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FAM177A1 Gene

protein-coding   GIFtS: 47
GCID: GC14P035514

Family With Sequence Similarity 177, Member A1

(Previous name: chromosome 14 open reading frame 24)
(Previous symbol: C14orf24)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 177, Member A11 2
C14orf241 2 3
Chromosome 14 Open Reading Frame 241
Protein FAM177A12

External Ids:    HGNC: 198291   Entrez Gene: 2836352   Ensembl: ENSG000001513277   UniProtKB: Q8N1283   

Export aliases for FAM177A1 gene to outside databases

Previous GC identifers: GC14P034583 GC14P015626


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM177A1 Gene:
FAM177A1 (family with sequence similarity 177, member A1) is a protein-coding gene. Diseases associated with FAM177A1 include arthritis. An important paralog of this gene is FAM177B.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAM177A1 gene promoter:
         ATF-2   Tal-1beta   En-1   RSRFC4   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM177A1 promoter sequence
   Search Chromatin IP Primers for FAM177A1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM177A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q13.2   Ensembl cytogenetic band:  14q13.2   HGNC cytogenetic band: 14q13.2

FAM177A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM177A1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P035514:  view genomic region     (about GC identifiers)

Start:
35,514,113 bp from pter      End:
35,582,336 bp from pter
Size:
68,224 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: F177A_HUMAN, Q8N128 (See protein sequence)
Recommended Name: Protein FAM177A1  
Size: 213 amino acids; 23757 Da
Secondary accessions: Q68CT2
Alternative splicing: 2 isoforms:  Q8N128-1   Q8N128-2   

Explore the universe of human proteins at neXtProt for FAM177A1: NX_Q8N128

Explore proteomics data for FAM177A1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys131
  • Modification sites at PhosphoSitePlus

  • See FAM177A1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001072987.1  NP_001275951.1  NP_775878.2  

    ENSEMBL proteins: 
     ENSP00000451508   ENSP00000371843   ENSP00000280987   ENSP00000451165   ENSP00000473546  
     ENSP00000450424   ENSP00000452223   ENSP00000452425   ENSP00000379734  

    FAM177A1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for FAM177A1

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    Cloud-Clone Corp. CLIAs for FAM177A1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR028260 FAM177

    Graphical View of Domain Structure for InterPro Entry Q8N128

    ProtoNet protein and cluster: Q8N128

    1 Blocks protein domain: IPB001792 Acylphosphatase

    UniProtKB/Swiss-Prot: F177A_HUMAN, Q8N128
    Similarity: Belongs to the FAM177 family


    FAM177A1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         1 GenomeRNAi human phenotype for FAM177A1:
     Decreased viability with cispl 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAM177A1
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FAM177A1

    miRNA
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    miRTarBase miRNAs that target FAM177A1:
    hsa-mir-142-3p (MIRT021622), hsa-mir-155-5p (MIRT020986), hsa-mir-186-5p (MIRT045179), hsa-mir-124-3p (MIRT002702)

    Block miRNA regulation of human, mouse, rat FAM177A1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FAM177A1 (see all 31):
    hsa-miR-3910 hsa-miR-448 hsa-miR-4307 hsa-miR-520f hsa-miR-128 hsa-miR-181a-2* hsa-miR-548l hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidFAM177A1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FAM177A1
    Predesigned siRNA for gene silencing in human, mouse, rat FAM177A1

    Gene Editing
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM177A1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular2
    cytosol1
    nucleus1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM177A1
    Interactions:

        Search GeneGlobe Interaction Network for FAM177A1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for FAM177A1 (ENSP000002809874) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM177A1 (F177A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FAM177A1 gene (3 alternative transcripts): 
    NM_001079519.1  NM_001289022.1  NM_173607.3  

    Unigene Cluster for FAM177A1:

    Family with sequence similarity 177, member A1
    Hs.446357  [show with all ESTs]
    Unigene Representative Sequence: NM_001079519
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000555211 ENST00000382406 ENST00000280987(uc001wsq.3) ENST00000554052
    ENST00000553852 ENST00000556858 ENST00000553955 ENST00000554794 ENST00000555260
    ENST00000553901(uc001wsv.1) ENST00000396472(uc001wsp.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FAM177A1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FAM177A1 (see all 31):
    hsa-miR-3910 hsa-miR-448 hsa-miR-4307 hsa-miR-520f hsa-miR-128 hsa-miR-181a-2* hsa-miR-548l hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidFAM177A1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for FAM177A1
    Predesigned siRNA for gene silencing in human, mouse, rat FAM177A1
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    OriGene clones in human, mouse for FAM177A1 (see all 13)
    OriGene ORF clones in mouse, rat for FAM177A1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FAM177A1 (NM_173607)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM177A1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM177A1
    Primer
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    OriGene qPCR primer pairs and template standards for FAM177A1
    OriGene qSTAR qPCR primer pairs in human, mouse for FAM177A1
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat FAM177A1
      QuantiTect SYBR Green Assays in human, mouse, rat FAM177A1
      QuantiFast Probe-based Assays in human, mouse, rat FAM177A1

    Additional mRNA sequence: 

