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Aliases for FAM171B Gene

Aliases for FAM171B Gene

  • Family With Sequence Similarity 171 Member B 2 3 5
  • KIAA1946 2 3 4
  • Family With Sequence Similarity 171, Member B 2
  • Protein FAM171B 3

External Ids for FAM171B Gene

Previous HGNC Symbols for FAM171B Gene

  • KIAA1946

Previous GeneCards Identifiers for FAM171B Gene

  • GC02P187268
  • GC02P187558
  • GC02P179418

Summaries for FAM171B Gene

GeneCards Summary for FAM171B Gene

FAM171B (Family With Sequence Similarity 171 Member B) is a Protein Coding gene. An important paralog of this gene is FAM171A1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM171B Gene

Genomics for FAM171B Gene

Regulatory Elements for FAM171B Gene

Enhancers for FAM171B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F186721 0.2 ENCODE 20.2 +28.1 28128 0.9 MTA2 HLF CEBPB TBX21 ZBTB40 GABPA CEBPA TARDBP FOS FAM171B ENSG00000227227 ZSWIM2
GH02F186693 0.6 ENCODE 14.5 +0.7 682 2.4 ZNF76 SIN3A ZNF48 ZNF2 GLIS2 EGR1 ZNF366 EGR2 ZNF263 SP3 FAM171B ITGAV TFPI ENSG00000227227
GH02F186848 0.6 ENCODE 12.8 +155.3 155305 1.4 ZNF76 SIN3A BMI1 GLIS2 FOS EGR2 SP3 REST ZEB2 ZFP69B FAM171B ZSWIM2 ITGAV GC02M187006 PIR60867
GH02F186736 0.3 FANTOM5 12.6 +42.7 42694 0.0 FAM171B ZSWIM2 ENSG00000227227
GH02F186724 0.2 ENCODE 12 +30.8 30782 0.9 ENSG00000227227 FAM171B ITGAV ZSWIM2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FAM171B on UCSC Golden Path with GeneCards custom track

Promoters for FAM171B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000603868 730 2599 ZNF76 SIN3A ZNF48 RAD21 ZNF2 GLIS2 ZNF366 EGR2 ZNF202 ZNF263

Genomic Location for FAM171B Gene

Chromosome:
2
Start:
186,693,971 bp from pter
End:
186,765,965 bp from pter
Size:
71,995 bases
Orientation:
Plus strand

Genomic View for FAM171B Gene

Genes around FAM171B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM171B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM171B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM171B Gene

Proteins for FAM171B Gene

  • Protein details for FAM171B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P995-F171B_HUMAN
    Recommended name:
    Protein FAM171B
    Protein Accession:
    Q6P995
    Secondary Accessions:
    • Q53SK3
    • Q8N1Y4
    • Q8N3K1
    • Q8N970
    • Q8NB81
    • Q8TF55
    • Q8WYR8

    Protein attributes for FAM171B Gene

    Size:
    826 amino acids
    Molecular mass:
    92181 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAL57220.1; Type=Frameshift; Positions=235, 262; Evidence={ECO:0000305}; Sequence=BAC04380.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC04586.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM171B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM171B Gene

Post-translational modifications for FAM171B Gene

  • Glycosylation at Asn 108, Asn 113, Asn 213, and Asn 268
  • Modification sites at PhosphoSitePlus

Other Protein References for FAM171B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM171B Gene

Domains & Families for FAM171B Gene

Protein Domains for FAM171B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM171B Gene

Graphical View of Domain Structure for InterPro Entry

Q6P995

UniProtKB/Swiss-Prot:

F171B_HUMAN :
  • Belongs to the FAM171 family.
Family:
  • Belongs to the FAM171 family.
genes like me logo Genes that share domains with FAM171B: view

