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Aliases for FAM171A2 Gene

Aliases for FAM171A2 Gene

  • Family With Sequence Similarity 171 Member A2 2 3 5
  • Family With Sequence Similarity 171, Member A2 2

External Ids for FAM171A2 Gene

Previous GeneCards Identifiers for FAM171A2 Gene

  • GC17M039788
  • GC17M042430
  • GC17M038196

Summaries for FAM171A2 Gene

GeneCards Summary for FAM171A2 Gene

FAM171A2 (Family With Sequence Similarity 171 Member A2) is a Protein Coding gene. An important paralog of this gene is FAM171A1.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM171A2 Gene

Genomics for FAM171A2 Gene

Regulatory Elements for FAM171A2 Gene

Enhancers for FAM171A2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G044541 2.3 VISTA FANTOM5 Ensembl ENCODE dbSUPER 10.4 -181.3 -181340 8.1 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A SLC30A9 ZNF766 ZNF143 FOS GPATCH8 MEIOC FAM171A2 SLC25A39 TMUB2 FZD2 GRN ADAM11 TMEM101 GJC1
GH17G044203 1.5 Ensembl ENCODE dbSUPER 11 +159.4 159423 1.7 HDGF PKNOX1 ARNT ARID4B GATA2 ZNF143 FOS ZNF263 SP3 SP5 ASB16 SLC25A39 FAM171A2 HDAC5 ENSG00000221044 NAGS ENSG00000267505 MIR6782 ATXN7L3
GH17G044085 1.5 Ensembl ENCODE dbSUPER 9.7 +276.9 276914 2.2 PKNOX1 FOXA2 AGO1 ARID4B SIN3A GLIS2 FOS ZNF263 SP3 SP5 ASB16 HDAC5 RNU6-131P C17orf53 FAM171A2 ASB16-AS1 PIR36554 GC17P044094 PIR35706
GH17G044389 1.2 Ensembl ENCODE 11.7 -26.4 -26424 1.5 HNRNPUL1 PKNOX1 CREB3L1 ARNT SIN3A TCF12 ZNF766 GATA2 NCOA1 REST FAM171A2 SLC25A39 HEXIM2 ITGA2B RN7SL258P
GH17G044392 1 ENCODE 12.1 -29.5 -29462 1.0 PKNOX1 ATF1 ARNT TCF12 GATA2 FOS JUNB NCOA1 ZNF592 MBD2 FAM171A2 MEIOC ITGA2B RN7SL258P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM171A2 on UCSC Golden Path with GeneCards custom track

Promoters for FAM171A2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000094760 275 1201 ELF3 ATF1 RB1 SIN3A RAD21 GLIS2 EGR1 ZNF143 BCLAF1 EGR2

Genomic Location for FAM171A2 Gene

Chromosome:
17
Start:
44,353,215 bp from pter
End:
44,363,875 bp from pter
Size:
10,661 bases
Orientation:
Minus strand

Genomic View for FAM171A2 Gene

Genes around FAM171A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM171A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM171A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM171A2 Gene

Proteins for FAM171A2 Gene

  • Protein details for FAM171A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MVW0-F1712_HUMAN
    Recommended name:
    Protein FAM171A2
    Protein Accession:
    A8MVW0
    Secondary Accessions:
    • A8MQB4

    Protein attributes for FAM171A2 Gene

    Size:
    826 amino acids
    Molecular mass:
    87435 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM171A2 Gene

Post-translational modifications for FAM171A2 Gene

  • Ubiquitination at Lys258
  • Glycosylation at Asn66, Asn201, Asn221, and isoforms=265
  • Modification sites at PhosphoSitePlus

Other Protein References for FAM171A2 Gene

No data available for DME Specific Peptides for FAM171A2 Gene

Domains & Families for FAM171A2 Gene

Protein Domains for FAM171A2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM171A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A8MVW0

UniProtKB/Swiss-Prot:

F1712_HUMAN :
  • Belongs to the FAM171 family.
Family:
  • Belongs to the FAM171 family.
genes like me logo Genes that share domains with FAM171A2: view

No data available for Gene Families for FAM171A2 Gene

Function for FAM171A2 Gene

Phenotypes for FAM171A2 Gene

genes like me logo Genes that share phenotypes with FAM171A2: view

Animal Model Products

CRISPR Products

miRNA for FAM171A2 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM171A2 Gene

Localization for FAM171A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM171A2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM171A2 gene
Compartment Confidence
plasma membrane 2
extracellular 2
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for FAM171A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM171A2: view

