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FAM174A Gene

protein-coding   GIFtS: 45
GCID: GC05P099900

Family With Sequence Similarity 174, Member A

(Previous name: transmembrane protein 157)
(Previous symbol: TMEM157)
  See FAM174A-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 174, Member A1 2     HGS_RE4082
Transmembrane Protein 1571 2 3     UNQ19122
TMEM1571 2 3     Membrane Protein FAM174A2
Hepatitis C Virus NS5A-Transactivated Protein 62 3     NS5ATP63
HCV NS5A-Transactivated Protein 62 3     

External Ids:    HGNC: 249431   Entrez Gene: 3457572   Ensembl: ENSG000001741327   UniProtKB: Q8TBP53   

Export aliases for FAM174A gene to outside databases

Previous GC identifer: GC05P095054


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM174A Gene:
FAM174A (family with sequence similarity 174, member A) is a protein-coding gene. Diseases associated with FAM174A include hepatitis c virus, and hepatitis c.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAM174A gene promoter:
         Pbx1a   HSF1 (long)   c-Ets-1   AREB6   Nkx6-1   POU2F1   NRF-2   POU2F1a   HSF1short   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM174A promoter sequence
   Search Chromatin IP Primers for FAM174A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM174A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q21.1   Ensembl cytogenetic band:  5q21.1   HGNC cytogenetic band: 5q21.1

FAM174A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM174A gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P099900:  view genomic region     (about GC identifiers)

Start:
99,871,009 bp from pter      End:
99,922,445 bp from pter
Size:
51,437 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: F174A_HUMAN, Q8TBP5 (See protein sequence)
Recommended Name: Membrane protein FAM174A precursor  
Size: 190 amino acids; 19954 Da
Secondary accessions: A8K0H4

Explore the universe of human proteins at neXtProt for FAM174A: NX_Q8TBP5

Explore proteomics data for FAM174A at MOPED

Post-translational modifications: 

  • Glycosylation2 at Thr52, Thr61, Asn83
  • Modification sites at PhosphoSitePlus

  • See FAM174A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_940909.1  
    ENSEMBL proteins: 
     ENSP00000307954  

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    Search eBioscience for ELISAs for FAM174A 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR009565 DUF1180

    Graphical View of Domain Structure for InterPro Entry Q8TBP5

    ProtoNet protein and cluster: Q8TBP5

    UniProtKB/Swiss-Prot: F174A_HUMAN, Q8TBP5
    Similarity: Belongs to the FAM174 family


    Find genes that share domains with FAM174A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAM174A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FAM174A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FAM174A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FAM174A

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    7 qRT-PCR Assays for microRNAs that regulate FAM174A:
    hsa-miR-411* hsa-miR-124 hsa-miR-379* hsa-miR-3920 hsa-miR-506 hsa-miR-103a-2* hsa-miR-1284
    SwitchGear 3'UTR luciferase reporter plasmidFAM174A 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FAM174A

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    Sino Biological Human cDNA Clone for FAM174A
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM174A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    F174A_HUMAN, Q8TBP5: Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    plasma membrane2
    cytosol1
    golgi apparatus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with FAM174A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM174A
    Interactions:

        Search GeneGlobe Interaction Network for FAM174A

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for FAM174A (ENSP000003079544) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LCKENSP000003378254STRING: ENSP00000337825
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM174A (F174A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FAM174A gene: 
    NM_198507.1  

    Unigene Cluster for FAM174A:

    Family with sequence similarity 174, member A
    Hs.356108  [show with all ESTs]
    Unigene Representative Sequence: AY359108
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000312637(uc003knj.1) ENST00000509040 ENST00000505792
    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate FAM174A:
    hsa-miR-411* hsa-miR-124 hsa-miR-379* hsa-miR-3920 hsa-miR-506 hsa-miR-103a-2* hsa-miR-1284
    SwitchGear 3'UTR luciferase reporter plasmidFAM174A 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for FAM174A
    Predesigned siRNA for gene silencing in human, mouse, rat FAM174A
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FAM174A (NM_198507)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM174A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM174A
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FAM174A
    OriGene qSTAR qPCR primer pairs in human, mouse for FAM174A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FAM174A
      QuantiTect SYBR Green Assays in human, mouse, rat FAM174A
      QuantiFast Probe-based Assays in human, mouse, rat FAM174A

    Additional mRNA sequence: 

    AF529367.1 AK289539.1 AY359108.1 BC027332.1 

    4 DOTS entries:

    DT.101980738  DT.91703628  DT.100815924  DT.100815925 

    Selected AceView cDNA sequences (see all 78):

