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FAM175A Gene

protein-coding   GIFtS: 50
GCID: GC04M084382

Family With Sequence Similarity 175, Member A

(Previous name: coiled-coil domain containing 98)
(Previous symbol: CCDC98)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Family With Sequence Similarity 175, Member A1 2     Coiled-Coil Domain-Containing Protein 982 3
CCDC981 2 3 5     BRCA1-A Complex Subunit Abraxas2
ABRA12 3 5     Protein FAM175A3
Coiled-Coil Domain Containing 981 2     ABRAXAS5
Abraxas Protein1 2     

External Ids:    HGNC: 258291   Entrez Gene: 841422   Ensembl: ENSG000001633227   OMIM: 6111435   UniProtKB: Q6UWZ73   
ORGUL members:         

Export aliases for FAM175A gene to outside databases

Previous GC identifers: GC04M084603 GC04M080124


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM175A Gene:
FAM175A (family with sequence similarity 175, member A) is a protein-coding gene. GO annotations related to this gene include polyubiquitin binding. An important paralog of this gene is FAM175B.

UniProtKB/Swiss-Prot: F175A_HUMAN, Q6UWZ7
Function: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated
histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage
at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically
removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold
protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of BRCA1




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAM175A gene promoter:
         RFX1   NF-1   NF-1/L   AML1a   FOXF2   Sp1   RREB-1   Pax-6   YY1   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM175A promoter sequence
   Search Chromatin IP Primers for FAM175A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM175A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.23   Ensembl cytogenetic band:  4q21.23   HGNC cytogenetic band: 4q21.23

FAM175A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM175A gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M084382:  view genomic region     (about GC identifiers)

Start:
84,382,092 bp from pter      End:
84,444,501 bp from pter
Size:
62,410 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: F175A_HUMAN, Q6UWZ7 (See protein sequence)
Recommended Name: BRCA1-A complex subunit Abraxas  
Size: 409 amino acids; 46663 Da
Subunit: Component of the BRCA1-A complex, at least composed of the BRCA1, BARD1, UIMC1/RAP80, FAM175A/Abraxas,
BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1. In the complex, interacts directly with UIMC1/RAP80, BRCC3/BRCC36 and
BRE/BRCC45. Interacts directly (when phosphorylated at Ser-406) with BRCA1. Binds polyubiquitin
Sequence caution: Sequence=AAH39573.1; Type=Erroneous initiation; Sequence=BAB14189.1; Type=Erroneous initiation;
Sequence=BAB14635.1; Type=Erroneous initiation;
Secondary accessions: A5JJ07 Q9H8I1 Q9H9N4

Explore the universe of human proteins at neXtProt for FAM175A: NX_Q6UWZ7

Explore proteomics data for FAM175A at MOPED

Post-translational modifications: 

  • Phosphorylation of Ser-406 of the pSXXF motif by ATM or ATR constitutes a specific recognition motif for the BRCT
    domain of BRCA11
  • Ubiquitination2 at Lys158, Lys201, Lys268, Lys347, Lys358, Lys398
  • Modification sites at PhosphoSitePlus

  • See FAM175A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_620775.2  
    ENSEMBL proteins: 
     ENSP00000369857   ENSP00000426080   ENSP00000426763   ENSP00000421876   ENSP00000421068  

    FAM175A Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for FAM175A
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    Novus Biologicals FAM175A Protein
    Novus Biologicals FAM175A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FAM175A

     
    Search eBioscience for Proteins for FAM175A 

     
    antibodies-online proteins for FAM175A (4 products) 

     
    antibodies-online peptides for FAM175A

    FAM175A Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    antibodies-online antibodies for FAM175A (38 products) 

    FAM175A Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for FAM175A
    Cloud-Clone Corp. CLIAs for FAM175A
    Search eBioscience for ELISAs for FAM175A 
    antibodies-online kits for FAM175A (10 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR023239 FAM175_BRCA1-A_cplx_Abraxas_su
     IPR023238 FAM175

    Graphical View of Domain Structure for InterPro Entry Q6UWZ7

    ProtoNet protein and cluster: Q6UWZ7

    UniProtKB/Swiss-Prot: F175A_HUMAN, Q6UWZ7
    Domain: The MPN-like region is similar to the MPN (JAB/Mov34) domain. Its presence reveals similarities between
    the structure of the 19S proteasome and the BRCA1-A complexes
    Similarity: Belongs to the FAM175 family. Abraxas subfamily


