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Aliases for FAM171A1 Gene

Aliases for FAM171A1 Gene

  • Family With Sequence Similarity 171 Member A1 2 3 5
  • Astroprincin 3 4
  • C10orf38 3 4
  • Family With Sequence Similarity 171, Member A1 2
  • Chromosome 10 Open Reading Frame 38 2
  • Protein FAM171A1 3

External Ids for FAM171A1 Gene

Previous HGNC Symbols for FAM171A1 Gene

  • C10orf38

Previous GeneCards Identifiers for FAM171A1 Gene

  • GC10M015294
  • GC10M015167

Summaries for FAM171A1 Gene

GeneCards Summary for FAM171A1 Gene

FAM171A1 (Family With Sequence Similarity 171 Member A1) is a Protein Coding gene. An important paralog of this gene is FAM171A2.

Additional gene information for FAM171A1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM171A1 Gene

Genomics for FAM171A1 Gene

GeneHancer (GH) Regulatory Elements for FAM171A1 Gene

Promoters and enhancers for FAM171A1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I015369 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 566.9 +0.5 461 2.4 CTCF SAP130 ARNT ZNF76 RAD21 ZNF335 GLIS2 POLR2A ZBTB48 PATZ1 FAM171A1 LOC105376434
GH10I015344 Enhancer 1.4 FANTOM5 Ensembl ENCODE 23.2 +25.2 25203 3.2 PKNOX1 ATF1 FOXA2 MLX ZFP64 ARID4B ETS1 TCF12 ATF7 RXRA FAM171A1 NMT2 LOC105376434
GH10I015333 Enhancer 1.1 Ensembl ENCODE 20.8 +36.4 36389 3.4 ELF3 PKNOX1 FOXA2 MLX ARID4B DMAP1 THRB RAD21 RARA YY1 FAM171A1 LOC105376434
GH10I015312 Enhancer 1.1 Ensembl ENCODE 19.6 +57.1 57076 2 PKNOX1 ATF1 ARNT TCF12 ZNF766 GATA2 ATF7 NCOA1 ZNF592 MEF2D FAM171A1 LOC105376434
GH10I015439 Enhancer 1.3 Ensembl ENCODE dbSUPER 16.1 -68.9 -68862 1.4 HDGF PKNOX1 ATF1 ARNT GTF3C2 ZNF143 ATF7 REST ZNF518A ZNF592 FAM171A1 GC10P015448
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM171A1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM171A1 gene promoter:

Genomic Locations for FAM171A1 Gene

Genomic Locations for FAM171A1 Gene
159,420 bases
Minus strand

Genomic View for FAM171A1 Gene

Genes around FAM171A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM171A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM171A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM171A1 Gene

Proteins for FAM171A1 Gene

  • Protein details for FAM171A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM171A1
    Protein Accession:
    Secondary Accessions:
    • D3DRT9
    • Q32M49
    • Q8N4I0

    Protein attributes for FAM171A1 Gene

    890 amino acids
    Molecular mass:
    97854 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM171A1 Gene

Post-translational modifications for FAM171A1 Gene

  • Glycosylation at posLast=159159, posLast=190190, and posLast=194194

Other Protein References for FAM171A1 Gene

No data available for DME Specific Peptides for FAM171A1 Gene

Domains & Families for FAM171A1 Gene

Gene Families for FAM171A1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for FAM171A1 Gene

Suggested Antigen Peptide Sequences for FAM171A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



F1711_HUMAN :
  • Belongs to the FAM171 family.
  • Belongs to the FAM171 family.
genes like me logo Genes that share domains with FAM171A1: view

Function for FAM171A1 Gene

Phenotypes From GWAS Catalog for FAM171A1 Gene

Animal Model Products

CRISPR Products

miRNA for FAM171A1 Gene

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM171A1 Gene

Localization for FAM171A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM171A1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM171A1 gene
Compartment Confidence
extracellular 5
plasma membrane 2
mitochondrion 1
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FAM171A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome HDA,IDA 23376485
genes like me logo Genes that share ontologies with FAM171A1: view

Pathways & Interactions for FAM171A1 Gene

SuperPathways for FAM171A1 Gene

No Data Available

Interacting Proteins for FAM171A1 Gene

Selected Interacting proteins: Q5VUB5-F1711_HUMAN for FAM171A1 Gene via IID

Gene Ontology (GO) - Biological Process for FAM171A1 Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM171A1 Gene

Drugs & Compounds for FAM171A1 Gene

No Compound Related Data Available

Transcripts for FAM171A1 Gene

Unigene Clusters for FAM171A1 Gene

Family with sequence similarity 171, member A1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM171A1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b
SP1: - -
SP3: - -

Relevant External Links for FAM171A1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM171A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM171A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM171A1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.5), Brain - Putamen (basal ganglia) (x4.2), Brain - Nucleus accumbens (basal ganglia) (x4.1), and Brain - Caudate (basal ganglia) (x4.1).

