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Aliases for FAM171A2 Gene

Aliases for FAM171A2 Gene

  • Family With Sequence Similarity 171 Member A2 2 3 5
  • Family With Sequence Similarity 171, Member A2 2

External Ids for FAM171A2 Gene

Previous GeneCards Identifiers for FAM171A2 Gene

  • GC17M039788
  • GC17M042430
  • GC17M038196

Summaries for FAM171A2 Gene

GeneCards Summary for FAM171A2 Gene

FAM171A2 (Family With Sequence Similarity 171 Member A2) is a Protein Coding gene. An important paralog of this gene is FAM171A1.

Additional gene information for FAM171A2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM171A2 Gene

Genomics for FAM171A2 Gene

Regulatory Elements for FAM171A2 Gene

Enhancers for FAM171A2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H044541 2.1 VISTA FANTOM5 Ensembl ENCODE dbSUPER 10.4 -181.3 -181340 8 HDGF ETS1 TCF12 GLIS2 GATA2 FOS ATF7 SMARCA4 GLIS1 KDM1A GPATCH8 MEIOC FAM171A2 SLC25A39 TMUB2 FZD2 GRN ADAM11 TMEM101 GJC1
GH17H045143 1.8 FANTOM5 ENCODE dbSUPER 11.8 -784.1 -784072 9 MLX FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC ENSG00000262372 UBTF ASB16-AS1 TMUB2 ENSG00000224505 LINC02210 HEXIM1 EFTUD2 MAP3K14-AS1 ENSG00000260793
GH17H044977 1.5 Ensembl ENCODE dbSUPER 11.8 -615.9 -615925 5 PKNOX1 FOXA2 MLX SIN3A YBX1 BRCA1 YY1 ZNF207 ATF7 FOS UBTF LINC02210 GJC1 NMT1 ASB16-AS1 ENSG00000266918 KIF18B FAM171A2 GFAP MAP3K14-AS1
GH17H045157 1.4 ENCODE dbSUPER 11.8 -796.6 -796573 5 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC SSRP1 ENSG00000262372 UBTF TMUB2 ASB16-AS1 ENSG00000224505 MAP3K14-AS1 EFTUD2 ENSG00000267788 RN7SL405P LINC01180
GH17H044203 1.4 Ensembl ENCODE dbSUPER 11 +159.4 159423 1 PKNOX1 TBL1XR1 ARNT ARID4B ZSCAN9 RAD21 GATA2 ZNF366 ZNF143 RCOR1 ASB16 SLC25A39 FAM171A2 HDAC5 ENSG00000221044 NAGS ENSG00000267505 ATXN7L3 MIR6782
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM171A2 on UCSC Golden Path with GeneCards custom track

Promoters for FAM171A2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000094760 275 1201 RB1 SIN3A RAD21 GLIS2 EGR1 ZNF143 ATF7 EGR2 SMARCA5 SP3

Genomic Location for FAM171A2 Gene

Chromosome:
17
Start:
44,353,215 bp from pter
End:
44,363,875 bp from pter
Size:
10,661 bases
Orientation:
Minus strand

Genomic View for FAM171A2 Gene

Genes around FAM171A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM171A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM171A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM171A2 Gene

Proteins for FAM171A2 Gene

  • Protein details for FAM171A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MVW0-F1712_HUMAN
    Recommended name:
    Protein FAM171A2
    Protein Accession:
    A8MVW0
    Secondary Accessions:
    • A8MQB4

    Protein attributes for FAM171A2 Gene

    Size:
    826 amino acids
    Molecular mass:
    87435 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM171A2 Gene

Post-translational modifications for FAM171A2 Gene

  • Ubiquitination at isoforms=258
  • Glycosylation at isoforms=66, posLast=201201, isoforms=221, and isoforms=265
  • Modification sites at PhosphoSitePlus

Other Protein References for FAM171A2 Gene

No data available for DME Specific Peptides for FAM171A2 Gene

Domains & Families for FAM171A2 Gene

Gene Families for FAM171A2 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for FAM171A2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM171A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A8MVW0

UniProtKB/Swiss-Prot:

F1712_HUMAN :
  • Belongs to the FAM171 family.
Family:
  • Belongs to the FAM171 family.
genes like me logo Genes that share domains with FAM171A2: view

Function for FAM171A2 Gene

Phenotypes From GWAS Catalog for FAM171A2 Gene

Phenotypes for FAM171A2 Gene

genes like me logo Genes that share phenotypes with FAM171A2: view

Animal Model Products

CRISPR Products

miRNA for FAM171A2 Gene

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FAM171A2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM171A2 Gene

Localization for FAM171A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM171A2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM171A2 gene
Compartment Confidence
plasma membrane 2
extracellular 2
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for FAM171A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM171A2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FAM171A2 Gene

