FAM171B Gene
protein-coding GIFtS: 43
GCID: GC02P187558
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|
family with sequence similarity 171, member B(Previous name: KIAA1946 )
(Previous symbol: KIAA1946)
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Aliases
for FAM171B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Family With Sequence Similarity 171, Member B1 2 | | KIAA19461 2 3 | | FLJ341041 | | Protein FAM171B2 |
Export aliases for FAM171B gene to outside databasesPrevious GC identifers: GC02P187268 GC02P179418 |
Summaries
for FAM171B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FAM171B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FAM171B gene promoter:
Egr-3 SRF C/EBPbeta Pax-5 SRF (504 AA) ATF-2 Cart-1 Pax-4a AP-2alpha AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM171B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM171B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q32.1 Ensembl cytogenetic band: 2q32.1 HGNC cytogenetic band: 2q32.2FAM171B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P187558: view genomic region
(about GC identifiers)
Start:
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187,558,698 bp from pter |
End:
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187,630,685 bp from pter |
Size:
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71,988 bases |
Orientation:
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plus strand |
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Proteins
for FAM171B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: F171B_HUMAN, Q6P995 (See
protein sequence)Recommended Name: Protein FAM171B precursor Size: 826 amino acids; 92181 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Sequence caution: Sequence=AAL57220.1; Type=Frameshift; Positions=235, 262; Sequence=BAC04380.1; Type=Erroneousinitiation; Note=Translation N-terminally extended; Sequence=BAC04586.1; Type=Erroneous initiation; Note=TranslationN-terminally extended;
Secondary accessions: Q53SK3 Q8N1Y4 Q8N3K1 Q8N970 Q8NB81 Q8TF55 Q8WYR8Alternative splicing: 2 isoforms: Q6P995-1 Q6P995-2 Explore the universe of human proteins at neXtProt for FAM171B: NX_Q6P995
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6P995
FAM171B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_803237.3
ENSEMBL proteins: ENSP00000304108
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
FAM171B for ontologies About GeneDecksing
FAM171B Antibody Products:
Assay Products for FAM171B: |
Protein
Domains /
Families
for FAM171B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FAM171B for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6P995ProtoNet protein and cluster: Q6P995 UniProtKB/Swiss-Prot: F171B_HUMAN, Q6P995Similarity: Belongs to the FAM171 family |
Function
for FAM171B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM171B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM171B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FAM171B (NM_177454) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM171B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM171B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM171B |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
IEA | -- |
FAM171B for ontologies About GeneDecksing
|
Pathways & Interactions
for FAM171B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM171B
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for FAM171B (ENSP000003041084) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for FAM171B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM171B
Search CenterWatch for drugs/clinical trials and news about FAM171B / F171B
|
Transcripts
for FAM171B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAM171B gene: NM_177454.3 Unigene Cluster for FAM171B: Family with sequence similarity 171, member B Hs.28872 [show with all ESTs]Unigene Representative Sequence: AB0758261 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000304698(uc002upr.1 uc002ups.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM171B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM171B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FAM171B (NM_177454) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM171B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM171B |
Additional cDNA sequence: AB075826.1 AF361495.1 AK091423.1 AK094578.1 AK095604.1 AK289737.1 AL834264.1 BC036478.2 BC060872.1 7 DOTS entries: DT.440410 DT.95335815 DT.441840 DT.304452 DT.91719210 DT.95323795 DT.97784977 24/94 AceView cDNA sequences (see all 94): BG289233 BE222701 BQ876735 AB075826 AA776059 BX494003 BF446791 AI581282 AI079906 AK095604 BX952929 AW028963 BF108555 BI493963 AI278781 BF060663 BM555938 BC060872 AA372349 BF109477 BI006609 AI978727 AL834264 AI124883
GeneLoc Exon Structure
|
Expression
for FAM171B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAM171B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACGAGCATT
About this image
See FAM171B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM171B
SOURCE GeneReport for Unigene cluster: Hs.28872
SABiosciences Custom PCR Arrays for FAM171B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM171B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FAM171B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM171B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM171B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM171B |
Orthologs
for FAM171B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for FAM171B gene from 3/10 species (see all 10) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
FAM171B1 |
family with sequence similarity 171, member B |
73.97(n)
72.23(a) |
|
423991 XM_421851.3 XP_421851.3 |
lizard
(Anolis carolinensis) |
Reptilia |
FAM171B6 |
-- |
68(a) |
1 ↔ 1 |
GL343737.1(168877-186017) |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC5612421 |
protein FAM171B-like |
53(n)
45.79(a) |
|
561242 XM_684648.5 XP_689740.2 |
ENSEMBL Gene Tree for FAM171B (if available)
TreeFam Gene Tree for FAM171B (if available) |
Paralogs
for FAM171B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAM171B gene
- FAM171A22 FAM171A12
3 SIMAP similar genes for FAM171B using alignment to 2 protein entries: F171B_HUMAN (see all proteins):KIAA1946 FAM171A1 C10orf38
FAM171B for paralogs About GeneDecksing
|
Genomic Variants
for FAM171B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM171B (187558698 - 187630685 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FAM171B
1 CNV: 3403 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM171B |
|
Disorders
/ Diseases
for FAM171B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for FAM171B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM171B gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM171B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PubMed id 11853319)1, 2, 3 Nagase T.... Ohara O. (2001)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for FAM171B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FAM171B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM171B gene
(According to HUGE)
About This Section
| |
Specialized Databases showing FAM171B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAM171B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FAM171B gene:
Search GeneIP for patents involving FAM171B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM171B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FAM171B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM171B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM171B | | | OriGene Protein Over-expression Lysate for FAM171B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FAM171B | | OriGene 3'-UTR Clone for FAM171B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM171B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM171B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FAM171B | | OriGene Custom Protein Services for FAM171B | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM171B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM171B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM171B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM171B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM171B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM171B |
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 |  |  |  | |
| | | | Search Tocris compounds for FAM171B |
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 | | | FAM171B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM171B |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM171B |
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