FAM168B Gene
protein-coding GIFtS: 44
GCID: GC02M131805
|
|
family with sequence similarity 168, member B
| |
Aliases
for FAM168B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Family With Sequence Similarity 168, Member B1 2 | | Myelin-Associated Neurite-Outgrowth Inhibitor2 | | KIAA0280L1 3 | | Protein FAM168B2 | | MANI2 3 | | Mani3 | | P201 | | |
Export aliases for FAM168B gene to outside databasesPrevious GC identifers: GC02M131524 GC02M123873 |
Summaries
for FAM168B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: F168B_HUMAN, A1KXE4Function: Modulates neuronal axonal outgrowth by acting as a negative regulator of CDC42 and STAT3 and a positiveregulator of STMN2. Positive regulator of CDC27 (By similarity)
|
Genomic Views
for FAM168B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022135.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FAM168B gene promoter:
AhR E4BP4 Arnt
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM168B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM168B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q21.1 Ensembl cytogenetic band: 2q21.1 HGNC cytogenetic band: 2q21.1FAM168B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M131805: view genomic region
(about GC identifiers)
Start:
|
131,805,449 bp from pter |
End:
|
131,851,033 bp from pter |
Size:
|
45,585 bases |
Orientation:
|
minus strand |
|
Proteins
for FAM168B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: F168B_HUMAN, A1KXE4 (See
protein sequence)Recommended Name: Myelin-associated neurite-outgrowth inhibitor Size: 195 amino acids; 20324 Da
Subunit: May form homodimers. May interact with DAZAP2, FAM168A, PRDX6, RBM6, TMTC1 and YPEL2. Interacts with CDC27
Subcellular location: Cytoplasm, perinuclear region (By similarity). Cell membrane; Multi-pass membrane protein (Bysimilarity). Cell projection, axon (By similarity). Note=Expressed in neuronal cell bodies and axonal fibers (Bysimilarity)
Secondary accessions: Q2TAZ6 Q6NZ40Alternative splicing: 2 isoforms: A1KXE4-1 A1KXE4-2 Explore the universe of human proteins at neXtProt for FAM168B: NX_A1KXE4
Post-translational modifications:
N-glycosylated (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A1KXE4
FAM168B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001009993.2
ENSEMBL proteins: ENSP00000387051 ENSP00000374565
Human Recombinant Protein Products for FAM168B:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
FAM168B for ontologies About GeneDecksing
FAM168B Antibody Products:
Assay Products for FAM168B: |
Protein
Domains /
Families
for FAM168B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: A1KXE4 UniProtKB/Swiss-Prot: F168B_HUMAN, A1KXE4Similarity: Belongs to the FAM168 protein family |
Function
for FAM168B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: F168B_HUMAN, A1KXE4Function: Modulates neuronal axonal outgrowth by acting as a negative regulator of CDC42 and STAT3 and a positiveregulator of STMN2. Positive regulator of CDC27 (By similarity)Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM168B (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM168B
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FAM168B (NM_001009993) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM168B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM168B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM168B |
|
Pathways & Interactions
for FAM168B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM168B
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
2 Interacting proteins for FAM168B (A1KXE42, 3 ENSP000003745654) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for FAM168B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM168B
Search CenterWatch for drugs/clinical trials and news about FAM168B / F168B
|
Transcripts
for FAM168B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAM168B gene: NM_001009993.2 Unigene Cluster for FAM168B: Family with sequence similarity 168, member B Hs.534679 [show with all ESTs]Unigene Representative Sequence: NM_0010099932 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000409185(uc002tsd.3) ENST00000389915
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM168B (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM168B
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FAM168B (NM_001009993) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM168B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM168B |
Additional cDNA sequence: AK022529.1 AK023868.1 AL137406.1 AL137413.1 AL833819.1 AY253283.1 BC035115.1 BC066347.1 BC110642.1 BC127804.1 BX647486.1 23 DOTS entries: DT.92053523 DT.101955989 DT.95155687 DT.99969272 DT.120980780 DT.95207827 DT.100667079 DT.120981186 DT.101969909 DT.120981368 DT.91846690 DT.120981245 DT.120981392 DT.92034728 DT.100667080 DT.91760223 DT.91842552 DT.100667076 DT.102837983 DT.120980723 DT.120981333 DT.91783289 DT.91808163
GeneLoc Exon Structure
|
Expression
for FAM168B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAM168B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCAAGGAATG
About this image
See FAM168B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM168B
SOURCE GeneReport for Unigene cluster: Hs.534679
UniProtKB/Swiss-Prot: F168B_HUMAN, A1KXE4Tissue specificity: Expressed in the brain, within neuronal axonal fibers and associated with myelin sheets (at proteinlevel). Expression tends to be lower in the brain of Alzheimer disease patients compared to healthy individuals (atprotein level)
SABiosciences Custom PCR Arrays for FAM168B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM168B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FAM168B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM168B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM168B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM168B |
Orthologs
for FAM168B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for FAM168B gene from 4/10 species (see all 10) About this table
ENSEMBL Gene Tree for FAM168B (if available)
TreeFam Gene Tree for FAM168B (if available) |
Paralogs
for FAM168B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAM168B gene
- FAM168A2
1 SIMAP similar gene for FAM168B using alignment to 1 protein entry: F168B_HUMAN:FAM168A
FAM168B for paralogs About GeneDecksing
|
Genomic Variants
for FAM168B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM168B (131805449 - 131851033 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for FAM168B
1 CNV: 3393
5 Indels: 97977 12095 45856 42179 33704 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM168B |
|
Disorders
/ Diseases
for FAM168B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FAM168B for disorders About GeneDecksing
2  diseases for FAM168B: About MalaCardsalzheimer's disease neuronitis
Export disorders for FAM168B gene to outside databases
|
Publications
for FAM168B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM168B gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM168B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The novel protein MANI modulates neurogenesis and neu rite-cone growth. (PubMed id 20716133)1, 2 Mishra M....Heese K. (2011)
- Characterizing the neurite outgrowth inhibitory effect of Mani. (PubMed id 22771904)2 Mishra M.... Heese K. (2012)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for FAM168B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FAM168B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM168B gene
(According to HUGE)
About This Section
| |
Specialized Databases showing FAM168B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAM168B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FAM168B gene:
Search GeneIP for patents involving FAM168B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM168B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FAM168B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM168B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM168B | | | OriGene Protein Over-expression Lysate for FAM168B | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for FAM168B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM168B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM168B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FAM168B | | OriGene Custom Protein Services for FAM168B | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM168B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM168B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM168B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM168B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM168B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM168B |
| |
 |  |  |  | |
| | | | Search Tocris compounds for FAM168B |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | FAM168B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM168B |
|  |  |  |  | | | | ThermoFisher Antibodies for FAM168B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM168B |
| |  | |
|
|
|
