Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FAM170B Gene

Aliases for FAM170B Gene

  • Family With Sequence Similarity 170 Member B 2 3 5
  • Family With Sequence Similarity 170, Member B 2 3
  • Acrosome-Related Protein 3 4
  • C10orf73 3 4
  • Chromosome 10 Open Reading Frame 73 2
  • Putative Protein FAM170B 3

External Ids for FAM170B Gene

Previous HGNC Symbols for FAM170B Gene

  • C10orf73

Previous GeneCards Identifiers for FAM170B Gene

  • GC10M050010
  • GC10M050339
  • GC10M044603

Summaries for FAM170B Gene

GeneCards Summary for FAM170B Gene

FAM170B (Family With Sequence Similarity 170 Member B) is a Protein Coding gene. An important paralog of this gene is FAM170A.

UniProtKB/Swiss-Prot for FAM170B Gene

  • Plays a role in fertilization through the acrosome reaction.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM170B Gene

Genomics for FAM170B Gene

Regulatory Elements for FAM170B Gene

Enhancers for FAM170B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FAM170B on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM170B Gene

49,131,154 bp from pter
49,134,020 bp from pter
2,867 bases
Minus strand

Genomic View for FAM170B Gene

Genes around FAM170B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM170B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM170B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM170B Gene

Proteins for FAM170B Gene

  • Protein details for FAM170B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM170B
    Protein Accession:
    Secondary Accessions:
    • Q86WY6
    • Q8N6K8

    Protein attributes for FAM170B Gene

    283 amino acids
    Molecular mass:
    32092 Da
    Quaternary structure:
    • Interacts with GOPC.
    • Sequence=AAH29839.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH47597.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for FAM170B Gene

Proteomics data for FAM170B Gene at MOPED

Post-translational modifications for FAM170B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM170B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM170B Gene

Domains & Families for FAM170B Gene

Protein Domains for FAM170B Gene


Suggested Antigen Peptide Sequences for FAM170B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM170 family.
  • Belongs to the FAM170 family.
genes like me logo Genes that share domains with FAM170B: view

No data available for Gene Families for FAM170B Gene

Function for FAM170B Gene

Molecular function for FAM170B Gene

UniProtKB/Swiss-Prot Function:
Plays a role in fertilization through the acrosome reaction.

Phenotypes for FAM170B Gene

GenomeRNAi human phenotypes for FAM170B:
genes like me logo Genes that share phenotypes with FAM170B: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM170B Gene

Localization for FAM170B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM170B Gene

Cytoplasmic vesicle, secretory vesicle, acrosome. Cytoplasmic vesicle, secretory vesicle, acrosome outer membrane.

Subcellular locations from

Jensen Localization Image for FAM170B Gene COMPARTMENTS Subcellular localization image for FAM170B gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for FAM170B Gene

Pathways & Interactions for FAM170B Gene

SuperPathways for FAM170B Gene

No Data Available

Interacting Proteins for FAM170B Gene

Gene Ontology (GO) - Biological Process for FAM170B Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM170B Gene

Drugs & Compounds for FAM170B Gene

No Compound Related Data Available

Transcripts for FAM170B Gene

mRNA/cDNA for FAM170B Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM170B Gene

Family with sequence similarity 170, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM170B Gene

No ASD Table

Relevant External Links for FAM170B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM170B Gene

mRNA expression in normal human tissues for FAM170B Gene

mRNA differential expression in normal tissues according to GTEx for FAM170B Gene

This gene is overexpressed in Testis (x42.1).

SOURCE GeneReport for Unigene cluster for FAM170B Gene Hs.646291

mRNA Expression by UniProt/SwissProt for FAM170B Gene

Tissue specificity: Exclusively expressed in adult testis.
genes like me logo Genes that share expression patterns with FAM170B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for FAM170B Gene

Orthologs for FAM170B Gene

This gene was present in the common ancestor of mammals.

Orthologs for FAM170B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM170B 35
  • 76.8 (n)
  • 67.14 (a)
FAM170B 36
  • 66 (a)
(Canis familiaris)
Mammalia FAM170B 35
  • 75.16 (n)
  • 61.96 (a)
-- 36
  • 15 (a)
(Mus musculus)
Mammalia Fam170b 35
  • 73.14 (n)
  • 62.23 (a)
Fam170b 16
Fam170b 36
  • 42 (a)
(Pan troglodytes)
Mammalia FAM170B 35
  • 98.36 (n)
  • 97.34 (a)
FAM170B 36
  • 96 (a)
(Rattus norvegicus)
Mammalia Fam170b 35
  • 73.21 (n)
  • 63.57 (a)
(Monodelphis domestica)
Mammalia FAM170B 36
  • 35 (a)
(Ornithorhynchus anatinus)
Mammalia FAM170B 36
  • 35 (a)
Species with no ortholog for FAM170B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM170B Gene

Gene Tree for FAM170B (if available)
Gene Tree for FAM170B (if available)

Paralogs for FAM170B Gene

Paralogs for FAM170B Gene

genes like me logo Genes that share paralogs with FAM170B: view

Variants for FAM170B Gene

Sequence variations from dbSNP and Humsavar for FAM170B Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_037062 -

Structural Variations from Database of Genomic Variants (DGV) for FAM170B Gene

Variant ID Type Subtype PubMed ID
nsv7203 OTHER Inversion 18451855
nsv895365 CNV Loss 21882294
nsv895369 CNV Gain 21882294
nsv895375 CNV Gain 21882294

Variation tolerance for FAM170B Gene

Gene Damage Index Score: 9.34; 88.35% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FAM170B Gene

Disorders for FAM170B Gene

Relevant External Links for FAM170B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM170B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM170B Gene

Publications for FAM170B Gene

  1. FAM170B, a novel acrosomal protein involved in fertilization in mice. (PMID: 26179146) Li Y. … Gui Y. (Mol. Reprod. Dev. 2015) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for FAM170B Gene

Sources for FAM170B Gene