Pathways & Interactions for FAM171A2 Gene

SuperPathways for FAM171A2 Gene

No Data Available

Interacting Proteins for FAM171A2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000293443%0d%0a9606.ENSP00000248996%0d%0a
Selected Interacting proteins: ENSP00000293443 A8MVW0-F1712_HUMAN for FAM171A2 Gene via STRING IID

Gene Ontology (GO) - Biological Process for FAM171A2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM171A2 Gene

Drugs & Compounds for FAM171A2 Gene

No Compound Related Data Available

Transcripts for FAM171A2 Gene

mRNA/cDNA for FAM171A2 Gene

Unigene Clusters for FAM171A2 Gene

Family with sequence similarity 171, member A2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FAM171A2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for FAM171A2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1: - -
SP2: -
SP3:
SP4: -

Relevant External Links for FAM171A2 Gene

GeneLoc Exon Structure for
FAM171A2
ECgene alternative splicing isoforms for
FAM171A2

Expression for FAM171A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM171A2 Gene

mRNA differential expression in normal tissues according to GTEx for FAM171A2 Gene

This gene is overexpressed in Brain - Cortex (x5.6), Brain - Frontal Cortex (BA9) (x4.7), Brain - Anterior cingulate cortex (BA24) (x4.4), and Brain - Cerebellum (x4.0).

Protein differential expression in normal tissues from HIPED for FAM171A2 Gene

This gene is overexpressed in Fetal Brain (46.5) and Retina (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM171A2 Gene



Protein tissue co-expression partners for FAM171A2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM171A2 Gene:

FAM171A2

SOURCE GeneReport for Unigene cluster for FAM171A2 Gene:

Hs.154001

Evidence on tissue expression from TISSUES for FAM171A2 Gene

  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with FAM171A2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM171A2 Gene

Orthologs for FAM171A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM171A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM171A2 33 34
  • 98.6 (n)
cow
(Bos Taurus)
Mammalia FAM171A2 33 34
  • 91.39 (n)
dog
(Canis familiaris)
Mammalia FAM171A2 33 34
  • 91.11 (n)
mouse
(Mus musculus)
Mammalia Fam171a2 33 16 34
  • 87.59 (n)
rat
(Rattus norvegicus)
Mammalia Fam171a2 33
  • 87.31 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM171A2 34
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM171A2 34
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM171A2 34
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam171a2 33
  • 60.07 (n)
Str.5450 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.11903 33
zebrafish
(Danio rerio)
Actinopterygii LOC556398 33
  • 53.78 (n)
fam171a2 34
  • 42 (a)
OneToMany
FAM171A2 (2 of 2) 34
  • 40 (a)
OneToMany
Species where no ortholog for FAM171A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM171A2 Gene

ENSEMBL:
Gene Tree for FAM171A2 (if available)
TreeFam:
Gene Tree for FAM171A2 (if available)

Paralogs for FAM171A2 Gene

Paralogs for FAM171A2 Gene

(2) SIMAP similar genes for FAM171A2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FAM171A2: view

Variants for FAM171A2 Gene

Sequence variations from dbSNP and Humsavar for FAM171A2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs116547342 Likely benign 44,353,078(+) TGTGC(A/G)TTTCA downstream-variant-500B, utr-variant-3-prime
rs5848 other 44,352,876(-) TAGGG(A/G)GAGGT downstream-variant-500B, utr-variant-3-prime
rs1000581693 -- 44,355,168(+) CTGTT(-/G)GCCTC reference, frameshift-variant
rs1000683038 -- 44,358,041(+) CCATT(C/T)CTCCT intron-variant
rs1000938518 -- 44,361,842(+) AGGAC(A/G)TGTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM171A2 Gene

Variant ID Type Subtype PubMed ID
dgv5606n54 CNV loss 21841781
dgv5607n54 CNV loss 21841781
dgv5608n54 CNV gain 21841781
dgv5609n54 CNV loss 21841781
esv26446 CNV loss 19812545
nsv1072738 CNV deletion 25765185
nsv1118760 CNV deletion 24896259
nsv1146669 OTHER inversion 26484159
nsv575090 CNV loss 21841781
nsv575091 CNV gain+loss 21841781
nsv978429 CNV duplication 23825009

Variation tolerance for FAM171A2 Gene

Gene Damage Index Score: 4.78; 66.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM171A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM171A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM171A2 Gene

Disorders for FAM171A2 Gene

Relevant External Links for FAM171A2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM171A2

No disorders were found for FAM171A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM171A2 Gene

Publications for FAM171A2 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  3. Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators. (PMID: 27880917) St-Denis N … Gingras AC (Cell reports 2016) 3 60
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta GD … Pelletier L (Cell 2015) 3 60

Products for FAM171A2 Gene

Sources for FAM171A2 Gene

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