FAM173B Gene
protein-coding GIFtS: 44
GCID: GC05M010226
|
|
family with sequence similarity 173, member B
| |
Aliases for FAM173B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Family With Sequence Similarity 173, Member B1 2 | | JS-22 | | Protein FAM173B2 |
Export aliases for FAM173B gene to outside databasesPrevious GC identifer: GC05M010280 |
Summaries for FAM173B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| -- |
Genomic Views for FAM173B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_006576.16
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the FAM173B gene promoter: Max1 AML1a NF-kappaB LCR-F1 GATA-1 E2F E2F-1 HOXA5 NF-kappaB1 c-Myc Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM173B
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM173B |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5p15.2 Ensembl cytogenetic band: 5p15.2 HGNC cytogenetic band: 5p15.2FAM173B Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M010226: view genomic region
(about GC identifiers)
Start:
|
10,226,438 bp from pter |
End:
|
10,250,014 bp from pter |
Size:
|
23,577 bases |
Orientation:
|
minus strand |
|
Proteins for FAM173B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: F173B_HUMAN, Q6P4H8 (See
protein sequence)Recommended Name: Protein FAM173B Size: 233 amino acids; 26110 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Secondary accessions: B4DT41 B4DXK2 E9PBZ4Alternative splicing: 2 isoforms: Q6P4H8-1 Q6P4H8-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for FAM173B: NX_Q6P4H8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6P4H8 FAM173B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001245317.1 NP_001245318.1 NP_954584.2 ENSEMBL proteins: ENSP00000280330 ENSP00000422338 ENSP00000420876 ENSP00000424210 ENSP00000427453 Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
FAM173B for ontologies About GeneDecksing
FAM173B Antibody Products: Assay Products for FAM173B: |
Protein
Domains / Families for FAM173B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FAM173B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6P4H8ProtoNet protein and cluster: Q6P4H8 UniProtKB/Swiss-Prot: F173B_HUMAN, Q6P4H8Similarity: Belongs to the FAM173 family |
Function for FAM173B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM173B (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM173B OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FAM173B (NM_199133) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM173B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM173B  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM173B |
1 GenomeRNAi human phenotype for FAM173B:
|
Pathways & Interactions for FAM173B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM173B
|
Drugs & Compounds for FAM173B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for FAM173B Search CenterWatch for drugs/clinical trials and news about FAM173B / F173B 
|
Transcripts for FAM173B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for FAM173B gene (3 alternative transcripts): NM_001258388.1 NM_001258389.1 NM_199133.3 Unigene Cluster for FAM173B: Family with sequence similarity 173, member B Hs.481569 [show with all ESTs]Unigene Representative Sequence: NR_0476697 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000280330(uc003jeo.2 uc003jep.2 uc010itr.2) ENST00000511437 ENST00000510047 ENST00000504390 ENST00000510052 ENST00000506108 ENST00000508553
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM173B (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM173B OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FAM173B (NM_199133) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM173B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM173B  |
Additional cDNA sequence: AK000674.1 AK055604.1 AK123462.1 AK300042.1 AK302012.1 AK316317.1 BC048801.1 BC063406.1 NR_047668.1 NR_047669.1 NR_047670.1 11 DOTS entries: DT.120821913 DT.100815471 DT.441913 DT.101982711 DT.100815469 DT.120822032 DT.92414022 DT.120821918 DT.100815470 DT.120822016 DT.120821804 24/137 AceView cDNA sequences (see all 137): BE018206 AI741836 AA233255 BE350816 AI754046 CB241897 AI050902 H96365 CB528857 CK821506 BI821731 BM353872 N68308 AI248125 AA702870 BM353596 BQ007513 AW014636 AI139075 BE890782 BM458761 AA418171 AA418330 AI693371 GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for FAM173B (see all 7) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | |
| SP1: | |   | |   | |   | |   | |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | - |   | |   | - |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | - |   | - |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | - |   | |   | - |   | - |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | - |   | |   | |   | - |   | - |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for FAM173B
|
Expression for FAM173B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAM173B expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: GCACCTAGTC
About this image See FAM173B Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for FAM173B
SOURCE GeneReport for Unigene cluster: Hs.481569 SABiosciences Custom PCR Arrays for FAM173B
