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Aliases for FAM172A Gene

Aliases for FAM172A Gene

  • Family With Sequence Similarity 172, Member A 2 3
  • C5orf21 3 4
  • Chromosome 5 Open Reading Frame 21 2
  • Protein FAM172A 3

External Ids for FAM172A Gene

Previous HGNC Symbols for FAM172A Gene

  • C5orf21

Previous GeneCards Identifiers for FAM172A Gene

  • GC05M092981

Summaries for FAM172A Gene

GeneCards Summary for FAM172A Gene

FAM172A (Family With Sequence Similarity 172, Member A) is a Protein Coding gene. Diseases associated with FAM172A include diabetic angiopathy.

Gene Wiki entry for FAM172A Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM172A Gene

Genomics for FAM172A Gene

Regulatory Elements for FAM172A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM172A Gene

93,617,725 bp from pter
94,111,699 bp from pter
493,975 bases
Minus strand

Genomic View for FAM172A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM172A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM172A Gene

Proteins for FAM172A Gene

  • Protein details for FAM172A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM172A
    Protein Accession:
    Secondary Accessions:
    • B2R7C6
    • B4DJ14
    • B4DLG5
    • Q9H0U8

    Protein attributes for FAM172A Gene

    416 amino acids
    Molecular mass:
    47972 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM172A Gene


neXtProt entry for FAM172A Gene

Proteomics data for FAM172A Gene at MOPED

Post-translational modifications for FAM172A Gene

  • Ubiquitination at Lys35 and Lys333
  • Modification sites at PhosphoSitePlus

Other Protein References for FAM172A Gene

Antibody Products

No data available for DME Specific Peptides for FAM172A Gene

Domains for FAM172A Gene

Protein Domains for FAM172A Gene


Suggested Antigen Peptide Sequences for FAM172A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPF0528 family.
  • Belongs to the UPF0528 family.
genes like me logo Genes that share domains with FAM172A: view

No data available for Gene Families for FAM172A Gene

Function for FAM172A Gene

Animal Model Products

CRISPR Products

miRNA for FAM172A Gene

miRTarBase miRNAs that target FAM172A

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM172A

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FAM172A Gene

Localization for FAM172A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM172A Gene


Subcellular locations from

Jensen Localization Image for FAM172A Gene COMPARTMENTS Subcellular localization image for FAM172A gene
Compartment Confidence
endoplasmic reticulum 4
extracellular 3
cytosol 1
mitochondrion 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FAM172A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005783 endoplasmic reticulum IDA --
genes like me logo Genes that share ontologies with FAM172A: view

Pathways for FAM172A Gene

SuperPathways for FAM172A Gene

No Data Available

Interacting Proteins for FAM172A Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000379294 Q8WUF8-F172A_HUMAN for FAM172A Gene via STRING I2D

Gene Ontology (GO) - Biological Process for FAM172A Gene


No data available for Pathways by source for FAM172A Gene

Transcripts for FAM172A Gene

Unigene Clusters for FAM172A Gene

Family with sequence similarity 172, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM172A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM172A Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - - - -

Relevant External Links for FAM172A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM172A Gene

mRNA expression in normal human tissues for FAM172A Gene

Protein differential expression in normal tissues for FAM172A Gene

This gene is overexpressed in Adipocyte (12.1), Peripheral blood mononuclear cells (7.7), and Fetal testis (7.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM172A Gene

SOURCE GeneReport for Unigene cluster for FAM172A Gene Hs.600086

genes like me logo Genes that share expressions with FAM172A: view

Expression partners for FAM172A Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM172A Gene

Orthologs for FAM172A Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM172A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM172A 35
  • 94.34 (n)
  • 97.27 (a)
FAM172A 36
  • 42 (a)
(Canis familiaris)
Mammalia FAM172A 35
  • 95.06 (n)
  • 98.11 (a)
FAM172A 36
  • 98 (a)
(Mus musculus)
Mammalia Fam172a 35
  • 89.63 (n)
  • 93.33 (a)
Fam172a 16
Fam172a 36
  • 93 (a)
(Pan troglodytes)
Mammalia FAM172A 35
  • 99.68 (n)
  • 99.52 (a)
FAM172A 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Fam172a 35
  • 89.28 (n)
  • 94.32 (a)
(Monodelphis domestica)
Mammalia FAM172A 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia FAM172A 36
  • 88 (a)
(Gallus gallus)
Aves FAM172A 35
  • 82.76 (n)
  • 89.11 (a)
FAM172A 36
  • 88 (a)
(Anolis carolinensis)
Reptilia FAM172A 36
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam172a 35
  • 76.58 (n)
  • 83.25 (a)
(Danio rerio)
Actinopterygii fam172a 35
  • 69.19 (n)
  • 76.26 (a)
zgc64188 35
fam172a 36
  • 73 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002541 35
  • 52.11 (n)
  • 50.54 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10038 35
  • 47.07 (n)
  • 41.2 (a)
CG10038 36
  • 37 (a)
(Caenorhabditis elegans)
Secernentea CELE_Y75B8A.31 35
  • 48.93 (n)
  • 40.38 (a)
Y75B8A.31 36
  • 34 (a)
Species with no ortholog for FAM172A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM172A Gene

Gene Tree for FAM172A (if available)
Gene Tree for FAM172A (if available)

Paralogs for FAM172A Gene

(1) SIMAP similar genes for FAM172A Gene using alignment to 3 proteins: Pseudogenes for FAM172A Gene

genes like me logo Genes that share paralogs with FAM172A: view

No data available for Paralogs for FAM172A Gene

Variants for FAM172A Gene

Sequence variations from dbSNP and Humsavar for FAM172A Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs15529 -- 93,619,975(-) TTTTT(A/T)TTGTC utr-variant-3-prime, nc-transcript-variant
rs167570 -- 93,706,642(-) gatgc(A/G)ccagt intron-variant
rs178432 -- 93,654,333(+) TATTT(C/T)ACAGT intron-variant
rs182648 -- 93,654,067(+) gaaga(C/T)acaaa intron-variant
rs188809 -- 93,652,168(+) GTAAG(A/G)ACATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM172A Gene

Variant ID Type Subtype PubMed ID
nsv830404 CNV Loss 17160897
dgv954n67 CNV Gain 20364138
esv2664180 CNV Deletion 23128226
nsv823133 CNV Loss 20364138
nsv830405 CNV Loss 17160897
nsv882384 CNV Loss 21882294
esv2730466 CNV Deletion 23290073
esv2730467 CNV Deletion 23290073
esv2730468 CNV Deletion 23290073
esv2730469 CNV Deletion 23290073

Relevant External Links for FAM172A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM172A Gene

Disorders for FAM172A Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for FAM172A Gene in MalaCards »

(1) Disease for FAM172A Gene

(1) University of Copenhagen DISEASES for FAM172A Gene

Relevant External Links for FAM172A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with FAM172A: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for FAM172A Gene

Publications for FAM172A Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  3. Identification of the novel protein FAM172A, and its up-regulation by high glucose in human aortic smooth muscle cells. (PMID: 20818486) Li L. … Hu R. (Int. J. Mol. Med. 2010) 3
  4. [Effect of FAM172A protein on apoptosis and proliferation in HEK293 cells]. (PMID: 21092515) Li L.X. … Hu R.M. (Zhonghua Yi Xue Za Zhi 2010) 3
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for FAM172A Gene

Sources for FAM172A Gene

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