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Aliases for FAM173B Gene

Aliases for FAM173B Gene

  • Family With Sequence Similarity 173, Member B 2 3
  • JS-2 3

External Ids for FAM173B Gene

Previous GeneCards Identifiers for FAM173B Gene

  • GC05M010280

Summaries for FAM173B Gene

GeneCards Summary for FAM173B Gene

FAM173B (Family With Sequence Similarity 173, Member B) is a Protein Coding gene. An important paralog of this gene is FAM173A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM173B Gene

Genomics for FAM173B Gene

Regulatory Elements for FAM173B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM173B Gene

10,225,507 bp from pter
10,250,036 bp from pter
24,530 bases
Minus strand

Genomic View for FAM173B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for FAM173B Gene

Proteins for FAM173B Gene

  • Protein details for FAM173B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM173B
    Protein Accession:
    Secondary Accessions:
    • B4DT41
    • B4DXK2
    • E9PBZ4

    Protein attributes for FAM173B Gene

    233 amino acids
    Molecular mass:
    26110 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM173B Gene


neXtProt entry for FAM173B Gene

Proteomics data for FAM173B Gene at MOPED

Post-translational modifications for FAM173B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM173B Gene

No data available for DME Specific Peptides for FAM173B Gene

Domains & Families for FAM173B Gene

Protein Domains for FAM173B Gene


Suggested Antigen Peptide Sequences for FAM173B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM173 family.
  • Belongs to the FAM173 family.
genes like me logo Genes that share domains with FAM173B: view

No data available for Gene Families for FAM173B Gene

Function for FAM173B Gene

Phenotypes for FAM173B Gene

GenomeRNAi human phenotypes for FAM173B:
genes like me logo Genes that share phenotypes with FAM173B: view

Animal Model Products

CRISPR Products

miRNA for FAM173B Gene

miRTarBase miRNAs that target FAM173B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM173B

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM173B Gene

Localization for FAM173B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM173B Gene

Membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for FAM173B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM173B: view

No data available for Subcellular locations from COMPARTMENTS for FAM173B Gene

Pathways & Interactions for FAM173B Gene

SuperPathways for FAM173B Gene

No Data Available

Interacting Proteins for FAM173B Gene

Gene Ontology (GO) - Biological Process for FAM173B Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM173B Gene

Drugs & Compounds for FAM173B Gene

No Compound Related Data Available

Transcripts for FAM173B Gene

Unigene Clusters for FAM173B Gene

Family with sequence similarity 173, member B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM173B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM173B Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - -
SP2: - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - -
SP6: - - -

Relevant External Links for FAM173B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM173B Gene

mRNA expression in normal human tissues for FAM173B Gene

Protein differential expression in normal tissues from HIPED for FAM173B Gene

This gene is overexpressed in Cervix (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for FAM173B Gene

SOURCE GeneReport for Unigene cluster for FAM173B Gene Hs.481569

genes like me logo Genes that share expression patterns with FAM173B: view

Protein tissue co-expression partners for FAM173B Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM173B Gene

Orthologs for FAM173B Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM173B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM173B 35
  • 81.26 (n)
  • 81.55 (a)
FAM173B 36
  • 83 (a)
(Canis familiaris)
Mammalia FAM173B 35
  • 82.96 (n)
  • 82.22 (a)
FAM173B 36
  • 83 (a)
(Mus musculus)
Mammalia Fam173b 35
  • 76.78 (n)
  • 81.04 (a)
Fam173b 16
Fam173b 36
  • 70 (a)
(Pan troglodytes)
Mammalia FAM173B 35
  • 99.43 (n)
  • 99.57 (a)
FAM173B 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Fam173b 35
  • 79.46 (n)
  • 81.99 (a)
(Monodelphis domestica)
Mammalia FAM173B 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia FAM173B 36
  • 62 (a)
(Gallus gallus)
Aves FAM173B 35
  • 66.67 (n)
  • 70.83 (a)
FAM173B 36
  • 64 (a)
(Anolis carolinensis)
Reptilia FAM173B 36
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam173b 35
  • 68.16 (n)
  • 70.65 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.29791 35
(Danio rerio)
Actinopterygii Dr.8653 35
fam173b 35
  • 67.24 (n)
  • 74.14 (a)
fam173b 36
  • 60 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4845 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002286 35
  • 50.91 (n)
  • 50.25 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3337 35
  • 51.98 (n)
  • 49.15 (a)
CG3337 36
  • 44 (a)
(Caenorhabditis elegans)
Secernentea CELE_Y39A1A.21 35
  • 50 (n)
  • 46.55 (a)
Y39A1A.21 36
  • 43 (a)
Species with no ortholog for FAM173B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM173B Gene

Gene Tree for FAM173B (if available)
Gene Tree for FAM173B (if available)

Paralogs for FAM173B Gene

Paralogs for FAM173B Gene

(1) SIMAP similar genes for FAM173B Gene using alignment to 4 proteins: Pseudogenes for FAM173B Gene

genes like me logo Genes that share paralogs with FAM173B: view

Variants for FAM173B Gene

Sequence variations from dbSNP and Humsavar for FAM173B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_039345 -
VAR_039346 -
VAR_039347 -
VAR_039348 -

Structural Variations from Database of Genomic Variants (DGV) for FAM173B Gene

Variant ID Type Subtype PubMed ID
esv33231 CNV Loss 17666407
nsv830201 CNV Gain 17160897
nsv881429 CNV Gain 21882294
nsv880633 CNV Loss 21882294
nsv525565 CNV Loss 19592680
nsv461975 CNV Gain 19166990

Variation tolerance for FAM173B Gene

Residual Variation Intolerance Score: 74.34% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.49; 92.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM173B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM173B Gene

Disorders for FAM173B Gene

Relevant External Links for FAM173B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FAM173B: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM173B Gene

Publications for FAM173B Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. Genome-wide association study meta-analysis of chronic widespread pain: evidence for involvement of the 5p15.2 region. (PMID: 22956598) Peters M.J. … van Meurs J.B. (Ann. Rheum. Dis. 2013) 67
  3. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P. … Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012) 67
  4. Altered JS-2 expression in colorectal cancers and its clinical pathological relevance. (PMID: 21802380) Lam A.K. … Smith R.A. (Mol Oncol 2011) 67
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 67

Products for FAM173B Gene

Sources for FAM173B Gene

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