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Aliases for FAM175B Gene

Aliases for FAM175B Gene

  • Family With Sequence Similarity 175, Member B 2 3
  • KIAA0157 2 3 4
  • Abraxas Brother Protein 1 3 4
  • ABRO1 3 4
  • Abraxas Brother 1 3
  • Abraxas Brother 2
  • Protein FAM175B 4

External Ids for FAM175B Gene

Previous HGNC Symbols for FAM175B Gene

  • KIAA0157

Previous GeneCards Identifiers for FAM175B Gene

  • GC10P126481
  • GC10P120177

Summaries for FAM175B Gene

GeneCards Summary for FAM175B Gene

FAM175B (Family With Sequence Similarity 175, Member B) is a Protein Coding gene. GO annotations related to this gene include polyubiquitin binding. An important paralog of this gene is FAM175A.

UniProtKB/Swiss-Prot for FAM175B Gene

  • Component of the BRISC complex, a multiprotein complex that specifically cleaves Lys-63-linked ubiquitin. May act as a central scaffold protein that assembles the various components of the BRISC complex

Gene Wiki entry for FAM175B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM175B Gene

Genomics for FAM175B Gene

Regulatory Elements for FAM175B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM175B Gene

Chromosome:
10
Start:
124,801,785 bp from pter
End:
124,836,670 bp from pter
Size:
34,886 bases
Orientation:
Plus strand

Genomic View for FAM175B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM175B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM175B Gene

Proteins for FAM175B Gene

  • Protein details for FAM175B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15018-F175B_HUMAN
    Recommended name:
    BRISC complex subunit Abro1
    Protein Accession:
    Q15018
    Secondary Accessions:
    • B4DKR2
    • Q96H11

    Protein attributes for FAM175B Gene

    Size:
    415 amino acids
    Molecular mass:
    46901 Da
    Quaternary structure:
    • Component of the BRISC complex, at least composed of the FAM175B/ABRO1, BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1. Does not interact with BRCA1. Binds polyubiquitin.
    SequenceCaution:
    • Sequence=BAA09927.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for FAM175B Gene

Proteomics data for FAM175B Gene at MOPED

Post-translational modifications for FAM175B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM175B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for FAM175B

No data available for DME Specific Peptides for FAM175B Gene

Domains & Families for FAM175B Gene

Protein Domains for FAM175B Gene

Suggested Antigen Peptide Sequences for FAM175B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15018

UniProtKB/Swiss-Prot:

F175B_HUMAN :
  • The MPN-like region is similar to the MPN (JAB/Mov34) domain.
  • Belongs to the FAM175 family. Abro1 subfamily.
Domain:
  • The MPN-like region is similar to the MPN (JAB/Mov34) domain.
Family:
  • Belongs to the FAM175 family. Abro1 subfamily.
genes like me logo Genes that share domains with FAM175B: view

No data available for Gene Families for FAM175B Gene

Function for FAM175B Gene

Molecular function for FAM175B Gene

UniProtKB/Swiss-Prot Function:
Component of the BRISC complex, a multiprotein complex that specifically cleaves Lys-63-linked ubiquitin. May act as a central scaffold protein that assembles the various components of the BRISC complex

Gene Ontology (GO) - Molecular Function for FAM175B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0031593 polyubiquitin binding IDA 19261749
genes like me logo Genes that share ontologies with FAM175B: view

Phenotypes for FAM175B Gene

genes like me logo Genes that share phenotypes with FAM175B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM175B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM175B Gene

Localization for FAM175B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM175B Gene COMPARTMENTS Subcellular localization image for FAM175B gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for FAM175B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005737 cytoplasm IEA --
GO:0070552 BRISC complex IDA 19214193
genes like me logo Genes that share ontologies with FAM175B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAM175B Gene

Pathways & Interactions for FAM175B Gene

SuperPathways for FAM175B Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM175B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0071497 cellular response to freezing IEA --
genes like me logo Genes that share ontologies with FAM175B: view

No data available for Pathways by source and SIGNOR curated interactions for FAM175B Gene

