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Aliases for FAM169A Gene

Aliases for FAM169A Gene

  • Family With Sequence Similarity 169, Member A 2 3
  • Protein FAM169A 3 4
  • SLAP75 3 4
  • Soluble Lamina-Associated Protein Of 75 KD 3
  • KIAA0888 4

External Ids for FAM169A Gene

Previous GeneCards Identifiers for FAM169A Gene

  • GC05M074111
  • GC05M069278

Summaries for FAM169A Gene

GeneCards Summary for FAM169A Gene

FAM169A (Family With Sequence Similarity 169, Member A) is a Protein Coding gene. An important paralog of this gene is FAM169B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM169A Gene

Genomics for FAM169A Gene

Regulatory Elements for FAM169A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM169A Gene

Chromosome:
5
Start:
74,777,574 bp from pter
End:
74,866,951 bp from pter
Size:
89,378 bases
Orientation:
Minus strand

Genomic View for FAM169A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM169A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM169A Gene

Proteins for FAM169A Gene

  • Protein details for FAM169A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6X4-F169A_HUMAN
    Recommended name:
    Soluble lamin-associated protein of 75 kDa
    Protein Accession:
    Q9Y6X4
    Secondary Accessions:
    • A8K1T9
    • Q6MZT0
    • Q9H989

    Protein attributes for FAM169A Gene

    Size:
    670 amino acids
    Molecular mass:
    74955 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA74911.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB14344.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAE45948.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM169A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM169A Gene

Proteomics data for FAM169A Gene at MOPED

Post-translational modifications for FAM169A Gene

  • Ubiquitination at Lys 226
  • Modification sites at PhosphoSitePlus

Other Protein References for FAM169A Gene

No data available for DME Specific Peptides for FAM169A Gene

Domains & Families for FAM169A Gene

Protein Domains for FAM169A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM169A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6X4

UniProtKB/Swiss-Prot:

F169A_HUMAN :
  • Belongs to the FAM169 family.
Family:
  • Belongs to the FAM169 family.
genes like me logo Genes that share domains with FAM169A: view

No data available for Gene Families for FAM169A Gene

Function for FAM169A Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM169A

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM169A Gene

Localization for FAM169A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM169A Gene

Nucleus envelope. Nucleus inner membrane; Peripheral membrane protein; Nucleoplasmic side. Note=Enriched at the nuclear lamina.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM169A Gene COMPARTMENTS Subcellular localization image for FAM169A gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for FAM169A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005637 nuclear inner membrane IEA --
genes like me logo Genes that share ontologies with FAM169A: view

Pathways & Interactions for FAM169A Gene

SuperPathways for FAM169A Gene

No Data Available

Interacting Proteins for FAM169A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000373808%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: Q9Y6X4-F169A_HUMAN ENSP00000373808 for FAM169A Gene via I2D STRING

Gene Ontology (GO) - Biological Process for FAM169A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM169A Gene

Drugs & Compounds for FAM169A Gene

No Compound Related Data Available

Transcripts for FAM169A Gene

Unigene Clusters for FAM169A Gene

Family with sequence similarity 169, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM169A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM169A Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - - -
SP2: -
SP3: - - -
SP4: - - - - -
SP5: - -
SP6: -

Relevant External Links for FAM169A Gene

GeneLoc Exon Structure for
FAM169A
ECgene alternative splicing isoforms for
FAM169A

Expression for FAM169A Gene

mRNA expression in normal human tissues for FAM169A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM169A Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.4) and Brain - Anterior cingulate cortex (BA24) (x4.2).

Protein differential expression in normal tissues from HIPED for FAM169A Gene

This gene is overexpressed in Retina (31.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM169A Gene



SOURCE GeneReport for Unigene cluster for FAM169A Gene Hs.91662

genes like me logo Genes that share expression patterns with FAM169A: view

Protein tissue co-expression partners for FAM169A Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FAM169A Gene

Orthologs for FAM169A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM169A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAM169A 35
  • 90.3 (n)
  • 88.06 (a)
FAM169A 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM169A 35
  • 91.59 (n)
  • 90.45 (a)
FAM169A 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam169a 35
  • 84.41 (n)
  • 80.3 (a)
Fam169a 16
Fam169a 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM169A 35
  • 99.7 (n)
  • 99.85 (a)
FAM169A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam169a 35
  • 83.61 (n)
  • 78.88 (a)
oppossum
(Monodelphis domestica)
Mammalia FAM169A 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM169A 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM169A 35
  • 64.55 (n)
  • 57.19 (a)
FAM169A 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM169A 36
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam169a 35
  • 58.62 (n)
  • 50.78 (a)
zebrafish
(Danio rerio)
Actinopterygii wufe11a06 35
fam169aa 36
  • 41 (a)
OneToMany
fam169ab 36
  • 27 (a)
OneToMany
Species with no ortholog for FAM169A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM169A Gene

ENSEMBL:
Gene Tree for FAM169A (if available)
TreeFam:
Gene Tree for FAM169A (if available)

Paralogs for FAM169A Gene

Paralogs for FAM169A Gene

(1) SIMAP similar genes for FAM169A Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with FAM169A: view

Variants for FAM169A Gene

Variation tolerance for FAM169A Gene

Residual Variation Intolerance Score: 19.64% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.41; 27.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM169A Gene

HapMap Linkage Disequilibrium report
FAM169A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for FAM169A Gene

Disorders for FAM169A Gene

Relevant External Links for FAM169A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM169A
genes like me logo Genes that share disorders with FAM169A: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM169A Gene

Publications for FAM169A Gene

  1. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 67
  2. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  3. A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells. (PMID: 22412018) Roux K.J. … Burke B. (J. Cell Biol. 2012) 67
  4. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 67
  5. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt K.T. … Blagoev B. (Sci. Signal. 2011) 67

Products for FAM169A Gene

Sources for FAM169A Gene

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