    AK096173.1 AK130402.1 AL833508.1 BC029559.1 BX640884.1 BX640984.1 CR749796.1 

    18 DOTS entries:

    DT.91871528  DT.91658814  DT.95170539  DT.100025355  DT.213016  DT.120788702  DT.120788730  DT.98132076 
    DT.454564  DT.100651074  DT.99934535  DT.100781480  DT.120788714  DT.75124659  DT.100781479  DT.95170537 
    DT.120788820  DT.97788688 

    Selected AceView cDNA sequences (see all 165):

    N54724 BC029559 CA308186 CD678775 AW292052 AA425255 BM782700 AW206626 
    AA917338 AL833508 AI148967 BE646327 BM761063 AA610042 BM782411 AI678489 
    CA448919 AI862813 AA307286 AI567886 AI627278 CD368145 BU633985 AI080319 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for FAM177A1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
    SP1:                    -     -     -     -                                       
    SP2:                    -     -     -     -     -     -                           
    SP3:                                -                                             
    SP4:                                -     -                                       
    SP5:                                      -                                       


    ECgene alternative splicing isoforms for FAM177A1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM177A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTAACCTGAC
    FAM177A1 Expression
    About this image

    FAM177A1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM177A1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.446357
        Custom PCR Arrays for FAM177A1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM177A1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FAM177A1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 1700047I17Rik25 RIKEN cDNA 1700047I17 gene 2   --   12 (23.88 cM) 55199533 
    chicken
    (Gallus gallus)
    Aves FAM177A11 family with sequence similarity 177, member A1 74.64(n)
    76.56(a)
      423323  NM_001031202.1  NP_001026373.1 
    lizard
    (Anolis carolinensis)
    Reptilia FAM177A16
    family with sequence similarity 177, member A1
    66(a)
    1 ↔ 1
    2(54552485-54567510)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.246652 Xenopus laevis transcribed sequences 76.76(n)    CB197156.2 
    zebrafish
    (Danio rerio)
    Actinopterygii fam177a11 family with sequence similarity 177, member A1 64.56(n)
    62.64(a)
      100126028  NM_001105707.1  NP_001099177.1 


    ENSEMBL Gene Tree for FAM177A1 (if available)
    TreeFam Gene Tree for FAM177A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM177A1 gene
    FAM177B2  
    1 SIMAP similar gene for FAM177A1 using alignment to 6 protein entries:     F177A_HUMAN (see all proteins):
    FAM177B

    FAM177A1 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for FAM177A1
    PGOHUM00000261892 PGOHUM00000261904 PGOHUM00000261905


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM177A1 (see all 814)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1165905771,2
    F--35512136(+) TTAATT/GAACAA 1 -- us2k11Minor allele frequency- G:0.05WA 118
    rs80072741,2
    C,F--35512218(+) TTAAAG/TCTTAC 1 -- us2k13Minor allele frequency- T:0.21WA NA EA 358
    rs7994771,2
    C,F,H--35512335(-) AATACT/CAGGCC 1 -- us2k114Minor allele frequency- C:0.07NS EA NA 1490
    rs7994761,2
    C,F,A,H--35512612(-) CTGAAG/TAAGTT 1 -- us2k122Minor allele frequency- T:0.19NS EA NA WA CSA 2349
    rs802820261,2
    C,F--35512685(+) TACACG/ACCAGC 1 -- us2k11Minor allele frequency- A:0.08EA 120
    rs80090931,2
    C--35512703(+) GAGGCT/AGAGGT 1 -- us2k15Minor allele frequency- A:0.20NA WA EA 362
    rs1907001281,2
    --35512752(+) CCACTC/GCACTC 1 -- us2k10--------
    rs2004494511,2
    C--35512789(+) GTCTC-/AAAAAAA 1 -- us2k10--------
    rs58078071,2
    C--35512911(+) AACTT-/AAAAAA 1 -- us2k10--------
    rs1819879331,2
    --35512937(+) ATATAC/TATGTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FAM177A1 (35514113 - 35582336 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for FAM177A1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2515788CNV Deletion19546169
    nsv901615CNV Loss21882294
    dgv1871n71CNV Loss21882294
    nsv1239CNV Loss18451855
    nsv901602CNV Loss21882294
    nsv901614CNV Loss21882294
    nsv901607CNV Loss21882294
    nsv901611CNV Gain21882294
    nsv901612CNV Gain+Loss21882294
    nsv483012CNV Complex15286789

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FAM177A1
    DNA2.0 Custom Variant and Variant Library Synthesis for FAM177A1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for FAM177A1:    
    About MalaCards
    arthritis


    FAM177A1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FAM177A1
    Human Genome Epidemiology (HuGE) Navigator: FAM177A1 (1 document)

    Export disorders for FAM177A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM177A1 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with FAM177A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    4. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    6. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. Identification of a novel candidate locus for juvenile idiopathic arthritis at 14q13.2 in the Latvian population by association analysis with microsatellite markers. (PubMed id 20136554)4 Sjakste T....Sjakste N. (DNA Cell Biol. 2010)
    9. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    10. Noninvasive imaging of microRNA124a-mediated repression of the chromosome 14 ORF 24 gene during neurogenesis. (PubMed id 19663910)1 Ko H.Y....Kim S. (FEBS J. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 283635 HGNC: 19829 AceView: C14orf24 Ensembl:ENSG00000151327 euGenes: HUgn283635
    ECgene: FAM177A1 H-InvDB: FAM177A1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM177A1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM177A1 gene:
    Search GeneIP for patents involving FAM177A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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