FAM177A1 Gene
protein-coding GIFtS: 43
GCID: GC14P035514
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|
family with sequence similarity 177, member A1(Previous name: chromosome 14 open reading frame 24 )
(Previous symbol: C14orf24)
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Aliases
for FAM177A1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Family With Sequence Similarity 177, Member A11 2 | | C14orf241 2 3 | | Chromosome 14 Open Reading Frame 241 | | Protein FAM177A12 |
Export aliases for FAM177A1 gene to outside databasesPrevious GC identifers: GC14P034583 GC14P015626 |
Summaries
for FAM177A1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FAM177A1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FAM177A1 gene promoter:
ATF-2 Tal-1beta En-1 RSRFC4 E47
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM177A1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM177A1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q13.2 Ensembl cytogenetic band: 14q13.2 HGNC cytogenetic band: 14q13.2FAM177A1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14P035514: view genomic region
(about GC identifiers)
Start:
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35,514,113 bp from pter |
End:
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35,582,336 bp from pter |
Size:
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68,224 bases |
Orientation:
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plus strand |
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Proteins
for FAM177A1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: F177A_HUMAN, Q8N128 (See
protein sequence)Recommended Name: Protein FAM177A1 Size: 213 amino acids; 23757 Da
Secondary accessions: Q68CT2Alternative splicing: 2 isoforms: Q8N128-1 Q8N128-2 Explore the universe of human proteins at neXtProt for FAM177A1: NX_Q8N128
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N128
FAM177A1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001072987.1 NP_775878.2
ENSEMBL proteins: ENSP00000451508 ENSP00000371843 ENSP00000280987 ENSP00000451165 ENSP00000450424 ENSP00000452223 ENSP00000452425 ENSP00000379734
Human Recombinant Protein Products:
FAM177A1 Antibody Products:
Assay Products for FAM177A1: |
Protein
Domains /
Families
for FAM177A1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q8N128 1 Blocks protein family: IPB001792 Acylphosphatase
UniProtKB/Swiss-Prot: F177A_HUMAN, Q8N128Similarity: Belongs to the FAM177 family |
Function
for FAM177A1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM177A1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM177A1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): FAM177A1 (NM_173607) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM177A1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM177A1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM177A1 |
1 GenomeRNAi human phenotype for FAM177A1:
|
Pathways & Interactions
for FAM177A1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM177A1
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for FAM177A1 (ENSP000002809874) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for FAM177A1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM177A1
Search CenterWatch for drugs/clinical trials and news about FAM177A1 / F177A
|
Transcripts
for FAM177A1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAM177A1 gene (2 alternative transcripts): NM_001079519.1 NM_173607.3 Unigene Cluster for FAM177A1: Family with sequence similarity 177, member A1 Hs.446357 [show with all ESTs]Unigene Representative Sequence: NM_00107951911 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000555211 ENST00000382406 ENST00000280987(uc001wsq.3) ENST00000554052
ENST00000553852 ENST00000553955 ENST00000556858 ENST00000554794 ENST00000555260
ENST00000553901(uc001wsv.1) ENST00000396472(uc001wsp.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM177A1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM177A1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): FAM177A1 (NM_173607) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM177A1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM177A1 |
Additional cDNA sequence: AK096173.1 AK130402.1 AL833508.1 BC029559.1 BX640884.1 BX640984.1 CR749796.1 18 DOTS entries: DT.91871528 DT.91658814 DT.95170539 DT.100025355 DT.213016 DT.120788702 DT.120788730 DT.98132076 DT.454564 DT.100651074 DT.99934535 DT.100781480 DT.120788714 DT.75124659 DT.100781479 DT.95170537 DT.120788820 DT.97788688 24/165 AceView cDNA sequences (see all 165): AI148967 AL833508 N54724 AW206626 AA917338 BM782700 AA425255 AW292052 CD678775 BC029559 CA308186 BU633985 CD368145 AA307286 AI567886 AI627278 AI678489 CA448919 AI862813 BM782411 AA610042 BM761063 BE646327 BE328279
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for FAM177A1 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b |
|---|
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| SP1: | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FAM177A1
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Expression
for FAM177A1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAM177A1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTAACCTGAC
About this image
See FAM177A1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM177A1
SOURCE GeneReport for Unigene cluster: Hs.446357
SABiosciences Custom PCR Arrays for FAM177A1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM177A1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat FAM177A1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM177A1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM177A1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM177A1 |
Orthologs
for FAM177A1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FAM177A1 gene from 6/19 species (see all 19) About this table
ENSEMBL Gene Tree for FAM177A1 (if available)
TreeFam Gene Tree for FAM177A1 (if available) |
Paralogs
for FAM177A1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAM177A1 gene
- FAM177B2
1 SIMAP similar gene for FAM177A1 using alignment to 5 protein entries: F177A_HUMAN (see all proteins):FAM177B
FAM177A1 for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for FAM177A1
PGOHUM00000261892 PGOHUM00000261904 PGOHUM00000261905
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Genomic Variants
for FAM177A1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM177A1 (35514113 - 35582336 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for FAM177A1
2 CNVs: 101923 0176 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM177A1 |
|
Disorders
/ Diseases
for FAM177A1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 FAM177A1 for disorders About MalaCards
FAM177A1 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: FAM177A1 (1 document)
Export disorders for FAM177A1 gene to outside databases
|
Publications
for FAM177A1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM177A1 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with FAM177A1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Noninvasive imaging of microRNA124a-mediated repressi on of the chromosome 14 ORF 24 gene during neurogenesis. (PubMed id 19663910)1 Ko H.Y....Kim S. (2009)
- Phosphoproteome of resting human platelets. (PubMed id 18088087)2 Zahedi R.P.... Sickmann A. (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
|
External Searches for FAM177A1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FAM177A1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM177A1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FAM177A1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAM177A1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FAM177A1 gene:
Search GeneIP for patents involving FAM177A1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM177A1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FAM177A1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM177A1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM177A1 | | | OriGene Protein Over-expression Lysate for FAM177A1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for FAM177A1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM177A1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM177A1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FAM177A1 | | OriGene Custom Protein Services for FAM177A1 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM177A1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM177A1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM177A1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM177A1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM177A1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM177A1 |
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 | | | FAM177A1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM177A1 |
|  |  |  | | | | Search ThermoFisher Antibodies for FAM177A1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM177A1 |
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