Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FAM172A Gene

Aliases for FAM172A Gene

  • Family With Sequence Similarity 172 Member A 2 3 5
  • C5orf21 3 4
  • Family With Sequence Similarity 172, Member A 2
  • Chromosome 5 Open Reading Frame 21 2
  • Protein FAM172A 3

External Ids for FAM172A Gene

Previous HGNC Symbols for FAM172A Gene

  • C5orf21

Previous GeneCards Identifiers for FAM172A Gene

  • GC05M092981

Summaries for FAM172A Gene

GeneCards Summary for FAM172A Gene

FAM172A (Family With Sequence Similarity 172 Member A) is a Protein Coding gene.

Gene Wiki entry for FAM172A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM172A Gene

Genomics for FAM172A Gene

Regulatory Elements for FAM172A Gene

Enhancers for FAM172A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G094422 1.2 FANTOM5 Ensembl ENCODE 3.5 -311.1 -311089 0.9 STAT1 TAF1 JUN ZNF398 EP300 JUND STAT3 FOS PRDM1 TCF7L2 KIAA0825 FAM172A GC05P094313 MTND5P12
GH05G093512 0.6 ENCODE 4.5 +598.6 598601 1.7 ZNF664 ZNF146 GATA2 JUN ZNF580 FOS FAM172A PIR38533 GC05P093476
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM172A on UCSC Golden Path with GeneCards custom track

Promoters for FAM172A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000184093 199 1800 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF766 CBX5

Genomic Location for FAM172A Gene

Chromosome:
5
Start:
93,617,725 bp from pter
End:
94,111,699 bp from pter
Size:
493,975 bases
Orientation:
Minus strand

Genomic View for FAM172A Gene

Genes around FAM172A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM172A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM172A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM172A Gene

Proteins for FAM172A Gene

  • Protein details for FAM172A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUF8-F172A_HUMAN
    Recommended name:
    Protein FAM172A
    Protein Accession:
    Q8WUF8
    Secondary Accessions:
    • B2R7C6
    • B4DJ14
    • B4DLG5
    • Q9H0U8

    Protein attributes for FAM172A Gene

    Size:
    416 amino acids
    Molecular mass:
    47972 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM172A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM172A Gene

Post-translational modifications for FAM172A Gene

  • Ubiquitination at Lys35 and Lys333
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FAM172A Gene

Domains & Families for FAM172A Gene

Protein Domains for FAM172A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM172A Gene

Graphical View of Domain Structure for InterPro Entry

Q8WUF8

UniProtKB/Swiss-Prot:

F172A_HUMAN :
  • Belongs to the UPF0528 family.
Family:
  • Belongs to the UPF0528 family.
genes like me logo Genes that share domains with FAM172A: view

No data available for Gene Families for FAM172A Gene

Function for FAM172A Gene

Phenotypes for FAM172A Gene

genes like me logo Genes that share phenotypes with FAM172A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM172A Gene

Localization for FAM172A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM172A Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM172A gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 4
nucleus 3
cytosol 3
plasma membrane 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FAM172A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005783 endoplasmic reticulum IDA --
genes like me logo Genes that share ontologies with FAM172A: view

Pathways & Interactions for FAM172A Gene

SuperPathways for FAM172A Gene

No Data Available

Interacting Proteins for FAM172A Gene

Gene Ontology (GO) - Biological Process for FAM172A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM172A Gene

Drugs & Compounds for FAM172A Gene

No Compound Related Data Available

Transcripts for FAM172A Gene

Unigene Clusters for FAM172A Gene

Family with sequence similarity 172, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM172A Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - - - -
SP2:
SP3:
SP4:

Relevant External Links for FAM172A Gene

GeneLoc Exon Structure for
FAM172A
ECgene alternative splicing isoforms for
FAM172A

Expression for FAM172A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM172A Gene

Protein differential expression in normal tissues from HIPED for FAM172A Gene

This gene is overexpressed in Adipocyte (12.1), Peripheral blood mononuclear cells (7.7), and Fetal testis (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM172A Gene



Protein tissue co-expression partners for FAM172A Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM172A Gene:

