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Aliases for FAM169A Gene

Aliases for FAM169A Gene

  • Family With Sequence Similarity 169 Member A 2 3 5
  • Soluble Lamina-Associated Protein Of 75 KD 2 3
  • Protein FAM169A 3 4
  • SLAP75 3 4
  • Family With Sequence Similarity 169, Member A 2
  • Soluble Lamin-Associated Protein Of 75 KDa 3
  • KIAA0888 4

External Ids for FAM169A Gene

Previous GeneCards Identifiers for FAM169A Gene

  • GC05M074111
  • GC05M069278

Summaries for FAM169A Gene

GeneCards Summary for FAM169A Gene

FAM169A (Family With Sequence Similarity 169 Member A) is a Protein Coding gene. An important paralog of this gene is FAM169B.

Additional gene information for FAM169A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM169A Gene

Genomics for FAM169A Gene

GeneHancer (GH) Regulatory Elements for FAM169A Gene

Promoters and enhancers for FAM169A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I074864 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 554.9 -0.6 -619 6.2 FOXA2 ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 ETS1 GLIS2 ATF7 FAM169A LOC441086 NSA2 RPS26P26 GFM2 GC05M074884
GH05I074684 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 10.2 +180.9 180883 3.6 ARID4B SIN3A YY1 POLR2B ZNF766 FOS SP3 SP5 ZHX2 REST HEXB ENSG00000272040 RNU6-658P RNU6-1330P FAM169A GC05M074726 ENC1
GH05I074764 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 6.9 +100.4 100415 3.9 ZFP64 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 ZC3H11A MEF2D NSA2 GFM2 RPS26P26 POLK POC5 ENSG00000272040 RNU6-658P FAM169A
GH05I074849 Enhancer 1 Ensembl ENCODE 6.1 +15.9 15860 3.6 ELF3 DMAP1 YY1 SCRT2 CEBPB KAT8 NFIL3 ATF4 RCOR2 ETV4 NSA2 RNU6-1330P FAM169A GC05M074847 LOC441086
GH05I074624 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 2.1 +237.9 237855 10.1 HDGF FOXA2 SMAD1 ARNT NEUROD1 SIN3A FEZF1 IRF4 ZNF766 ZNF213 ENC1 ENSG00000272040 RPS26P26 FAM169A HEXB LINC01331
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM169A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM169A gene promoter:

Genomic Locations for FAM169A Gene

Genomic Locations for FAM169A Gene
89,378 bases
Minus strand

Genomic View for FAM169A Gene

Genes around FAM169A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM169A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM169A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM169A Gene

Proteins for FAM169A Gene

  • Protein details for FAM169A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Soluble lamin-associated protein of 75 kDa
    Protein Accession:
    Secondary Accessions:
    • A8K1T9
    • Q6MZT0
    • Q9H989

    Protein attributes for FAM169A Gene

    670 amino acids
    Molecular mass:
    74955 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA74911.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB14344.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAE45948.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM169A Gene


neXtProt entry for FAM169A Gene

Post-translational modifications for FAM169A Gene

No data available for DME Specific Peptides for FAM169A Gene

Domains & Families for FAM169A Gene

Gene Families for FAM169A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM169A Gene


Suggested Antigen Peptide Sequences for FAM169A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM169 family.
  • Belongs to the FAM169 family.
genes like me logo Genes that share domains with FAM169A: view

Function for FAM169A Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM169A Gene

Localization for FAM169A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM169A Gene

Nucleus envelope. Nucleus inner membrane; Peripheral membrane protein; Nucleoplasmic side. Note=Enriched at the nuclear lamina.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM169A gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (4)
  • Cytosol (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FAM169A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope IEA --
GO:0005637 nuclear inner membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with FAM169A: view

Pathways & Interactions for FAM169A Gene

SuperPathways for FAM169A Gene

No Data Available

Interacting Proteins for FAM169A Gene

Gene Ontology (GO) - Biological Process for FAM169A Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM169A Gene

Drugs & Compounds for FAM169A Gene

No Compound Related Data Available

Transcripts for FAM169A Gene

Unigene Clusters for FAM169A Gene

Family with sequence similarity 169, member A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM169A Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - - -
SP2: -
SP3: - - -
SP4: - - - - -
SP5: - -
SP6: -

Relevant External Links for FAM169A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM169A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM169A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM169A Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.4) and Brain - Anterior cingulate cortex (BA24) (x4.2).

Protein differential expression in normal tissues from HIPED for FAM169A Gene

This gene is overexpressed in Retina (31.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM169A Gene

Protein tissue co-expression partners for FAM169A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM169A Gene:


SOURCE GeneReport for Unigene cluster for FAM169A Gene:


Evidence on tissue expression from TISSUES for FAM169A Gene

  • Nervous system(4.5)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with FAM169A: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM169A Gene

Orthologs for FAM169A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM169A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM169A 33 34
  • 99.7 (n)
(Canis familiaris)
Mammalia FAM169A 33 34
  • 91.59 (n)
(Bos Taurus)
Mammalia FAM169A 33 34
  • 90.3 (n)
(Mus musculus)
Mammalia Fam169a 33 16 34
  • 84.41 (n)
(Rattus norvegicus)
Mammalia Fam169a 33
  • 83.61 (n)
(Ornithorhynchus anatinus)
Mammalia FAM169A 34
  • 68 (a)
(Monodelphis domestica)
Mammalia FAM169A 34
  • 63 (a)
(Gallus gallus)
Aves FAM169A 33 34
  • 64.55 (n)
(Anolis carolinensis)
Reptilia FAM169A 34
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam169a 33
  • 58.62 (n)
(Danio rerio)
Actinopterygii fam169aa 34
  • 41 (a)
fam169ab 34
  • 27 (a)
wufe11a06 33
Species where no ortholog for FAM169A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM169A Gene

Gene Tree for FAM169A (if available)
Gene Tree for FAM169A (if available)

Paralogs for FAM169A Gene

Paralogs for FAM169A Gene

(1) SIMAP similar genes for FAM169A Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with FAM169A: view

Variants for FAM169A Gene

Sequence variations from dbSNP and Humsavar for FAM169A Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000044230 -- 74,866,638(-) A/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000050933 -- 74,815,919(-) A/G intron_variant
rs1000067812 -- 74,809,354(-) G/A intron_variant
rs1000147478 -- 74,834,098(-) A/T intron_variant
rs1000154054 -- 74,860,424(-) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM169A Gene

Variant ID Type Subtype PubMed ID
esv3329876 CNV insertion 20981092
nsv598653 CNV loss 21841781
nsv968949 CNV duplication 23825009

Variation tolerance for FAM169A Gene

Residual Variation Intolerance Score: 19.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.41; 27.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM169A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM169A Gene

Disorders for FAM169A Gene

Additional Disease Information for FAM169A

No disorders were found for FAM169A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM169A Gene

Publications for FAM169A Gene

  1. A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells. (PMID: 22412018) Roux KJ … Burke B (The Journal of cell biology 2012) 2 3 4 58
  2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert JP … Gingras AC (Journal of proteomics 2015) 3 58

Products for FAM169A Gene

Sources for FAM169A Gene

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