    Find genes that share domains with FAM175A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: F175A_HUMAN, Q6UWZ7
    Function: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated
    histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage
    at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically
    removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold
    protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of BRCA1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17525340
    GO:0031593polyubiquitin binding IDA19261749
         
    Find genes that share ontologies with FAM175A           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for FAM175A

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat FAM175A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FAM175A (see all 9):
    hsa-miR-3128 hsa-miR-548t hsa-miR-3675-3p hsa-miR-130b* hsa-miR-3674 hsa-miR-3126-3p hsa-miR-323b-5p hsa-miR-888
    SwitchGear 3'UTR luciferase reporter plasmidFAM175A 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for FAM175A
    Predesigned siRNA for gene silencing in human, mouse, rat FAM175A

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for FAM175A (see all 9)
    OriGene ORF clones in mouse, rat for FAM175A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FAM175A (NM_139076)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM175A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM175A
    Addgene plasmids for FAM175A 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    F175A_HUMAN, Q6UWZ7: Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    extracellular2
    cytosol1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0070531BRCA1-A complex IDA17525340

    Find genes that share ontologies with FAM175A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM175A
    Interactions:

        GeneGlobe Interaction Network for FAM175A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for FAM175A (Q6UWZ71, 3 ENSP000003698574) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BRCA1P383981, 3, ENSP000003502834EBI-1263451,EBI-349905 I2D: score=3 STRING: ENSP00000350283
    UIMC1Q96RL11, 3, ENSP000003664344EBI-1263451,EBI-725300 I2D: score=3 STRING: ENSP00000366434
    BABAM1Q9NWV83, ENSP000003524084I2D: score=2 STRING: ENSP00000352408
    BREQ9NXR73, ENSP000003434124I2D: score=2 STRING: ENSP00000343412
    BRIP1Q9BX633, ENSP000002590084I2D: score=1 STRING: ENSP00000259008
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006302double-strand break repair IMP17525340
    GO:0010212response to ionizing radiation IMP17525340
    GO:0016568chromatin modification IEA--
    GO:0031572G2 DNA damage checkpoint IMP17525340
    GO:0045739positive regulation of DNA repair IMP17525340

    Find genes that share ontologies with FAM175A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM175A (F175A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FAM175A gene: 
    NM_139076.2  

    Unigene Cluster for FAM175A:

    Family with sequence similarity 175, member A
    Hs.334772  [show with all ESTs]
    Unigene Representative Sequence: NM_139076
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000321945(uc003hot.2 uc003hou.2 uc003hov.2) ENST00000475656
    ENST00000506553 ENST00000504777 ENST00000505489 ENST00000511801 ENST00000503217
    ENST00000515303
    miRNA
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    Block miRNA regulation of human, mouse, rat FAM175A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FAM175A (see all 9):
    hsa-miR-3128 hsa-miR-548t hsa-miR-3675-3p hsa-miR-130b* hsa-miR-3674 hsa-miR-3126-3p hsa-miR-323b-5p hsa-miR-888
    SwitchGear 3'UTR luciferase reporter plasmidFAM175A 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FAM175A
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FAM175A (NM_139076)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM175A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM175A
    Addgene plasmids for FAM175A 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FAM175A
    OriGene qSTAR qPCR primer pairs in human, mouse for FAM175A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FAM175A
      QuantiTect SYBR Green Assays in human, mouse, rat FAM175A
      QuantiFast Probe-based Assays in human, mouse, rat FAM175A

    Additional mRNA sequence: 

    AK022704.1 AK023676.1 AY358576.1 BC016905.1 BC039573.1 EF531340.1 

    10 DOTS entries:

    DT.91761919  DT.121274495  DT.121274506  DT.444592  DT.100789230  DT.97862508  DT.99988694  DT.100789227 
    DT.95183907  DT.100789228 

    Selected AceView cDNA sequences (see all 82):

    BM479419 AI418781 AL602519 BC039573 AI452418 BQ221128 AA485192 BX089041 
    BQ775930 AA485081 AK023676 BF475914 NM_139076 BQ422301 BQ216065 BQ921560 
    AA905493 CA944863 BI771321 AI360586 AA737809 AA280141 AA831922 BG570593 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM175A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAATAAATTT
    FAM175A Expression
    About this image

