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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAM175A Gene

protein-coding   GIFtS: 48
GCID: GC04M084382

Family With Sequence Similarity 175, Member A

(Previous name: coiled-coil domain containing 98)
(Previous symbol: CCDC98)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Family With Sequence Similarity 175, Member A1 2     Coiled-Coil Domain-Containing Protein 982 3
CCDC981 2 3 5     BRCA1-A Complex Subunit Abraxas2
ABRA12 3 5     Protein FAM175A3
Coiled-Coil Domain Containing 981 2     ABRAXAS5
Abraxas Protein1 2     

External Ids:    HGNC: 258291   Entrez Gene: 841422   Ensembl: ENSG000001633227   OMIM: 6111435   UniProtKB: Q6UWZ73   

Export aliases for FAM175A gene to outside databases

Previous GC identifers: GC04M084603 GC04M080124


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FAM175A Gene: 
FAM175A (family with sequence similarity 175, member A) is a protein-coding gene. Diseases associated with FAM175A include familial breast cancer, and breast cancer susceptibility. GO annotations related to this gene include protein binding and polyubiquitin binding. An important paralog of this gene is FAM175B.

UniProtKB/Swiss-Prot: F175A_HUMAN, Q6UWZ7
Function: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated
histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage
at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically
removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold
protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of BRCA1




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_016354.19  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FAM175A gene promoter:
         RFX1   NF-1   NF-1/L   AML1a   FOXF2   Sp1   RREB-1   Pax-6   YY1   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM175A promoter sequence
   Search SABiosciences Chromatin IP Primers for FAM175A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM175A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.23   Ensembl cytogenetic band:  4q21.23   HGNC cytogenetic band: 4q21.23

FAM175A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM175A gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M084382:  view genomic region     (about GC identifiers)

Start:
84,382,092 bp from pter      End:
84,444,501 bp from pter
Size:
62,410 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: F175A_HUMAN, Q6UWZ7 (See protein sequence)
Recommended Name: BRCA1-A complex subunit Abraxas  
Size: 409 amino acids; 46663 Da
Subunit: Component of the BRCA1-A complex, at least composed of the BRCA1, BARD1, UIMC1/RAP80, FAM175A/Abraxas,
BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1. In the complex, interacts directly with UIMC1/RAP80, BRCC3/BRCC36 and
BRE/BRCC45. Interacts directly (when phosphorylated at Ser-406) with BRCA1. Binds polyubiquitin
Subcellular location: Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs)
Sequence caution: Sequence=AAH39573.1; Type=Erroneous initiation; Sequence=BAB14189.1; Type=Erroneous initiation;
Sequence=BAB14635.1; Type=Erroneous initiation;
Secondary accessions: A5JJ07 Q9H8I1 Q9H9N4

Explore the universe of human proteins at neXtProt for FAM175A: NX_Q6UWZ7

Explore proteomics data for FAM175A at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation of Ser-406 of the pSXXF motif by ATM or ATR constitutes a specific recognition motif for the BRCT
    domain of BRCA1
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6UWZ7

  • FAM175A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FAM175A Protein Expression
    REFSEQ proteins: NP_620775.2  
    ENSEMBL proteins: 
     ENSP00000369857   ENSP00000426080   ENSP00000426763   ENSP00000421876   ENSP00000421068  

    Human Recombinant Protein Products for FAM175A: 
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    Novus Biologicals FAM175A Protein
    Novus Biologicals FAM175A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FAM175A 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA17525340
    GO:0070531BRCA1-A complex IDA17525340

    FAM175A for ontologies           About GeneDecksing



    FAM175A Antibody Products: 
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    Abcam antibodies for FAM175A
    Cloud-Clone Corp. Antibodies for FAM175A 
    ThermoFisher Antibodies for FAM175A
    LSBio Antibodies in human, mouse, rat for FAM175A 

    Assay Products for FAM175A: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for FAM175A 
    Cloud-Clone Corp. CLIAs for FAM175A


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR023239 FAM175_BRCA1-A_cplx_Abraxas_su
     IPR023238 FAM175

    Graphical View of Domain Structure for InterPro Entry Q6UWZ7

    ProtoNet protein and cluster: Q6UWZ7

    UniProtKB/Swiss-Prot: F175A_HUMAN, Q6UWZ7
    Domain: The MPN-like region is similar to the MPN (JAB/Mov34) domain. Its presence reveals similarities between
    the structure of the 19S proteasome and the BRCA1-A complexes
    Similarity: Belongs to the FAM175 family. Abraxas subfamily


