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Aliases for FAM177A1 Gene

Aliases for FAM177A1 Gene

  • Family With Sequence Similarity 177, Member A1 2 3
  • C14orf24 3 4
  • Chromosome 14 Open Reading Frame 24 2

External Ids for FAM177A1 Gene

Previous HGNC Symbols for FAM177A1 Gene

  • C14orf24

Previous GeneCards Identifiers for FAM177A1 Gene

  • GC14P034583
  • GC14P035514
  • GC14P015626

Summaries for FAM177A1 Gene

GeneCards Summary for FAM177A1 Gene

FAM177A1 (Family With Sequence Similarity 177, Member A1) is a Protein Coding gene. An important paralog of this gene is FAM177B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM177A1 Gene

Genomics for FAM177A1 Gene

Regulatory Elements for FAM177A1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM177A1 Gene

35,044,907 bp from pter
35,113,130 bp from pter
68,224 bases
Plus strand

Genomic View for FAM177A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM177A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM177A1 Gene

Proteins for FAM177A1 Gene

  • Protein details for FAM177A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM177A1
    Protein Accession:
    Secondary Accessions:
    • Q68CT2

    Protein attributes for FAM177A1 Gene

    213 amino acids
    Molecular mass:
    23757 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM177A1 Gene


neXtProt entry for FAM177A1 Gene

Proteomics data for FAM177A1 Gene at MOPED

Post-translational modifications for FAM177A1 Gene

  • Ubiquitination at Lys 131
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FAM177A1 Gene

Domains & Families for FAM177A1 Gene

Protein Domains for FAM177A1 Gene


Suggested Antigen Peptide Sequences for FAM177A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM177 family.
  • Belongs to the FAM177 family.
genes like me logo Genes that share domains with FAM177A1: view

No data available for Gene Families for FAM177A1 Gene

Function for FAM177A1 Gene

Phenotypes for FAM177A1 Gene

genes like me logo Genes that share phenotypes with FAM177A1: view

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM177A1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM177A1 Gene

Localization for FAM177A1 Gene

Subcellular locations from

Jensen Localization Image for FAM177A1 Gene COMPARTMENTS Subcellular localization image for FAM177A1 gene
Compartment Confidence
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM177A1 Gene

Pathways & Interactions for FAM177A1 Gene

SuperPathways for FAM177A1 Gene

No Data Available

Interacting Proteins for FAM177A1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000280987 for FAM177A1 Gene via STRING

Gene Ontology (GO) - Biological Process for FAM177A1 Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM177A1 Gene

Drugs & Compounds for FAM177A1 Gene

No Compound Related Data Available

Transcripts for FAM177A1 Gene

Unigene Clusters for FAM177A1 Gene

Family with sequence similarity 177, member A1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM177A1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM177A1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
SP1: - - - -
SP2: - - - - - -
SP3: -
SP4: - -
SP5: -

Relevant External Links for FAM177A1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM177A1 Gene

mRNA expression in normal human tissues for FAM177A1 Gene

Protein differential expression in normal tissues from HIPED for FAM177A1 Gene

This gene is overexpressed in Liver (19.3), Peripheral blood mononuclear cells (6.7), and Bone marrow stromal cell (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM177A1 Gene

SOURCE GeneReport for Unigene cluster for FAM177A1 Gene Hs.446357

genes like me logo Genes that share expression patterns with FAM177A1: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FAM177A1 Gene

Orthologs for FAM177A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM177A1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM177A1 35
  • 88.31 (n)
  • 89.57 (a)
FAM177A1 36
  • 89 (a)
(Canis familiaris)
Mammalia FAM177A1 35
  • 90.17 (n)
  • 88.46 (a)
FAM177A1 36
  • 90 (a)
(Pan troglodytes)
Mammalia FAM177A1 35
  • 99.29 (n)
  • 98.73 (a)
FAM177A1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Fam177a1 35
  • 87 (n)
  • 90.66 (a)
(Mus musculus)
Mammalia 1700047I17Rik2 16
1700047I17Rik2 36
  • 85 (a)
Fam177a 36
  • 85 (a)
(Monodelphis domestica)
Mammalia FAM177A1 36
  • 53 (a)
(Ornithorhynchus anatinus)
Mammalia FAM177A1 36
  • 77 (a)
(Gallus gallus)
Aves FAM177A1 35
  • 74.64 (n)
  • 76.56 (a)
FAM177A1 36
  • 73 (a)
(Anolis carolinensis)
Reptilia FAM177A1 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam177a1 35
  • 70.1 (n)
  • 69.14 (a)
Str.3217 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.24665 35
(Danio rerio)
Actinopterygii fam177a1 35
  • 64.56 (n)
  • 62.64 (a)
fam177a1 36
  • 52 (a)
FAM177A1 (1 of 2) 36
  • 46 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12525 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4574 36
  • 38 (a)
Species with no ortholog for FAM177A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM177A1 Gene

Gene Tree for FAM177A1 (if available)
Gene Tree for FAM177A1 (if available)

Paralogs for FAM177A1 Gene

Paralogs for FAM177A1 Gene

(1) SIMAP similar genes for FAM177A1 Gene using alignment to 6 proteins: Pseudogenes for FAM177A1 Gene

genes like me logo Genes that share paralogs with FAM177A1: view

Variants for FAM177A1 Gene

Sequence variations from dbSNP and Humsavar for FAM177A1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs799471 -- 35,061,422(-) TCAGC(C/T)CCTAA intron-variant
rs799472 -- 35,061,262(-) atctc(C/T)tccca intron-variant
rs799473 -- 35,047,007(-) ATGCC(A/C)AGGCA intron-variant
rs799474 -- 35,046,893(-) TGGTA(C/G)ACCAG intron-variant
rs799475 -- 35,045,744(-) TGTGC(A/G)TATGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FAM177A1 Gene

Variant ID Type Subtype PubMed ID
nsv483012 CNV Complex 15286789
nsv901602 CNV Loss 21882294
nsv901607 CNV Loss 21882294
dgv1871n71 CNV Loss 21882294
nsv901611 CNV Gain 21882294
nsv901612 CNV Gain+Loss 21882294
nsv1239 CNV Loss 18451855
nsv901614 CNV Loss 21882294
nsv901615 CNV Loss 21882294
esv2515788 CNV Deletion 19546169

Variation tolerance for FAM177A1 Gene

Residual Variation Intolerance Score: 49.59% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.21; 24.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM177A1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM177A1 Gene

Disorders for FAM177A1 Gene

Relevant External Links for FAM177A1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FAM177A1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM177A1 Gene

Publications for FAM177A1 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  3. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P. … Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012) 67
  4. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 67
  5. Identification of a novel candidate locus for juvenile idiopathic arthritis at 14q13.2 in the Latvian population by association analysis with microsatellite markers. (PMID: 20136554) Sjakste T. … Sjakste N. (DNA Cell Biol. 2010) 67

Products for FAM177A1 Gene

Sources for FAM177A1 Gene

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