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Aliases for FAM170B Gene

Aliases for FAM170B Gene

  • Family With Sequence Similarity 170 Member B 2 3 5
  • Acrosome-Related Protein 3 4
  • C10orf73 3 4
  • Family With Sequence Similarity 170, Member B 2
  • Chromosome 10 Open Reading Frame 73 2
  • Putative Protein FAM170B 3
  • Protein FAM170B 3

External Ids for FAM170B Gene

Previous HGNC Symbols for FAM170B Gene

  • C10orf73

Previous GeneCards Identifiers for FAM170B Gene

  • GC10M050010
  • GC10M050339
  • GC10M044603

Summaries for FAM170B Gene

GeneCards Summary for FAM170B Gene

FAM170B (Family With Sequence Similarity 170 Member B) is a Protein Coding gene. An important paralog of this gene is FAM170A.

UniProtKB/Swiss-Prot for FAM170B Gene

  • Plays a role in fertilization through the acrosome reaction.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM170B Gene

Genomics for FAM170B Gene

Regulatory Elements for FAM170B Gene

Enhancers for FAM170B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G049108 1.3 Ensembl ENCODE dbSUPER 29.3 +23.8 23831 2.8 HDGF HDAC1 TBL1XR1 NFRKB SMARCA5 ZBTB2 NR2F2 ZNF592 CREB3 SMARCA4 FAM170B GC10P049105 FAM170B-AS1
GH10G049137 1.3 FANTOM5 Ensembl ENCODE 20.2 -5.5 -5470 3.4 HDGF CTCF ATF1 RB1 JUN YBX1 FOSL1 ZNF316 POLR2A FOS FAM170B C10orf128
GH10G049106 0.8 dbSUPER 28.4 +26.8 26838 1.4 BCOR FOXA2 RAD21 RELA ZNF507 ZNF316 ZNF766 HNF4G ZSCAN29 ZNF639 FAM170B GC10P049105 FAM170B-AS1
GH10G049001 1.7 ENCODE 12.6 +132.0 131951 1.3 CTCF TEAD4 REST ZIC2 EP300 RAD21 NR2F2 MBD2 IKZF1 ZBTB33 FAM170B LOC105378298 GC10M049015
GH10G049135 1 Ensembl ENCODE 20.5 -2.0 -1952 1.5 FOXA2 CBX3 ZBTB21 BHLHE40 TRIM22 ZMYM3 ZNF398 ATF2 FOXA1 TARDBP FAM170B C10orf128
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM170B on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM170B Gene

Chromosome:
10
Start:
49,131,154 bp from pter
End:
49,134,020 bp from pter
Size:
2,867 bases
Orientation:
Minus strand

Genomic View for FAM170B Gene

Genes around FAM170B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM170B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM170B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM170B Gene

Proteins for FAM170B Gene

  • Protein details for FAM170B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NMN3-F170B_HUMAN
    Recommended name:
    Protein FAM170B
    Protein Accession:
    A6NMN3
    Secondary Accessions:
    • Q86WY6
    • Q8N6K8

    Protein attributes for FAM170B Gene

    Size:
    283 amino acids
    Molecular mass:
    32092 Da
    Quaternary structure:
    • Interacts with GOPC.
    SequenceCaution:
    • Sequence=AAH29839.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH47597.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for FAM170B Gene

Post-translational modifications for FAM170B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM170B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM170B Gene

Domains & Families for FAM170B Gene

Protein Domains for FAM170B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM170B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NMN3

UniProtKB/Swiss-Prot:

F170B_HUMAN :
  • Belongs to the FAM170 family.
Family:
  • Belongs to the FAM170 family.
genes like me logo Genes that share domains with FAM170B: view

No data available for Gene Families for FAM170B Gene

Function for FAM170B Gene

Molecular function for FAM170B Gene

UniProtKB/Swiss-Prot Function:
Plays a role in fertilization through the acrosome reaction.

