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Aliases for FAM173B Gene

Aliases for FAM173B Gene

  • Family With Sequence Similarity 173 Member B 2 3 5
  • Family With Sequence Similarity 173, Member B 2
  • Protein FAM173B 3
  • JS-2 3

External Ids for FAM173B Gene

Previous GeneCards Identifiers for FAM173B Gene

  • GC05M010280

Summaries for FAM173B Gene

GeneCards Summary for FAM173B Gene

FAM173B (Family With Sequence Similarity 173 Member B) is a Protein Coding gene. An important paralog of this gene is FAM173A.

Additional gene information for FAM173B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM173B Gene

Genomics for FAM173B Gene

Regulatory Elements for FAM173B Gene

Enhancers for FAM173B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H010606 1.6 FANTOM5 Ensembl ENCODE 10.8 -357.7 -357729 2.5 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF2 ZNF766 JUNB REST ZNF592 ROPN1L-AS1 ANKRD33B CTD-2154B17.1 LINC02221 ENSG00000248525 ANKRD33B-AS1 LINC02213 ROPN1L FAM173B LINC01513
GH05H010288 1.5 Ensembl ENCODE dbSUPER 8.4 -39.5 -39512 3 FOXA2 PKNOX1 SIN3A FEZF1 YY1 ZNF121 GLIS2 FOS KLF7 REST ENSG00000271980 ENSG00000272417 CMBL FAM173B CCT5 GC05M010293 ENSG00000252341 ENSG00000271715
GH05H010228 0.5 ENCODE 24.3 +20.6 20567 1.5 CTCF FOS RAD21 FAM173B PIR42000 GC05P010230
GH05H010248 1.4 ENCODE dbSUPER 8.1 -0.3 -325 4.1 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ROPN1L-AS1 CCT5 LINC02221 CTD-2154B17.1 ENSG00000248525 ENSG00000250001 MARCH6 CMBL ENSG00000271980 ROPN1L
GH05H010304 1.6 Ensembl ENCODE dbSUPER 6.9 -58.2 -58165 6.6 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 MARCH6 CMBL ROPN1L-AS1 ROPN1L FAM173B CCT5 ENSG00000271980 LOC105374651
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM173B on UCSC Golden Path with GeneCards custom track

Promoters for FAM173B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for FAM173B Gene

Genomic Locations for FAM173B Gene
24,530 bases
Minus strand

Genomic View for FAM173B Gene

Genes around FAM173B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM173B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM173B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM173B Gene

Proteins for FAM173B Gene

  • Protein details for FAM173B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM173B
    Protein Accession:
    Secondary Accessions:
    • B4DT41
    • B4DXK2
    • E9PBZ4

    Protein attributes for FAM173B Gene

    233 amino acids
    Molecular mass:
    26110 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM173B Gene


neXtProt entry for FAM173B Gene

Post-translational modifications for FAM173B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM173B Gene

No data available for DME Specific Peptides for FAM173B Gene

Domains & Families for FAM173B Gene

Gene Families for FAM173B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for FAM173B Gene


Suggested Antigen Peptide Sequences for FAM173B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM173 family.
  • Belongs to the FAM173 family.
genes like me logo Genes that share domains with FAM173B: view

Function for FAM173B Gene

Phenotypes From GWAS Catalog for FAM173B Gene

genes like me logo Genes that share phenotypes with FAM173B: view

Animal Model Products

CRISPR Products

miRNA for FAM173B Gene

miRTarBase miRNAs that target FAM173B

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM173B Gene

Localization for FAM173B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM173B Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM173B gene
Compartment Confidence
peroxisome 2
cytosol 2
plasma membrane 1
extracellular 1
mitochondrion 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FAM173B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM173B: view

Pathways & Interactions for FAM173B Gene

SuperPathways for FAM173B Gene

No Data Available

Interacting Proteins for FAM173B Gene

Gene Ontology (GO) - Biological Process for FAM173B Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM173B Gene

