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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FAM170A Gene

protein-coding GIFtS: 39
GCID: GC05P118994

family with sequence similarity 170, member A

Search for FAM170A
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Family With Sequence Similarity 170, Member A¹ ²
Zinc Finger Domain-Containing Protein² ³
Zinc Finger Protein ZNFD² ³
ZNFD² ³
Protein FAM170A²
Znf Domain Containing Protein²

External Ids:	HGNC: 27963¹	Entrez Gene: 340069²	Ensembl: ENSG00000164334⁷	UniProtKB: A1A519³

Export aliases for FAM170A gene to outside databases

Previous GC identifer: GC05P114160

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_034772.6

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FAM170A gene promoter:
FOXF2 HOXA3 FOXO3 FOXD3 CUTL1 NF-AT FOXO3b Gfi-1 FOXO3a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FAM170A promoter sequence

Search SABiosciences Chromatin IP Primers for FAM170A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM170A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q23.1 Ensembl cytogenetic band: 5q23.1 HGNC cytogenetic band: 5q23.1

FAM170A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM170A gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P118994: view genomic region (about GC identifiers)

Start:	118,965,254 bp from pter	End:	118,971,517 bp from pter
Size:	6,264 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: F170A_HUMAN, A1A519 (See protein sequence)

Recommended Name: Protein FAM170A

Size: 330 amino acids; 37158 Da

Sequence caution: Sequence=AAH40622.1; Type=Erroneous initiation;

Secondary accessions: Q66LM8 Q7Z4V2 Q8IW94

Alternative splicing: 4 isoforms: A1A519-1 A1A519-2 A1A519-3 A1A519-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FAM170A: NX_A1A519

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_A1A519

FAM170A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001157463.1 NP_877438.2

ENSEMBL proteins:

ENSP00000425939 ENSP00000368873 ENSP00000422684 ENSP00000334285 ENSP00000423697

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--

FAM170A for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FAM170A for domains About GeneDecksing

1 InterPro domain/family:

IPR015880 Znf_C2H2-like

Graphical View of Domain Structure for InterPro Entry A1A519

ProtoNet protein and cluster: A1A519

UniProtKB/Swiss-Prot: F170A_HUMAN, A1A519

Similarity: Belongs to the FAM170 family

Similarity: Contains 1 C2H2-type zinc finger

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008270	zinc ion binding	IEA	--

FAM170A for ontologies About GeneDecksing

Animal Models:

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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for FAM170A

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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Search CenterWatch for drugs/clinical trials and news about FAM170A / F170A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for FAM170A gene (2 alternative transcripts):

NM_001163991.1 NM_182761.3

Unigene Cluster for FAM170A:

Family with sequence similarity 170, member A

Hs.713304

Unigene Representative Sequence: NM_182761

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000504819 ENST00000379555(uc003kso.3) ENST00000515256(uc003ksl.2 uc003ksm.2)

ENST00000335286(uc003ksn.3) ENST00000509264

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Additional cDNA sequence:

AY692447.1 BC040622.1 BC128242.1 BC128243.1

1 DOTS entry:

DT.97798569

5 AceView cDNA sequences:

AF427126 BC040622 NM_182761 AY692447 BM564122

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for FAM170A About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5
SP1:
SP2:					-

ECgene alternative splicing isoforms for FAM170A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FAM170A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAACATCAT

About this image

FAM170A expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Testis

Seminiferous Tubules

Mature Sertoli Cells

Testis

Bone

Maxillary Process

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See FAM170A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM170A

SOURCE GeneReport for Unigene cluster: Hs.713304

SABiosciences Custom PCR Arrays for FAM170A

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for FAM170A gene from 1/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Fam170a^{1 , 5}	family with sequence similarity 170, member A^{1, 5}	83.23(n)¹ 75.79(a)¹		18 (27.30 cM)⁵ 225497¹ NM_001004061.1¹ NP_001004061.1¹ 50278369⁵

ENSEMBL Gene Tree for FAM170A (if available)
TreeFam Gene Tree for FAM170A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FAM170A gene

FAM170B²

FAM170A for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for FAM170A
PGOHUM00000235741

