FAM175B Gene
protein-coding GIFtS: 48
GCID: GC10P126481
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|
family with sequence similarity 175, member B(Previous name: KIAA0157 )
(Previous symbol: KIAA0157)
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Aliases
for FAM175B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Family With Sequence Similarity 175, Member B1 2 | | Em:AC068896.41 | | ABRO11 2 3 5 | | Abraxas Brother 12 | | KIAA01571 2 3 5 | | BRISC Complex Subunit Abro12 | | Abraxas Brother Protein 12 3 | | Protein FAM175B3 |
Export aliases for FAM175B gene to outside databasesPrevious GC identifer: GC10P120177 |
Summaries
for FAM175B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: F175B_HUMAN, Q15018Function: Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin.May act as a central scaffold protein that assembles the various components of the BRISC complex
Gene Wiki entry for FAM175B (KIAA0157)
|
Genomic Views
for FAM175B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FAM175B gene promoter:
E2F-4 E2F-3a E2F-5 E2F-2 E2F E2F-1 POU2F1 FOXO4 POU2F1a Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM175B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM175B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q26.13 Ensembl cytogenetic band: 10q26.13 HGNC cytogenetic band: 10q26.2FAM175B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P126481: view genomic region
(about GC identifiers)
Start:
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126,490,354 bp from pter |
End:
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126,525,239 bp from pter |
Size:
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34,886 bases |
Orientation:
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plus strand |
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Proteins
for FAM175B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: F175B_HUMAN, Q15018 (See
protein sequence)Recommended Name: BRISC complex subunit Abro1 Size: 415 amino acids; 46901 Da
Subunit: Component of the BRISC complex, at least composed of the FAM175B/ABRO1, BRCC3/BRCC36, BRE/BRCC45 andBABAM1/NBA1. Does not interact with BRCA1. Binds polyubiquitin
Caution: Although strongly related to the FAM175A/CCDC98 protein, lacks the C-terminal pSXXF that constitutes aspecific recognition motif for the BRCT domain of BRCA1
Sequence caution: Sequence=BAA09927.1; Type=Erroneous initiation;
Secondary accessions: B4DKR2 Q96H11Explore the universe of human proteins at neXtProt for FAM175B: NX_Q15018
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q15018
FAM175B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_115558.3
ENSEMBL proteins: ENSP00000298492
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
FAM175B for ontologies About GeneDecksing
FAM175B Antibody Products:
Assay Products for FAM175B: |
Protein
Domains /
Families
for FAM175B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FAM175B for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q15018ProtoNet protein and cluster: Q15018 UniProtKB/Swiss-Prot: F175B_HUMAN, Q15018Domain: The MPN-like region is similar to the MPN (JAB/Mov34) domainSimilarity: Belongs to the FAM175 family. Abro1 subfamily |
Function
for FAM175B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: F175B_HUMAN, Q15018Function: Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin.May act as a central scaffold protein that assembles the various components of the BRISC complex
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM175B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM175B (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FAM175B (NM_032182) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM175B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM175B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM175B |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
FAM175B for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for FAM175B:
|
Pathways & Interactions
for FAM175B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM175B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)
5/12 Interacting proteins for FAM175B (Q150182, 3 ENSP000002984924) via UniProtKB, MINT, STRING, and/or I2D (see all 12)About this table
|
Drugs & Compounds
for FAM175B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM175B
Search CenterWatch for drugs/clinical trials and news about FAM175B / F175B
|
Transcripts
for FAM175B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAM175B gene: NM_032182.3 Unigene Cluster for FAM175B: Family with sequence similarity 175, member B Hs.280695 [show with all ESTs]Unigene Representative Sequence: NM_0321823 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000298492(uc001lib.4) ENST00000486933 ENST00000475077
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM175B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM175B (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FAM175B (NM_032182) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM175B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM175B |
Additional cDNA sequence: AK025991.1 AK296677.1 BC008999.1 D63877.1 6 DOTS entries: DT.316831 DT.95166138 DT.102823957 DT.40203606 DT.92018776 DT.95182665 24/136 AceView cDNA sequences (see all 136): BX425308 AI431779 BU170386 AA278200 R96624 AI537680 CB215227 D31384 BI063476 BP342101 AA361800 BG110364 BX280523 CN481607 NM_032182 AA700670 BQ440855 BU176241 AW949485 BM728970 BC008999 AU122659 CA390149 AA453925
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for FAM175B (see all 6) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 |
|---|
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| SP1: | | | - | | | | - | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | - | | | | - | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | - | | | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FAM175B
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Expression
for FAM175B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAM175B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAAGGAGTG
About this image
See FAM175B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM175B
SOURCE GeneReport for Unigene cluster: Hs.280695
SABiosciences Custom PCR Arrays for FAM175B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM175B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FAM175B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM175B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM175B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM175B |
Orthologs
for FAM175B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FAM175B gene from 6/16 species (see all 16) About this table
ENSEMBL Gene Tree for FAM175B (if available)
TreeFam Gene Tree for FAM175B (if available) |
Paralogs
for FAM175B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAM175B gene
- FAM175A2
1 SIMAP similar gene for FAM175B using alignment to 1 protein entry: F175B_HUMAN:FAM175A
FAM175B for paralogs About GeneDecksing
|
Genomic Variants
for FAM175B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM175B (126490354 - 126525239 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FAM175B: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM175B |
|
Disorders
/ Diseases
for FAM175B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FAM175B for disorders About GeneDecksing
OMIM gene information: 611144
OMIM disorders: --
1  disease for FAM175B: About MalaCardsmyocardial infarcation
Export disorders for FAM175B gene to outside databases
|
Publications
for FAM175B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM175B gene, integrated from 9 sources (see all 29):
(articles sorted by number of sources associating them with FAM175B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8590280)1, 2, 3 Nagase T....Nomura N. (1995)
- NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control. (PubMed id 19261749)1, 2 Wang B.... Elledge S.J. (2009)
- K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC- associated Brcc36 and proteasomal Poh1. (PubMed id 19214193)1, 2 Cooper E.M....Cohen R.E. (2009)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Regulation of Abro1/KIAA0157 during myocardial infarc tion and cell death reveals a novel cardioprotective mechanism for Lys63-specif ic deubiquitination. (PubMed id 21195082)1 Cilenti L....Zervos A.S. (2011)
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External Searches for FAM175B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FAM175B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM175B gene
(According to HUGE)
About This Section
| |
Specialized Databases showing FAM175B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAM175B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FAM175B gene:
Search GeneIP for patents involving FAM175B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM175B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FAM175B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM175B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM175B | | | OriGene Protein Over-expression Lysate for FAM175B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FAM175B | | OriGene 3'-UTR Clone for FAM175B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM175B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM175B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FAM175B | | OriGene Custom Protein Services for FAM175B | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM175B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM175B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM175B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM175B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM175B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM175B |
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| | | | Search Tocris compounds for FAM175B |
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 | | | FAM175B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM175B |
|  |  |  | | | | Search ThermoFisher Antibodies for FAM175B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM175B |
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