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Aliases for FAM170A Gene

Aliases for FAM170A Gene

  • Family With Sequence Similarity 170, Member A 2 3
  • Zinc Finger Domain-Containing Protein 3 4
  • Zinc Finger Protein ZNFD 3 4
  • ZNFD 3 4
  • Znf Domain Containing Protein 3
  • Protein FAM170A 3

External Ids for FAM170A Gene

Previous GeneCards Identifiers for FAM170A Gene

  • GC05P118994
  • GC05P114160

Summaries for FAM170A Gene

GeneCards Summary for FAM170A Gene

FAM170A (Family With Sequence Similarity 170, Member A) is a Protein Coding gene. An important paralog of this gene is FAM170B.

UniProtKB/Swiss-Prot for FAM170A Gene

  • Acts as a nuclear transcription factor that positively regulates the expression of heat shock genes. Binds to heat shock promoter elements (HSE).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM170A Gene

Genomics for FAM170A Gene

Regulatory Elements for FAM170A Gene

Genomic Location for FAM170A Gene

Start:
119,629,559 bp from pter
End:
119,635,822 bp from pter
Size:
6,264 bases
Orientation:
Plus strand

Genomic View for FAM170A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM170A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM170A Gene

Proteins for FAM170A Gene

  • Protein details for FAM170A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A1A519-F170A_HUMAN
    Recommended name:
    Protein FAM170A
    Protein Accession:
    A1A519
    Secondary Accessions:
    • Q66LM8
    • Q7Z4V2
    • Q8IW94

    Protein attributes for FAM170A Gene

    Size:
    330 amino acids
    Molecular mass:
    37158 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH40622.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM170A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM170A Gene

Proteomics data for FAM170A Gene at MOPED

Post-translational modifications for FAM170A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM170A Gene

No data available for DME Specific Peptides for FAM170A Gene

Domains for FAM170A Gene

Protein Domains for FAM170A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM170A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A1A519

UniProtKB/Swiss-Prot:

F170A_HUMAN :
  • A1A519
Domain:
  • The N-terminus is necessary for nuclear localization. The C-terminus is necessary for transcriptional activity
Family:
  • Belongs to the FAM170 family.
Similarity:
  • Contains 1 C2H2-type zinc finger.
genes like me logo Genes that share domains with FAM170A: view

No data available for Gene Families for FAM170A Gene

Function for FAM170A Gene

Molecular function for FAM170A Gene

UniProtKB/Swiss-Prot Function: Acts as a nuclear transcription factor that positively regulates the expression of heat shock genes. Binds to heat shock promoter elements (HSE).

Gene Ontology (GO) - Molecular Function for FAM170A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with FAM170A: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM170A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FAM170A Gene

Localization for FAM170A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM170A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM170A Gene COMPARTMENTS Subcellular localization image for FAM170A gene
Compartment Confidence
nucleus 3
cytosol 1

Gene Ontology (GO) - Cellular Components for FAM170A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
genes like me logo Genes that share ontologies with FAM170A: view

Pathways for FAM170A Gene

SuperPathways for FAM170A Gene

No Data Available

Interacting Proteins for FAM170A Gene

Gene Ontology (GO) - Biological Process for FAM170A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription from RNA polymerase II promoter ISS --
GO:0045893 positive regulation of transcription, DNA-templated ISS --
genes like me logo Genes that share ontologies with FAM170A: view

No data available for Pathways by source for FAM170A Gene

Transcripts for FAM170A Gene

mRNA/cDNA for FAM170A Gene

(5) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM170A Gene

Family with sequence similarity 170, member A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM170A

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for FAM170A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM170A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5
SP1:
SP2: -

Relevant External Links for FAM170A Gene

GeneLoc Exon Structure for
FAM170A
ECgene alternative splicing isoforms for
FAM170A

Expression for FAM170A Gene

mRNA expression in normal human tissues for FAM170A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM170A Gene

This gene is overexpressed in Testis (44.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for FAM170A Gene

SOURCE GeneReport for Unigene cluster for FAM170A Gene Hs.713304

mRNA Expression by UniProt/SwissProt for FAM170A Gene

A1A519-F170A_HUMAN
Tissue specificity: Expressed strongly in testis and brain and weakly in prostate, spleen, pancreas and uterus.
genes like me logo Genes that share expressions with FAM170A: view

In Situ Assay Products

Orthologs for FAM170A Gene

This gene was present in the common ancestor of mammals.

Orthologs for FAM170A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM170A 35
  • 99.39 (n)
  • 99.09 (a)
FAM170A 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM170A 36
  • 73 (a)
OneToOne
LOC540403 35
  • 80.65 (n)
  • 72.95 (a)
dog
(Canis familiaris)
Mammalia FAM170A 35
  • 81.04 (n)
  • 75.86 (a)
FAM170A 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam170a 35
  • 81.61 (n)
  • 73.04 (a)
Fam170a 16
Fam170a 36
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM170A 36
  • 31 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM170A 36
  • 27 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam170a 35
  • 81.5 (n)
  • 77.5 (a)
Species with no ortholog for FAM170A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM170A Gene

ENSEMBL:
Gene Tree for FAM170A (if available)
TreeFam:
Gene Tree for FAM170A (if available)

Paralogs for FAM170A Gene

Paralogs for FAM170A Gene

Pseudogenes.org Pseudogenes for FAM170A Gene

genes like me logo Genes that share paralogs with FAM170A: view

Variants for FAM170A Gene

Sequence variations from dbSNP and Humsavar for FAM170A Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs167886 -- 119,630,362(-) aaccc(C/T)gtctc intron-variant
rs328692 -- 119,636,228(-) AGAGA(C/T)AGATG downstream-variant-500B
rs328693 -- 119,636,148(-) GTAGA(A/T)CACTT downstream-variant-500B
rs328694 - 119,634,265(-) AGAGG(A/G)GGGAG reference, missense
rs328695 -- 119,633,757(+) CCCCT(A/G)TATAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM170A Gene

Variant ID Type Subtype PubMed ID
nsv882777 CNV Loss 21882294

Relevant External Links for FAM170A Gene

HapMap Linkage Disequilibrium report
FAM170A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM170A Gene

Disorders for FAM170A Gene

Relevant External Links for FAM170A

Genetic Association Database (GAD)
FAM170A
genes like me logo Genes that share disorders with FAM170A: view

No data available for UniProtKB/Swiss-Prot for FAM170A Gene

Publications for FAM170A Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Isolation and characterization of a novel zinc finger gene, ZNFD, activating AP1(PMA) transcriptional activities. (PMID: 20162441) Lei C. … Wang M. (Mol. Cell. Biochem. 2010) 3 4
  3. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PMID: 17903296) Kiel D.P. … Karasik D. (BMC Med. Genet. 2007) 48
  4. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PMID: 17903299) Kathiresan S. … Cupples L.A. (BMC Med. Genet. 2007) 48
  5. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 4

Products for FAM170A Gene

Sources for FAM170A Gene

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