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FAM169B Gene

protein-coding   GIFtS: 36
GCID: GC15M098980

Family With Sequence Similarity 169, Member B

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 169, Member B1 2
Protein FAM169B2
KIAA0888L3

External Ids:    HGNC: 268351   Entrez Gene: 2837772   Ensembl: ENSG000001850877   UniProtKB: Q8N8A83   

Export aliases for FAM169B gene to outside databases

Previous GC identifers: GC15M096797 GC15M075108


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM169B Gene:
FAM169B (family with sequence similarity 169, member B) is a protein-coding gene. An important paralog of this gene is FAM169A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the FAM169B gene promoter:
         AML1a   FOXD3   Tal-1beta   NF-kappaB   E47   GATA-1   Evi-1   FOXJ2   NF-kappaB1   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FAM169B promoter sequence
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM169B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.3   Ensembl cytogenetic band:  15q26.3   HGNC cytogenetic band: 15q26.3

FAM169B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM169B gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M098980:  view genomic region     (about GC identifiers)

Start:
98,980,391 bp from pter      End:
99,057,611 bp from pter
Size:
77,221 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: F169B_HUMAN, Q8N8A8 (See protein sequence)
Recommended Name: Protein FAM169B  
Size: 192 amino acids; 21411 Da
Secondary accessions: B5MDL8

Explore the universe of human proteins at neXtProt for FAM169B: NX_Q8N8A8

Explore proteomics data for FAM169B at MOPED


See FAM169B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_872368.2  
ENSEMBL proteins: 
 ENSP00000453554   ENSP00000332615  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q8N8A8

UniProtKB/Swiss-Prot: F169B_HUMAN, Q8N8A8
Similarity: Belongs to the FAM169 family


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Phenotypes:
     3 GenomeRNAi human phenotypes for FAM169B:
 Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for FAM169B

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular3
mitochondrion1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM169B
Interactions:

    Search GeneGlobe Interaction Network for FAM169B

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for FAM169B (F169B)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for FAM169B gene: 
NM_182562.2  

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000558256(uc002buk.1) ENST00000332908
miRNA
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SwitchGear 3'UTR luciferase reporter plasmidFAM169B 3' UTR sequence
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3 AceView cDNA sequences:

AI239516 AK097062 NM_182562 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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FAM169B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
FAM169B Expression
About this image

FAM169B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

FAM169B Protein Expression
    Custom PCR Arrays for FAM169B
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM169B

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for FAM169B gene from Selected species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Fam169b5 family with sequence similarity 169, member B   --   7 (37.49 cM) 68273839 
chicken
(Gallus gallus)
Aves FAM169B6
family with sequence similarity 169, member B
26(a)
1 ↔ 1
10(16123491-16147538)
lizard
(Anolis carolinensis)
Reptilia FAM169B6
family with sequence similarity 169, member B
40(a)
1 ↔ 1
GL343363.1(1113441-1123045)
zebrafish
(Danio rerio)
Actinopterygii fam169b6
family with sequence similarity 169, member B
20(a)
1 ↔ 1
18(20840686-20845433) ENSDARG00000069321


ENSEMBL Gene Tree for FAM169B (if available)
TreeFam Gene Tree for FAM169B (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for FAM169B gene
FAM169A2  
1 SIMAP similar gene for FAM169B using alignment to 1 protein entry:     F169B_HUMAN:
FAM169A

Find genes that share paralogs with FAM169B           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for FAM169B (see all 1746)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 15 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1416545031,2
C--98979919(+) TAGCTA/GGGACT 1 -- ds50010--------
rs1837589231,2
--98979946(+) ACACCC/TGGCTG 1 -- ds50010--------
rs80352821,2
C,A--98980023(+) caagtG/Tatcca 1 -- ds50018Minor allele frequency- T:0.00NA WA CSA 133
rs1874015581,2
C--98980030(+) TCCACA/GTGCCT 1 -- ds50010--------
rs1436297791,2
--98980044(+) CCTCCA/CAAATT 1 -- ds50010--------
rs80303201,2
C,F,A--98980067(+) ggtgtG/Aagcca 1 -- ds50013Minor allele frequency- A:0.40WA 122
rs1480991151,2
--98980223(+) AAAGAC/TGTGCA 1 -- ds50010--------
rs1420031511,2
--98980266(+) GACCCC/TTGCAC 1 -- ds50010--------
rs1480270831,2
C--98980276(+) ACGGC-/CTCA  
        
CTCAC
1 -- ds50010--------
rs1502799561,2
C--98980424(+) AGTAAC/TTTCAT 1 -- ut310--------

HapMap Linkage Disequilibrium report for FAM169B (98980391 - 99057611 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for FAM169B:    About this table    
Variant IDTypeSubtypePubMed ID
esv990309CNV Deletion20482838
nsv1685CNV Insertion18451855
nsv904539CNV Loss21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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Find genes that share disorders with FAM169B           About GenesLikeMe

Genetic Association Database (GAD): FAM169B

Export disorders for FAM169B gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for FAM169B gene integrated from 10 sources:
(articles sorted by number of sources associating them with FAM169B)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Genome-wide association analysis of juvenile idiopathic arthritis identifies a new susceptibility locus at chromosomal region 3q13. (PubMed id 22354554)1, 4 Thompson S.D....Glass D.N. (Arthritis Rheum. 2012)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  3. Genome-wide population-based association study of extremely overweight young adults--the GOYA study. (PubMed id 21935397)1 Paternoster L....rensen T.I. (PLoS ONE 2011)
  4. Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)2 Zody M.C....Nusbaum C. (Nature 2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 283777 HGNC: 26835 AceView: FLJ39743 Ensembl:ENSG00000185087 euGenes: HUgn283777
ECgene: FAM169B H-InvDB: FAM169B

(According to HUGE)
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HUGE: KIAA0888L

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for FAM169B Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for FAM169B gene:
Search GeneIP for patents involving FAM169B

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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