    FAM175A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM175A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.334772
        Custom PCR Arrays for FAM175A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM175A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FAM175A gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam175a1 , 5 family with sequence similarity 175, member A1, 5 77.64(n)1
    72.73(a)1
      5 (48.52 cM)5
    706811  NM_172405.31  NP_765993.11 
     1008051925 
    chicken
    (Gallus gallus)
    Aves FAM175A1 family with sequence similarity 175, member A 68.82(n)
    64.52(a)
      422608  NM_001031144.2  NP_001026315.2 
    lizard
    (Anolis carolinensis)
    Reptilia FAM175A6
    family with sequence similarity 175, member A
    58(a)
    1 ↔ 1
    5(43359712-43373489)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.115182 Xenopus laevis transcribed sequence with weak similarity more 74.46(n)    BU901917.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fam175a1 family with sequence similarity 175, member A 53.12(n)
    44.15(a)
      449820  NM_001005993.1  NP_001005993.1 


    ENSEMBL Gene Tree for FAM175A (if available)
    TreeFam Gene Tree for FAM175A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM175A gene
    FAM175B2  
    Selected SIMAP similar genes for FAM175A using alignment to 6 protein entries:     F175A_HUMAN (see all proteins) (see all similar genes):
    RPL27A    ZNF169    APOPT1    HOOK2    C17orf86    ATP6V1E1
    NDUFA7    RANBP3    PMS1    CRCP    WARS    ZNF527
    CCNG2    ZNF212    CHID1    COL24A1    CTSS    DCTN5

    Find genes that share paralogs with FAM175A           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for FAM175A
    PGOHUM00000250251 PGOHUM00000249259


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM175A (see all 596)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1859631871,2
    --84196454(+) GTTTAC/TGTAGT 1 -- ds50010--------
    rs1164155821,2
    F--84196455(+) TTTACG/ATAGTG 1 -- ds50011Minor allele frequency- A:0.02NA 120
    rs1908285091,2
    --84196517(+) GACTGC/TATGGC 1 -- ds50010--------
    rs729314871,2
    C--84196572(+) TACCAA/GTCCTT 1 -- ds50013Minor allele frequency- G:0.39WA 122
    rs1832143881,2
    --84196574(+) CCAATC/TCTTGA 1 -- ds50010--------
    rs1116630851,2
    C,F--84196692(+) GGCCAG/ATATGG 1 -- ds50012Minor allele frequency- A:0.33CSA 3
    rs1879487291,2
    --84196697(+) ATATGA/GTGAAA 1 -- ds50010--------
    rs347347281,2
    C--84196880(+) ATCTC-/AAAAAA 1 -- ds50011Minor allele frequency- A:0.00NA 2
    rs1904209001,2
    --84196894(+) AATTGC/TAAACT 1 -- ds50010--------
    rs1830081101,2
    C--84197033(+) ACTGAA/GTTGAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for FAM175A (84382092 - 84444501 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FAM175A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv829994CNV Loss17160897
    nsv879512CNV Gain21882294

    Human Gene Mutation Database (HGMD): FAM175A
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FAM175A
    DNA2.0 Custom Variant and Variant Library Synthesis for FAM175A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611143    OMIM disorders: --


    Find genes that share disorders with FAM175A           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: FAM175A (0 documents)

    Export disorders for FAM175A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM175A gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with FAM175A)
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    1. Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response. (PubMed id 17525340)1, 2, 3 Wang B....Elledge S.J. (Science 2007)
    2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (Genome Res. 2003)
    3. MERIT40 facilitates BRCA1 localization and DNA damage repair. (PubMed id 19261748)1, 2 Feng L.... Chen J. (Genes Dev. 2009)
    4. Analysis of the genes coding for the BRCA1-interacting proteins, RAP80 and Abraxas (CCDC98), in high-risk, non-BRCA1/2, multiethnic breast cancer cases. (PubMed id 18695986)1, 2 Novak D.J....Tischkowitz M. (Breast Cancer Res. Treat. 2009)
    5. MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks. (PubMed id 19261746)1, 2 Shao G.... Greenberg R.A. (Genes Dev. 2009)
    6. NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control. (PubMed id 19261749)1, 2 Wang B.... Elledge S.J. (Genes Dev. 2009)
    7. CCDC98 targets BRCA1 to DNA damage sites. (PubMed id 17643121)1, 2 Liu Z.... Yu X. (Nat. Struct. Mol. Biol. 2007)
    8. Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage. (PubMed id 18077395)1, 2 Wang B. and Elledge S.J. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    9. CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response. (PubMed id 17643122)1, 2 Kim H.... Chen J. (Nat. Struct. Mol. Biol. 2007)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84142 HGNC: 25829 AceView: FLJ13614 Ensembl:ENSG00000163322 euGenes: HUgn84142
    ECgene: FAM175A H-InvDB: FAM175A

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM175A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM175A gene:
    Search GeneIP for patents involving FAM175A

    GeneCards and IP:
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