Drugs & Compounds for FAM175B Gene

No Compound Related Data Available

Transcripts for FAM175B Gene

mRNA/cDNA for FAM175B Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(136) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM175B Gene

Family with sequence similarity 175, member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM175B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM175B Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9
SP1: - - -
SP2: - - -
SP3: - - - -
SP4: - -
SP5: -
SP6: - -

Relevant External Links for FAM175B Gene

GeneLoc Exon Structure for
FAM175B
ECgene alternative splicing isoforms for
FAM175B

Expression for FAM175B Gene

mRNA expression in normal human tissues for FAM175B Gene

Protein differential expression in normal tissues from HIPED for FAM175B Gene

This gene is overexpressed in Urinary Bladder (19.1), Colon muscle (9.3), Uterus (7.8), and Amniocyte (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM175B Gene



SOURCE GeneReport for Unigene cluster for FAM175B Gene Hs.280695

genes like me logo Genes that share expression patterns with FAM175B: view

Protein tissue co-expression partners for FAM175B Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM175B Gene

Orthologs for FAM175B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM175B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAM175B 35
  • 90.92 (n)
  • 93.73 (a)
-- 36
  • 91 (a)
OneToMany
FAM175B 36
  • 93 (a)
OneToMany
dog
(Canis familiaris)
Mammalia FAM175B 35
  • 92.77 (n)
  • 95.66 (a)
FAM175B 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam175b 35
  • 90.44 (n)
  • 93.49 (a)
Fam175b 16
Fam175b 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM175B 35
  • 99.84 (n)
  • 99.76 (a)
FAM175B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam175b 35
  • 91 (n)
  • 94.22 (a)
oppossum
(Monodelphis domestica)
Mammalia FAM175B 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM175B 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM175B 35
  • 81.74 (n)
  • 85.51 (a)
FAM175B 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM175B 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam175b 35
  • 71.22 (n)
  • 77.02 (a)
LOC394764 35
zebrafish
(Danio rerio)
Actinopterygii LOC100538340 35
  • 67.26 (n)
  • 70.41 (a)
fam175b 36
  • 58 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7469 35
Species with no ortholog for FAM175B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM175B Gene

ENSEMBL:
Gene Tree for FAM175B (if available)
TreeFam:
Gene Tree for FAM175B (if available)

Paralogs for FAM175B Gene

Paralogs for FAM175B Gene

(1) SIMAP similar genes for FAM175B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM175B: view

Variants for FAM175B Gene

Sequence variations from dbSNP and Humsavar for FAM175B Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs9054 -- 124,835,331(+) CAAAA(A/G)CTTAC utr-variant-3-prime
rs1051041 -- 124,834,597(+) CTGAA(G/T)GCAGA reference, missense
rs1131479 -- 124,801,896(+) ACGCG(G/T)ACCAC reference, missense, utr-variant-5-prime
rs1351977 -- 124,807,752(-) CACCC(C/T)CATTG intron-variant
rs1807952 -- 124,807,588(-) GCAAC(C/T)TCCGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM175B Gene

Variant ID Type Subtype PubMed ID
nsv832014 CNV Loss 17160897
esv2660881 CNV Deletion 23128226

Variation tolerance for FAM175B Gene

Residual Variation Intolerance Score: 33.07% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.30; 25.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM175B Gene

HapMap Linkage Disequilibrium report
FAM175B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM175B Gene

Disorders for FAM175B Gene

Relevant External Links for FAM175B

Genetic Association Database (GAD)
FAM175B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM175B
genes like me logo Genes that share disorders with FAM175B: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM175B Gene

Publications for FAM175B Gene

  1. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8590280) Nagase T. … Nomura N. (DNA Res. 1995) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. ABRO1 suppresses tumourigenesis and regulates the DNA damage response by stabilizing p53. (PMID: 25283148) Zhang J. … Yang X. (Nat Commun 2014) 67
  4. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan J.A. … Goldberg A.L. (EMBO J. 2013) 67
  5. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PMID: 24255178) Couzens A.L. … Gingras A.C. (Sci Signal 2013) 67

Products for FAM175B Gene

Sources for FAM175B Gene

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