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Aliases for FAM177A1 Gene

Aliases for FAM177A1 Gene

  • Family With Sequence Similarity 177 Member A1 2 3 5
  • C14orf24 3 4
  • Family With Sequence Similarity 177, Member A1 2
  • Chromosome 14 Open Reading Frame 24 2
  • Protein FAM177A1 3

External Ids for FAM177A1 Gene

Previous HGNC Symbols for FAM177A1 Gene

  • C14orf24

Previous GeneCards Identifiers for FAM177A1 Gene

  • GC14P034583
  • GC14P035514
  • GC14P015626

Summaries for FAM177A1 Gene

Entrez Gene Summary for FAM177A1 Gene

  • This gene encodes a member of a conserved protein family. Alternative splicing results in multiple transcript variants. This gene is thought to be associated with susceptibility to juvenile idiopathic arthritis. [provided by RefSeq, Apr 2017]

GeneCards Summary for FAM177A1 Gene

FAM177A1 (Family With Sequence Similarity 177 Member A1) is a Protein Coding gene. An important paralog of this gene is FAM177B.

Additional gene information for FAM177A1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM177A1 Gene

Genomics for FAM177A1 Gene

Regulatory Elements for FAM177A1 Gene

Enhancers for FAM177A1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H035044 1.1 ENCODE 29.7 +1.8 1771 3.5 HDGF FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 FAM177A1 PPP2R3C RALGAPA1 RNU1-27P EAPP BAZ1A LOC101927178
GH14H035383 1.8 FANTOM5 Ensembl ENCODE dbSUPER 14 +340.3 340333 3.9 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF121 SLC30A9 FOS SP5 EAPP NFKBIA FAM177A1 PSMA6 RPS19P3 PPP2R3C RALGAPA1 RPLP0P3 ENSG00000258860
GH14H034980 1.2 ENCODE 19.1 -62.6 -62551 3.9 PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 EAPP SRP54 FAM177A1 PSMA6 PPP2R3C RPS19P3 BAZ1A NFKBIA SRP54-AS1
GH14H035284 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12.2 +241.9 241864 5.1 PKNOX1 TBL1XR1 BMI1 BATF RAD21 YY1 ATF7 ETV6 RUNX3 CREM NFKBIA BAZ1A PSMA6 FAM177A1 PPP2R3C SRP54 GC14P035292 GC14P035293
GH14H035364 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.2 +322.6 322577 6.4 PKNOX1 FOXA2 MLX ZFP64 ARID4B DMAP1 SLC30A9 ZNF766 FOS SP5 NFKBIA PSMA6 BAZ1A EAPP PPP2R3C RPS19P3 FAM177A1 RALGAPA1 SRP54 ENSG00000258860
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM177A1 on UCSC Golden Path with GeneCards custom track

Promoters for FAM177A1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000067618 1493 2001 HDGF MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 ZNF143

Genomic Locations for FAM177A1 Gene

Genomic Locations for FAM177A1 Gene
chr14:35,044,907-35,113,130
(GRCh38/hg38)
Size:
68,224 bases
Orientation:
Plus strand
chr14:35,514,113-35,582,336
(GRCh37/hg19)

Genomic View for FAM177A1 Gene

Genes around FAM177A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM177A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM177A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM177A1 Gene

Proteins for FAM177A1 Gene

  • Protein details for FAM177A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N128-F177A_HUMAN
    Recommended name:
    Protein FAM177A1
    Protein Accession:
    Q8N128
    Secondary Accessions:
    • Q68CT2

    Protein attributes for FAM177A1 Gene

    Size:
    213 amino acids
    Molecular mass:
    23757 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM177A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM177A1 Gene

Post-translational modifications for FAM177A1 Gene

  • Ubiquitination at posLast=131131
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FAM177A1 Gene

Domains & Families for FAM177A1 Gene

Gene Families for FAM177A1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for FAM177A1 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM177A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N128

UniProtKB/Swiss-Prot:

F177A_HUMAN :
  • Belongs to the FAM177 family.
Family:
  • Belongs to the FAM177 family.
genes like me logo Genes that share domains with FAM177A1: view

Function for FAM177A1 Gene

Phenotypes From GWAS Catalog for FAM177A1 Gene

genes like me logo Genes that share phenotypes with FAM177A1: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM177A1 Gene

Localization for FAM177A1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM177A1 gene
Compartment Confidence
nucleus 3
extracellular 2
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM177A1 Gene

Pathways & Interactions for FAM177A1 Gene

SuperPathways for FAM177A1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM177A1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM177A1 Gene

