FAM169A Gene
protein-coding GIFtS: 41
GCID: GC05M074111
|
|
family with sequence similarity 169, member A
| |
Aliases
for FAM169A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Family With Sequence Similarity 169, Member A1 2 | | KIAA08881 3 | | Protein FAM169A2 3 | | SLAP752 3 | | Soluble Lamin-Associated Protein Of 75 KDa2 | | Soluble Lamina-Associated Protein Of 75 KD2 |
Export aliases for FAM169A gene to outside databasesPrevious GC identifer: GC05M069278 |
Summaries
for FAM169A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FAM169A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_006713.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FAM169A gene promoter:
HOXA9 HOXA9B Sox5 MyoD Cdc5 Evi-1 MZF-1 RORalpha1 Meis-1a Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM169A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM169A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q13.3 Ensembl cytogenetic band: 5q13.3 HGNC cytogenetic band: 5q13.3FAM169A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M074111: view genomic region
(about GC identifiers)
Start:
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74,073,399 bp from pter |
End:
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74,162,776 bp from pter |
Size:
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89,378 bases |
Orientation:
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minus strand |
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Proteins
for FAM169A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: F169A_HUMAN, Q9Y6X4 (See
protein sequence)Recommended Name: Soluble lamin-associated protein of 75 kDa Size: 670 amino acids; 74955 Da
Subcellular location: Nucleus envelope. Nucleus inner membrane; Peripheral membrane protein; Nucleoplasmic side.Note=Enriched at the nuclear lamina
Sequence caution: Sequence=BAA74911.1; Type=Erroneous initiation; Sequence=BAB14344.1; Type=Erroneous initiation;Sequence=CAE45948.1; Type=Erroneous initiation;
Secondary accessions: A8K1T9 Q6MZT0 Q9H989Alternative splicing: 2 isoforms: Q9Y6X4-1 Q9Y6X4-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for FAM169A: NX_Q9Y6X4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y6X4
FAM169A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_056381.1
ENSEMBL proteins: ENSP00000373808 ENSP00000425319 ENSP00000424578 ENSP00000423905 ENSP00000423631 ENSP00000423883 ENSP00000421451 ENSP00000369886
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005637 | nuclear inner membrane |
IEA | -- |
FAM169A for ontologies About GeneDecksing
FAM169A Antibody Products:
Assay Products for FAM169A: |
Protein
Domains /
Families
for FAM169A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9Y6X4 UniProtKB/Swiss-Prot: F169A_HUMAN, Q9Y6X4Similarity: Belongs to the FAM169 family |
Function
for FAM169A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM169A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM169A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FAM169A (NM_015566) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM169A | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FAM169A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM169A |
|
Pathways & Interactions
for FAM169A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM169A
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for FAM169A (Q9Y6X43 ENSP000003738084) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for FAM169A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM169A
Search CenterWatch for drugs/clinical trials and news about FAM169A / F169A
|
Transcripts
for FAM169A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAM169A gene: NM_015566.2 Unigene Cluster for FAM169A: Family with sequence similarity 169, member A Hs.91662 [show with all ESTs]Unigene Representative Sequence: CR9367918 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000389156(uc003kdm.3) ENST00000514215 ENST00000510496(uc010izm.3)
ENST00000510609(uc003kdl.3) ENST00000513277 ENST00000514200 ENST00000506954
ENST00000380515
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM169A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM169A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FAM169A (NM_015566) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM169A | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FAM169A |
Additional cDNA sequence: AB020695.1 AK022981.1 AK290004.1 BC040298.1 BC044766.1 BX640902.1 BX647536.1 CR936791.1 NR_046462.1 9 DOTS entries: DT.97862484 DT.441433 DT.310498 DT.101980448 DT.120814255 DT.120814521 DT.95346478 DT.40263646 DT.95194224 24/87 AceView cDNA sequences (see all 87): BX647536 BU685168 AK022981 BM693037 Z45867 AI638662 BU728711 AI001944 CB114685 CB117882 CA397371 BM552069 BU726376 BM982750 F04730 AA059295 BX103498 BI518969 AB020695 BM929460 AL133748 AA968586 CD656817 N52136
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for FAM169A (see all 6) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 |
|---|
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| SP1: | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FAM169A
|
Expression
for FAM169A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAM169A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGATGTTTC
About this image
See FAM169A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM169A
SOURCE GeneReport for Unigene cluster: Hs.91662
SABiosciences Custom PCR Arrays for FAM169A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM169A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat FAM169A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM169A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM169A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM169A |
Orthologs
for FAM169A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for FAM169A gene from 4/11 species (see all 11) About this table
ENSEMBL Gene Tree for FAM169A (if available)
TreeFam Gene Tree for FAM169A (if available) |
Paralogs
for FAM169A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAM169A gene
- FAM169B2
1 SIMAP similar gene for FAM169A using alignment to 6 protein entries: F169A_HUMAN (see all proteins):FAM169B
FAM169A for paralogs About GeneDecksing
|
Genomic Variants
for FAM169A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM169A (74073399 - 74162776 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FAM169A
1 Indel: 40766 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM169A |
|
Disorders
/ Diseases
for FAM169A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for FAM169A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM169A gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with FAM169A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2, 3 Nagase T....Ohara O. (1998)
- A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells. (PubMed id 22412018)1, 2 Roux K.J.... Burke B. (2012)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
|
External Searches for FAM169A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FAM169A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM169A gene
(According to HUGE)
About This Section
| |
Specialized Databases showing FAM169A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAM169A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FAM169A gene:
Search GeneIP for patents involving FAM169A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM169A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | Browse OriGene 29mer shRNA kits in GFP-retroviral vector | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM169A | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FAM169A | | OriGene 3'-UTR Clone for FAM169A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM169A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM169A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FAM169A | | OriGene Custom Protein Services for FAM169A | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM169A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM169A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM169A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM169A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM169A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM169A |
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| | | | Search Tocris compounds for FAM169A |
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 | | | FAM169A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM169A |
|  |  |  | | | | ThermoFisher Antibodies for FAM169A |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FAM169A |
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