA 120
rs1145581171,2
C,F--222909083(+) TGTACA/GATAAT 1 -- us2k11Minor allele frequency- G:0.02WA 118
rs1402633961,2
C--222909210(+) AAAATA/GCTGGG 1 -- us2k10--------
rs1929060461,2
--222909269(+) GTTACC/TATAAG 1 -- us2k10--------

HapMap Linkage Disequilibrium report for FAM177B (222910549 - 222924147 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for FAM177B:    About this table    
Variant IDTypeSubtypePubMed ID
nsv873205CNV Loss21882294

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing FAM177B
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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FAM177B for disorders           About GeneDecksing

Genetic Association Database (GAD): FAM177B

Export disorders for FAM177B gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for FAM177B gene integrated from 10 sources:
(articles sorted by number of sources associating them with FAM177B)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. (PubMed id 19734545)1, 4 Need A.C....Goldstein D.B. (Hum. Mol. Genet. 2009)
  2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 400823 HGNC: 34395 AceView: FLJ43505 Ensembl:ENSG00000197520 euGenes: HUgn400823
ECgene: FAM177B H-InvDB: FAM177B

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for FAM177B Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for FAM177B gene:
Search GeneIP for patents involving FAM177B

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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