No data available for Gene Families for FAM171B Gene

Function for FAM171B Gene

genes like me logo Genes that share phenotypes with FAM171B: view

Animal Model Products

miRNA for FAM171B Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM171B Gene

Localization for FAM171B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM171B Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM171B Gene COMPARTMENTS Subcellular localization image for FAM171B gene
Compartment Confidence
extracellular 2
mitochondrion 2
nucleus 2
plasma membrane 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for FAM171B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM171B: view

Pathways & Interactions for FAM171B Gene

SuperPathways for FAM171B Gene

No Data Available

Interacting Proteins for FAM171B Gene

Gene Ontology (GO) - Biological Process for FAM171B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM171B Gene

Transcripts for FAM171B Gene

mRNA/cDNA for FAM171B Gene

Unigene Clusters for FAM171B Gene

Family with sequence similarity 171, member B:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM171B Gene

No ASD Table

Relevant External Links for FAM171B Gene

GeneLoc Exon Structure for
FAM171B
ECgene alternative splicing isoforms for
FAM171B

Expression for FAM171B Gene

mRNA expression in normal human tissues for FAM171B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM171B Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x5.3), Brain - Caudate (basal ganglia) (x4.8), Brain - Amygdala (x4.7), Brain - Frontal Cortex (BA9) (x4.6), Brain - Anterior cingulate cortex (BA24) (x4.6), Brain - Putamen (basal ganglia) (x4.1), and Brain - Cortex (x4.0).

Protein differential expression in normal tissues from HIPED for FAM171B Gene

This gene is overexpressed in Frontal cortex (33.3), Fetal Brain (18.0), and Pancreatic juice (12.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FAM171B Gene



Protein tissue co-expression partners for FAM171B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM171B Gene:

FAM171B

SOURCE GeneReport for Unigene cluster for FAM171B Gene:

Hs.28872
genes like me logo Genes that share expression patterns with FAM171B: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for FAM171B Gene

Orthologs for FAM171B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM171B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1946 34 35
  • 99.27 (n)
cow
(Bos Taurus)
Mammalia FAM171B 34 35
  • 90.72 (n)
dog
(Canis familiaris)
Mammalia FAM171B 34 35
  • 87.64 (n)
mouse
(Mus musculus)
Mammalia Fam171b 34 16 35
  • 86.34 (n)
rat
(Rattus norvegicus)
Mammalia Fam171b 34
  • 85.16 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM171B 35
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM171B 35
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM171B 34 35
  • 74.57 (n)
lizard
(Anolis carolinensis)
Reptilia FAM171B 35
  • 58 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC561242 34
  • 53.98 (n)
march7 35
  • 40 (a)
OneToOne
Species where no ortholog for FAM171B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM171B Gene

ENSEMBL:
Gene Tree for FAM171B (if available)
TreeFam:
Gene Tree for FAM171B (if available)

Paralogs for FAM171B Gene

Paralogs for FAM171B Gene

(3) SIMAP similar genes for FAM171B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FAM171B: view

Variants for FAM171B Gene

Sequence variations from dbSNP and Humsavar for FAM171B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10165992 -- 186,733,194(+) ATAAA(A/G)TGGAT intron-variant
rs10170441 -- 186,752,031(+) ccttt(C/T)tagga intron-variant
rs10195294 -- 186,739,902(+) aacac(A/G)tgagt intron-variant
rs10549627 -- 186,718,197(+) TCTGA(-/CTGT)CTAAG intron-variant
rs10660120 -- 186,736,538(+) GTGGC(-/TG/TGTGTGTG)TGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM171B Gene

Variant ID Type Subtype PubMed ID
esv2759107 CNV gain 17122850

Variation tolerance for FAM171B Gene

Residual Variation Intolerance Score: 5.04% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.59; 56.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM171B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM171B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM171B Gene

Disorders for FAM171B Gene

Relevant External Links for FAM171B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM171B

No disorders were found for FAM171B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM171B Gene

Publications for FAM171B Gene

  1. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 64
  4. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3 64
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64

Products for FAM171B Gene

Sources for FAM171B Gene

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