    FAM175A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: F175A_HUMAN, Q6UWZ7
    Function: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated
    histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage
    at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically
    removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold
    protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of BRCA1

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17525340
    GO:0031593polyubiquitin binding IDA19261749
         
    FAM175A for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FAM175A 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FAM175A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FAM175A 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FAM175A 

    miRNA
    Products:
        
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    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate FAM175A (see all 9):
    hsa-miR-3128 hsa-miR-548t hsa-miR-3675-3p hsa-miR-130b* hsa-miR-3674 hsa-miR-3126-3p hsa-miR-323b-5p hsa-miR-888
    SwitchGear 3'UTR luciferase reporter plasmidFAM175A 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FAM175A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM175A

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: FAM175A (NM_139076)
    Browse Sino Biological Human cDNA Clones
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    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM175A


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FAM175A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/17 Interacting proteins for FAM175A (Q6UWZ71, 3 ENSP000003698574) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BRCA1P383981, 3, ENSP000003502834EBI-1263451,EBI-349905 I2D: score=3 STRING: ENSP00000350283
    UIMC1Q96RL11, 3, ENSP000003664344EBI-1263451,EBI-725300 I2D: score=3 STRING: ENSP00000366434
    BABAM1Q9NWV83, ENSP000003524084I2D: score=2 STRING: ENSP00000352408
    BREQ9NXR73, ENSP000003434124I2D: score=2 STRING: ENSP00000343412
    BRIP1Q9BX633, ENSP000002590084I2D: score=1 STRING: ENSP00000259008
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006302double-strand break repair IMP17525340
    GO:0010212response to ionizing radiation IMP17525340
    GO:0016568chromatin modification IEA--
    GO:0031572G2 DNA damage checkpoint IMP17525340
    GO:0045739positive regulation of DNA repair IMP17525340

    FAM175A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FAM175A (F175A)

    Search CenterWatch for drugs/clinical trials and news about FAM175A / F175A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FAM175A gene: 
    NM_139076.2  

    Unigene Cluster for FAM175A:

    Family with sequence similarity 175, member A
    Hs.334772  [show with all ESTs]
    Unigene Representative Sequence: NM_139076
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000321945(uc003hot.2 uc003hou.2 uc003hov.2) ENST00000475656
    ENST00000506553 ENST00000504777 ENST00000505489 ENST00000511801 ENST00000503217
    ENST00000515303
    miRNA
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    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate FAM175A (see all 9):
    hsa-miR-3128 hsa-miR-548t hsa-miR-3675-3p hsa-miR-130b* hsa-miR-3674 hsa-miR-3126-3p hsa-miR-323b-5p hsa-miR-888
    SwitchGear 3'UTR luciferase reporter plasmidFAM175A 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FAM175A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM175A
    Clone
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    OriGene clones in human, mouse for FAM175A (see all 9)
    OriGene ORF clones in mouse, rat for FAM175A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FAM175A (NM_139076)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM175A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM175A
    Sirion Biotech Customized lentivirus for stable overexpression of FAM175A 
                         Customized lentivirus expression plasmids for stable overexpression of FAM175A 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FAM175A
    OriGene qSTAR qPCR primer pairs in human, mouse for FAM175A
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FAM175A
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM175A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM175A

    Additional mRNA sequence: 

    AK022704.1 AK023676.1 AY358576.1 BC016905.1 BC039573.1 EF531340.1 

    10 DOTS entries:

    DT.91761919  DT.121274495  DT.121274506  DT.444592  DT.100789230  DT.97862508  DT.99988694  DT.100789227 
    DT.95183907  DT.100789228 

    24/82 AceView cDNA sequences (see all 82):

    BQ775930 AI418781 AA485081 BX089041 BM479419 BC039573 AA905493 BQ921560 
    BI771321 AA737809 BQ216065 AA280141 AI452418 AL602519 BQ422301 BF475914 
    NM_139076 BQ221128 AK023676 CA944863 AI360586 AA485192 AI707642 BM783957 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FAM175A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAATAAATTT
    FAM175A Expression
    About this image


