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Aliases for FAM175B Gene

Aliases for FAM175B Gene

  • Family With Sequence Similarity 175, Member B 2 3
  • KIAA0157 2 3 4 6
  • ABRO1 3 4 6
  • Abraxas Brother Protein 1 3 4
  • BRISC Complex Subunit Abro1 3
  • Abraxas Brother 1 3
  • Abraxas Brother 2
  • Protein FAM175B 4

External Ids for FAM175B Gene

Previous Symbols for FAM175B Gene

  • KIAA0157

Summaries for FAM175B Gene

GeneCards Summary for FAM175B Gene

FAM175B (Family With Sequence Similarity 175, Member B) is a Protein Coding gene. GO annotations related to this gene include polyubiquitin binding. An important paralog of this gene is FAM175A.

UniProtKB/Swiss-Prot for FAM175B Gene

  • Component of the BRISC complex, a multiprotein complex that specifically cleaves Lys-63-linked ubiquitin. May act as a central scaffold protein that assembles the various components of the BRISC complex

Gene Wiki entry for FAM175B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM175B Gene

Genomics for FAM175B Gene

Genomic Location for FAM175B Gene

124,801,785 bp from pter
124,836,670 bp from pter
34,886 bases
Plus strand

Genomic View for FAM175B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM175B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM175B Gene

Regulatory Elements for FAM175B Gene

Proteins for FAM175B Gene

  • Protein details for FAM175B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BRISC complex subunit Abro1
    Protein Accession:
    Secondary Accessions:
    • B4DKR2
    • Q96H11

    Protein attributes for FAM175B Gene

    415 amino acids
    Molecular mass:
    46901 Da
    Quaternary structure:
    • Component of the BRISC complex, at least composed of the FAM175B/ABRO1, BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1. Does not interact with BRCA1. Binds polyubiquitin.
    • Sequence=BAA09927.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for FAM175B Gene

Proteomics data for FAM175B Gene at MOPED

Post-translational modifications for FAM175B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM175B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM175B Gene

Domains for FAM175B Gene

Protein Domains for FAM175B Gene


  • The MPN-like region is similar to the MPN (JAB/Mov34) domain.:
    • Q15018
  • Belongs to the FAM175 family. Abro1 subfamily.:
    • Q15018
genes like me logo Genes that share domains with FAM175B: view

No data available for Gene Families for FAM175B Gene

Function for FAM175B Gene

Molecular function for FAM175B Gene

UniProtKB/Swiss-Prot Function: Component of the BRISC complex, a multiprotein complex that specifically cleaves Lys-63-linked ubiquitin. May act as a central scaffold protein that assembles the various components of the BRISC complex

Gene Ontology (GO) - Molecular Function for FAM175B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0031593 polyubiquitin binding IDA 19261749
genes like me logo Genes that share ontologies with FAM175B: view

Phenotypes for FAM175B Gene

GenomeRNAi human phenotypes for FAM175B:
genes like me logo Genes that share phenotypes with FAM175B: view

miRNA for FAM175B Gene

miRTarBase miRNAs that target FAM175B

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FAM175B Gene

Localization for FAM175B Gene

Subcellular locations from

Jensen Localization Image for FAM175B Gene COMPARTMENTS Subcellular localization image for FAM175B gene
Compartment Confidence
nucleus 5
cytosol 1
extracellular 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FAM175B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005737 cytoplasm IEA --
GO:0070552 BRISC complex IDA 19214193
genes like me logo Genes that share ontologies with FAM175B: view

Pathways for FAM175B Gene

SuperPathways for FAM175B Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM175B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0071497 cellular response to freezing IEA --
genes like me logo Genes that share ontologies with FAM175B: view

No data available for Pathways by source for FAM175B Gene

Transcripts for FAM175B Gene

mRNA/cDNA for FAM175B Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(136) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM175B Gene

Family with sequence similarity 175, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM175B Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9
SP1: - - -
SP2: - - -
SP3: - - - -
SP4: - -
SP5: -
SP6: - -

Relevant External Links for FAM175B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM175B Gene

mRNA expression in normal human tissues for FAM175B Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM175B Gene

SOURCE GeneReport for Unigene cluster for FAM175B Gene Hs.280695

genes like me logo Genes that share expressions with FAM175B: view

Orthologs for FAM175B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM175B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM175B 36
  • 99.84 (n)
  • 99.76 (a)
FAM175B 37
  • 100 (a)
(Bos Taurus)
Mammalia -- 37
  • 91 (a)
FAM175B 36
  • 90.92 (n)
  • 93.73 (a)
FAM175B 37
  • 93 (a)
(Canis familiaris)
Mammalia FAM175B 36
  • 92.77 (n)
  • 95.66 (a)
FAM175B 37
  • 90 (a)
(Mus musculus)
Mammalia Fam175b 36
  • 90.44 (n)
  • 93.49 (a)
Fam175b 16
Fam175b 37
  • 92 (a)
(Monodelphis domestica)
Mammalia FAM175B 37
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia FAM175B 37
  • 63 (a)
(Rattus norvegicus)
Mammalia Fam175b 36
  • 91 (n)
  • 94.22 (a)
(Gallus gallus)
Aves FAM175B 36
  • 81.74 (n)
  • 85.51 (a)
FAM175B 37
  • 85 (a)
(Anolis carolinensis)
Reptilia FAM175B 37
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam175b 36
  • 71.22 (n)
  • 77.02 (a)
LOC394764 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7469 36
(Danio rerio)
Actinopterygii fam175b 37
  • 58 (a)
LOC100538340 36
  • 67.26 (n)
  • 70.41 (a)
Species with no ortholog for FAM175B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM175B Gene

Gene Tree for FAM175B (if available)
Gene Tree for FAM175B (if available)

Paralogs for FAM175B Gene

Paralogs for FAM175B Gene

Selected SIMAP similar genes for FAM175B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM175B: view

Variants for FAM175B Gene

Sequence variations from dbSNP and Humsavar for FAM175B Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs9054 -- 124,835,331(+) CAAAA(A/G)CTTAC utr-variant-3-prime
rs1051041 -- 124,834,597(+) CTGAA(G/T)GCAGA reference, missense
rs1131479 -- 124,801,896(+) ACGCG(G/T)ACCAC reference, missense
rs1351977 -- 124,807,752(-) CACCC(C/T)CATTG intron-variant
rs1807952 -- 124,807,588(-) GCAAC(C/T)TCCGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM175B Gene

Variant ID Type Subtype PubMed ID
nsv832014 CNV Loss 17160897
esv2660881 CNV Deletion 23128226

Relevant External Links for FAM175B Gene

HapMap Linkage Disequilibrium report

Disorders for FAM175B Gene

Relevant External Links for FAM175B

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with FAM175B: view

No data available for UniProtKB/Swiss-Prot for FAM175B Gene

Publications for FAM175B Gene

  1. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8590280) Nagase T. … Nomura N. (DNA Res. 1995) 2 3 4
  2. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PMID: 15144186) Brill L.M. … Peters E.C. (Anal. Chem. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  5. K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC- associated Brcc36 and proteasomal Poh1. (PMID: 19214193) Cooper E.M. … Cohen R.E. (EMBO J. 2009) 3 4

Products for FAM175B Gene

Sources for FAM175B Gene

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