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Aliases for FAM169A Gene

Aliases for FAM169A Gene

  • Family With Sequence Similarity 169 Member A 2 3 5
  • Soluble Lamina-Associated Protein Of 75 KD 2 3
  • Protein FAM169A 3 4
  • SLAP75 3 4
  • Family With Sequence Similarity 169, Member A 2
  • Soluble Lamin-Associated Protein Of 75 KDa 3
  • KIAA0888 4

External Ids for FAM169A Gene

Previous GeneCards Identifiers for FAM169A Gene

  • GC05M074111
  • GC05M069278

Summaries for FAM169A Gene

GeneCards Summary for FAM169A Gene

FAM169A (Family With Sequence Similarity 169 Member A) is a Protein Coding gene. An important paralog of this gene is FAM169B.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM169A Gene

Genomics for FAM169A Gene

Regulatory Elements for FAM169A Gene

Enhancers for FAM169A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G074684 1.3 FANTOM5 ENCODE 10.2 +180.9 180884 3.7 CREB3L1 ARID4B SIN3A YY1 ZNF766 FOS SP3 SP5 ZHX2 JUNB RNU6-658P RNU6-1330P FAM169A HEXB GC05M074726 ENC1
GH05G074764 1.4 ENCODE dbSUPER 6.9 +100.4 100416 3.9 HDGF PKNOX1 FOXA2 CREB3L1 ARNT ZFP64 WRNIP1 ARID4B SIN3A DMAP1 NSA2 RNU6-658P GFM2 FAM169A
GH05G074849 1.1 Ensembl ENCODE 6.1 +15.9 15861 3.6 ELF3 DMAP1 YY1 SCRT2 CEBPB KAT8 ATF4 CEBPA RCOR2 ETV4 NSA2 RNU6-1330P FAM169A GC05M074847 LOC441086
GH05G074864 1 ENCODE 4.8 -0.6 -620 6.2 FOXA2 ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 ETS1 GLIS2 GATA2 NSA2 RPS26P26 GFM2 FAM169A GC05M074884
GH05G074624 1.9 FANTOM5 Ensembl ENCODE dbSUPER 2.1 +237.9 237855 10.1 HDGF PKNOX1 FOXA2 SIN3A FEZF1 ZNF2 ZNF766 CBX5 FOS PAF1 ENC1 FAM169A HEXB LINC01331
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM169A on UCSC Golden Path with GeneCards custom track

Promoters for FAM169A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000182632 851 1401 TBP ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 GLIS2 SCRT2 CREM

Genomic Location for FAM169A Gene

Chromosome:
5
Start:
74,777,574 bp from pter
End:
74,866,951 bp from pter
Size:
89,378 bases
Orientation:
Minus strand

Genomic View for FAM169A Gene

Genes around FAM169A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM169A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM169A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM169A Gene

Proteins for FAM169A Gene

  • Protein details for FAM169A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6X4-F169A_HUMAN
    Recommended name:
    Soluble lamin-associated protein of 75 kDa
    Protein Accession:
    Q9Y6X4
    Secondary Accessions:
    • A8K1T9
    • Q6MZT0
    • Q9H989

    Protein attributes for FAM169A Gene

    Size:
    670 amino acids
    Molecular mass:
    74955 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA74911.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB14344.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAE45948.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM169A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM169A Gene

Post-translational modifications for FAM169A Gene

  • Ubiquitination at isoforms=226
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FAM169A Gene

Domains & Families for FAM169A Gene

Protein Domains for FAM169A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM169A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6X4

UniProtKB/Swiss-Prot:

F169A_HUMAN :
  • Belongs to the FAM169 family.
Family:
  • Belongs to the FAM169 family.
genes like me logo Genes that share domains with FAM169A: view

No data available for Gene Families for FAM169A Gene

Function for FAM169A Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM169A Gene

Localization for FAM169A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM169A Gene

