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Aliases for FAM174B Gene

Aliases for FAM174B Gene

  • Family With Sequence Similarity 174 Member B 2 3 5
  • Family With Sequence Similarity 174, Member B 2

External Ids for FAM174B Gene

Previous GeneCards Identifiers for FAM174B Gene

  • GC15M090962
  • GC15M093160
  • GC15M069297

Summaries for FAM174B Gene

GeneCards Summary for FAM174B Gene

FAM174B (Family With Sequence Similarity 174 Member B) is a Protein Coding gene.

Additional gene information for FAM174B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM174B Gene

Genomics for FAM174B Gene

GeneHancer (GH) Regulatory Elements for FAM174B Gene

Promoters and enhancers for FAM174B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I092652 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 556.7 +158.2 158189 4.2 HDGF CLOCK SMAD1 NEUROD1 SIN3A GLIS2 ELK1 ZNF143 FOS ZNF592 FAM174B CHD2 HMGN1P38 LOC105370975 GC15M096533 PIR42313
GH15I092898 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 13 -96.8 -96831 20.4 MLX FEZF1 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC PPARGC1A CHD2 ASB9P1 FAM174B HMGN1P38 MIR3175 GC15P095754 LINC01578 ENSG00000279765 LOC105370979
GH15I092876 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE dbSUPER 12.6 -70.6 -70573 12.3 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B NEUROD1 SIN3A DMAP1 YY1 LINC01578 ENSG00000279765 FAM174B CHD2 C15orf32
GH15I092664 Enhancer 1.3 Ensembl ENCODE dbSUPER 19.7 +145.9 145924 4.3 HDGF FOXA2 KLF17 SIN3A FEZF1 RAD21 RARA YY1 SCRT2 ATF7 FAM174B ST8SIA2 LOC105370975 PIR42313 GC15M096533
GH15I092680 Enhancer 1.2 Ensembl ENCODE dbSUPER 17.1 +130.2 130216 2.7 HDGF ZNF493 MZF1 RAD21 YY1 ARID2 ZNF207 RCOR1 EGR2 ZNF654 FAM174B PIR42313 GC15M096533 LOC105370975
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM174B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM174B gene promoter:

Genomic Locations for FAM174B Gene

Genomic Locations for FAM174B Gene
194,896 bases
Minus strand

Genomic View for FAM174B Gene

Genes around FAM174B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM174B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM174B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM174B Gene

Proteins for FAM174B Gene

  • Protein details for FAM174B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Membrane protein FAM174B
    Protein Accession:
    Secondary Accessions:
    • Q3ZCR9
    • Q8NBH7

    Protein attributes for FAM174B Gene

    159 amino acids
    Molecular mass:
    16967 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH45729.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for FAM174B Gene

Post-translational modifications for FAM174B Gene

No data available for DME Specific Peptides for FAM174B Gene

Domains & Families for FAM174B Gene

Gene Families for FAM174B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for FAM174B Gene


Suggested Antigen Peptide Sequences for FAM174B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM174 family.
  • Belongs to the FAM174 family.
genes like me logo Genes that share domains with FAM174B: view

Function for FAM174B Gene

Phenotypes From GWAS Catalog for FAM174B Gene

genes like me logo Genes that share phenotypes with FAM174B: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM174B Gene

Localization for FAM174B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM174B Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM174B gene
Compartment Confidence
extracellular 3
plasma membrane 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FAM174B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM174B: view

Pathways & Interactions for FAM174B Gene

SuperPathways for FAM174B Gene

No Data Available

Interacting Proteins for FAM174B Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q3ZCQ3-F174B_HUMAN ENSP00000329040 for FAM174B Gene via IID STRING

Gene Ontology (GO) - Biological Process for FAM174B Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM174B Gene

Drugs & Compounds for FAM174B Gene

No Compound Related Data Available

Transcripts for FAM174B Gene

Unigene Clusters for FAM174B Gene

Family with sequence similarity 174, member B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM174B Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d
SP2: - - - -
SP3: - -
SP4: -

Relevant External Links for FAM174B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM174B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM174B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM174B Gene

This gene is overexpressed in Pancreas (x6.4).

Protein differential expression in normal tissues from HIPED for FAM174B Gene

This gene is overexpressed in Pancreas (36.8), Adipocyte (18.0), and CD4 Tcells (12.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FAM174B Gene

Protein tissue co-expression partners for FAM174B Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM174B Gene:


SOURCE GeneReport for Unigene cluster for FAM174B Gene:


Evidence on tissue expression from TISSUES for FAM174B Gene

  • Nervous system(4.6)
  • Lung(2.4)
genes like me logo Genes that share expression patterns with FAM174B: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM174B Gene

Orthologs for FAM174B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM174B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM174B 33 34
  • 97.74 (n)
(Bos Taurus)
Mammalia FAM174B 34
  • 84 (a)
(Rattus norvegicus)
Mammalia Fam174b 33
  • 78.48 (n)
(Mus musculus)
Mammalia Fam174b 33 16 34
  • 77.17 (n)
(Ornithorhynchus anatinus)
Mammalia FAM174B 34
  • 69 (a)
(Monodelphis domestica)
Mammalia FAM174B 34
  • 62 (a)
(Canis familiaris)
Mammalia FAM174B 34
  • 42 (a)
(Gallus gallus)
Aves FAM174B 34
  • 59 (a)
(Anolis carolinensis)
Reptilia FAM174B 34
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam174b 33
  • 68.65 (n)
(Danio rerio)
Actinopterygii fam174b 34
  • 41 (a)
Species where no ortholog for FAM174B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM174B Gene

Gene Tree for FAM174B (if available)
Gene Tree for FAM174B (if available)

Paralogs for FAM174B Gene

No data available for Paralogs for FAM174B Gene

Variants for FAM174B Gene

Sequence variations from dbSNP and Humsavar for FAM174B Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000013663 -- 92,636,366(-) T/G intron_variant
rs1000021459 -- 92,729,580(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000046574 -- 92,706,688(-) C/A/T genic_upstream_transcript_variant, intron_variant
rs1000088523 -- 92,636,081(-) C/T intron_variant
rs1000090357 -- 92,653,836(-) C/A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM174B Gene

Variant ID Type Subtype PubMed ID
esv3637267 CNV loss 21293372
nsv1037972 CNV loss 25217958
nsv1122994 CNV deletion 24896259
nsv1674 CNV insertion 18451855

Variation tolerance for FAM174B Gene

Residual Variation Intolerance Score: 71.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.82; 34.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM174B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM174B Gene

Disorders for FAM174B Gene

Additional Disease Information for FAM174B

No disorders were found for FAM174B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM174B Gene

Publications for FAM174B Gene

  1. Common human genetic variants and HIV-1 susceptibility: a genome-wide survey in a homogeneous African population. (PMID: 21160409) Petrovski S … Center for HIV/AIDS Vaccine Immunology (AIDS (London, England) 2011) 3 44 58
  2. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody MC … Nusbaum C (Nature 2006) 4 58
  3. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for FAM174B Gene

Sources for FAM174B Gene

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