    See FAM175A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FAM175A

    SOURCE GeneReport for Unigene cluster: Hs.334772
        SABiosciences Custom PCR Arrays for FAM175A
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM175A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM175A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FAM175A gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam175a1 , 5 family with sequence similarity 175, member A1, 5 77.64(n)1
    72.73(a)1
      5 (48.52 cM)5
    706811  NM_172405.31  NP_765993.11 
     1008051925 
    chicken
    (Gallus gallus)
    Aves FAM175A1 family with sequence similarity 175, member A 68.82(n)
    64.52(a)
      422608  NM_001031144.2  NP_001026315.2 
    lizard
    (Anolis carolinensis)
    Reptilia FAM175A6
    family with sequence similarity 175, member A
    57(a)
    1 ↔ 1
    5(43359712-43373489)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.115182 Xenopus laevis transcribed sequence with weak similarity more 74.46(n)    BU901917.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fam175a1 family with sequence similarity 175, member A 52.74(n)
    42.65(a)
      449820  NM_001005993.1  NP_001005993.1 


    ENSEMBL Gene Tree for FAM175A (if available)
    TreeFam Gene Tree for FAM175A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FAM175A gene
    FAM175B2  
    18/145 SIMAP similar genes for FAM175A using alignment to 6 protein entries:     F175A_HUMAN (see all proteins) (see all similar genes):
    RPL27A    ZNF169    APOPT1    HOOK2    C17orf86    ATP6V1E1
    NDUFA7    RANBP3    PMS1    CRCP    WARS    ZNF527
    CCNG2    ZNF212    CHID1    COL24A1    DCTN5    ERBB2

    FAM175A for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for FAM175A
    PGOHUM00000250251 PGOHUM00000249259


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/596 SNPs in FAM175A are shown (see all 596)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1859631871,2
    --84196454(+) GTTTAC/TGTAGT 1 -- ds50010--------
    rs1164155821,2
    F--84196455(+) TTTACG/ATAGTG 1 -- ds50011Minor allele frequency- A:0.02NA 120
    rs1908285091,2
    --84196517(+) GACTGC/TATGGC 1 -- ds50010--------
    rs729314871,2
    C--84196572(+) TACCAA/GTCCTT 1 -- ds50013Minor allele frequency- G:0.39WA 122
    rs1832143881,2
    --84196574(+) CCAATC/TCTTGA 1 -- ds50010--------
    rs1116630851,2
    C,F--84196692(+) GGCCAG/ATATGG 1 -- ds50012Minor allele frequency- A:0.33CSA 3
    rs1879487291,2
    --84196697(+) ATATGA/GTGAAA 1 -- ds50010--------
    rs347347281,2
    C--84196880(+) ATCTC-/AAAAAA 1 -- ds50011Minor allele frequency- A:0.00NA 2
    rs1904209001,2
    --84196894(+) AATTGC/TAAACT 1 -- ds50010--------
    rs1830081101,2
    C--84197033(+) ACTGAA/GTTGAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for FAM175A (84382092 - 84444501 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FAM175A:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv829994CNV Loss17160897
    nsv879512CNV Gain21882294


    Human Gene Mutation Database (HGMD): FAM175A
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing FAM175A
    DNA2.0 Custom Variant and Variant Library Synthesis for FAM175A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611143    OMIM disorders: --

    4 diseases for FAM175A:    About MalaCards
    familial breast cancer    breast cancer susceptibility    breast cancer    lung cancer


    FAM175A for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: FAM175A (0 documents)

    Export disorders for FAM175A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM175A gene, integrated from 9 sources (see all 41):
    (articles sorted by number of sources associating them with FAM175A)
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    1. Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response. (PubMed id 17525340)1, 2, 3 Wang B....Elledge S.J. (2007)
    2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
    3. MERIT40 facilitates BRCA1 localization and DNA damage repair. (PubMed id 19261748)1, 2 Feng L.... Chen J. (2009)
    4. Analysis of the genes coding for the BRCA1-interacting proteins, RAP80 and Abraxas (CCDC98), in high-risk, non-BRCA1/2, multiethnic breast cancer cases. (PubMed id 18695986)1, 2 Novak D.J....Tischkowitz M. (2009)
    5. MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks. (PubMed id 19261746)1, 2 Shao G.... Greenberg R.A. (2009)
    6. NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control. (PubMed id 19261749)1, 2 Wang B.... Elledge S.J. (2009)
    7. CCDC98 targets BRCA1 to DNA damage sites. (PubMed id 17643121)1, 2 Liu Z.... Yu X. (2007)
    8. Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage. (PubMed id 18077395)1, 2 Wang B. and Elledge S.J. (2007)
    9. CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response. (PubMed id 17643122)1, 2 Kim H.... Chen J. (2007)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84142 HGNC: 25829 AceView: FLJ13614 Ensembl:ENSG00000163322 euGenes: HUgn84142
    ECgene: FAM175A H-InvDB: FAM175A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FAM175A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FAM175A gene:
    Search GeneIP for patents involving FAM175A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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