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Aliases for FAM171A1 Gene

Aliases for FAM171A1 Gene

  • Family With Sequence Similarity 171 Member A1 2 3 5
  • Family With Sequence Similarity 171, Member A1 2 3
  • Astroprincin 3 4
  • C10orf38 3 4
  • Chromosome 10 Open Reading Frame 38 2

External Ids for FAM171A1 Gene

Previous HGNC Symbols for FAM171A1 Gene

  • C10orf38

Previous GeneCards Identifiers for FAM171A1 Gene

  • GC10M015294
  • GC10M015167

Summaries for FAM171A1 Gene

GeneCards Summary for FAM171A1 Gene

FAM171A1 (Family With Sequence Similarity 171 Member A1) is a Protein Coding gene. An important paralog of this gene is FAM171A2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM171A1 Gene

Genomics for FAM171A1 Gene

Regulatory Elements for FAM171A1 Gene

Promoters for FAM171A1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAM171A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM171A1 Gene

15,211,643 bp from pter
15,371,062 bp from pter
159,420 bases
Minus strand

Genomic View for FAM171A1 Gene

Genes around FAM171A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM171A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM171A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM171A1 Gene

Proteins for FAM171A1 Gene

  • Protein details for FAM171A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM171A1
    Protein Accession:
    Secondary Accessions:
    • D3DRT9
    • Q32M49
    • Q8N4I0

    Protein attributes for FAM171A1 Gene

    890 amino acids
    Molecular mass:
    97854 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM171A1 Gene

Proteomics data for FAM171A1 Gene at MOPED

Post-translational modifications for FAM171A1 Gene

  • Glycosylation at Asn 159, Asn 190, and Asn 194
  • Modification sites at PhosphoSitePlus

Other Protein References for FAM171A1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for FAM171A1 Gene

Domains & Families for FAM171A1 Gene

Protein Domains for FAM171A1 Gene


Suggested Antigen Peptide Sequences for FAM171A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



F1711_HUMAN :
  • Belongs to the FAM171 family.
  • Belongs to the FAM171 family.
genes like me logo Genes that share domains with FAM171A1: view

No data available for Gene Families for FAM171A1 Gene

Function for FAM171A1 Gene

Animal Model Products

CRISPR Products

miRNA for FAM171A1 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM171A1 Gene

Localization for FAM171A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM171A1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for FAM171A1 Gene COMPARTMENTS Subcellular localization image for FAM171A1 gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytosol 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FAM171A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with FAM171A1: view

Pathways & Interactions for FAM171A1 Gene

SuperPathways for FAM171A1 Gene

No Data Available

Interacting Proteins for FAM171A1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q5VUB5-F1711_HUMAN ENSP00000367356 for FAM171A1 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for FAM171A1 Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM171A1 Gene

Drugs & Compounds for FAM171A1 Gene

No Compound Related Data Available

Transcripts for FAM171A1 Gene

Unigene Clusters for FAM171A1 Gene

Family with sequence similarity 171, member A1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM171A1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b
SP1: - -
SP3: - -

Relevant External Links for FAM171A1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM171A1 Gene

mRNA expression in normal human tissues for FAM171A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM171A1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.5), Brain - Putamen (basal ganglia) (x4.2), Brain - Nucleus accumbens (basal ganglia) (x4.1), and Brain - Caudate (basal ganglia) (x4.1).

Protein differential expression in normal tissues from HIPED for FAM171A1 Gene

This gene is overexpressed in Frontal cortex (26.6), Bone (19.2), Spinal cord (8.5), and Fetal Brain (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for FAM171A1 Gene

SOURCE GeneReport for Unigene cluster for FAM171A1 Gene Hs.66762

genes like me logo Genes that share expression patterns with FAM171A1: view

Protein tissue co-expression partners for FAM171A1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FAM171A1 Gene

Orthologs for FAM171A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM171A1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM171A1 35
  • 86.44 (n)
  • 92.06 (a)
C13H10ORF38 36
  • 91 (a)
(Canis familiaris)
Mammalia FAM171A1 35
  • 87.64 (n)
  • 92.09 (a)
FAM171A1 36
  • 91 (a)
(Mus musculus)
Mammalia Fam171a1 35
  • 86.44 (n)
  • 91.8 (a)
Fam171a1 16
Fam171a1 36
  • 92 (a)
(Pan troglodytes)
Mammalia FAM171A1 35
  • 99.65 (n)
  • 99.87 (a)
FAM171A1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Fam171a1 35
  • 84.2 (n)
  • 89.06 (a)
(Monodelphis domestica)
Mammalia FAM171A1 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia FAM171A1 36
  • 68 (a)
(Gallus gallus)
Aves FAM171A1 35
  • 76.38 (n)
  • 81.36 (a)
FAM171A1 36
  • 80 (a)
(Anolis carolinensis)
Reptilia FAM171A1 36
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam171a1 35
  • 70.73 (n)
  • 72.39 (a)
(Danio rerio)
Actinopterygii fam171a1 35
  • 59.45 (n)
  • 56.23 (a)
fam171a1 36
  • 47 (a)
Species with no ortholog for FAM171A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM171A1 Gene

Gene Tree for FAM171A1 (if available)
Gene Tree for FAM171A1 (if available)

Paralogs for FAM171A1 Gene

Paralogs for FAM171A1 Gene

(4) SIMAP similar genes for FAM171A1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FAM171A1: view

Variants for FAM171A1 Gene

Sequence variations from dbSNP and Humsavar for FAM171A1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_030220 -
rs987484 -- 15,355,718(+) TCAAA(A/T)AATAA intron-variant
rs1122064 -- 15,358,309(-) AAAAG(C/T)TTAAT intron-variant
rs1475331 -- 15,366,808(+) ATTTA(C/T)TAAAA intron-variant
rs1878622 -- 15,299,921(+) TGCAG(C/T)GAACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM171A1 Gene

Variant ID Type Subtype PubMed ID
nsv509344 CNV Insertion 20534489
nsv5921 CNV Insertion 18451855
esv2502312 CNV Deletion 19546169
esv2733528 CNV Deletion 23290073
esv2080157 CNV Deletion 18987734
esv4462 CNV Deletion 18987735
esv2733539 CNV Deletion 23290073
esv2733550 CNV Deletion 23290073
esv1481642 CNV Deletion 17803354
nsv894900 CNV Gain 21882294
nsv894901 CNV Gain 21882294
nsv523449 CNV Loss 19592680
nsv466755 CNV Gain 19166990
esv1057266 CNV Insertion 17803354
nsv466756 CNV Loss 19166990

Variation tolerance for FAM171A1 Gene

Residual Variation Intolerance Score: 13.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.89; 79.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM171A1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM171A1 Gene

Disorders for FAM171A1 Gene

Relevant External Links for FAM171A1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM171A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM171A1 Gene

Publications for FAM171A1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles. (PMID: 25187353) Goldstein J.I. … Sullivan P.F. (Nat Commun 2014) 3
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for FAM171A1 Gene

Sources for FAM171A1 Gene

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