Nucleus envelope. Nucleus inner membrane; Peripheral membrane protein; Nucleoplasmic side. Note=Enriched at the nuclear lamina.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM169A gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for FAM169A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope IEA --
GO:0005637 nuclear inner membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with FAM169A: view

Pathways & Interactions for FAM169A Gene

SuperPathways for FAM169A Gene

No Data Available

Interacting Proteins for FAM169A Gene

Gene Ontology (GO) - Biological Process for FAM169A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM169A Gene

Drugs & Compounds for FAM169A Gene

No Compound Related Data Available

Transcripts for FAM169A Gene

Unigene Clusters for FAM169A Gene

Family with sequence similarity 169, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM169A Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - - -
SP2: -
SP3: - - -
SP4: - - - - -
SP5: - -
SP6: -

Relevant External Links for FAM169A Gene

GeneLoc Exon Structure for
FAM169A
ECgene alternative splicing isoforms for
FAM169A

Expression for FAM169A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM169A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM169A Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.4) and Brain - Anterior cingulate cortex (BA24) (x4.2).

Protein differential expression in normal tissues from HIPED for FAM169A Gene

This gene is overexpressed in Retina (31.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM169A Gene



Protein tissue co-expression partners for FAM169A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM169A Gene:

FAM169A

SOURCE GeneReport for Unigene cluster for FAM169A Gene:

Hs.91662

Evidence on tissue expression from TISSUES for FAM169A Gene

  • Nervous system(4.5)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with FAM169A: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM169A Gene

Orthologs for FAM169A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM169A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM169A 34 35
  • 99.7 (n)
dog
(Canis familiaris)
Mammalia FAM169A 34 35
  • 91.59 (n)
cow
(Bos Taurus)
Mammalia FAM169A 34 35
  • 90.3 (n)
mouse
(Mus musculus)
Mammalia Fam169a 34 16 35
  • 84.41 (n)
rat
(Rattus norvegicus)
Mammalia Fam169a 34
  • 83.61 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FAM169A 35
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM169A 35
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM169A 34 35
  • 64.55 (n)
lizard
(Anolis carolinensis)
Reptilia FAM169A 35
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam169a 34
  • 58.62 (n)
zebrafish
(Danio rerio)
Actinopterygii fam169aa 35
  • 41 (a)
OneToMany
fam169ab 35
  • 27 (a)
OneToMany
wufe11a06 34
Species where no ortholog for FAM169A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM169A Gene

ENSEMBL:
Gene Tree for FAM169A (if available)
TreeFam:
Gene Tree for FAM169A (if available)

Paralogs for FAM169A Gene

Paralogs for FAM169A Gene

(1) SIMAP similar genes for FAM169A Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with FAM169A: view

Variants for FAM169A Gene

Sequence variations from dbSNP and Humsavar for FAM169A Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000044230 -- 74,866,638(+) CGCCC(A/T)GCTCA intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1000050933 -- 74,815,919(+) TTAGC(A/G)TATCA intron-variant
rs1000067812 -- 74,809,354(+) CTTTG(A/G)GAGGC intron-variant
rs1000147478 -- 74,834,098(+) CAGCA(A/T)CAGGA intron-variant
rs1000154054 -- 74,860,424(+) CACTA(A/T)ATTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM169A Gene

Variant ID Type Subtype PubMed ID
esv3329876 CNV insertion 20981092
nsv598653 CNV loss 21841781
nsv968949 CNV duplication 23825009

Variation tolerance for FAM169A Gene

Residual Variation Intolerance Score: 19.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.41; 27.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM169A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM169A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM169A Gene

Disorders for FAM169A Gene

Relevant External Links for FAM169A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM169A

No disorders were found for FAM169A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM169A Gene

Publications for FAM169A Gene

  1. A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells. (PMID: 22412018) Roux K.J. … Burke B. (J. Cell Biol. 2012) 2 3 4 64
  2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3 64
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64

Products for FAM169A Gene

Sources for FAM169A Gene

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