FAM174A Gene
protein-coding GIFtS: 41
GCID: GC05P099900
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|
family with sequence similarity 174, member A(Previous name: transmembrane protein 157 )
(Previous symbol: TMEM157)
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Aliases
for FAM174A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Family With Sequence Similarity 174, Member A1 2 | | HCV NS5A-Transactivated Protein 62 3 | | Transmembrane Protein 1571 2 3 | | HGS_RE4082 | | TMEM1571 2 3 | | Membrane Protein FAM174A2 | | UNQ19121 2 | | NS5ATP63 | | Hepatitis C Virus NS5A-Transactivated Protein 62 3 | | |
Export aliases for FAM174A gene to outside databasesPrevious GC identifer: GC05P095054 |
Summaries
for FAM174A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FAM174A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_034772.6
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FAM174A gene promoter:
Pbx1a HSF1 (long) c-Ets-1 AREB6 Nkx6-1 POU2F1 NRF-2 POU2F1a HSF1short Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM174A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM174A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q21.1 Ensembl cytogenetic band: 5q21.1 HGNC cytogenetic band: 5q21.1FAM174A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P099900: view genomic region
(about GC identifiers)
Start:
|
99,871,009 bp from pter |
End:
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99,922,445 bp from pter |
Size:
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51,437 bases |
Orientation:
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plus strand |
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Proteins
for FAM174A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: F174A_HUMAN, Q8TBP5 (See
protein sequence)Recommended Name: Membrane protein FAM174A precursor Size: 190 amino acids; 19954 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Secondary accessions: A8K0H4Explore the universe of human proteins at neXtProt for FAM174A: NX_Q8TBP5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TBP5
FAM174A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_940909.1
ENSEMBL proteins: ENSP00000307954
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
FAM174A for ontologies About GeneDecksing
FAM174A Antibody Products:
Assay Products for FAM174A: |
Protein
Domains /
Families
for FAM174A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FAM174A for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8TBP5ProtoNet protein and cluster: Q8TBP5 UniProtKB/Swiss-Prot: F174A_HUMAN, Q8TBP5Similarity: Belongs to the FAM174 family |
Function
for FAM174A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM174A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM174A (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FAM174A (NM_198507) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM174A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM174A |
|
Pathways & Interactions
for FAM174A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM174A
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for FAM174A (ENSP000003079544) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for FAM174A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM174A
Search CenterWatch for drugs/clinical trials and news about FAM174A / F174A
|
Transcripts
for FAM174A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAM174A gene: NM_198507.1 Unigene Cluster for FAM174A: Family with sequence similarity 174, member A Hs.356108 [show with all ESTs]Unigene Representative Sequence: AY3591084 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000312637(uc003knj.1) ENST00000509040 ENST00000505111 ENST00000505792
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM174A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM174A (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FAM174A (NM_198507) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM174A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM174A |
Additional cDNA sequence: AF529367.1 AK289539.1 AY359108.1 BC027332.1 4 DOTS entries: DT.101980738 DT.91703628 DT.100815924 DT.100815925 24/78 AceView cDNA sequences (see all 78): CB154243 BI828615 CR601145 BU838489 AF529367 CB114889 BU183528 AA338451 CB306968 BF727408 AI815990 D12158 CD106244 AW631476 BC027332 AW261874 BU738611 BG714560 AW163370 CD244155 AL515525 BG742728 BI919267 CK002904
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for FAM174A About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b |
|---|
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| SP1: | | | | | | | | | | | |
| SP2: | | | | | - | | | | | |
ECgene alternative splicing isoforms for FAM174A
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Expression
for FAM174A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAM174A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACCCAGCGGG
About this image
See FAM174A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM174A
SOURCE GeneReport for Unigene cluster: Hs.356108
SABiosciences Custom PCR Arrays for FAM174A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM174A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FAM174A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM174A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM174A |
Orthologs
for FAM174A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for FAM174A gene from 4/11 species (see all 11) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Fam174a1 , 5 |
family with sequence similarity 174, member A1, 5 |
77.02(n)1
68.42(a)1 |
|
1 (47.76 cM)5
676981 NM_026321.41 NP_080597.21
953136285 |
chicken
(Gallus gallus) |
Aves |
FAM174A1 |
family with sequence similarity 174, member A |
68.91(n)
68.27(a) |
|
427273 XM_003643058.1 XP_003643106.1 |
lizard
(Anolis carolinensis) |
Reptilia |
FAM174A6 |
-- |
52(a) |
1 ↔ 1 |
GL343193.1(423340-431137) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.76832 |
Xenopus laevis transcribed sequence with weak similarity to protein refNP_080597.1 (M.musculus) RIKEN cDNA 2310044D20 [Mus musculus] less |
72.58(n) |
|
AW646643.1 |
ENSEMBL Gene Tree for FAM174A (if available)
TreeFam Gene Tree for FAM174A (if available) |
Paralogs
for FAM174A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAM174A gene
- FAM174B2
FAM174A for paralogs About GeneDecksing
|
Genomic Variants
for FAM174A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM174A (99871009 - 99922445 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for FAM174A
2 CNVs: 2587 9515 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM174A |
|
Disorders
/ Diseases
for FAM174A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FAM174A for disorders About GeneDecksing
2  diseases for FAM174A: About MalaCardshepatitis c hepatitis
Human Genome Epidemiology (HuGE) Navigator: FAM174A (1 document)
Export disorders for FAM174A gene to outside databases
|
Publications
for FAM174A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM174A gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM174A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Insights into human Lck SH3 domain binding specificity: different binding modes of artificial and native ligands. (PubMed id 16274251)1 Tran T....Willbold D. (2005)
- The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for FAM174A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FAM174A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM174A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FAM174A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAM174A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FAM174A gene:
Search GeneIP for patents involving FAM174A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM174A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FAM174A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM174A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM174A | | | OriGene Protein Over-expression Lysate for FAM174A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FAM174A | | OriGene 3'-UTR Clone for FAM174A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM174A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM174A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FAM174A | | OriGene Custom Protein Services for FAM174A | | | OriGene Custom Immunoassay Development | | |
| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM174A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM174A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM174A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM174A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM174A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM174A |
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 |  |  |  | |
| | | | Search Tocris compounds for FAM174A |
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 | | | FAM174A Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for FAM174A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM174A |
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