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Aliases for FAM173B Gene

Aliases for FAM173B Gene

  • Family With Sequence Similarity 173, Member B 2 3
  • Protein FAM173B 3
  • JS-2 3

External Ids for FAM173B Gene

Previous GeneCards Identifiers for FAM173B Gene

  • GC05M010280

Summaries for FAM173B Gene

GeneCards Summary for FAM173B Gene

FAM173B (Family With Sequence Similarity 173, Member B) is a Protein Coding gene. An important paralog of this gene is FAM173A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM173B Gene

Genomics for FAM173B Gene

Regulatory Elements for FAM173B Gene

Genomic Location for FAM173B Gene

Start:
10,225,507 bp from pter
End:
10,249,954 bp from pter
Size:
24,448 bases
Orientation:
Minus strand

Genomic View for FAM173B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM173B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM173B Gene

Proteins for FAM173B Gene

  • Protein details for FAM173B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P4H8-F173B_HUMAN
    Recommended name:
    Protein FAM173B
    Protein Accession:
    Q6P4H8
    Secondary Accessions:
    • B4DT41
    • B4DXK2
    • E9PBZ4

    Protein attributes for FAM173B Gene

    Size:
    233 amino acids
    Molecular mass:
    26110 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM173B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM173B Gene

Proteomics data for FAM173B Gene at MOPED

Post-translational modifications for FAM173B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM173B Gene

No data available for DME Specific Peptides for FAM173B Gene

Domains for FAM173B Gene

Protein Domains for FAM173B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM173B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P4H8

UniProtKB/Swiss-Prot:

F173B_HUMAN :
  • Q6P4H8
Family:
  • Belongs to the FAM173 family.
genes like me logo Genes that share domains with FAM173B: view

No data available for Gene Families for FAM173B Gene

Function for FAM173B Gene

Phenotypes for FAM173B Gene

GenomeRNAi human phenotypes for FAM173B:
genes like me logo Genes that share phenotypes with FAM173B: view

miRNA for FAM173B Gene

miRTarBase miRNAs that target FAM173B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for FAM173B Gene

Localization for FAM173B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM173B Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM173B Gene COMPARTMENTS Subcellular localization image for FAM173B gene
Compartment Confidence
cytosol 2
peroxisome 2
extracellular 1
mitochondrion 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FAM173B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM173B: view

Pathways for FAM173B Gene

SuperPathways for FAM173B Gene

No Data Available

Interacting Proteins for FAM173B Gene

Gene Ontology (GO) - Biological Process for FAM173B Gene

None

No data available for Pathways by source for FAM173B Gene

Transcripts for FAM173B Gene

Unigene Clusters for FAM173B Gene

Family with sequence similarity 173, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM173B Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - -
SP2: - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - -
SP6: - - -
SP7:

Relevant External Links for FAM173B Gene

GeneLoc Exon Structure for
FAM173B
ECgene alternative splicing isoforms for
FAM173B

Expression for FAM173B Gene

mRNA expression in normal human tissues for FAM173B Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for FAM173B Gene

SOURCE GeneReport for Unigene cluster for FAM173B Gene Hs.481569

genes like me logo Genes that share expressions with FAM173B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM173B Gene

Orthologs for FAM173B Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM173B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM173B 35
  • 99.43 (n)
  • 99.57 (a)
FAM173B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM173B 35
  • 81.26 (n)
  • 81.55 (a)
FAM173B 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM173B 35
  • 82.96 (n)
  • 82.22 (a)
FAM173B 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam173b 35
  • 76.78 (n)
  • 81.04 (a)
Fam173b 16
Fam173b 36
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM173B 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM173B 36
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam173b 35
  • 79.46 (n)
  • 81.99 (a)
chicken
(Gallus gallus)
Aves FAM173B 35
  • 66.67 (n)
  • 70.83 (a)
FAM173B 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM173B 36
  • 64 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.29791 35
tropical clawed frog
(Silurana tropicalis)
Amphibia fam173b 35
  • 68.16 (n)
  • 70.65 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4845 35
zebrafish
(Danio rerio)
Actinopterygii Dr.8653 35
fam173b 35
  • 67.24 (n)
  • 74.14 (a)
fam173b 36
  • 60 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002286 35
  • 50.91 (n)
  • 50.25 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3337 35
  • 51.98 (n)
  • 49.15 (a)
CG3337 36
  • 44 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea CELE_Y39A1A.21 35
  • 50 (n)
  • 46.55 (a)
Y39A1A.21 36
  • 43 (a)
OneToMany
Species with no ortholog for FAM173B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM173B Gene

ENSEMBL:
Gene Tree for FAM173B (if available)
TreeFam:
Gene Tree for FAM173B (if available)

Paralogs for FAM173B Gene

Paralogs for FAM173B Gene

Selected SIMAP similar genes for FAM173B Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for FAM173B Gene

genes like me logo Genes that share paralogs with FAM173B: view

Variants for FAM173B Gene

Sequence variations from dbSNP and Humsavar for FAM173B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs15757 - 10,227,458(-) TCCAG(A/C)TGCCC missense, reference, utr-variant-3-prime, nc-transcript-variant
rs906685 -- 10,228,469(+) TGCTA(A/G)AAGTA intron-variant
rs906686 -- 10,228,713(+) CAAGA(C/T)TTATC intron-variant
rs906687 -- 10,230,134(+) GTGCT(C/T)AGAAA intron-variant
rs1045369 -- 10,226,727(-) GGGGA(C/T)CAATT utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM173B Gene

Variant ID Type Subtype PubMed ID
esv33231 CNV Loss 17666407
nsv830201 CNV Gain 17160897
nsv881429 CNV Gain 21882294
nsv880633 CNV Loss 21882294
nsv525565 CNV Loss 19592680
nsv461975 CNV Gain 19166990

Relevant External Links for FAM173B Gene

HapMap Linkage Disequilibrium report
FAM173B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM173B Gene

Disorders for FAM173B Gene

Relevant External Links for FAM173B

Genetic Association Database (GAD)
FAM173B
Human Genome Epidemiology (HuGE) Navigator
FAM173B
genes like me logo Genes that share disorders with FAM173B: view

No data available for UniProtKB/Swiss-Prot for FAM173B Gene

Publications for FAM173B Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Altered JS-2 expression in colorectal cancers and its clinical pathological relevance. (PMID: 21802380) Lam A.K. … Smith R.A. (Mol Oncol 2011) 3
  5. Genome-wide association study meta-analysis of chronic widespread pain: evidence for involvement of the 5p15.2 region. (PMID: 22956598) Peters M.J. … van Meurs J.B. (Ann. Rheum. Dis. 2013) 3

Products for FAM173B Gene

  • antibodies-online proteins for FAM173B
  • antibodies-online antibodies for FAM173B
  • antibodies-online kits for FAM173B

Sources for FAM173B Gene

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