    BF727408 BU183528 AI815990 AF529367 D12158 AW631476 CB114889 CD106244 
    AA338451 CB306968 BU838489 CR601145 CB154243 BI828615 AW001897 BI544299 
    BM685606 NM_198507 BC027332 N62855 AL515525 BG715805 AW236835 AW151173 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for FAM174A    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b
    SP1:                              
    SP2:              -               


    ECgene alternative splicing isoforms for FAM174A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM174A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCCAGCGGG
    FAM174A Expression
    About this image

    FAM174A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM174A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.356108
        Custom PCR Arrays for FAM174A
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat FAM174A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM174A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FAM174A gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam174a1 , 5 family with sequence similarity 174, member A1, 5 84.9(n)1
    80.47(a)1
      1 (47.76 cM)5
    676981  NM_026321.41  NP_080597.21 
     953136285 
    chicken
    (Gallus gallus)
    Aves FAM174A1 family with sequence similarity 174, member A 64.44(n)
    62.86(a)
      427273  XM_003643058.2  XP_003643106.1 
    lizard
    (Anolis carolinensis)
    Reptilia FAM174A6
    family with sequence similarity 174, member A
    51(a)
    1 ↔ 1
    GL343193.1(423163-433766)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.76832 Xenopus laevis transcribed sequence with weak similarity to protein refNP_080597.1 (M.musculus) RIKEN cDNA 2310044D20 [Mus musculus] less 72.58(n)    AW646643.1 


    ENSEMBL Gene Tree for FAM174A (if available)
    TreeFam Gene Tree for FAM174A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM174A (see all 1047)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1453868861,2
    --99869130(+) AGTTAA/CAATTT 1 -- int10--------
    rs1848381911,2
    --99869242(+) TATCAA/GTTGGC 1 -- int10--------
    rs1420191501,2
    C--99869279(+) GATAT-/AAAAAA 1 -- int10--------
    rs1896565801,2
    --99869368(+) ATTAAC/TACCAT 1 -- int10--------
    rs737744241,2
    C,F--99869434(+) AACCAT/CAGAAA 1 -- int12Minor allele frequency- C:0.05WA 120
    rs1384076291,2
    --99869512(+) TAAGCC/TAACCT 1 -- int10--------
    rs793965831,2
    C,F--99869598(+) GACTAG/TCTGGG 1 -- int12Minor allele frequency- T:0.08CSA WA 120
    rs1419659441,2
    C--99869615(+) TCTTTA/TCAAGG 1 -- int10--------
    rs100724091,2
    C,F,H--99869685(+) GAGAGA/CGGTAG 1 -- int1 tfbs313Minor allele frequency- C:0.08NS EA NA WA 1882
    rs2008019801,2
    --99869720(+) TCTGG-/CTCTCTC 1 -- int10--------

    HapMap Linkage Disequilibrium report for FAM174A (99871009 - 99922445 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for FAM174A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv882462CNV Loss21882294
    dgv6235n71CNV Loss21882294
    nsv882461CNV Loss21882294
    nsv823158CNV Loss20364138
    nsv818363CNV Gain17921354
    esv730CNV CNV17122850
    dgv1826e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FAM174A
    DNA2.0 Custom Variant and Variant Library Synthesis for FAM174A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    3 diseases for FAM174A:    
    About MalaCards
    hepatitis c virus    hepatitis c    hepatitis


    Find genes that share disorders with FAM174A           About GenesLikeMe

    Genetic Association Database (GAD): FAM174A
    Human Genome Epidemiology (HuGE) Navigator: FAM174A (1 document)

    Export disorders for FAM174A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM174A gene integrated from 10 sources:
    (articles sorted by number of sources associating them with FAM174A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (Genome Res. 2003)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Genome-wide association study of panic disorder in the Japanese population. (PubMed id 19165232)4 Otowa T....Okazaki Y. (J. Hum. Genet. 2009)
    4. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PubMed id 17903296)4 Kiel D.P....Karasik D. (BMC Med. Genet. 2007)
    5. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PubMed id 17903300)4 Fox C.S....Atwood L.D. (BMC Med. Genet. 2007)
    6. Insights into human Lck SH3 domain binding specificity: different binding modes of artificial and native ligands. (PubMed id 16274251)1 Tran T....Willbold D. (Biochemistry 2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (Nature 2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 345757 HGNC: 24943 AceView: UNQ1912 Ensembl:ENSG00000174132 euGenes: HUgn345757
    ECgene: FAM174A H-InvDB: FAM174A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM174A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM174A gene:
    Search GeneIP for patents involving FAM174A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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