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Aliases for FAM175B Gene

Aliases for FAM175B Gene

  • Family With Sequence Similarity 175 Member B 2 3 5
  • KIAA0157 2 3 4
  • Family With Sequence Similarity 175, Member B 2 3
  • Abraxas Brother Protein 1 3 4
  • ABRO1 3 4
  • Abraxas Brother 1 3
  • Abraxas Brother 2
  • Protein FAM175B 4

External Ids for FAM175B Gene

Previous HGNC Symbols for FAM175B Gene

  • KIAA0157

Previous GeneCards Identifiers for FAM175B Gene

  • GC10P126481
  • GC10P120177

Summaries for FAM175B Gene

GeneCards Summary for FAM175B Gene

FAM175B (Family With Sequence Similarity 175 Member B) is a Protein Coding gene. GO annotations related to this gene include polyubiquitin binding. An important paralog of this gene is FAM175A.

UniProtKB/Swiss-Prot for FAM175B Gene

  • Component of the BRISC complex, a multiprotein complex that specifically cleaves Lys-63-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates (PubMed:19214193, PubMed:20032457, PubMed:20656690, PubMed:24075985). May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm (PubMed:20656690). Plays a role in regulating the onset of apoptosis via its role in modulating Lys-63-linked ubiquitination of target proteins (By similarity). Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). Required for normal induction of p53/TP53 in response to DNA damage (PubMed:25283148). Independent of the BRISC complex, promotes interaction between USP7 and p53/TP53, and thereby promotes deubiquitination of p53/TP53, preventing its degradation and resulting in increased p53/TP53-mediated transcription regulation and p53/TP53-dependent apoptosis in response to DNA damage (PubMed:25283148).

Gene Wiki entry for FAM175B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM175B Gene

Genomics for FAM175B Gene

Regulatory Elements for FAM175B Gene

Promoters for FAM175B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAM175B on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM175B Gene

Chromosome:
10
Start:
124,801,785 bp from pter
End:
124,836,670 bp from pter
Size:
34,886 bases
Orientation:
Plus strand

Genomic View for FAM175B Gene

Genes around FAM175B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM175B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM175B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM175B Gene

Proteins for FAM175B Gene

  • Protein details for FAM175B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15018-F175B_HUMAN
    Recommended name:
    BRISC complex subunit Abro1
    Protein Accession:
    Q15018
    Secondary Accessions:
    • B4DKR2
    • Q96H11

    Protein attributes for FAM175B Gene

    Size:
    415 amino acids
    Molecular mass:
    46901 Da
    Quaternary structure:
    • Component of the BRISC complex, at least composed of FAM175B/ABRO1, BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1 (PubMed:19214193, PubMed:20032457, PubMed:21282113, PubMed:24075985, PubMed:25283148, PubMed:26344097, PubMed:26195665). Interacts with BRCC3/BRCC36; the interaction is direct (PubMed:20032457, PubMed:20656690, PubMed:26344097). Interacts with BABAM1 (PubMed:21282113). Does not interact with BRCA1 (PubMed:17525340, PubMed:21282113). Interacts with SHMT1 and SHMT2; the interaction is direct. Identified in a complex with SHMT2 and the other subunits of the BRISC complex (PubMed:24075985). Identified in complexes with INAR1, INAR2 and SHMT2 (PubMed:24075985). Interacts with THAP5 (PubMed:21195082). Interacts with ATF4 (PubMed:22974638). Interacts with p53/TP53; the interaction is direct. Interacts with USP7; the interaction is direct. Identified in a complex with p53/TP53 and USP7 (PubMed:25283148). Interacts with NUMA1 (PubMed:26195665). Interacts with microtubule minus ends (PubMed:26195665). Binds polyubiquitin (PubMed:19261749). The BRISC complex binds monoubiquitin and both Lys-48- and Lys-63-linked polyubiquitin (PubMed:20032457).
    SequenceCaution:
    • Sequence=BAA09927.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for FAM175B Gene

