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Aliases for FAM169A Gene

Aliases for FAM169A Gene

  • Family With Sequence Similarity 169, Member A 2 3
  • Protein FAM169A 3 4
  • SLAP75 3 4
  • Soluble Lamin-Associated Protein Of 75 KDa 3
  • Soluble Lamina-Associated Protein Of 75 KD 3
  • KIAA0888 4

External Ids for FAM169A Gene

Previous GeneCards Identifiers for FAM169A Gene

  • GC05M074111
  • GC05M069278

Summaries for FAM169A Gene

GeneCards Summary for FAM169A Gene

FAM169A (Family With Sequence Similarity 169, Member A) is a Protein Coding gene. An important paralog of this gene is FAM169B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM169A Gene

Genomics for FAM169A Gene

Regulatory Elements for FAM169A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM169A Gene

74,777,574 bp from pter
74,868,005 bp from pter
90,432 bases
Minus strand

Genomic View for FAM169A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM169A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM169A Gene

Proteins for FAM169A Gene

  • Protein details for FAM169A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Soluble lamin-associated protein of 75 kDa
    Protein Accession:
    Secondary Accessions:
    • A8K1T9
    • Q6MZT0
    • Q9H989

    Protein attributes for FAM169A Gene

    670 amino acids
    Molecular mass:
    74955 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA74911.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB14344.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAE45948.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM169A Gene


neXtProt entry for FAM169A Gene

Proteomics data for FAM169A Gene at MOPED

Post-translational modifications for FAM169A Gene

  • Ubiquitination at Lys226
  • Modification sites at PhosphoSitePlus

Other Protein References for FAM169A Gene

No data available for DME Specific Peptides for FAM169A Gene

Domains for FAM169A Gene

Protein Domains for FAM169A Gene


Suggested Antigen Peptide Sequences for FAM169A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM169 family.
  • Belongs to the FAM169 family.
genes like me logo Genes that share domains with FAM169A: view

No data available for Gene Families for FAM169A Gene

Function for FAM169A Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM169A

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM169A Gene

Localization for FAM169A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM169A Gene

Nucleus envelope. Nucleus inner membrane; Peripheral membrane protein; Nucleoplasmic side. Note=Enriched at the nuclear lamina.

Subcellular locations from

Jensen Localization Image for FAM169A Gene COMPARTMENTS Subcellular localization image for FAM169A gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for FAM169A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005637 nuclear inner membrane IEA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with FAM169A: view

Pathways for FAM169A Gene

SuperPathways for FAM169A Gene

No Data Available

Interacting Proteins for FAM169A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000373808 Q9Y6X4-F169A_HUMAN for FAM169A Gene via STRING I2D

Gene Ontology (GO) - Biological Process for FAM169A Gene


No data available for Pathways by source for FAM169A Gene

Transcripts for FAM169A Gene

Unigene Clusters for FAM169A Gene

Family with sequence similarity 169, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM169A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM169A Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - - -
SP2: -
SP3: - - -
SP4: - - - - -
SP5: - -
SP6: -

Relevant External Links for FAM169A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM169A Gene

mRNA expression in normal human tissues for FAM169A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM169A Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (4.4) and Brain - Anterior cingulate cortex (BA24) (4.2).

Protein differential expression in normal tissues for FAM169A Gene

This gene is overexpressed in Retina (31.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM169A Gene

SOURCE GeneReport for Unigene cluster for FAM169A Gene Hs.91662

genes like me logo Genes that share expressions with FAM169A: view

Expression partners for FAM169A Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FAM169A Gene

Orthologs for FAM169A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM169A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM169A 35
  • 90.3 (n)
  • 88.06 (a)
FAM169A 36
  • 88 (a)
(Canis familiaris)
Mammalia FAM169A 35
  • 91.59 (n)
  • 90.45 (a)
FAM169A 36
  • 90 (a)
(Mus musculus)
Mammalia Fam169a 35
  • 84.41 (n)
  • 80.3 (a)
Fam169a 16
Fam169a 36
  • 80 (a)
(Pan troglodytes)
Mammalia FAM169A 35
  • 99.7 (n)
  • 99.85 (a)
FAM169A 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Fam169a 35
  • 83.61 (n)
  • 78.88 (a)
(Monodelphis domestica)
Mammalia FAM169A 36
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia FAM169A 36
  • 68 (a)
(Gallus gallus)
Aves FAM169A 35
  • 64.55 (n)
  • 57.19 (a)
FAM169A 36
  • 54 (a)
(Anolis carolinensis)
Reptilia FAM169A 36
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam169a 35
  • 58.62 (n)
  • 50.78 (a)
(Danio rerio)
Actinopterygii wufe11a06 35
fam169aa 36
  • 41 (a)
fam169ab 36
  • 27 (a)
Species with no ortholog for FAM169A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM169A Gene

Gene Tree for FAM169A (if available)
Gene Tree for FAM169A (if available)

Paralogs for FAM169A Gene

Paralogs for FAM169A Gene

(1) SIMAP similar genes for FAM169A Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with FAM169A: view

Variants for FAM169A Gene

Sequence variations from dbSNP and Humsavar for FAM169A Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs15694 -- 74,777,717(+) GGAAA(A/G)GAATT utr-variant-3-prime, nc-transcript-variant
rs1051864 -- 74,780,038(-) TTCTA(C/T)TCTTT utr-variant-3-prime, nc-transcript-variant
rs1052058 -- 74,777,600(-) TCTTT(A/T)aaaaa utr-variant-3-prime, nc-transcript-variant
rs1146144 -- 74,781,093(+) TTAGT(A/C)TAAAA utr-variant-3-prime, nc-transcript-variant
rs1146145 -- 74,816,105(-) TGTTG(A/C)TGAGA intron-variant

Relevant External Links for FAM169A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FAM169A Gene

Disorders for FAM169A Gene

No disorders were found for FAM169A Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for FAM169A Gene

Publications for FAM169A Gene

  1. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells. (PMID: 22412018) Roux K.J. … Burke B. (J. Cell Biol. 2012) 3 4
  4. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4
  5. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PMID: 19413330) Gauci S. … Mohammed S. (Anal. Chem. 2009) 4

Products for FAM169A Gene

Sources for FAM169A Gene

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