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Aliases for FAM177A1 Gene

Aliases for FAM177A1 Gene

  • Family With Sequence Similarity 177 Member A1 2 3 5
  • C14orf24 3 4
  • Family With Sequence Similarity 177, Member A1 2
  • Chromosome 14 Open Reading Frame 24 2
  • Protein FAM177A1 3

External Ids for FAM177A1 Gene

Previous HGNC Symbols for FAM177A1 Gene

  • C14orf24

Previous GeneCards Identifiers for FAM177A1 Gene

  • GC14P034583
  • GC14P035514
  • GC14P015626

Summaries for FAM177A1 Gene

GeneCards Summary for FAM177A1 Gene

FAM177A1 (Family With Sequence Similarity 177 Member A1) is a Protein Coding gene. An important paralog of this gene is FAM177B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM177A1 Gene

Genomics for FAM177A1 Gene

Regulatory Elements for FAM177A1 Gene

Enhancers for FAM177A1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F035044 0.2 ENCODE 29.7 +1.8 1771 3.5 HDGF CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 CBX5 FAM177A1 PPP2R3C RNU1-27P EAPP BAZ1A LOC101927178
GH14F034980 0.5 ENCODE 19 -62.6 -62551 3.9 PKNOX1 ARNT CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 EAPP SRP54 FAM177A1 PSMA6 PPP2R3C RPS19P3 BAZ1A NFKBIA SRP54-AS1
GH14F035383 1 FANTOM5 Ensembl ENCODE 14 +340.3 340333 3.9 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF48 YY1 SLC30A9 ZNF121 FOS EAPP NFKBIA FAM177A1 PSMA6 RPS19P3 PPP2R3C RALGAPA1 RPLP0P3 ENSG00000258860
GH14F035284 1.1 FANTOM5 Ensembl ENCODE 12.2 +241.8 241762 5.3 PKNOX1 TBL1XR1 BMI1 RAD21 RARA YY1 EGR1 ETV6 CREM MIXL1 NFKBIA BAZ1A PSMA6 FAM177A1 PPP2R3C SRP54 GC14P035292 GC14P035293
GH14F034936 0.4 Ensembl 12 -108.8 -108807 0.2 MLX ARID4B DMAP1 THRB DNMT3B ZNF48 YY1 RARA ZNF335 CREM FAM177A1 GC14M034933 IGBP1P1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FAM177A1 on UCSC Golden Path with GeneCards custom track

Promoters for FAM177A1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001456632 1693 2801 HDGF CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 CBX5

Genomic Location for FAM177A1 Gene

Chromosome:
14
Start:
35,044,907 bp from pter
End:
35,113,130 bp from pter
Size:
68,224 bases
Orientation:
Plus strand

Genomic View for FAM177A1 Gene

Genes around FAM177A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM177A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM177A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM177A1 Gene

Proteins for FAM177A1 Gene

  • Protein details for FAM177A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N128-F177A_HUMAN
    Recommended name:
    Protein FAM177A1
    Protein Accession:
    Q8N128
    Secondary Accessions:
    • Q68CT2

    Protein attributes for FAM177A1 Gene

    Size:
    213 amino acids
    Molecular mass:
    23757 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM177A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM177A1 Gene

Post-translational modifications for FAM177A1 Gene

  • Ubiquitination at Lys 131
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FAM177A1 Gene

Domains & Families for FAM177A1 Gene

Protein Domains for FAM177A1 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM177A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N128

UniProtKB/Swiss-Prot:

F177A_HUMAN :
  • Belongs to the FAM177 family.
Family:
  • Belongs to the FAM177 family.
genes like me logo Genes that share domains with FAM177A1: view

No data available for Gene Families for FAM177A1 Gene

Function for FAM177A1 Gene

genes like me logo Genes that share phenotypes with FAM177A1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM177A1 Gene

Localization for FAM177A1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM177A1 Gene COMPARTMENTS Subcellular localization image for FAM177A1 gene
Compartment Confidence
nucleus 3
extracellular 2
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM177A1 Gene

Pathways & Interactions for FAM177A1 Gene

SuperPathways for FAM177A1 Gene

No Data Available

Interacting Proteins for FAM177A1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000280987%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000349658%0d%0a
Selected Interacting proteins: ENSP00000280987 Q8N128-F177A_HUMAN for FAM177A1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for FAM177A1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM177A1 Gene

