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Aliases for FAM169B Gene

Aliases for FAM169B Gene

  • Family With Sequence Similarity 169 Member B 2 3 5
  • Family With Sequence Similarity 169, Member B 2
  • KIAA0888L 4

External Ids for FAM169B Gene

Previous GeneCards Identifiers for FAM169B Gene

  • GC15M096797
  • GC15M098980
  • GC15M075108

Summaries for FAM169B Gene

GeneCards Summary for FAM169B Gene

FAM169B (Family With Sequence Similarity 169 Member B) is a Protein Coding gene. An important paralog of this gene is FAM169A.

Additional gene information for FAM169B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM169B Gene

Genomics for FAM169B Gene

Regulatory Elements for FAM169B Gene

Enhancers for FAM169B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15H098546 1.4 FANTOM5 ENCODE 0.7 -0.4 -440 2 PKNOX1 ARNT SIN3A FEZF1 GLI4 ZNF2 GLIS2 FOS SP3 TSHZ1 FAM169B GC15M098923
GH15H098977 0.3 FANTOM5 1.2 -429.3 -429281 0 PGPEP1L FAM169B PIR60140 LOC105371013
GH15H098519 1 Ensembl ENCODE 0.3 +28.4 28442 0 CTCF MXI1 MAX ZNF2 RAD21 GATA3 ZNF366 SMC3 ZNF143 DEK FAM169B LOC100421087
GH15H098555 0.7 ENCODE 0.4 -7.0 -6999 0 REST FEZF1 ZIC2 ZFHX2 GLIS1 PRDM1 SP7 TRIM28 EGR2 SETDB1 FAM169B GC15M098923
GH15H098554 0.7 ENCODE 0.4 -7.4 -7430 0 REST FEZF1 ZIC2 POLR2A GLIS1 PRDM10 PRDM1 SP7 TRIM28 EGR2 FAM169B GC15M098923
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM169B on UCSC Golden Path with GeneCards custom track

Promoters for FAM169B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000081689 -672 1201 PKNOX1 ARNT SIN3A FEZF1 GLI4 ZNF2 GLIS2 FOS SP3 TSHZ1

Genomic Location for FAM169B Gene

Chromosome:
15
Start:
98,437,162 bp from pter
End:
98,547,728 bp from pter
Size:
110,567 bases
Orientation:
Minus strand

Genomic View for FAM169B Gene

Genes around FAM169B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM169B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM169B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM169B Gene

Proteins for FAM169B Gene

  • Protein details for FAM169B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N8A8-F169B_HUMAN
    Recommended name:
    Protein FAM169B
    Protein Accession:
    Q8N8A8
    Secondary Accessions:
    • B5MDL8

    Protein attributes for FAM169B Gene

    Size:
    192 amino acids
    Molecular mass:
    21411 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM169B Gene

Post-translational modifications for FAM169B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM169B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM169B Gene

Domains & Families for FAM169B Gene

Gene Families for FAM169B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM169B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM169B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N8A8

UniProtKB/Swiss-Prot:

F169B_HUMAN :
  • Belongs to the FAM169 family.
Family:
  • Belongs to the FAM169 family.
genes like me logo Genes that share domains with FAM169B: view

Function for FAM169B Gene

Phenotypes From GWAS Catalog for FAM169B Gene

genes like me logo Genes that share phenotypes with FAM169B: view

Animal Model Products

CRISPR Products

miRNA for FAM169B Gene

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FAM169B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM169B Gene

Localization for FAM169B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM169B gene
Compartment Confidence
extracellular 3
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for FAM169B Gene

Pathways & Interactions for FAM169B Gene

SuperPathways for FAM169B Gene

No Data Available

Interacting Proteins for FAM169B Gene

Gene Ontology (GO) - Biological Process for FAM169B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM169B Gene

Drugs & Compounds for FAM169B Gene

No Compound Related Data Available

Transcripts for FAM169B Gene

mRNA/cDNA for FAM169B Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM169B Gene

Family with sequence similarity 169, member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FAM169B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for FAM169B Gene

No ASD Table

Relevant External Links for FAM169B Gene

GeneLoc Exon Structure for
FAM169B
ECgene alternative splicing isoforms for
FAM169B

Expression for FAM169B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM169B Gene

mRNA differential expression in normal tissues according to GTEx for FAM169B Gene

This gene is overexpressed in Liver (x16.9) and Pancreas (x7.2).

Protein differential expression in normal tissues from HIPED for FAM169B Gene

This gene is overexpressed in Lung (38.7) and Peripheral blood mononuclear cells (24.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM169B Gene



Protein tissue co-expression partners for FAM169B Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM169B Gene:

FAM169B

SOURCE GeneReport for Unigene cluster for FAM169B Gene:

Hs.668070
genes like me logo Genes that share expression patterns with FAM169B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM169B Gene

Orthologs for FAM169B Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for FAM169B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM169B 33
  • 97.92 (n)
Species where no ortholog for FAM169B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM169B Gene

ENSEMBL:
Gene Tree for FAM169B (if available)
TreeFam:
Gene Tree for FAM169B (if available)

Paralogs for FAM169B Gene

Paralogs for FAM169B Gene

(1) SIMAP similar genes for FAM169B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM169B: view

Variants for FAM169B Gene

Sequence variations from dbSNP and Humsavar for FAM169B Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000001029 -- 98,450,791(+) GCCTG(A/G)GCCCC intron-variant
rs1000029433 -- 98,489,839(+) GAGAA(A/C)CCTGA intron-variant
rs1000045592 -- 98,504,751(+) ATCCC(A/C)AACTC intron-variant
rs1000096998 -- 98,499,459(+) TGGAT(G/T)TCCAT intron-variant
rs1000112959 -- 98,442,806(+) TTCAC(A/C)TCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM169B Gene

Variant ID Type Subtype PubMed ID
esv3435433 CNV insertion 20981092
esv990309 CNV deletion 20482838
nsv1685 CNV insertion 18451855
nsv476937 CNV novel sequence insertion 20440878

Variation tolerance for FAM169B Gene

Residual Variation Intolerance Score: 96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.40; 27.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM169B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM169B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM169B Gene

Disorders for FAM169B Gene

Relevant External Links for FAM169B

Genetic Association Database (GAD)
FAM169B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM169B

No disorders were found for FAM169B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM169B Gene

Publications for FAM169B Gene

  1. Genome-wide association analysis of juvenile idiopathic arthritis identifies a new susceptibility locus at chromosomal region 3q13. (PMID: 22354554) Thompson SD … Glass DN (Arthritis and rheumatism 2012) 3 45 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Genome-wide population-based association study of extremely overweight young adults--the GOYA study. (PMID: 21935397) Paternoster L … Sørensen TI (PloS one 2011) 3 60
  4. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody MC … Nusbaum C (Nature 2006) 4 60

Products for FAM169B Gene

Sources for FAM169B Gene

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