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Aliases for FAM170A Gene

Aliases for FAM170A Gene

  • Family With Sequence Similarity 170 Member A 2 3 5
  • Zinc Finger Domain-Containing Protein 3 4
  • Zinc Finger Protein ZNFD 3 4
  • ZNFD 3 4
  • Family With Sequence Similarity 170, Member A 2
  • Znf Domain Containing Protein 3
  • Protein FAM170A 3

External Ids for FAM170A Gene

Previous GeneCards Identifiers for FAM170A Gene

  • GC05P118994
  • GC05P114160

Summaries for FAM170A Gene

GeneCards Summary for FAM170A Gene

FAM170A (Family With Sequence Similarity 170 Member A) is a Protein Coding gene. An important paralog of this gene is FAM170B.

UniProtKB/Swiss-Prot for FAM170A Gene

  • Acts as a nuclear transcription factor that positively regulates the expression of heat shock genes. Binds to heat shock promoter elements (HSE).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM170A Gene

Genomics for FAM170A Gene

Regulatory Elements for FAM170A Gene

Enhancers for FAM170A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G119410 1.7 FANTOM5 Ensembl ENCODE dbSUPER 9.7 -217.8 -217792 2.1 HDAC1 PKNOX1 ATF1 RB1 ARNT ARID4B SIN3A ZNF2 RAD21 YY1 TNFAIP8 DTWD2 ENSG00000250678 RNU6-373P HSD17B4 FAM170A DMXL1 GC05P119446 LOC102723444
GH05G119417 1.4 Ensembl ENCODE dbSUPER 10.8 -210.1 -210104 3.5 HDAC1 YBX3 TBP PKNOX1 NFIB TBL1XR1 RAD21 ZNF766 GATA2 IKZF2 HSD17B4 FAM170A DTWD2 PTMAP2 GC05P119446 LOC102723444
GH05G119451 1.1 ENCODE 12.8 -176.6 -176598 2.2 HDGF PKNOX1 MLX CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 FAM170A HSD17B4 RPL21P58
GH05G119438 1.2 Ensembl ENCODE 11 -190.4 -190391 1.3 HDAC1 PKNOX1 FOXA2 ARID4B CHAMP1 YY1 TCF12 ZNF766 BCLAF1 CEBPB FAM170A GC05P119446 LOC102723444
GH05G119317 2 FANTOM5 Ensembl ENCODE dbSUPER 5.8 -298.0 -298013 27.1 CREB3L1 FEZF1 ZNF143 ZNF263 TBX21 MEF2D ZNF610 ZNF585B GLIS1 NBN TNFAIP8 DMXL1 LOC105379143 FAM170A HSD17B4 ENSG00000249426 GC05P119341 RN7SL174P GC05M119307
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM170A on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM170A Gene

Chromosome:
5
Start:
119,629,559 bp from pter
End:
119,635,822 bp from pter
Size:
6,264 bases
Orientation:
Plus strand

Genomic View for FAM170A Gene

Genes around FAM170A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM170A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM170A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM170A Gene

Proteins for FAM170A Gene

  • Protein details for FAM170A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A1A519-F170A_HUMAN
    Recommended name:
    Protein FAM170A
    Protein Accession:
    A1A519
    Secondary Accessions:
    • Q66LM8
    • Q7Z4V2
    • Q8IW94

    Protein attributes for FAM170A Gene

    Size:
    330 amino acids
    Molecular mass:
    37158 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH40622.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM170A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM170A Gene

Post-translational modifications for FAM170A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM170A Gene

No data available for DME Specific Peptides for FAM170A Gene

Domains & Families for FAM170A Gene

Protein Domains for FAM170A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM170A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A1A519

UniProtKB/Swiss-Prot:

F170A_HUMAN :
  • The N-terminus is necessary for nuclear localization. The C-terminus is necessary for transcriptional activity.
  • Belongs to the FAM170 family.
Domain:
  • The N-terminus is necessary for nuclear localization. The C-terminus is necessary for transcriptional activity.
Family:
  • Belongs to the FAM170 family.
genes like me logo Genes that share domains with FAM170A: view

No data available for Gene Families for FAM170A Gene

Function for FAM170A Gene

Molecular function for FAM170A Gene

UniProtKB/Swiss-Prot Function:
Acts as a nuclear transcription factor that positively regulates the expression of heat shock genes. Binds to heat shock promoter elements (HSE).

