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Aliases for FAM174B Gene

Aliases for FAM174B Gene

  • Family With Sequence Similarity 174 Member B 2 3 5
  • Family With Sequence Similarity 174, Member B 2

External Ids for FAM174B Gene

Previous GeneCards Identifiers for FAM174B Gene

  • GC15M090962
  • GC15M093160
  • GC15M069297

Summaries for FAM174B Gene

GeneCards Summary for FAM174B Gene

FAM174B (Family With Sequence Similarity 174 Member B) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM174B Gene

Genomics for FAM174B Gene

Regulatory Elements for FAM174B Gene

Enhancers for FAM174B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F092664 1.1 Ensembl ENCODE 19.7 +145.9 145924 4.3 HDGF KLF17 FEZF1 RAD21 YY1 RARA SCRT2 FOS ZHX2 TBX21 FAM174B ST8SIA2 LOC105370975 GC15M095677 PIR42313
GH15F092876 1.7 FANTOM5 Ensembl ENCODE 12.6 -70.6 -70573 12.3 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9 FAM174B ASB9P1 CHD2 C15orf32 ENSG00000279765 LINC01578
GH15F092680 1 Ensembl ENCODE 17 +130.1 130096 3.0 ZSCAN5A HDGF CTCF HINFP ZNF493 ZNF384 CEBPG RAD21 ZFHX2 SMC3 FAM174B C15orf32 LOC104613533 ENO1P2 SEPHS1P2 LOC100421632 ENSG00000258909 PIR42313 GC15M095677 LOC105370975
GH15F092898 1.2 ENCODE 12.9 -96.8 -96832 20.4 CREB3L1 MLX FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 FAM174B ASB9P1 HMGN1P38 CHD2 MIR3175 LOC105370979
GH15F092842 1.2 Ensembl ENCODE 11.9 -34.3 -34263 7.6 ELF3 TBP HDAC1 ATF1 TBL1XR1 CHAMP1 GTF3C2 GATA2 CREM ZBTB2 CHD2 FAM174B HMGN1P38 ASB9P1 LINC00930 GC15P095281 ENSG00000275175
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM174B on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM174B Gene

Chromosome:
15
Start:
92,617,443 bp from pter
End:
92,812,338 bp from pter
Size:
194,896 bases
Orientation:
Minus strand

Genomic View for FAM174B Gene

Genes around FAM174B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM174B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM174B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM174B Gene

Proteins for FAM174B Gene

  • Protein details for FAM174B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3ZCQ3-F174B_HUMAN
    Recommended name:
    Membrane protein FAM174B
    Protein Accession:
    Q3ZCQ3
    Secondary Accessions:
    • Q3ZCR9
    • Q8NBH7

    Protein attributes for FAM174B Gene

    Size:
    159 amino acids
    Molecular mass:
    16967 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH45729.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for FAM174B Gene

Post-translational modifications for FAM174B Gene

  • Glycosylation at Asn 53
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FAM174B Gene

Domains & Families for FAM174B Gene

Protein Domains for FAM174B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM174B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3ZCQ3

UniProtKB/Swiss-Prot:

F174B_HUMAN :
  • Belongs to the FAM174 family.
Family:
  • Belongs to the FAM174 family.
genes like me logo Genes that share domains with FAM174B: view

No data available for Gene Families for FAM174B Gene

Function for FAM174B Gene

genes like me logo Genes that share phenotypes with FAM174B: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM174B Gene

Localization for FAM174B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM174B Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM174B gene
Compartment Confidence
extracellular 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for FAM174B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM174B: view

Pathways & Interactions for FAM174B Gene

SuperPathways for FAM174B Gene

No Data Available

Interacting Proteins for FAM174B Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000329040%0d%0a9606.ENSP00000363822%0d%0a9606.ENSP00000381891%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000329040 Q3ZCQ3-F174B_HUMAN for FAM174B Gene via STRING IID

Gene Ontology (GO) - Biological Process for FAM174B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM174B Gene

Transcripts for FAM174B Gene

Unigene Clusters for FAM174B Gene

Family with sequence similarity 174, member B:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM174B Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d
SP1:
SP2: - - - -
SP3: - -
SP4: -

Relevant External Links for FAM174B Gene

GeneLoc Exon Structure for
FAM174B
ECgene alternative splicing isoforms for
FAM174B

Expression for FAM174B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM174B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM174B Gene

This gene is overexpressed in Pancreas (x6.4).

Protein differential expression in normal tissues from HIPED for FAM174B Gene

This gene is overexpressed in Pancreas (36.8), Adipocyte (18.0), and CD4 Tcells (12.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FAM174B Gene



Protein tissue co-expression partners for FAM174B Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM174B Gene:

FAM174B

SOURCE GeneReport for Unigene cluster for FAM174B Gene:

Hs.27373
genes like me logo Genes that share expression patterns with FAM174B: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for FAM174B Gene

Orthologs for FAM174B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM174B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM174B 34 35
  • 97.74 (n)
cow
(Bos Taurus)
Mammalia FAM174B 35
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam174b 34
  • 78.48 (n)
mouse
(Mus musculus)
Mammalia Fam174b 34 16 35
  • 77.17 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FAM174B 35
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM174B 35
  • 62 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM174B 35
  • 42 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM174B 35
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM174B 35
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam174b 34
  • 68.65 (n)
zebrafish
(Danio rerio)
Actinopterygii fam174b 35
  • 41 (a)
OneToOne
Species where no ortholog for FAM174B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM174B Gene

ENSEMBL:
Gene Tree for FAM174B (if available)
TreeFam:
Gene Tree for FAM174B (if available)

Paralogs for FAM174B Gene

No data available for Paralogs for FAM174B Gene

Variants for FAM174B Gene

Sequence variations from dbSNP and Humsavar for FAM174B Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1004309 -- 92,716,138(+) GGAGT(G/T)GGAGG intron-variant
rs10162933 -- 92,697,817(+) tagta(A/G)aaagg intron-variant
rs10163057 -- 92,697,754(+) cagcc(C/T)cccaa intron-variant
rs1018075 -- 92,692,110(+) CTGGT(A/G)AAAAT intron-variant
rs1046544 -- 92,617,669(-) TCAAC(C/T)TTTGA intron-variant, nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FAM174B Gene

Variant ID Type Subtype PubMed ID
esv3637267 CNV loss 21293372
nsv1037972 CNV loss 25217958
nsv1122994 CNV deletion 24896259
nsv1674 CNV insertion 18451855

Variation tolerance for FAM174B Gene

Residual Variation Intolerance Score: 71.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.82; 34.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM174B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM174B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM174B Gene

Disorders for FAM174B Gene

Relevant External Links for FAM174B

Genetic Association Database (GAD)
FAM174B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM174B

No disorders were found for FAM174B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM174B Gene

Publications for FAM174B Gene

  1. Common human genetic variants and HIV-1 susceptibility: a genome-wide survey in a homogeneous African population. (PMID: 21160409) Petrovski S. … Goldstein D.B. (AIDS 2011) 3 46 64
  2. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody M.C. … Nusbaum C. (Nature 2006) 4 64
  3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for FAM174B Gene

Sources for FAM174B Gene

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