Protein differential expression in normal tissues from HIPED for FAM171A1 Gene

This gene is overexpressed in Frontal cortex (26.6), Bone (19.2), Spinal cord (8.5), and Fetal Brain (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM171A1 Gene

Protein tissue co-expression partners for FAM171A1 Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM171A1 Gene:


SOURCE GeneReport for Unigene cluster for FAM171A1 Gene:


Evidence on tissue expression from TISSUES for FAM171A1 Gene

  • Nervous system(5)
  • Kidney(4.2)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with FAM171A1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM171A1 Gene

Orthologs for FAM171A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM171A1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM171A1 33 34
  • 99.65 (n)
(Bos Taurus)
Mammalia C13H10ORF38 34
  • 91 (a)
FAM171A1 33
  • 86.44 (n)
(Canis familiaris)
Mammalia FAM171A1 33 34
  • 87.64 (n)
(Mus musculus)
Mammalia Fam171a1 33 16 34
  • 86.44 (n)
(Monodelphis domestica)
Mammalia FAM171A1 34
  • 86 (a)
(Rattus norvegicus)
Mammalia Fam171a1 33
  • 84.2 (n)
(Ornithorhynchus anatinus)
Mammalia FAM171A1 34
  • 68 (a)
(Gallus gallus)
Aves FAM171A1 33 34
  • 76.38 (n)
(Anolis carolinensis)
Reptilia FAM171A1 34
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam171a1 33
  • 70.73 (n)
(Danio rerio)
Actinopterygii fam171a1 33 34
  • 59.45 (n)
Species where no ortholog for FAM171A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM171A1 Gene

Gene Tree for FAM171A1 (if available)
Gene Tree for FAM171A1 (if available)

Paralogs for FAM171A1 Gene

Paralogs for FAM171A1 Gene

(4) SIMAP similar genes for FAM171A1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FAM171A1: view

Variants for FAM171A1 Gene

Sequence variations from dbSNP and Humsavar for FAM171A1 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000027271 -- 15,348,765(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000035516 -- 15,290,004(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000045966 -- 15,270,339(-) T/A intron_variant
rs1000056494 -- 15,306,679(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000059562 -- 15,365,783(-) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM171A1 Gene

Variant ID Type Subtype PubMed ID
esv1057266 CNV insertion 17803354
esv1481642 CNV deletion 17803354
esv2080157 CNV deletion 18987734
esv2502312 CNV deletion 19546169
esv2733528 CNV deletion 23290073
esv2733539 CNV deletion 23290073
esv2733550 CNV deletion 23290073
esv3622441 CNV loss 21293372
esv3622442 CNV loss 21293372
esv4462 CNV loss 18987735
nsv1068676 CNV deletion 25765185
nsv1069455 CNV deletion 25765185
nsv1115157 CNV deletion 24896259
nsv1118161 CNV deletion 24896259
nsv1132838 CNV insertion 24896259
nsv1135770 CNV deletion 24896259
nsv1150152 CNV deletion 26484159
nsv1151586 CNV insertion 26484159
nsv1152247 CNV insertion 26484159
nsv466755 CNV gain 19166990
nsv466756 CNV loss 19166990
nsv472939 CNV novel sequence insertion 20440878
nsv509344 CNV insertion 20534489
nsv523449 CNV loss 19592680
nsv550016 CNV gain 21841781
nsv550017 CNV loss 21841781
nsv5921 CNV insertion 18451855
nsv956150 CNV deletion 24416366

Variation tolerance for FAM171A1 Gene

Residual Variation Intolerance Score: 13.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.89; 79.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM171A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM171A1 Gene

Disorders for FAM171A1 Gene

Additional Disease Information for FAM171A1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FAM171A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM171A1 Gene

Publications for FAM171A1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators. (PMID: 27880917) St-Denis N … Gingras AC (Cell reports 2016) 3 58

Products for FAM171A1 Gene

Sources for FAM171A1 Gene

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