FAM172A

SOURCE GeneReport for Unigene cluster for FAM172A Gene:

Hs.600086

Evidence on tissue expression from TISSUES for FAM172A Gene

  • Nervous system(4.8)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with FAM172A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM172A Gene

Orthologs for FAM172A Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM172A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM172A 34 35
  • 99.68 (n)
dog
(Canis familiaris)
Mammalia FAM172A 34 35
  • 95.06 (n)
cow
(Bos Taurus)
Mammalia FAM172A 34 35
  • 94.34 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM172A 35
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam172a 34 16 35
  • 89.63 (n)
rat
(Rattus norvegicus)
Mammalia Fam172a 34
  • 89.28 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FAM172A 35
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM172A 34 35
  • 82.76 (n)
lizard
(Anolis carolinensis)
Reptilia FAM172A 35
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam172a 34
  • 76.58 (n)
zebrafish
(Danio rerio)
Actinopterygii fam172a 34 35
  • 69.19 (n)
zgc64188 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002541 34
  • 52.11 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10038 34 35
  • 47.07 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_Y75B8A.31 34
  • 48.93 (n)
Y75B8A.31 35
  • 34 (a)
OneToOne
Species where no ortholog for FAM172A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM172A Gene

ENSEMBL:
Gene Tree for FAM172A (if available)
TreeFam:
Gene Tree for FAM172A (if available)

Paralogs for FAM172A Gene

(1) SIMAP similar genes for FAM172A Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for FAM172A Gene

genes like me logo Genes that share paralogs with FAM172A: view

No data available for Paralogs for FAM172A Gene

Variants for FAM172A Gene

Sequence variations from dbSNP and Humsavar for FAM172A Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000010610 -- 93,972,771(+) TTCTG(A/G)TATTG intron-variant
rs1000011429 -- 93,828,155(+) GGGAT(G/T)GCATT intron-variant
rs1000012584 -- 93,822,595(+) AAAAA(C/T)AAGCT intron-variant
rs1000019332 -- 93,852,330(+) TTGGA(A/G)TTCAT intron-variant
rs1000025956 -- 93,749,363(+) GTTTG(A/T)TCTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM172A Gene

Variant ID Type Subtype PubMed ID
dgv5717n100 CNV loss 25217958
dgv954n67 CNV gain 20364138
esv2664180 CNV deletion 23128226
esv2730466 CNV deletion 23290073
esv2730467 CNV deletion 23290073
esv2730468 CNV deletion 23290073
esv2730469 CNV deletion 23290073
esv3605808 CNV loss 21293372
esv3605809 CNV loss 21293372
esv3605810 CNV loss 21293372
esv3605811 CNV gain 21293372
esv3605814 CNV loss 21293372
nsv1030870 CNV loss 25217958
nsv1033466 CNV loss 25217958
nsv823133 CNV loss 20364138
nsv830404 CNV loss 17160897
nsv830405 CNV loss 17160897
nsv950107 CNV duplication 24416366
nsv964905 CNV duplication 23825009

Variation tolerance for FAM172A Gene

Residual Variation Intolerance Score: 22.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.07; 50.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM172A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM172A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM172A Gene

Disorders for FAM172A Gene

Relevant External Links for FAM172A

Genetic Association Database (GAD)
FAM172A
Human Genome Epidemiology (HuGE) Navigator
FAM172A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM172A

No disorders were found for FAM172A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM172A Gene

Publications for FAM172A Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. FAM172A protein promotes the proliferation of human papillary thyroid carcinoma cells via the p38 mitogen-activated protein kinase pathway. (PMID: 26573560) Li M.F. … Jia W.P. (Mol Med Rep 2016) 3 64
  4. FAM172A is a tumor suppressor in colorectal carcinoma. (PMID: 26637224) Cui C. … Yu J. (Tumour Biol. 2016) 3 64
  5. FAM172A modulates apoptosis and proliferation of colon cancer cells via STAT1 binding to its promoter. (PMID: 26676844) Qian K. … Liu H. (Oncol. Rep. 2016) 3 64

Products for FAM172A Gene

Sources for FAM172A Gene

Content
Loading form....