Gene Ontology (GO) - Molecular Function for FAM170B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 26179146
genes like me logo Genes that share ontologies with FAM170B: view

Phenotypes for FAM170B Gene

GenomeRNAi human phenotypes for FAM170B:
genes like me logo Genes that share phenotypes with FAM170B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM170B Gene

Localization for FAM170B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM170B Gene

Cytoplasmic vesicle, secretory vesicle, acrosome. Cytoplasmic vesicle, secretory vesicle, acrosome outer membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM170B gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for FAM170B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IDA 26179146
GO:0002081 outer acrosomal membrane ISS --
GO:0016020 membrane IEA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with FAM170B: view

Pathways & Interactions for FAM170B Gene

SuperPathways for FAM170B Gene

No Data Available

Interacting Proteins for FAM170B Gene

Gene Ontology (GO) - Biological Process for FAM170B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0080154 regulation of fertilization ISS --
GO:2000344 positive regulation of acrosome reaction ISS --
genes like me logo Genes that share ontologies with FAM170B: view

No data available for Pathways by source and SIGNOR curated interactions for FAM170B Gene

Drugs & Compounds for FAM170B Gene

No Compound Related Data Available

Transcripts for FAM170B Gene

mRNA/cDNA for FAM170B Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM170B Gene

Family with sequence similarity 170, member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM170B Gene

No ASD Table

Relevant External Links for FAM170B Gene

GeneLoc Exon Structure for
FAM170B
ECgene alternative splicing isoforms for
FAM170B

Expression for FAM170B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM170B Gene

mRNA differential expression in normal tissues according to GTEx for FAM170B Gene

This gene is overexpressed in Testis (x42.1).

NURSA nuclear receptor signaling pathways regulating expression of FAM170B Gene:

FAM170B

SOURCE GeneReport for Unigene cluster for FAM170B Gene:

Hs.646291

mRNA Expression by UniProt/SwissProt for FAM170B Gene:

A6NMN3-F170B_HUMAN
Tissue specificity: Exclusively expressed in adult testis.

Evidence on tissue expression from TISSUES for FAM170B Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with FAM170B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM170B Gene

Orthologs for FAM170B Gene

This gene was present in the common ancestor of mammals.

Orthologs for FAM170B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM170B 34 35
  • 98.36 (n)
cow
(Bos Taurus)
Mammalia FAM170B 34 35
  • 76.8 (n)
dog
(Canis familiaris)
Mammalia FAM170B 34
  • 75.16 (n)
-- 35
  • 15 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Fam170b 34
  • 73.21 (n)
mouse
(Mus musculus)
Mammalia Fam170b 34 16 35
  • 73.14 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM170B 35
  • 35 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM170B 35
  • 35 (a)
OneToOne
Species where no ortholog for FAM170B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM170B Gene

ENSEMBL:
Gene Tree for FAM170B (if available)
TreeFam:
Gene Tree for FAM170B (if available)

Paralogs for FAM170B Gene

Paralogs for FAM170B Gene

genes like me logo Genes that share paralogs with FAM170B: view

Variants for FAM170B Gene

Sequence variations from dbSNP and Humsavar for FAM170B Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1001928647 -- 49,135,450(+) TAGGC(A/G)GGTAG intron-variant, upstream-variant-2KB
rs1001937976 -- 49,134,640(+) CCAAA(C/T)ACCTC intron-variant, upstream-variant-2KB
rs1002098928 -- 49,130,985(+) TGTAT(A/C/G)GTTGA intron-variant, upstream-variant-2KB
rs1002372918 -- 49,135,272(+) CAGAG(A/G)AGCCT intron-variant, upstream-variant-2KB
rs1003978817 -- 49,135,754(+) CTGCA(A/G)CACGC nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FAM170B Gene

Variant ID Type Subtype PubMed ID
esv3623164 CNV loss 21293372
nsv1042677 CNV loss 25217958

Variation tolerance for FAM170B Gene

Gene Damage Index Score: 9.34; 88.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM170B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM170B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM170B Gene

Disorders for FAM170B Gene

Relevant External Links for FAM170B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM170B

No disorders were found for FAM170B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM170B Gene

Publications for FAM170B Gene

  1. FAM170B, a novel acrosomal protein involved in fertilization in mice. (PMID: 26179146) Li Y. … Gui Y. (Mol. Reprod. Dev. 2015) 2 3 4 64
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for FAM170B Gene

Sources for FAM170B Gene

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