Pathways & Interactions for FAM171A2 Gene

SuperPathways for FAM171A2 Gene

No Data Available

Interacting Proteins for FAM171A2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000293443%0d%0a9606.ENSP00000248996%0d%0a
Selected Interacting proteins: A8MVW0-F1712_HUMAN ENSP00000293443 for FAM171A2 Gene via IID STRING

Gene Ontology (GO) - Biological Process for FAM171A2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM171A2 Gene

Transcripts for FAM171A2 Gene

mRNA/cDNA for FAM171A2 Gene

Unigene Clusters for FAM171A2 Gene

Family with sequence similarity 171, member A2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM171A2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1: - -
SP2: -
SP3:
SP4: -

Relevant External Links for FAM171A2 Gene

GeneLoc Exon Structure for
FAM171A2
ECgene alternative splicing isoforms for
FAM171A2

Expression for FAM171A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM171A2 Gene

mRNA differential expression in normal tissues according to GTEx for FAM171A2 Gene

This gene is overexpressed in Brain - Cortex (x5.6), Brain - Frontal Cortex (BA9) (x4.7), Brain - Anterior cingulate cortex (BA24) (x4.4), and Brain - Cerebellum (x4.0).

Protein differential expression in normal tissues from HIPED for FAM171A2 Gene

This gene is overexpressed in Fetal Brain (46.5) and Retina (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM171A2 Gene



Protein tissue co-expression partners for FAM171A2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM171A2 Gene:

FAM171A2

SOURCE GeneReport for Unigene cluster for FAM171A2 Gene:

Hs.154001

Evidence on tissue expression from TISSUES for FAM171A2 Gene

  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with FAM171A2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM171A2 Gene

Orthologs for FAM171A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM171A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM171A2 34 35
  • 98.6 (n)
cow
(Bos Taurus)
Mammalia FAM171A2 34 35
  • 91.39 (n)
dog
(Canis familiaris)
Mammalia FAM171A2 34 35
  • 91.11 (n)
mouse
(Mus musculus)
Mammalia Fam171a2 34 16 35
  • 87.59 (n)
rat
(Rattus norvegicus)
Mammalia Fam171a2 34
  • 87.31 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM171A2 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM171A2 35
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM171A2 35
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam171a2 34
  • 60.07 (n)
Str.5450 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.11903 34
zebrafish
(Danio rerio)
Actinopterygii LOC556398 34
  • 53.78 (n)
fam171a2 35
  • 42 (a)
OneToMany
FAM171A2 (2 of 2) 35
  • 40 (a)
OneToMany
Species where no ortholog for FAM171A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM171A2 Gene

ENSEMBL:
Gene Tree for FAM171A2 (if available)
TreeFam:
Gene Tree for FAM171A2 (if available)

Paralogs for FAM171A2 Gene

Paralogs for FAM171A2 Gene

(2) SIMAP similar genes for FAM171A2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FAM171A2: view

Variants for FAM171A2 Gene

Sequence variations from dbSNP and Humsavar for FAM171A2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs116547342 Likely benign 44,353,078(+) TGTGC(A/G)TTTCA downstream-variant-500B, utr-variant-3-prime
rs5848 other 44,352,876(-) TAGGG(A/G)GAGGT downstream-variant-500B, utr-variant-3-prime
rs1000581693 -- 44,355,168(+) CTGTT(-/G)GCCTC reference, frameshift-variant
rs1000683038 -- 44,358,041(+) CCATT(C/T)CTCCT intron-variant
rs1000938518 -- 44,361,842(+) AGGAC(A/G)TGTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM171A2 Gene

Variant ID Type Subtype PubMed ID
dgv5606n54 CNV loss 21841781
dgv5607n54 CNV loss 21841781
dgv5608n54 CNV gain 21841781
dgv5609n54 CNV loss 21841781
esv26446 CNV loss 19812545
nsv1072738 CNV deletion 25765185
nsv1118760 CNV deletion 24896259
nsv1146669 OTHER inversion 26484159
nsv575090 CNV loss 21841781
nsv575091 CNV gain+loss 21841781
nsv978429 CNV duplication 23825009

Variation tolerance for FAM171A2 Gene

Gene Damage Index Score: 4.78; 66.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM171A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM171A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM171A2 Gene

Disorders for FAM171A2 Gene

Relevant External Links for FAM171A2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM171A2

No disorders were found for FAM171A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM171A2 Gene

Publications for FAM171A2 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64

Products for FAM171A2 Gene

Sources for FAM171A2 Gene

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