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs78426370^1,2	C,F	--	118963258(+)	`TAAAAG/TATGTA`	2	--	us2k¹		1		EA	120
rs57498181^1,2	C	--	118963267(+)	`TATCAA/TCCAAT`	2	--	us2k¹		2		WA	120
rs181967307^1,2		--	118963314(+)	`CAATAC/GAGTTA`	2	--	us2k¹		0	--	--	--	--
rs58793254^1,2	C	--	118963352(+)	`GAAATT/CGAGTA`	2	--	us2k¹		2		WA	120
rs7706019^1,2	C,F,H	--	118963360(+)	`GTATGG/ACTTGG`	2	--	us2k¹		10		NS EA NA	1078
rs146402460^1,2		--	118963380(+)	`TATATA/GAAAGA`	2	--	us2k¹		0	--	--	--	--
rs112318246^1,2		--	118963410(+)	`GGTGAC/GATAAT`	2	--	us2k¹		2		CSA	3
rs1366357^1,2	C,F,A,H	--	118963654(+)	`ATGAAG/ACTGCA`	2	--	us2k¹		16		NS EA NA WA CSA	789
rs145909627^1,2	C	--	118963681(+)	`CTCTC-/TACTT TAGTC`	2	--	us2k¹		0	--	--	--	--
rs921492^1,2	C,F,A,H	--	118963779(+)	`AGCAAA/TTTTTT`	2	--	us2k¹		12		NS EA NA WA	774

HapMap Linkage Disequilibrium report for FAM170A (118965254 - 118971517 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FAM170A: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FAM170A gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM170A)

Utopia: connect your pdf to the dynamic
world of online information

Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
Isolation and characterization of a novel zinc finger gene, ZNFD, activating AP1(PMA) transcriptional activities. (PubMed id 20162441)¹ Lei C....Wang M. (2010)
The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)² Schmutz J.... Rubin E.M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 340069	HGNC: 27963	AceView: LOC340069	Ensembl:ENSG00000164334	euGenes: HUgn340069
ECgene: FAM170A	H-InvDB: FAM170A

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FAM170A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FAM170A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for FAM170A gene:
Search GeneIP for patents involving FAM170A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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Search LifeMap BioReagents cell lines for FAM170A

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM170A

	SwitchGear 3'UTR luciferase reporter plasmids for FAM170A
	SwitchGear Promoter luciferase reporter plasmids for FAM170A

Search ThermoFisher Antibodies for FAM170A

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM170A

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for FAM170A

Sirion Biotech Customized:

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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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FAM170A Gene

family with sequence similarity 170, member A

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for FAM170A gene

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Export list of displayed genes

FAM170A Gene

family with sequence similarity 170, member A

Aliasesfor FAM170A gene

Summariesfor FAM170A gene

Genomic Viewsfor FAM170A gene

Proteinsfor FAM170A gene

Protein Domains /Familiesfor FAM170A gene

Functionfor FAM170A gene

Pathways & Interactionsfor FAM170A gene

Drugs & Compoundsfor FAM170A gene

Transcriptsfor FAM170A gene

Expression for FAM170A gene

Orthologsfor FAM170A gene

Paralogsfor FAM170A gene

Genomic Variantsfor FAM170A gene

Disorders / Diseasesfor FAM170A gene

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External Searches for FAM170A gene

Genome Databases showing FAM170A gene

Other Databases showing FAM170A gene

Specialized Databases showing FAM170A gene

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Productsfor FAM170A gene

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Aliases
for FAM170A gene

Summaries
for FAM170A gene

Genomic Views
for FAM170A gene

Proteins
for FAM170A gene

Protein Domains /
Families
for FAM170A gene

Function
for FAM170A gene

Pathways & Interactions
for FAM170A gene

Drugs & Compounds
for FAM170A gene

Transcripts
for FAM170A gene

Expression
for FAM170A gene

Orthologs
for FAM170A gene

Paralogs
for FAM170A gene

Genomic Variants
for FAM170A gene

Disorders / Diseases
for FAM170A gene

Publications
for FAM170A gene

Intellectual Property
for FAM170A gene

Products
for FAM170A gene