Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FAM174B Gene

Aliases for FAM174B Gene

  • Family With Sequence Similarity 174 Member B 2 3 5
  • Family With Sequence Similarity 174, Member B 2

External Ids for FAM174B Gene

Previous GeneCards Identifiers for FAM174B Gene

  • GC15M090962
  • GC15M093160
  • GC15M069297

Summaries for FAM174B Gene

GeneCards Summary for FAM174B Gene

FAM174B (Family With Sequence Similarity 174 Member B) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM174B Gene

Genomics for FAM174B Gene

Regulatory Elements for FAM174B Gene

Genomic Location for FAM174B Gene

Chromosome:
15
Start:
92,617,443 bp from pter
End:
92,812,338 bp from pter
Size:
194,896 bases
Orientation:
Minus strand

Genomic View for FAM174B Gene

Genes around FAM174B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM174B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM174B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM174B Gene

Proteins for FAM174B Gene

  • Protein details for FAM174B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3ZCQ3-F174B_HUMAN
    Recommended name:
    Membrane protein FAM174B
    Protein Accession:
    Q3ZCQ3
    Secondary Accessions:
    • Q3ZCR9
    • Q8NBH7

    Protein attributes for FAM174B Gene

    Size:
    159 amino acids
    Molecular mass:
    16967 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH45729.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for FAM174B Gene

Proteomics data for FAM174B Gene at MOPED

Post-translational modifications for FAM174B Gene

  • Glycosylation at Asn 53
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FAM174B Gene

Domains & Families for FAM174B Gene

Protein Domains for FAM174B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM174B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3ZCQ3

UniProtKB/Swiss-Prot:

F174B_HUMAN :
  • Belongs to the FAM174 family.
Family:
  • Belongs to the FAM174 family.
genes like me logo Genes that share domains with FAM174B: view

No data available for Gene Families for FAM174B Gene

Function for FAM174B Gene

genes like me logo Genes that share phenotypes with FAM174B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM174B Gene

Localization for FAM174B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM174B Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM174B Gene COMPARTMENTS Subcellular localization image for FAM174B gene
Compartment Confidence
extracellular 3
plasma membrane 2

No data available for Gene Ontology (GO) - Cellular Components for FAM174B Gene

Pathways & Interactions for FAM174B Gene

SuperPathways for FAM174B Gene

No Data Available

Interacting Proteins for FAM174B Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000329040%0d%0a9606.ENSP00000381891%0d%0a9606.ENSP00000363822%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000329040 Q3ZCQ3-F174B_HUMAN for FAM174B Gene via STRING I2D

Gene Ontology (GO) - Biological Process for FAM174B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM174B Gene

Drugs & Compounds for FAM174B Gene

No Compound Related Data Available

Transcripts for FAM174B Gene

Unigene Clusters for FAM174B Gene

Family with sequence similarity 174, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM174B Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d
SP1:
SP2: - - - -
SP3: - -
SP4: -

Relevant External Links for FAM174B Gene

GeneLoc Exon Structure for
FAM174B
ECgene alternative splicing isoforms for
FAM174B

Expression for FAM174B Gene

mRNA expression in normal human tissues for FAM174B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM174B Gene

This gene is overexpressed in Pancreas (x6.4).

Protein differential expression in normal tissues from HIPED for FAM174B Gene

This gene is overexpressed in Pancreas (36.8), Adipocyte (18.0), and CD4 Tcells (12.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FAM174B Gene



SOURCE GeneReport for Unigene cluster for FAM174B Gene Hs.27373

genes like me logo Genes that share expression patterns with FAM174B: view

Protein tissue co-expression partners for FAM174B Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FAM174B Gene

Orthologs for FAM174B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM174B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM174B 36
  • 97 (a)
OneToOne
FAM174B 35
  • 97.74 (n)
  • 96.24 (a)
cow
(Bos Taurus)
Mammalia FAM174B 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM174B 36
  • 42 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam174b 16
Fam174b 35
  • 77.17 (n)
  • 81.1 (a)
Fam174b 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM174B 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM174B 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam174b 35
  • 78.48 (n)
  • 77.17 (a)
chicken
(Gallus gallus)
Aves FAM174B 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM174B 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam174b 35
  • 68.65 (n)
  • 61.9 (a)
zebrafish
(Danio rerio)
Actinopterygii fam174b 36
  • 41 (a)
OneToOne
Species with no ortholog for FAM174B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM174B Gene

ENSEMBL:
Gene Tree for FAM174B (if available)
TreeFam:
Gene Tree for FAM174B (if available)

Paralogs for FAM174B Gene

No data available for Paralogs for FAM174B Gene

Variants for FAM174B Gene

Sequence variations from dbSNP and Humsavar for FAM174B Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs34052034 - 92,630,343(+) TTCCC(A/G)ACCTG nc-transcript-variant, reference, missense
rs426798 -- 92,641,514(+) CACTC(A/G)GACAC intron-variant
rs285749 -- 92,673,093(+) GAGGC(A/G)TGTGT intron-variant
rs285750 -- 92,673,781(+) gcctc(A/G)ctcct intron-variant
rs285751 -- 92,674,194(+) gagac(A/G)gagtc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM174B Gene

Variant ID Type Subtype PubMed ID
nsv904499 CNV Gain 21882294
nsv1674 CNV Insertion 18451855

Variation tolerance for FAM174B Gene

Residual Variation Intolerance Score: 71.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.82; 34.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM174B Gene

HapMap Linkage Disequilibrium report
FAM174B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM174B Gene

Disorders for FAM174B Gene

Relevant External Links for FAM174B

Genetic Association Database (GAD)
FAM174B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM174B

No disorders were found for FAM174B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM174B Gene

Publications for FAM174B Gene

  1. Common human genetic variants and HIV-1 susceptibility: a genome-wide survey in a homogeneous African population. (PMID: 21160409) Petrovski S. … Goldstein D.B. (AIDS 2011) 3 48 67
  2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for FAM174B Gene

Sources for FAM174B Gene

Back to Top

Content