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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAM170A Gene

protein-coding   GIFtS: 41
GCID: GC05P118994

Family With Sequence Similarity 170, Member A

  Search for FAM170A
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Family With Sequence Similarity 170, Member A1 2
Zinc Finger Domain-Containing Protein2 3
Zinc Finger Protein ZNFD2 3
ZNFD2 3
Protein FAM170A2
Znf Domain Containing Protein2

External Ids:    HGNC: 279631   Entrez Gene: 3400692   Ensembl: ENSG000001643347   UniProtKB: A1A5193   

Export aliases for FAM170A gene to outside databases

Previous GC identifer: GC05P114160


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FAM170A Gene: 
FAM170A (family with sequence similarity 170, member A) is a protein-coding gene. GO annotations related to this gene include zinc ion binding. An important paralog of this gene is FAM170B.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_034772.6  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FAM170A gene promoter:
         FOXF2   HOXA3   FOXO3   FOXD3   CUTL1   NF-AT   FOXO3b   Gfi-1   FOXO3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM170A promoter sequence
   Search SABiosciences Chromatin IP Primers for FAM170A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM170A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q23.1   Ensembl cytogenetic band:  5q23.1   HGNC cytogenetic band: 5q23.1

FAM170A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM170A gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P118994:  view genomic region     (about GC identifiers)

Start:
118,965,254 bp from pter      End:
118,971,517 bp from pter
Size:
6,264 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: F170A_HUMAN, A1A519 (See protein sequence)
Recommended Name: Protein FAM170A  
Size: 330 amino acids; 37158 Da
Sequence caution: Sequence=AAH40622.1; Type=Erroneous initiation;
Secondary accessions: Q66LM8 Q7Z4V2 Q8IW94
Alternative splicing: 4 isoforms:  A1A519-1   A1A519-2   A1A519-3   A1A519-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FAM170A: NX_A1A519

Explore proteomics data for FAM170A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A1A519

  • FAM170A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FAM170A Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001157463.1  NP_877438.2  

    ENSEMBL proteins: 
     ENSP00000425939   ENSP00000368873   ENSP00000422684   ENSP00000334285   ENSP00000423697  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--

    FAM170A for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR015880 Znf_C2H2-like

    Graphical View of Domain Structure for InterPro Entry A1A519

    ProtoNet protein and cluster: A1A519

    UniProtKB/Swiss-Prot: F170A_HUMAN, A1A519
    Similarity: Belongs to the FAM170 family
    Similarity: Contains 1 C2H2-type zinc finger


    FAM170A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    FAM170A for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FAM170A 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FAM170A 
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM170A


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM170A

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006366transcription from RNA polymerase II promoter ISS--
    GO:0045893positive regulation of transcription, DNA-dependent ISS--

    FAM170A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FAM170A (F170A)

    Search CenterWatch for drugs/clinical trials and news about FAM170A / F170A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FAM170A gene (2 alternative transcripts): 
    NM_001163991.1  NM_182761.3  

    Unigene Cluster for FAM170A:

    Family with sequence similarity 170, member A
    Hs.713304
    Unigene Representative Sequence: NM_182761
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000504819 ENST00000379555(uc003kso.3) ENST00000515256(uc003ksl.2 uc003ksm.2)
    ENST00000335286(uc003ksn.3) ENST00000509264
    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate FAM170A:
    hsa-miR-629* hsa-miR-4287
    SwitchGear 3'UTR luciferase reporter plasmidFAM170A 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FAM170A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM170A
    Clone
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    OriGene clones in human, mouse for FAM170A (see all 11)
    OriGene ORF clones in mouse, rat for FAM170A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FAM170A (NM_182761)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM170A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM170A
    Sirion Biotech Customized lentivirus for stable overexpression of FAM170A 
                         Customized lentivirus expression plasmids for stable overexpression of FAM170A 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for FAM170A
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM170A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM170A

    Additional mRNA sequence: 

    AY692447.1 BC040622.1 BC128242.1 BC128243.1 

    1 DOTS entry:

    DT.97798569 

    5 AceView cDNA sequences:

    BC040622 AF427126 NM_182761 AY692447 BM564122 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for FAM170A    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5
    SP1:                                    
    SP2:              -                     


    ECgene alternative splicing isoforms for FAM170A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FAM170A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAACATCAT
    FAM170A Expression
    About this image


    See FAM170A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FAM170A

    SOURCE GeneReport for Unigene cluster: Hs.713304
        SABiosciences Custom PCR Arrays for FAM170A
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for FAM170A
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM170A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM170A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for FAM170A gene from 1/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam170a1 , 5 family with sequence similarity 170, member A1, 5 83.23(n)1
    75.79(a)1
      18 (27.30 cM)5
    2254971  NM_001004061.11  NP_001004061.11 
     502783695 


    ENSEMBL Gene Tree for FAM170A (if available)
    TreeFam Gene Tree for FAM170A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FAM170A gene
    FAM170B2  

    FAM170A for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for FAM170A
    PGOHUM00000235741


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/260 SNPs in FAM170A are shown (see all 260)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs784263701,2
    C,F--118963258(+) TAAAAG/TATGTA 2 -- us2k11Minor allele frequency- T:0.04EA 120
    rs574981811,2
    C,F--118963267(+) TATCAA/TCCAAT 2 -- us2k12Minor allele frequency- T:0.15WA 120
    rs1819673071,2
    C--118963314(+) CAATAC/GAGTTA 2 -- us2k10--------
    rs587932541,2
    C,F--118963352(+) GAAATT/CGAGTA 2 -- us2k12Minor allele frequency- C:0.15WA 120
    rs77060191,2
    C,F,H--118963360(+) gtatgG/Acttgg 2 -- us2k110Minor allele frequency- A:0.06NS EA NA 1078
    rs1464024601,2
    --118963380(+) TATATA/GAAAGA 2 -- us2k10--------
    rs1123182461,2
    C--118963410(+) GGTGAC/GATAAT 2 -- us2k12Minor allele frequency- G:0.33CSA 3
    rs13663571,2
    C,F,A,H--118963654(+) ATGAAG/ACTGCA 2 -- us2k116Minor allele frequency- A:0.27NS EA NA WA CSA 789
    rs1459096271,2
    C--118963681(+) CTCTC-/TACTT 
            
    TAGTC
    2 -- us2k10--------
    rs9214921,2
    C,F,A,H--118963779(+) AGCAAA/TTTTTT 2 -- us2k112Minor allele frequency- T:0.46NS EA NA WA 774

    HapMap Linkage Disequilibrium report for FAM170A (118965254 - 118971517 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FAM170A:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv882777CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    FAM170A for disorders           About MalaCards

    FAM170A for disorders           About GeneDecksing

    Genetic Association Database (GAD): FAM170A

    Export disorders for FAM170A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FAM170A gene integrated from 9 sources:
    (articles sorted by number of sources associating them with FAM170A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    2. Isolation and characterization of a novel zinc finger gene, ZNFD, activating AP1(PMA) transcriptional activities. (PubMed id 20162441)1 Lei C....Wang M. (2010)
    3. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PubMed id 17903296)4 Kiel D.P....Karasik D. (2007)
    4. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (2007)
    5. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    7. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 340069 HGNC: 27963 AceView: LOC340069 Ensembl:ENSG00000164334 euGenes: HUgn340069
    ECgene: FAM170A H-InvDB: FAM170A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FAM170A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FAM170A gene:
    Search GeneIP for patents involving FAM170A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
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