Transcripts for FAM177A1 Gene

Unigene Clusters for FAM177A1 Gene

Family with sequence similarity 177, member A1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM177A1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
SP1: - - - -
SP2: - - - - - -
SP3: -
SP4: - -
SP5: -

Relevant External Links for FAM177A1 Gene

GeneLoc Exon Structure for
FAM177A1
ECgene alternative splicing isoforms for
FAM177A1

Expression for FAM177A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM177A1 Gene

Protein differential expression in normal tissues from HIPED for FAM177A1 Gene

This gene is overexpressed in Liver (19.3), Peripheral blood mononuclear cells (6.7), and Bone marrow stromal cell (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM177A1 Gene



NURSA nuclear receptor signaling pathways regulating expression of FAM177A1 Gene:

FAM177A1

SOURCE GeneReport for Unigene cluster for FAM177A1 Gene:

Hs.446357
genes like me logo Genes that share expression patterns with FAM177A1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for FAM177A1 Gene

Orthologs for FAM177A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM177A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM177A1 34 35
  • 99.29 (n)
dog
(Canis familiaris)
Mammalia FAM177A1 34 35
  • 90.17 (n)
cow
(Bos Taurus)
Mammalia FAM177A1 34 35
  • 88.31 (n)
rat
(Rattus norvegicus)
Mammalia Fam177a1 34
  • 87 (n)
mouse
(Mus musculus)
Mammalia 1700047I17Rik2 35
  • 85 (a)
OneToMany
Fam177a 35
  • 85 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia FAM177A1 35
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM177A1 35
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM177A1 34 35
  • 74.64 (n)
lizard
(Anolis carolinensis)
Reptilia FAM177A1 35
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam177a1 34
  • 70.1 (n)
Str.3217 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.24665 34
zebrafish
(Danio rerio)
Actinopterygii fam177a1 34 35
  • 64.56 (n)
FAM177A1 (1 of 2) 35
  • 46 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12525 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4574 35
  • 38 (a)
OneToMany
Species where no ortholog for FAM177A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM177A1 Gene

ENSEMBL:
Gene Tree for FAM177A1 (if available)
TreeFam:
Gene Tree for FAM177A1 (if available)

Paralogs for FAM177A1 Gene

Paralogs for FAM177A1 Gene

(1) SIMAP similar genes for FAM177A1 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for FAM177A1 Gene

genes like me logo Genes that share paralogs with FAM177A1: view

Variants for FAM177A1 Gene

Sequence variations from dbSNP and Humsavar for FAM177A1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs730882244 Likely pathogenic 35,077,176(+) ACTTA(-/A)TGGTT reference, frameshift-variant
rs10135138 -- 35,053,061(+) TTTCC(A/T)GATTT intron-variant
rs10136692 -- 35,048,404(+) AATAA(C/G)TACTT intron-variant
rs10139351 -- 35,048,786(+) TGGCA(A/G)AACTG intron-variant
rs10146343 -- 35,044,260(+) tggga(A/C)tacag upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FAM177A1 Gene

Variant ID Type Subtype PubMed ID
dgv1868n100 CNV gain 25217958
esv2515788 CNV deletion 19546169
esv3584249 CNV gain 25503493
esv3892499 CNV loss 25118596
nsv1042625 CNV gain 25217958
nsv1043801 CNV loss 25217958
nsv1239 CNV deletion 18451855
nsv483012 CNV gain+loss 15286789
nsv564263 CNV loss 21841781
nsv564264 CNV gain 21841781
nsv564265 CNV loss 21841781

Variation tolerance for FAM177A1 Gene

Residual Variation Intolerance Score: 49.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.21; 24.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM177A1 Gene

Human Gene Mutation Database (HGMD)
FAM177A1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM177A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM177A1 Gene

Disorders for FAM177A1 Gene

Relevant External Links for FAM177A1

Genetic Association Database (GAD)
FAM177A1
Human Genome Epidemiology (HuGE) Navigator
FAM177A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM177A1

No disorders were found for FAM177A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM177A1 Gene

Publications for FAM177A1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64

Products for FAM177A1 Gene

Sources for FAM177A1 Gene

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