Aliases for FAM175A Gene
External Ids for FAM175A Gene
Previous HGNC Symbols for FAM175A Gene
Previous GeneCards Identifiers for FAM175A Gene
GeneCards Summary for FAM175A Gene
FAM175A (Family With Sequence Similarity 175 Member A) is a Protein Coding gene. Diseases associated with FAM175A include Breast Cancer and Luminal Breast Carcinoma. Among its related pathways are DNA Double-Strand Break Repair and DNA Double Strand Break Response. GO annotations related to this gene include polyubiquitin binding. An important paralog of this gene is FAM175B.
UniProtKB/Swiss-Prot for FAM175A Gene
Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes Lys-63-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes Lys-63-linked ubiquitin on histones H2A and H2AX.