Drugs & Compounds for FAM177A1 Gene

No Compound Related Data Available

Transcripts for FAM177A1 Gene

Unigene Clusters for FAM177A1 Gene

Family with sequence similarity 177, member A1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM177A1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
SP1: - - - -
SP2: - - - - - -
SP3: -
SP4: - -
SP5: -

Relevant External Links for FAM177A1 Gene

GeneLoc Exon Structure for
FAM177A1
ECgene alternative splicing isoforms for
FAM177A1

Expression for FAM177A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM177A1 Gene

Protein differential expression in normal tissues from HIPED for FAM177A1 Gene

This gene is overexpressed in Liver (19.3), Peripheral blood mononuclear cells (6.7), and Bone marrow stromal cell (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FAM177A1 Gene



NURSA nuclear receptor signaling pathways regulating expression of FAM177A1 Gene:

FAM177A1

SOURCE GeneReport for Unigene cluster for FAM177A1 Gene:

Hs.446357

Evidence on tissue expression from TISSUES for FAM177A1 Gene

  • Nervous system(3.4)
genes like me logo Genes that share expression patterns with FAM177A1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM177A1 Gene

Orthologs for FAM177A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM177A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM177A1 33 34
  • 99.29 (n)
dog
(Canis familiaris)
Mammalia FAM177A1 33 34
  • 90.17 (n)
cow
(Bos Taurus)
Mammalia FAM177A1 33 34
  • 88.31 (n)
rat
(Rattus norvegicus)
Mammalia Fam177a1 33
  • 87 (n)
mouse
(Mus musculus)
Mammalia 1700047I17Rik2 34
  • 85 (a)
OneToMany
Fam177a 34
  • 85 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia FAM177A1 34
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM177A1 34
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM177A1 33 34
  • 74.64 (n)
lizard
(Anolis carolinensis)
Reptilia FAM177A1 34
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam177a1 33
  • 70.1 (n)
Str.3217 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.24665 33
zebrafish
(Danio rerio)
Actinopterygii fam177a1 33 34
  • 64.56 (n)
FAM177A1 (1 of 2) 34
  • 46 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12525 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4574 34
  • 38 (a)
OneToMany
Species where no ortholog for FAM177A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM177A1 Gene

ENSEMBL:
Gene Tree for FAM177A1 (if available)
TreeFam:
Gene Tree for FAM177A1 (if available)

Paralogs for FAM177A1 Gene

Paralogs for FAM177A1 Gene

(1) SIMAP similar genes for FAM177A1 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for FAM177A1 Gene

genes like me logo Genes that share paralogs with FAM177A1: view

Variants for FAM177A1 Gene

Sequence variations from dbSNP and Humsavar for FAM177A1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs730882244 Likely pathogenic 35,077,176(+) ACTTA(-/A)TGGTT reference, frameshift-variant
rs1000023907 -- 35,044,751(+) GCGTG(A/G)TAGTG upstream-variant-2KB
rs1000071847 -- 35,077,725(+) GATCC(A/C)CCCGC intron-variant
rs1000092159 -- 35,061,064(+) CATAG(C/G)CATGT intron-variant
rs1000157214 -- 35,043,161(+) TGGGG(C/T)GGAAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FAM177A1 Gene

Variant ID Type Subtype PubMed ID
nsv564265 CNV loss 21841781
nsv564264 CNV gain 21841781
nsv564263 CNV loss 21841781
nsv483012 CNV gain+loss 15286789
nsv1239 CNV deletion 18451855
nsv1043801 CNV loss 25217958
nsv1042625 CNV gain 25217958
esv3892499 CNV loss 25118596
esv3584249 CNV gain 25503493
esv2515788 CNV deletion 19546169
dgv1868n100 CNV gain 25217958

Variation tolerance for FAM177A1 Gene

Residual Variation Intolerance Score: 49.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.21; 24.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM177A1 Gene

Human Gene Mutation Database (HGMD)
FAM177A1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM177A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM177A1 Gene

Disorders for FAM177A1 Gene

Relevant External Links for FAM177A1

Genetic Association Database (GAD)
FAM177A1
Human Genome Epidemiology (HuGE) Navigator
FAM177A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM177A1

No disorders were found for FAM177A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM177A1 Gene

Publications for FAM177A1 Gene

  1. Identification of a novel candidate locus for juvenile idiopathic arthritis at 14q13.2 in the Latvian population by association analysis with microsatellite markers. (PMID: 20136554) Sjakste T … Sjakste N (DNA and cell biology 2010) 3 45 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. (PMID: 27432908) Li X … Wang W (Molecular & cellular proteomics : MCP 2016) 3 60

Products for FAM177A1 Gene

Sources for FAM177A1 Gene

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