Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FAM174A Gene

Aliases for FAM174A Gene

  • Family With Sequence Similarity 174 Member A 2 3 5
  • Transmembrane Protein 157 2 3 4
  • Hepatitis C Virus Nonstructural Protein 5A Trans-Activated Protein 6 2 3
  • Hepatitis C Virus NS5A-Transactivated Protein 6 3 4
  • HCV NS5A-Transactivated Protein 6 3 4
  • TMEM157 3 4
  • NS5ATP6 3 4
  • Family With Sequence Similarity 174, Member A 2
  • Membrane Protein FAM174A 3
  • HGS_RE408 3
  • UNQ1912 3

External Ids for FAM174A Gene

Previous HGNC Symbols for FAM174A Gene

  • TMEM157

Previous GeneCards Identifiers for FAM174A Gene

  • GC05P099900
  • GC05P095054

Summaries for FAM174A Gene

GeneCards Summary for FAM174A Gene

FAM174A (Family With Sequence Similarity 174 Member A) is a Protein Coding gene.

Additional gene information for FAM174A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM174A Gene

Genomics for FAM174A Gene

Regulatory Elements for FAM174A Gene

Enhancers for FAM174A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H100594 1.1 FANTOM5 Ensembl ENCODE 16.5 +60.2 60214 2 TFAP4 GATA3 JUND POLR2A JUN FOSL2 FOS FAM174A ENSG00000247877 GC05P100589 ENSG00000250806
GH05H100666 0.9 Ensembl ENCODE 4.6 +132.4 132422 1 PKNOX1 JUN MAX CEBPB CEBPG EP300 RFX5 JUND STAT3 FAM174A ENSG00000250806 PIR62127
GH05H100270 0.2 ENCODE 4.6 -264.9 -264892 0 FAM174A LOC105379101 LOC100133050
GH05H100534 1 ENCODE 0.7 +0.4 414 2 ATF1 ARID4B SIN3A FEZF1 DMAP1 BRCA1 ZNF2 YY1 GLIS2 ELK1 FAM174A GC05P100589
GH05H100550 0.9 Ensembl ENCODE 0.4 +15.7 15743 1 PKNOX1 DPF2 IKZF1 EED ETV6 IKZF2 RUNX3 SPI1 FAM174A GC05P100589
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM174A on UCSC Golden Path with GeneCards custom track

Promoters for FAM174A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000184591 396 2200 ATF1 ARID4B SIN3A FEZF1 DMAP1 BRCA1 ZNF2 YY1 GLIS2 ELK1

Genomic Location for FAM174A Gene

100,535,305 bp from pter
100,586,741 bp from pter
51,437 bases
Plus strand

Genomic View for FAM174A Gene

Genes around FAM174A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM174A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM174A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM174A Gene

Proteins for FAM174A Gene

  • Protein details for FAM174A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Membrane protein FAM174A
    Protein Accession:
    Secondary Accessions:
    • A8K0H4

    Protein attributes for FAM174A Gene

    190 amino acids
    Molecular mass:
    19954 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM174A Gene

Post-translational modifications for FAM174A Gene

  • Glycosylation at posLast=5252 and posLast=8383
  • Modification sites at PhosphoSitePlus

Other Protein References for FAM174A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM174A Gene

Domains & Families for FAM174A Gene

Gene Families for FAM174A Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for FAM174A Gene


Suggested Antigen Peptide Sequences for FAM174A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM174 family.
  • Belongs to the FAM174 family.
genes like me logo Genes that share domains with FAM174A: view

Function for FAM174A Gene

Phenotypes From GWAS Catalog for FAM174A Gene

genes like me logo Genes that share phenotypes with FAM174A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for FAM174A

CRISPR Products

miRNA for FAM174A Gene

miRTarBase miRNAs that target FAM174A

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FAM174A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM174A Gene

Localization for FAM174A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM174A Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM174A gene
Compartment Confidence
extracellular 3
plasma membrane 2
cytosol 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FAM174A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM174A: view

Pathways & Interactions for FAM174A Gene

SuperPathways for FAM174A Gene

No Data Available

Interacting Proteins for FAM174A Gene

Gene Ontology (GO) - Biological Process for FAM174A Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM174A Gene

Drugs & Compounds for FAM174A Gene

No Compound Related Data Available

Transcripts for FAM174A Gene

mRNA/cDNA for FAM174A Gene

Unigene Clusters for FAM174A Gene

Family with sequence similarity 174, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FAM174A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for FAM174A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP2: -

Relevant External Links for FAM174A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM174A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM174A Gene

Protein differential expression in normal tissues from HIPED for FAM174A Gene

This gene is overexpressed in Nasal epithelium (67.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM174A Gene

Protein tissue co-expression partners for FAM174A Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM174A Gene:


SOURCE GeneReport for Unigene cluster for FAM174A Gene:


Evidence on tissue expression from TISSUES for FAM174A Gene

  • Nervous system(4.5)
  • Adrenal gland(4.2)
genes like me logo Genes that share expression patterns with FAM174A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM174A Gene

Orthologs for FAM174A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM174A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM174A 33
  • 99.47 (n)
TMEM157 34
  • 99 (a)
(Canis familiaris)
Mammalia FAM174A 33 34
  • 86.09 (n)
(Mus musculus)
Mammalia Fam174a 33 16 34
  • 84.9 (n)
(Rattus norvegicus)
Mammalia Fam174a 33
  • 84.9 (n)
(Bos Taurus)
Mammalia FAM174A 34
  • 75 (a)
(Monodelphis domestica)
Mammalia FAM174A 34
  • 53 (a)
(Gallus gallus)
Aves FAM174A 33 34
  • 64.44 (n)
(Anolis carolinensis)
Reptilia FAM174A 34
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam174 33
  • 60.19 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.7683 33
Species where no ortholog for FAM174A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM174A Gene

Gene Tree for FAM174A (if available)
Gene Tree for FAM174A (if available)

Paralogs for FAM174A Gene

No data available for Paralogs for FAM174A Gene

Variants for FAM174A Gene

Sequence variations from dbSNP and Humsavar for FAM174A Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000018798 -- 100,578,809(+) GCCCA(A/G)TGTGT intron-variant
rs1000026506 -- 100,539,680(+) GCACA(C/T)ACAGG intron-variant
rs1000034987 -- 100,546,056(+) GTACA(A/G)GCTAC intron-variant
rs1000047374 -- 100,562,898(+) ACAAA(G/T)ATTCA intron-variant
rs1000099793 -- 100,552,388(+) TGTGT(A/G)TAGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM174A Gene

Variant ID Type Subtype PubMed ID
esv2759359 CNV gain+loss 17122850
esv2763473 CNV loss 21179565
esv3890678 CNV gain 25118596
esv3890679 CNV loss 25118596
nsv1021183 CNV gain 25217958
nsv1023765 CNV loss 25217958
nsv599165 CNV loss 21841781
nsv818363 CNV gain 17921354
nsv823158 CNV loss 20364138

Variation tolerance for FAM174A Gene

Residual Variation Intolerance Score: 52.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.19; 39.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM174A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM174A Gene

Disorders for FAM174A Gene

Relevant External Links for FAM174A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM174A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM174A Gene

Publications for FAM174A Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. NS5ATP6 modulates intracellular triglyceride content through FGF21 and independently of SIRT1 and SREBP1. (PMID: 27179781) Li Z … Cheng J (Biochemical and biophysical research communications 2016) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for FAM174A Gene

Sources for FAM174A Gene

Loading form....