Drugs & Compounds for FAM173B Gene

No Compound Related Data Available

Transcripts for FAM173B Gene

Unigene Clusters for FAM173B Gene

Family with sequence similarity 173, member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM173B Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - -
SP2: - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - -
SP6: - - -

Relevant External Links for FAM173B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM173B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM173B Gene

Protein differential expression in normal tissues from HIPED for FAM173B Gene

This gene is overexpressed in Cervix (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM173B Gene

Protein tissue co-expression partners for FAM173B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM173B Gene:


SOURCE GeneReport for Unigene cluster for FAM173B Gene:


Evidence on tissue expression from TISSUES for FAM173B Gene

  • Intestine(4.1)
genes like me logo Genes that share expression patterns with FAM173B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM173B Gene

Orthologs for FAM173B Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM173B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM173B 33 34
  • 99.43 (n)
(Canis familiaris)
Mammalia FAM173B 33 34
  • 82.96 (n)
(Bos Taurus)
Mammalia FAM173B 33 34
  • 81.26 (n)
(Rattus norvegicus)
Mammalia Fam173b 33
  • 79.46 (n)
(Mus musculus)
Mammalia Fam173b 33 16 34
  • 76.78 (n)
(Monodelphis domestica)
Mammalia FAM173B 34
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia FAM173B 34
  • 62 (a)
(Gallus gallus)
Aves FAM173B 33 34
  • 66.67 (n)
(Anolis carolinensis)
Reptilia FAM173B 34
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam173b 33
  • 68.16 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.29791 33
(Danio rerio)
Actinopterygii fam173b 33 34
  • 67.24 (n)
Dr.8653 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4845 33
fruit fly
(Drosophila melanogaster)
Insecta CG3337 33 34
  • 51.98 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002286 33
  • 50.91 (n)
(Caenorhabditis elegans)
Secernentea CELE_Y39A1A.21 33
  • 50 (n)
Y39A1A.21 34
  • 43 (a)
Species where no ortholog for FAM173B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM173B Gene

Gene Tree for FAM173B (if available)
Gene Tree for FAM173B (if available)

Paralogs for FAM173B Gene

Paralogs for FAM173B Gene

(1) SIMAP similar genes for FAM173B Gene using alignment to 4 proteins: Pseudogenes for FAM173B Gene

genes like me logo Genes that share paralogs with FAM173B: view

Variants for FAM173B Gene

Sequence variations from dbSNP and Humsavar for FAM173B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs141133834 Uncertain significance 10,250,426(+) TCTTA(C/T)GGGAC intron-variant, upstream-variant-2KB, reference, missense
rs552002776 Uncertain significance 10,250,216(+) GAAAC(A/C/G)TAAGT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs574425461 Uncertain significance 10,250,293(+) GCTTC(C/T)GTAGC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs748544536 Uncertain significance 10,250,282(+) AGTGC(A/G)TTCTC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs2548546 Benign 10,250,318(-) TACTT(A/C/T)CCCCC intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for FAM173B Gene

Variant ID Type Subtype PubMed ID
nsv830201 CNV gain 17160897
nsv597112 CNV gain 21841781
nsv525565 CNV loss 19592680
nsv461975 CNV gain 19166990
nsv1029129 CNV gain 25217958
esv33231 CNV loss 17666407

Variation tolerance for FAM173B Gene

Residual Variation Intolerance Score: 74.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.49; 92.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM173B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM173B Gene

Disorders for FAM173B Gene

Relevant External Links for FAM173B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM173B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM173B Gene

Publications for FAM173B Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  4. Genome-wide association study meta-analysis of chronic widespread pain: evidence for involvement of the 5p15.2 region. (PMID: 22956598) Peters MJ … van Meurs JB (Annals of the rheumatic diseases 2013) 3 60
  5. N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P … Aldabe R (Proceedings of the National Academy of Sciences of the United States of America 2012) 4 60

Products for FAM173B Gene

Sources for FAM173B Gene

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