FAM172A Gene
protein-coding GIFtS: 48
GCID: GC05M092981
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family with sequence similarity 172, member A(Previous name: chromosome 5 open reading frame 21 ) (Previous symbol: C5orf21)
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Aliases for FAM172A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
| This gene clusters with an RNA gene Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Family With Sequence Similarity 172, Member A1 2 | | C5orf211 2 3 | | DKFZP564D1721 | | Chromosome 5 Open Reading Frame 211 | | Protein FAM172A2 |
| External Ids: | HGNC: 253651 | Entrez Gene: 839892 | Ensembl: ENSG000001133917 | UniProtKB: Q8WUF83 | | ORGUL members: | |
|---|
| NONCODE:n408132 | |
Export aliases for FAM172A gene to outside databases
Summaries for FAM172A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Gene Wiki entry for FAM172A (C5orf21)
|
Genomic Views for FAM172A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_034772.6
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the FAM172A gene promoter: STAT1 p300 STAT1beta STAT1alpha AREB6 CP2 FOXJ2 (long isoform) STAT3 PPAR-gamma2 FOXJ2 Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM172A
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM172A |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q15 Ensembl cytogenetic band: 5q15 HGNC cytogenetic band: 5q15FAM172A Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M092981: view genomic region
(about GC identifiers)
Start:
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92,953,431 bp from pter |
End:
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93,447,404 bp from pter |
Size:
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493,974 bases |
Orientation:
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minus strand |
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Proteins for FAM172A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: F172A_HUMAN, Q8WUF8 (See
protein sequence)Recommended Name: Protein FAM172A precursor Size: 416 amino acids; 47972 Da
Subcellular location: Secreted (Potential)
Secondary accessions: B2R7C6 B4DJ14 B4DLG5 Q9H0U8Alternative splicing: 4 isoforms: Q8WUF8-1 Q8WUF8-2 Q8WUF8-3 Q8WUF8-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for FAM172A: NX_Q8WUF8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WUF8 FAM172A Protein expression data from MOPED and PaxDb: About this image 
 REFSEQ proteins (3 alternative transcripts):
NP_001156889.1 NP_001156890.1 NP_114431.2 ENSEMBL proteins: ENSP00000379294 ENSP00000426284 ENSP00000421834 ENSP00000423841 ENSP00000424097 Human Recombinant Protein Products for FAM172A:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- | | GO:0005783 | endoplasmic reticulum |
IDA | -- |
FAM172A for ontologies About GeneDecksing
FAM172A Antibody Products: Assay Products for FAM172A: |
Protein
Domains / Families for FAM172A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FAM172A for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8WUF8ProtoNet protein and cluster: Q8WUF8 UniProtKB/Swiss-Prot: F172A_HUMAN, Q8WUF8Similarity: Belongs to the UPF0528 family |
Function for FAM172A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Animal Models:
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM172A (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM172A (see all 4) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): FAM172A (NM_032042) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM172A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM172A  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM172A |
|
Pathways & Interactions for FAM172A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM172A
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
 3 Interacting proteins for FAM172A (Q8WUF83 ENSP000003792944) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds for FAM172A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for FAM172A Search CenterWatch for drugs/clinical trials and news about FAM172A / F172A 
|
Transcripts for FAM172A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for FAM172A gene (3 alternative transcripts): NM_001163417.1 NM_001163418.1 NM_032042.5 Unigene Cluster for FAM172A: Family with sequence similarity 172, member A Hs.600086 [show with all ESTs]Unigene Representative Sequence: NM_0320429 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000395965(uc010jbd.3 uc011cuf.2 uc011cug.2 uc011cuh.2 uc011cui.2 uc011cuj.2) ENST00000505869 ENST00000509739 ENST00000509163 ENST00000502503 ENST00000511139 ENST00000510445 ENST00000506398(uc003kkm.4) ENST00000504768
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM172A (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM172A (see all 4) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): FAM172A (NM_032042) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM172A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM172A  |
Additional cDNA sequence: AF070617.1 AK295127.1 AK295879.1 AK296683.1 AK296986.1 AK297471.1 AK309742.1 AK312930.1 AL136630.1 BC012007.1 BC020584.2 NR_028080.1 13 DOTS entries: DT.100025788 DT.114145 DT.95158760 DT.100788474 DT.120876442 DT.40227808 DT.100718923 DT.100788469 DT.120876360 DT.120876435 DT.91754400 DT.91754401 DT.97815055 24/147 AceView cDNA sequences (see all 147): BM555117 NM_032042 AW958085 CB052434 BI916568 BX280740 BM980381 BM789633 BX427891 AI983620 BU689105 BM801927 AI224844 AA603316 BQ720126 BX279883 AI868565 AI888506 BC020584 AA947660 AI434236 AI637652 CR605117 CB215800 GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for FAM172A About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | |
| SP1: | |   | |   | |   | - |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | - |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for FAM172A
|
Expression for FAM172A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAM172A expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: TACCTTTAAT
 About this image See FAM172A Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for FAM172A
SOURCE GeneReport for Unigene cluster: Hs.600086 SABiosciences Custom PCR Arrays for FAM172A
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM172A Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FAM172A | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM172A | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM172A | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM172A |
Orthologs for FAM172A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FAM172A gene from 6/18 species (see all 18) About this table
ENSEMBL Gene Tree for FAM172A (if available) TreeFam Gene Tree for FAM172A (if available)  |
Paralogs for FAM172A gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for FAM172A gene
1 SIMAP similar gene for FAM172A using alignment to 3 protein entries: F172A_HUMAN (see all proteins):FAM172BP
FAM172A for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for FAM172A PGOHUM00000250295
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Genomic Variants for FAM172A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 5 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM172A (92953431 - 93203431 bp, first 250kb of FAM172A)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for FAM172A 1 Indel: 40785  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM172A |
|
Disorders
/ Diseases for FAM172A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FAM172A for disorders About GeneDecksing
1 disease for FAM172A: About MalaCardsdiabetic angiopathy 1 disease from the University of Copenhagen DISEASES database for FAM172A:Diabetic angiopathy Human Genome Epidemiology (HuGE) Navigator: FAM172A (1 document) Export disorders for FAM172A gene to outside databases
|
Publications for FAM172A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM172A gene, integrated from 9 sources (see all 19): (articles sorted by number of sources associating them with FAM172A) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- [Effect of FAM172A protein on apoptosis and prolifera tion in HEK293 cells]. (PubMed id 21092515)1 Li L.X....Hu R.M. (2010)
- Identification of the novel protein FAM172A, and its up-regulation by high glucose in human aortic smooth muscle cells. (PubMed id 20818486)1 Li L....Hu R. (2010)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- [Molecular cloning of a novel gene, C5orf21 gene and its roles in diabetic macroangiopathy] (PubMed id 20137623)1 Li L.X....Hu R.M. (2009)
- The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
|
External Searches for FAM172A gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing FAM172A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM172A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FAM172A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for FAM172A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FAM172A gene: Search GeneIP for patents involving FAM172A
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for FAM172A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory) About This Section
|
 | |
 | |
 |
| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for FAM172A | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM172A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM172A | | OriGene Protein Over-expression Lysate for FAM172A | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for FAM172A | | OriGene 3'-UTR Clone for FAM172A | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM172A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM172A | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | OriGene Purified Protein for FAM172A | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | OriGene Custom Antibody Services for FAM172A | | OriGene Custom Protein Services for FAM172A | | OriGene Custom Immunoassay Development | | |
| |  |
 |
| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM172A | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM172A | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM172A | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM172A | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM172A | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM172A |
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 |  |  |  | |
| | | Search Tocris compounds for FAM172A |
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 | | FAM172A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM172A |
|  |  |  |  | | | Search ThermoFisher Antibodies for FAM172A |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM172A |
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