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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAM177B Gene

protein-coding   GIFtS: 34
GCID: GC01P222910

Family With Sequence Similarity 177, Member B

  Search for FAM177B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Family With Sequence Similarity 177, Member B1 2
Protein FAM177B2

External Ids:    HGNC: 343951   Entrez Gene: 4008232   Ensembl: ENSG000001975207   UniProtKB: A6PVY33   

Export aliases for FAM177B gene to outside databases

Previous GC identifers: GC01P220978 GC01P193584


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FAM177B Gene: 
FAM177B (family with sequence similarity 177, member B) is a protein-coding gene. An important paralog of this gene is FAM177A1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_167186.1  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FAM177B gene promoter:
         HOXA9B   HOXA9   RP58   Pax-6   HNF-3beta   Meis-1b   AREB6   POU2F1   POU2F1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM177B promoter sequence
   Search SABiosciences Chromatin IP Primers for FAM177B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM177B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q41   Ensembl cytogenetic band:  1q41   HGNC cytogenetic band: 1q41

FAM177B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM177B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P222910:  view genomic region     (about GC identifiers)

Start:
222,910,549 bp from pter      End:
222,924,147 bp from pter
Size:
13,599 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: F177B_HUMAN, A6PVY3 (See protein sequence)
Recommended Name: Protein FAM177B  
Size: 158 amino acids; 18145 Da
Secondary accessions: Q6ZUN8
Alternative splicing: 2 isoforms:  A6PVY3-1   A6PVY3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FAM177B: NX_A6PVY3

Explore proteomics data for FAM177B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A6PVY3

  • FAM177B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FAM177B Protein Expression
    REFSEQ proteins: NP_997351.2  
    ENSEMBL proteins: 
     ENSP00000391615   ENSP00000375752   ENSP00000354070   ENSP00000400233   ENSP00000414451  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: A6PVY3

    UniProtKB/Swiss-Prot: F177B_HUMAN, A6PVY3
    Similarity: Belongs to the FAM177 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         1 GenomeRNAi human phenotype for FAM177B:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FAM177B 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM177B

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FAM177B (F177B)

    Search CenterWatch for drugs/clinical trials and news about FAM177B / F177B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FAM177B gene: 
    NM_207468.2  

    Unigene Cluster for FAM177B:

    Family with sequence similarity 177, member B
    Hs.697608  [show with all ESTs]
    Unigene Representative Sequence: NM_207468
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000434700 ENST00000391880(uc009xeb.3) ENST00000360827 ENST00000460763
    ENST00000456298 ENST00000445590(uc001hnt.3)
    miRNA
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    Inhib. RNA
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    5 DOTS entries:

    DT.75160204  DT.121395375  DT.100000743  DT.121395259  DT.121395264 

    5 AceView cDNA sequences:

    AK125494 NM_207468 AI814075 CD688648 CD703544 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FAM177B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGACGAGGGT
    FAM177B Expression
    About this image


    See FAM177B Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.697608
        SABiosciences Custom PCR Arrays for FAM177B
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM177B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FAM177B gene from 3/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia FAM177B1 family with sequence similarity 177, member B 84.6(n)
    76.58(a)
      478995  XM_536150.3  XP_536150.1 
    lizard
    (Anolis carolinensis)
    Reptilia FAM177B6
    Uncharacterized protein
    37(a)
    1 ↔ 1
    1(244532502-244543742)
    zebrafish
    (Danio rerio)
    Actinopterygii FAM177B6
    family with sequence similarity 177, member B
    18(a)
    1 ↔ 1
    20(51998315-52009956)


    ENSEMBL Gene Tree for FAM177B (if available)
    TreeFam Gene Tree for FAM177B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FAM177B gene
    FAM177A12  
    1 SIMAP similar gene for FAM177B using alignment to 3 protein entries:     F177B_HUMAN (see all proteins):
    FAM177A1

    FAM177B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/281 SNPs in FAM177B are shown (see all 281)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1895717691,2
    --222908735(+) GACAAC/TGTGGT 1 -- us2k10--------
    rs1155783621,2
    F--222908738(+) AACGTG/AGTGAA 1 -- us2k11Minor allele frequency- A:0.13WA 118
    rs790598621,2
    C,F--222908874(+) CAAACA/GTTTGC 1 -- us2k11Minor allele frequency- G:0.02EA 120
    rs174739361,2
    C,F,H--222908921(+) TCAACG/ACTCCT 1 -- us2k112Minor allele frequency- A:0.04NA NS 1206
    rs1487805441,2
    C--222908924(+) CGCTC-/CTTGA 
            
    CTTGT
    1 -- us2k10--------
    rs1880860981,2
    --222909052(+) TACGCC/TAAGCT 1 -- us2k10--------
    rs1179199831,2
    C,F--222909065(+) AGAGTG/TTATCA 1 -- us2k11Minor allele frequency- T:0.02EA 120
    rs1145581171,2
    C,F--222909083(+) TGTACA/GATAAT 1 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1402633961,2
    C--222909210(+) AAAATA/GCTGGG 1 -- us2k10--------
    rs1929060461,2
    --222909269(+) GTTACC/TATAAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FAM177B (222910549 - 222924147 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FAM177B:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv873205CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    FAM177B for disorders           About MalaCards

    FAM177B for disorders           About GeneDecksing

    Genetic Association Database (GAD): FAM177B

    Export disorders for FAM177B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FAM177B gene integrated from 9 sources:
    (articles sorted by number of sources associating them with FAM177B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A genome-wide study of common SNPs and CNVs in cognit ive performance in the CANTAB. (PubMed id 19734545)1, 4 Need A.C....Goldstein D.B. (2009)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 400823 HGNC: 34395 AceView: FLJ43505 Ensembl:ENSG00000197520 euGenes: HUgn400823
    ECgene: FAM177B H-InvDB: FAM177B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FAM177B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FAM177B gene:
    Search GeneIP for patents involving FAM177B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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     SwitchGear Promoter luciferase reporter plasmids for FAM177B
     Search ThermoFisher Antibodies for FAM177B
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FAM177B
     inGenious Targeting Laboratory - Custom generated mouse model solutions for FAM177B
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FAM177B
    Customized:
     lentivirus for stable overexpression of FAM177B
     lentivirus expression plasmids for stable overexpression of FAM177B
     adenovirus for overexpression of FAM177B
     Search LSBio for Antibodies for FAM177B
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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