Gene Ontology (GO) - Molecular Function for FAM170A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with FAM170A: view

Phenotypes for FAM170A Gene

GenomeRNAi human phenotypes for FAM170A:
genes like me logo Genes that share phenotypes with FAM170A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM170A Gene

Localization for FAM170A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM170A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM170A gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for FAM170A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
genes like me logo Genes that share ontologies with FAM170A: view

Pathways & Interactions for FAM170A Gene

SuperPathways for FAM170A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM170A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter ISS --
GO:0045893 positive regulation of transcription, DNA-templated IEA,ISS --
genes like me logo Genes that share ontologies with FAM170A: view

No data available for Pathways by source and SIGNOR curated interactions for FAM170A Gene

Drugs & Compounds for FAM170A Gene

No Compound Related Data Available

Transcripts for FAM170A Gene

mRNA/cDNA for FAM170A Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM170A Gene

Family with sequence similarity 170, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM170A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5
SP1:
SP2: -

Relevant External Links for FAM170A Gene

GeneLoc Exon Structure for
FAM170A
ECgene alternative splicing isoforms for
FAM170A

Expression for FAM170A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM170A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM170A Gene

This gene is overexpressed in Testis (x44.8).

Protein differential expression in normal tissues from HIPED for FAM170A Gene

This gene is overexpressed in Pancreatic juice (52.1) and Plasma (12.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FAM170A Gene



Protein tissue co-expression partners for FAM170A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM170A Gene:

FAM170A

SOURCE GeneReport for Unigene cluster for FAM170A Gene:

Hs.713304

mRNA Expression by UniProt/SwissProt for FAM170A Gene:

A1A519-F170A_HUMAN
Tissue specificity: Expressed strongly in testis and brain and weakly in prostate, spleen, pancreas and uterus.

Evidence on tissue expression from TISSUES for FAM170A Gene

  • Nervous system(4.9)
  • Skin(3.4)
  • Blood(2.6)
genes like me logo Genes that share expression patterns with FAM170A: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM170A Gene

Orthologs for FAM170A Gene

This gene was present in the common ancestor of mammals.

Orthologs for FAM170A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM170A 34 35
  • 99.39 (n)
mouse
(Mus musculus)
Mammalia Fam170a 34 16 35
  • 81.61 (n)
rat
(Rattus norvegicus)
Mammalia Fam170a 34
  • 81.5 (n)
dog
(Canis familiaris)
Mammalia FAM170A 35 34
  • 81.04 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LOC540403 34
  • 80.65 (n)
FAM170A 35
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM170A 35
  • 31 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM170A 35
  • 27 (a)
OneToOne
Species where no ortholog for FAM170A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM170A Gene

ENSEMBL:
Gene Tree for FAM170A (if available)
TreeFam:
Gene Tree for FAM170A (if available)

Paralogs for FAM170A Gene

Paralogs for FAM170A Gene

Pseudogenes.org Pseudogenes for FAM170A Gene

genes like me logo Genes that share paralogs with FAM170A: view

Variants for FAM170A Gene

Sequence variations from dbSNP and Humsavar for FAM170A Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000300582 -- 119,635,615(+) CAAAA(C/T)AAAGG intron-variant
rs1000716691 -- 119,634,973(+) GAGAA(C/T)TTCAA intron-variant
rs1001173639 -- 119,630,477(+) GCCTG(A/G)GCCTT intron-variant
rs1001353768 -- 119,635,691(+) TTCTT(C/T)ACTTC intron-variant
rs1001662829 -- 119,631,600(+) TGATA(C/T)AGAGA intron-variant

Variation tolerance for FAM170A Gene

Residual Variation Intolerance Score: 93.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.09; 80.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM170A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM170A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FAM170A Gene

Disorders for FAM170A Gene

Relevant External Links for FAM170A

Genetic Association Database (GAD)
FAM170A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM170A

No disorders were found for FAM170A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM170A Gene

Publications for FAM170A Gene

  1. Isolation and characterization of a novel zinc finger gene, ZNFD, activating AP1(PMA) transcriptional activities. (PMID: 20162441) Lei C. … Wang M. (Mol. Cell. Biochem. 2010) 2 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PMID: 17903296) Kiel D.P. … Karasik D. (BMC Med. Genet. 2007) 46 64
  5. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PMID: 17903299) Kathiresan S. … Cupples L.A. (BMC Med. Genet. 2007) 46 64

Products for FAM170A Gene

Sources for FAM170A Gene

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