Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FAM171A2 Gene

Aliases for FAM171A2 Gene

  • Family With Sequence Similarity 171, Member A2 2 3

External Ids for FAM171A2 Gene

Summaries for FAM171A2 Gene

GeneCards Summary for FAM171A2 Gene

FAM171A2 (Family With Sequence Similarity 171, Member A2) is a Protein Coding gene. An important paralog of this gene is FAM171A1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM171A2 Gene

Genomics for FAM171A2 Gene

Genomic Location for FAM171A2 Gene

Start:
44,353,215 bp from pter
End:
44,363,875 bp from pter
Size:
10,661 bases
Orientation:
Minus strand

Genomic View for FAM171A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM171A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM171A2 Gene

Regulatory Elements for FAM171A2 Gene

Proteins for FAM171A2 Gene

  • Protein details for FAM171A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MVW0-F1712_HUMAN
    Recommended name:
    Protein FAM171A2
    Protein Accession:
    A8MVW0
    Secondary Accessions:
    • A8MQB4

    Protein attributes for FAM171A2 Gene

    Size:
    826 amino acids
    Molecular mass:
    87435 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM171A2 Gene

Proteomics data for FAM171A2 Gene at MOPED

Post-translational modifications for FAM171A2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys258
  • Glycosylation at Asn66, Asn201, Asn221, and Asn265

Other Protein References for FAM171A2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM171A2 Gene

Domains for FAM171A2 Gene

Protein Domains for FAM171A2 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

F1712_HUMAN
Family:
  • Belongs to the FAM171 family.:
    • A8MVW0
genes like me logo Genes that share domains with FAM171A2: view

No data available for Gene Families for FAM171A2 Gene

Function for FAM171A2 Gene

Phenotypes for FAM171A2 Gene

GenomeRNAi human phenotypes for FAM171A2:
genes like me logo Genes that share phenotypes with FAM171A2: view

miRNA for FAM171A2 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for FAM171A2 Gene

Localization for FAM171A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM171A2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM171A2 Gene COMPARTMENTS Subcellular localization image for FAM171A2 gene
Compartment Confidence
extracellular 2
plasma membrane 2
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FAM171A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM171A2: view

Pathways for FAM171A2 Gene

SuperPathways for FAM171A2 Gene

No Data Available

Interacting Proteins for FAM171A2 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000293443%0d%0a9606.ENSP00000379098%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000216455%0d%0a
Selected Interacting proteins: ENSP00000293443 for FAM171A2 Gene via STRING

Gene Ontology (GO) - Biological Process for FAM171A2 Gene

None

No data available for Pathways by source for FAM171A2 Gene

Transcripts for FAM171A2 Gene

mRNA/cDNA for FAM171A2 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM171A2 Gene

Family with sequence similarity 171, member A2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM171A2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1: - -
SP2: -
SP3:
SP4: -

Relevant External Links for FAM171A2 Gene

GeneLoc Exon Structure for
FAM171A2
ECgene alternative splicing isoforms for
FAM171A2

Expression for FAM171A2 Gene

mRNA expression in normal human tissues for FAM171A2 Gene

mRNA differential expression in normal tissues according to GTEx for FAM171A2 Gene

This gene is overexpressed in Brain - Cortex (5.6), Brain - Frontal Cortex (BA9) (4.7), Brain - Anterior cingulate cortex (BA24) (4.4), and Brain - Cerebellum (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM171A2 Gene

SOURCE GeneReport for Unigene cluster for FAM171A2 Gene Hs.154001

genes like me logo Genes that share expressions with FAM171A2: view

Orthologs for FAM171A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM171A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM171A2 36
  • 98.6 (n)
  • 98.01 (a)
FAM171A2 37
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM171A2 36
  • 91.39 (n)
  • 92.55 (a)
FAM171A2 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM171A2 36
  • 91.11 (n)
  • 93.58 (a)
FAM171A2 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam171a2 36
  • 87.59 (n)
  • 92.21 (a)
Fam171a2 16
Fam171a2 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM171A2 37
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM171A2 37
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam171a2 36
  • 87.31 (n)
  • 92.34 (a)
lizard
(Anolis carolinensis)
Reptilia FAM171A2 37
  • 63 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.11903 36
tropical clawed frog
(Silurana tropicalis)
Amphibia fam171a2 36
  • 60.07 (n)
  • 61.61 (a)
Str.5450 36
zebrafish
(Danio rerio)
Actinopterygii fam171a2 37
  • 42 (a)
OneToMany
FAM171A2 (2 of 2) 37
  • 40 (a)
OneToMany
LOC556398 36
  • 53.78 (n)
  • 48.49 (a)
Species with no ortholog for FAM171A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM171A2 Gene

ENSEMBL:
Gene Tree for FAM171A2 (if available)
TreeFam:
Gene Tree for FAM171A2 (if available)

Paralogs for FAM171A2 Gene

Paralogs for FAM171A2 Gene

Selected SIMAP similar genes for FAM171A2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FAM171A2: view

Variants for FAM171A2 Gene

Sequence variations from dbSNP and Humsavar for FAM171A2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs708382 -- 44,364,976(-) AATGA(A/G)GTGGA upstream-variant-2KB
rs708383 -- 44,360,386(-) TAGCC(C/T)GAGTT intron-variant
rs708384 -- 44,360,314(-) CCTCC(G/T)GCATG intron-variant
rs850738 -- 44,357,262(-) tcaag(C/T)gattc intron-variant
rs2023189 -- 44,358,499(-) GCCAG(A/G)CTAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM171A2 Gene

Variant ID Type Subtype PubMed ID
nsv908270 CNV Loss 21882294
dgv3175n71 CNV Loss 21882294
dgv3176n71 CNV Loss 21882294
esv26446 CNV Loss 19812545

Relevant External Links for FAM171A2 Gene

HapMap Linkage Disequilibrium report
FAM171A2

Disorders for FAM171A2 Gene

No disorders were found for FAM171A2 Gene.

No data available for UniProtKB/Swiss-Prot for FAM171A2 Gene

Publications for FAM171A2 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  3. New gene functions in megakaryopoiesis and platelet formation. (PMID: 22139419) Gieger C. … Soranzo N. (Nature 2011) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 4

Products for FAM171A2 Gene

Sources for FAM171A2 Gene

Back to Top

Content