Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FAM170A Gene

Aliases for FAM170A Gene

  • Family With Sequence Similarity 170 Member A 2 3 5
  • Family With Sequence Similarity 170, Member A 2 3
  • Zinc Finger Domain-Containing Protein 3 4
  • Zinc Finger Protein ZNFD 3 4
  • ZNFD 3 4
  • Znf Domain Containing Protein 3

External Ids for FAM170A Gene

Previous GeneCards Identifiers for FAM170A Gene

  • GC05P118994
  • GC05P114160

Summaries for FAM170A Gene

GeneCards Summary for FAM170A Gene

FAM170A (Family With Sequence Similarity 170 Member A) is a Protein Coding gene. An important paralog of this gene is FAM170B.

UniProtKB/Swiss-Prot for FAM170A Gene

  • Acts as a nuclear transcription factor that positively regulates the expression of heat shock genes. Binds to heat shock promoter elements (HSE).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM170A Gene

Genomics for FAM170A Gene

Regulatory Elements for FAM170A Gene

Genomic Location for FAM170A Gene

Chromosome:
5
Start:
119,629,559 bp from pter
End:
119,635,822 bp from pter
Size:
6,264 bases
Orientation:
Plus strand

Genomic View for FAM170A Gene

Genes around FAM170A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM170A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM170A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM170A Gene

Proteins for FAM170A Gene

  • Protein details for FAM170A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A1A519-F170A_HUMAN
    Recommended name:
    Protein FAM170A
    Protein Accession:
    A1A519
    Secondary Accessions:
    • Q66LM8
    • Q7Z4V2
    • Q8IW94

    Protein attributes for FAM170A Gene

    Size:
    330 amino acids
    Molecular mass:
    37158 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH40622.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM170A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM170A Gene

Proteomics data for FAM170A Gene at MOPED

Post-translational modifications for FAM170A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM170A Gene

No data available for DME Specific Peptides for FAM170A Gene

Domains & Families for FAM170A Gene

Protein Domains for FAM170A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM170A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A1A519

UniProtKB/Swiss-Prot:

F170A_HUMAN :
  • The N-terminus is necessary for nuclear localization. The C-terminus is necessary for transcriptional activity.
  • Belongs to the FAM170 family.
  • Contains 1 C2H2-type zinc finger.
Domain:
  • The N-terminus is necessary for nuclear localization. The C-terminus is necessary for transcriptional activity.
Family:
  • Belongs to the FAM170 family.
Similarity:
  • Contains 1 C2H2-type zinc finger.
genes like me logo Genes that share domains with FAM170A: view

No data available for Gene Families for FAM170A Gene

Function for FAM170A Gene

Molecular function for FAM170A Gene

UniProtKB/Swiss-Prot Function:
Acts as a nuclear transcription factor that positively regulates the expression of heat shock genes. Binds to heat shock promoter elements (HSE).

Phenotypes for FAM170A Gene

GenomeRNAi human phenotypes for FAM170A:
genes like me logo Genes that share phenotypes with FAM170A: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM170A Gene

Localization for FAM170A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM170A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM170A Gene COMPARTMENTS Subcellular localization image for FAM170A gene
Compartment Confidence
nucleus 5
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for FAM170A Gene

Pathways & Interactions for FAM170A Gene

SuperPathways for FAM170A Gene

No Data Available

Interacting Proteins for FAM170A Gene

Gene Ontology (GO) - Biological Process for FAM170A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM170A Gene

Drugs & Compounds for FAM170A Gene

No Compound Related Data Available

Transcripts for FAM170A Gene

mRNA/cDNA for FAM170A Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM170A Gene

Family with sequence similarity 170, member A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM170A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5
SP1:
SP2: -

Relevant External Links for FAM170A Gene

GeneLoc Exon Structure for
FAM170A
ECgene alternative splicing isoforms for
FAM170A

Expression for FAM170A Gene

mRNA expression in normal human tissues for FAM170A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM170A Gene

This gene is overexpressed in Testis (x44.8).

Protein differential expression in normal tissues from HIPED for FAM170A Gene

This gene is overexpressed in Pancreatic juice (52.1) and Plasma (12.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM170A Gene



SOURCE GeneReport for Unigene cluster for FAM170A Gene Hs.713304

mRNA Expression by UniProt/SwissProt for FAM170A Gene

A1A519-F170A_HUMAN
Tissue specificity: Expressed strongly in testis and brain and weakly in prostate, spleen, pancreas and uterus.
genes like me logo Genes that share expression patterns with FAM170A: view

Protein tissue co-expression partners for FAM170A Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for FAM170A Gene

This gene was present in the common ancestor of mammals.

Orthologs for FAM170A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC540403 35
  • 80.65 (n)
  • 72.95 (a)
FAM170A 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM170A 35
  • 81.04 (n)
  • 75.86 (a)
FAM170A 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam170a 35
  • 81.61 (n)
  • 73.04 (a)
Fam170a 16
Fam170a 36
  • 70 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM170A 35
  • 99.39 (n)
  • 99.09 (a)
FAM170A 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam170a 35
  • 81.5 (n)
  • 77.5 (a)
oppossum
(Monodelphis domestica)
Mammalia FAM170A 36
  • 31 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM170A 36
  • 27 (a)
OneToOne
Species with no ortholog for FAM170A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM170A Gene

ENSEMBL:
Gene Tree for FAM170A (if available)
TreeFam:
Gene Tree for FAM170A (if available)

Paralogs for FAM170A Gene

Paralogs for FAM170A Gene

Pseudogenes.org Pseudogenes for FAM170A Gene

genes like me logo Genes that share paralogs with FAM170A: view

Variants for FAM170A Gene

Sequence variations from dbSNP and Humsavar for FAM170A Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs328694 - 119,634,265(-) AGAGG(A/G)GGGAG reference, missense
rs167886 -- 119,630,362(-) aaccc(C/T)gtctc intron-variant
rs328692 -- 119,636,228(-) AGAGA(C/T)AGATG downstream-variant-500B
rs328693 -- 119,636,148(-) GTAGA(A/T)CACTT downstream-variant-500B
rs328695 -- 119,633,757(+) CCCCT(A/G)TATAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM170A Gene

Variant ID Type Subtype PubMed ID
nsv882777 CNV Loss 21882294

Variation tolerance for FAM170A Gene

Residual Variation Intolerance Score: 93.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.09; 80.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM170A Gene

HapMap Linkage Disequilibrium report
FAM170A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM170A Gene

Disorders for FAM170A Gene

Relevant External Links for FAM170A

Genetic Association Database (GAD)
FAM170A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM170A

No disorders were found for FAM170A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM170A Gene

Publications for FAM170A Gene

  1. Isolation and characterization of a novel zinc finger gene, ZNFD, activating AP1(PMA) transcriptional activities. (PMID: 20162441) Lei C. … Wang M. (Mol. Cell. Biochem. 2010) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for FAM170A Gene

Sources for FAM170A Gene

Back to Top

Content