Proteomics data for FAM175B Gene at MOPED

Post-translational modifications for FAM175B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM175B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for FAM175B

No data available for DME Specific Peptides for FAM175B Gene

Domains & Families for FAM175B Gene

Protein Domains for FAM175B Gene

Suggested Antigen Peptide Sequences for FAM175B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15018

UniProtKB/Swiss-Prot:

F175B_HUMAN :
  • The MPN-like region is similar to the MPN (JAB/Mov34) domain.
  • Belongs to the FAM175 family. Abro1 subfamily.
Domain:
  • The MPN-like region is similar to the MPN (JAB/Mov34) domain.
Family:
  • Belongs to the FAM175 family. Abro1 subfamily.
genes like me logo Genes that share domains with FAM175B: view

No data available for Gene Families for FAM175B Gene

Function for FAM175B Gene

Molecular function for FAM175B Gene

UniProtKB/Swiss-Prot Function:
Component of the BRISC complex, a multiprotein complex that specifically cleaves Lys-63-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates (PubMed:19214193, PubMed:20032457, PubMed:20656690, PubMed:24075985). May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm (PubMed:20656690). Plays a role in regulating the onset of apoptosis via its role in modulating Lys-63-linked ubiquitination of target proteins (By similarity). Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). Required for normal induction of p53/TP53 in response to DNA damage (PubMed:25283148). Independent of the BRISC complex, promotes interaction between USP7 and p53/TP53, and thereby promotes deubiquitination of p53/TP53, preventing its degradation and resulting in increased p53/TP53-mediated transcription regulation and p53/TP53-dependent apoptosis in response to DNA damage (PubMed:25283148).
UniProtKB/Swiss-Prot Induction:
Up-regulated in response to DNA damage (PubMed:25283148). Up-regulated in myocardial infarction area (at protein level) (PubMed:21195082).
genes like me logo Genes that share phenotypes with FAM175B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM175B Gene

Localization for FAM175B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM175B Gene

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton. Note=A minor proportion is detected in the nucleus (PubMed:21282113, PubMed:22974638). Translocates into the nucleus in response to DNA damage (PubMed:25283148). Directly binds to microtubules and is detected at the minus end of K-fibers (PubMed:26195665). Co-localizes with NUMA1 at mitotic spindle poles (PubMed:26195665). {ECO:0000269 PubMed:21282113, ECO:0000269 PubMed:22974638, ECO:0000269 PubMed:25283148, ECO:0000269 PubMed:26195665}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM175B Gene COMPARTMENTS Subcellular localization image for FAM175B gene
Compartment Confidence
nucleus 5
cytoskeleton 3
cytosol 1
extracellular 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FAM175B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031616 colocalizes_with spindle pole centrosome IDA 26195665
GO:0036449 colocalizes_with microtubule minus-end IDA 26195665
genes like me logo Genes that share ontologies with FAM175B: view

Pathways & Interactions for FAM175B Gene

SuperPathways for FAM175B Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM175B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle IMP 26195665
GO:0008608 attachment of spindle microtubules to kinetochore IMP 26195665
GO:0070536 protein K63-linked deubiquitination IMP 24075985
GO:0090307 mitotic spindle assembly IMP 26195665
genes like me logo Genes that share ontologies with FAM175B: view

No data available for Pathways by source and SIGNOR curated interactions for FAM175B Gene

Drugs & Compounds for FAM175B Gene

No Compound Related Data Available

Transcripts for FAM175B Gene

mRNA/cDNA for FAM175B Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(136) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM175B Gene

Family with sequence similarity 175, member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM175B Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9
SP1: - - -
SP2: - - -
SP3: - - - -
SP4: - -
SP5: -
SP6: - -

Relevant External Links for FAM175B Gene

GeneLoc Exon Structure for
FAM175B
ECgene alternative splicing isoforms for
FAM175B

