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Aliases for FAM169B Gene

Aliases for FAM169B Gene

  • Family With Sequence Similarity 169 Member B 2 3 5
  • Family With Sequence Similarity 169, Member B 2
  • KIAA0888L 4

External Ids for FAM169B Gene

Previous GeneCards Identifiers for FAM169B Gene

  • GC15M096797
  • GC15M098980
  • GC15M075108

Summaries for FAM169B Gene

GeneCards Summary for FAM169B Gene

FAM169B (Family With Sequence Similarity 169 Member B) is a Protein Coding gene. An important paralog of this gene is FAM169A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM169B Gene

Genomics for FAM169B Gene

Regulatory Elements for FAM169B Gene

Enhancers for FAM169B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F098977 0.6 FANTOM5 1.2 -462.6 -462627 0.0 PGPEP1L FAM169B PIR60140 LOC105371013
GH15F098519 1.3 Ensembl ENCODE 0.8 -4.9 -4919 0.6 CTCF MAX ZNF2 RAD21 GATA3 ZNF366 ADNP ZNF143 SMC3 ZNF263 FAM169B ENSG00000283597
GH15F098503 1.3 Ensembl ENCODE 0.4 +9.8 9818 2.1 MAX CEBPB CEBPG MYC FAM169B LOC100421087
GH15F098505 0.5 ENCODE 0.4 +8.5 8456 0.2 MAX ZIC2 MYC FAM169B LOC100421087
GH15F098524 1 Ensembl ENCODE 0.4 -11.1 -11121 1.9 ZFHX2 FOXP2 MIXL1 FAM169B ENSG00000283597
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FAM169B on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM169B Gene

98,437,162 bp from pter
98,514,382 bp from pter
77,221 bases
Minus strand

Genomic View for FAM169B Gene

Genes around FAM169B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM169B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM169B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM169B Gene

Proteins for FAM169B Gene

  • Protein details for FAM169B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM169B
    Protein Accession:
    Secondary Accessions:
    • B5MDL8

    Protein attributes for FAM169B Gene

    192 amino acids
    Molecular mass:
    21411 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM169B Gene

Post-translational modifications for FAM169B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM169B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM169B Gene

Domains & Families for FAM169B Gene

Protein Domains for FAM169B Gene


Suggested Antigen Peptide Sequences for FAM169B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM169 family.
  • Belongs to the FAM169 family.
genes like me logo Genes that share domains with FAM169B: view

No data available for Gene Families for FAM169B Gene

Function for FAM169B Gene

genes like me logo Genes that share phenotypes with FAM169B: view

Animal Model Products

miRNA for FAM169B Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM169B Gene

Localization for FAM169B Gene

Subcellular locations from

Jensen Localization Image for FAM169B Gene COMPARTMENTS Subcellular localization image for FAM169B gene
Compartment Confidence
extracellular 3
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM169B Gene

Pathways & Interactions for FAM169B Gene

SuperPathways for FAM169B Gene

No Data Available

Interacting Proteins for FAM169B Gene

Gene Ontology (GO) - Biological Process for FAM169B Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM169B Gene

Transcripts for FAM169B Gene

mRNA/cDNA for FAM169B Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM169B Gene

Family with sequence similarity 169, member B:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM169B Gene

No ASD Table

Relevant External Links for FAM169B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM169B Gene

mRNA expression in normal human tissues for FAM169B Gene

mRNA differential expression in normal tissues according to GTEx for FAM169B Gene

This gene is overexpressed in Liver (x16.9) and Pancreas (x7.2).

Protein differential expression in normal tissues from HIPED for FAM169B Gene

This gene is overexpressed in Lung (38.7) and Peripheral blood mononuclear cells (24.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM169B Gene

Protein tissue co-expression partners for FAM169B Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM169B Gene:


SOURCE GeneReport for Unigene cluster for FAM169B Gene:

genes like me logo Genes that share expression patterns with FAM169B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FAM169B Gene

Orthologs for FAM169B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM169B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM169B 34 35
  • 97.92 (n)
(Bos Taurus)
Mammalia FAM169B 35
  • 35 (a)
(Monodelphis domestica)
Mammalia FAM169B 35
  • 26 (a)
(Canis familiaris)
Mammalia FAM169B 35
  • 24 (a)
(Gallus gallus)
Aves FAM169B 35
  • 26 (a)
(Anolis carolinensis)
Reptilia FAM169B 35
  • 40 (a)
(Danio rerio)
Actinopterygii fam169b 35
  • 20 (a)
Species where no ortholog for FAM169B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM169B Gene

Gene Tree for FAM169B (if available)
Gene Tree for FAM169B (if available)

Paralogs for FAM169B Gene

Paralogs for FAM169B Gene

(1) SIMAP similar genes for FAM169B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM169B: view

Variants for FAM169B Gene

Sequence variations from dbSNP and Humsavar for FAM169B Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs10400860 -- 98,442,564(+) AATGG(A/C)CACTA intron-variant
rs10451039 -- 98,470,767(+) acaca(C/T)tggaa intron-variant
rs10598914 -- 98,437,750(+) TGGAT(-/AGA)GGATG cds-indel
rs10902603 -- 98,487,722(+) AATCC(C/T)AGCAC intron-variant
rs111229710 -- 98,444,784(+) CCCCT(C/T)ACCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM169B Gene

Variant ID Type Subtype PubMed ID
esv3435433 CNV insertion 20981092
esv990309 CNV deletion 20482838
nsv1685 CNV insertion 18451855
nsv476937 CNV novel sequence insertion 20440878

Variation tolerance for FAM169B Gene

Residual Variation Intolerance Score: 96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.40; 27.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM169B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM169B Gene

Disorders for FAM169B Gene

Relevant External Links for FAM169B

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM169B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM169B Gene

Publications for FAM169B Gene

  1. Genome-wide association analysis of juvenile idiopathic arthritis identifies a new susceptibility locus at chromosomal region 3q13. (PMID: 22354554) Thompson S.D. … Glass D.N. (Arthritis Rheum. 2012) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Genome-wide population-based association study of extremely overweight young adults--the GOYA study. (PMID: 21935397) Paternoster L. … rensen T.I. (PLoS ONE 2011) 3 64
  4. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody M.C. … Nusbaum C. (Nature 2006) 4 64

Products for FAM169B Gene

Sources for FAM169B Gene

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