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM173B Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FAM173B | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM173B | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM173B | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM173B |
Orthologs for FAM173B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FAM173B gene from 7/24 species (see all 24) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
mouse (Mus musculus) |
Mammalia |
Fam173b1 , 5 |
family with sequence similarity 173, member B1, 5 |
76.78(n)1 81.04(a)1 |
  |
15 (13.02 cM)5 680731 NM_026546.31 NP_080822.11 316018525 |
chicken (Gallus gallus) |
Aves |
FAM173B1 |
family with sequence similarity 173, member B |
70.54(n) 75.76(a) |
  |
428500 XM_426055.3 XP_426055.3 |
lizard (Anolis carolinensis) |
Reptilia |
FAM173B6 |
-- |
66(a) |
1 ↔ 1 |
4(82256314-82262191) |
African clawed frog (Xenopus laevis) |
Amphibia |
Xl.297912 |
Xenopus laevis transcribed sequence with weak similarity more |
74.83(n) |
  |
CB592751.1 |
zebrafish (Danio rerio) |
Actinopterygii |
Dr.86532 |
Transcribed sequence with weak similarity to protein more |
75.32(n) |
  |
57049196 |
fruit fly (Drosophila melanogaster) |
Insecta |
CG33371 |
CG3337 |
51.98(n) 49.15(a) |
  |
42519 NM_142700.2 NP_650957.1 |
worm (Caenorhabditis elegans) |
Secernentea |
CELE_Y39A1A.211 |
Protein Y39A1A.21 |
50(n) 46.55(a) |
  |
176493 NM_001027669.2 NP_001022840.1 |
ENSEMBL Gene Tree for FAM173B (if available) TreeFam Gene Tree for FAM173B (if available)  |
Paralogs for FAM173B gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for FAM173B gene
- FAM173A2
1 SIMAP similar gene for FAM173B using alignment to 4 protein entries: F173B_HUMAN (see all proteins):FAM173A
FAM173B for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for FAM173B PGOHUM00000239420
|
Genomic Variants for FAM173B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 5 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM173B (10226438 - 10250014 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for FAM173B 1 CNV: 7462  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM173B |
|
Disorders
/ Diseases for FAM173B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FAM173B for disorders About GeneDecksing
4 diseases for FAM173B: About MalaCardsesophageal squamous cell carcinoma squamous cell carcinoma esophagitis carcinoma Human Genome Epidemiology (HuGE) Navigator: FAM173B (1 document) Export disorders for FAM173B gene to outside databases
|
Publications for FAM173B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM173B gene, integrated from 9 sources (see all 11): (articles sorted by number of sources associating them with FAM173B) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Altered JS-2 expression in colorectal cancers and its clinical pathological relevance. (PubMed id 21802380)1 Lam A.K....Smith R.A. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- The transcriptome of human CD34+ hematopoietic stem-p rogenitor cells. (PubMed id 19416867)1 Kim Y.C....Wang S.M. (2009)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Transforming capacity of two novel genes JS-1 and JS-2 located in chromosome 5p and their overexpression in human esophageal squamous cell carcinoma. (PubMed id 16328025)1 Fatima S....Tang J.C. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (2004)
|
External Searches for FAM173B gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing FAM173B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM173B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FAM173B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for FAM173B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FAM173B gene: Search GeneIP for patents involving FAM173B
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for FAM173B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for FAM173B | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM173B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM173B | | OriGene Protein Over-expression Lysate for FAM173B | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for FAM173B | | OriGene 3'-UTR Clone for FAM173B | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM173B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM173B | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | OriGene Custom Antibody Services for FAM173B | | OriGene Custom Protein Services for FAM173B | | OriGene Custom Immunoassay Development | | |
| |  |
 |
| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM173B | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM173B | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM173B | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM173B | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM173B | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM173B |
| |
 |  |  |  | |
| | | Search Tocris compounds for FAM173B |
| |  |  |  |  | | | | |
 |
 |
 |
 | | FAM173B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM173B |
|  |  |  | | | Search ThermoFisher Antibodies for FAM173B |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM173B |
|
|
|
|