Expression for FAM175B Gene

mRNA expression in normal human tissues for FAM175B Gene

Protein differential expression in normal tissues from HIPED for FAM175B Gene

This gene is overexpressed in Urinary Bladder (19.1), Colon muscle (9.3), Uterus (7.8), and Amniocyte (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM175B Gene



SOURCE GeneReport for Unigene cluster for FAM175B Gene Hs.280695

mRNA Expression by UniProt/SwissProt for FAM175B Gene

Q15018-F175B_HUMAN
Tissue specificity: Detected in heart muscle (at protein level). Detected in heart and muscle, and at much lower levels in brain (PubMed:21195082).
genes like me logo Genes that share expression patterns with FAM175B: view

Protein tissue co-expression partners for FAM175B Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for FAM175B Gene

Orthologs for FAM175B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM175B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM175B 35
  • 99.84 (n)
  • 99.76 (a)
FAM175B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 91 (a)
OneToMany
FAM175B 36
  • 93 (a)
OneToMany
FAM175B 35
  • 90.92 (n)
  • 93.73 (a)
dog
(Canis familiaris)
Mammalia FAM175B 35
  • 92.77 (n)
  • 95.66 (a)
FAM175B 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam175b 16
Fam175b 35
  • 90.44 (n)
  • 93.49 (a)
Fam175b 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM175B 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM175B 36
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam175b 35
  • 91 (n)
  • 94.22 (a)
chicken
(Gallus gallus)
Aves FAM175B 35
  • 81.74 (n)
  • 85.51 (a)
FAM175B 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM175B 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam175b 35
  • 71.22 (n)
  • 77.02 (a)
LOC394764 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7469 35
zebrafish
(Danio rerio)
Actinopterygii fam175b 36
  • 58 (a)
OneToOne
LOC100538340 35
  • 67.26 (n)
  • 70.41 (a)
Species with no ortholog for FAM175B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM175B Gene

ENSEMBL:
Gene Tree for FAM175B (if available)
TreeFam:
Gene Tree for FAM175B (if available)

Paralogs for FAM175B Gene

Paralogs for FAM175B Gene

(1) SIMAP similar genes for FAM175B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM175B: view

Variants for FAM175B Gene

Sequence variations from dbSNP and Humsavar for FAM175B Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1351977 -- 124,807,752(-) CACCC(C/T)CATTG intron-variant
rs2277263 -- 124,813,572(+) GAGGC(A/T)GCCCA intron-variant
rs2559503 -- 124,805,362(+) aGTGT(C/G)TGTCT intron-variant
rs2559510 -- 124,812,436(+) ggcca(C/G)gagtt intron-variant
rs2559511 -- 124,812,569(+) gccta(G/T)gagat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM175B Gene

Variant ID Type Subtype PubMed ID
nsv832014 CNV Loss 17160897
esv2660881 CNV Deletion 23128226

Variation tolerance for FAM175B Gene

Residual Variation Intolerance Score: 33.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.30; 25.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM175B Gene

HapMap Linkage Disequilibrium report
FAM175B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM175B Gene

Disorders for FAM175B Gene

Relevant External Links for FAM175B

Genetic Association Database (GAD)
FAM175B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM175B

No disorders were found for FAM175B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM175B Gene

Publications for FAM175B Gene

  1. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8590280) Nagase T. … Nomura N. (DNA Res. 1995) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. ABRO1 suppresses tumourigenesis and regulates the DNA damage response by stabilizing p53. (PMID: 25283148) Zhang J. … Yang X. (Nat Commun 2014) 3
  4. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan J.A. … Goldberg A.L. (EMBO J. 2013) 3
  5. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PMID: 24255178) Couzens A.L. … Gingras A.C. (Sci Signal 2013) 3

Products for FAM175B Gene

Sources for FAM175B Gene

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