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Aliases for FAM168B Gene

Aliases for FAM168B Gene

  • Family With Sequence Similarity 168 Member B 2 3 5
  • MANI 3 4
  • Myelin Associated Neurite Outgrowth Inhibitor 2
  • Family With Sequence Similarity 168, Member B 2
  • Myelin-Associated Neurite-Outgrowth Inhibitor 3
  • Protein FAM168B 3
  • KIAA0280L 4
  • P20 4

External Ids for FAM168B Gene

Previous GeneCards Identifiers for FAM168B Gene

  • GC02M131524
  • GC02M131805
  • GC02M123873

Summaries for FAM168B Gene

GeneCards Summary for FAM168B Gene

FAM168B (Family With Sequence Similarity 168 Member B) is a Protein Coding gene. An important paralog of this gene is FAM168A.

UniProtKB/Swiss-Prot for FAM168B Gene

  • Modulates neuronal axonal outgrowth by acting as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27 (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM168B Gene

Genomics for FAM168B Gene

Regulatory Elements for FAM168B Gene

Enhancers for FAM168B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F131092 0.5 Ensembl ENCODE 0.8 -0.3 -251 3.2 HDGF CREB3L1 ARID4B SIN3A YY1 ZNF143 SP5 ZHX2 REST TBX21 ENSG00000227632 FAM168B PIR44934
GH02F131076 0.6 ENCODE 0.3 +16.5 16518 0.2 SAP130 ATF3 CEBPA CREB1 ZBTB33 RAD21 NR2F2 YY1 PLEKHB2 PIR46037 FAM168B
GH02F131077 0.4 ENCODE 0.3 +16.0 16029 0.8 NFIA SAP130 RAD21 NR2F2 YY1 ATF3 CEBPA CREB1 ZBTB33 PLEKHB2 PIR46037 FAM168B
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FAM168B on UCSC Golden Path with GeneCards custom track

Promoters for FAM168B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001546415 360 2601 CREB3L1 ARID4B SIN3A YY1 ZNF143 SP5 ZHX2 REST SREBF1 SSRP1

Transcription factor binding sites by QIAGEN in the FAM168B gene promoter:

Genomic Location for FAM168B Gene

131,047,876 bp from pter
131,093,460 bp from pter
45,585 bases
Minus strand

Genomic View for FAM168B Gene

Genes around FAM168B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM168B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM168B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM168B Gene

Proteins for FAM168B Gene

  • Protein details for FAM168B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Myelin-associated neurite-outgrowth inhibitor
    Protein Accession:
    Secondary Accessions:
    • Q2TAZ6
    • Q6NZ40

    Protein attributes for FAM168B Gene

    195 amino acids
    Molecular mass:
    20324 Da
    Quaternary structure:
    • May form homodimers. May interact with DAZAP2, FAM168A, PRDX6, RBM6, TMTC1 and YPEL2. Interacts with CDC27.

    Alternative splice isoforms for FAM168B Gene


neXtProt entry for FAM168B Gene

Post-translational modifications for FAM168B Gene

No data available for DME Specific Peptides for FAM168B Gene

Domains & Families for FAM168B Gene

Protein Domains for FAM168B Gene


Suggested Antigen Peptide Sequences for FAM168B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM168 family.
  • Belongs to the FAM168 family.
genes like me logo Genes that share domains with FAM168B: view

No data available for Gene Families for FAM168B Gene

Function for FAM168B Gene

Molecular function for FAM168B Gene

UniProtKB/Swiss-Prot Function:
Modulates neuronal axonal outgrowth by acting as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27 (By similarity).

Phenotypes for FAM168B Gene

GenomeRNAi human phenotypes for FAM168B:
genes like me logo Genes that share phenotypes with FAM168B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for FAM168B

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM168B Gene

Localization for FAM168B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM168B Gene

Cytoplasm, perinuclear region. Cell membrane; Multi-pass membrane protein. Cell projection, axon. Note=Expressed in neuronal cell bodies and axonal fibers. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for FAM168B Gene COMPARTMENTS Subcellular localization image for FAM168B gene
Compartment Confidence
extracellular 5
plasma membrane 3
mitochondrion 2
cytosol 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FAM168B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030424 axon IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with FAM168B: view

Pathways & Interactions for FAM168B Gene

SuperPathways for FAM168B Gene

No Data Available

Interacting Proteins for FAM168B Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: A1KXE4-F168B_HUMAN ENSP00000374565 for FAM168B Gene via MINT STRING IID

Gene Ontology (GO) - Biological Process for FAM168B Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM168B Gene

Transcripts for FAM168B Gene

mRNA/cDNA for FAM168B Gene

(10) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM168B Gene

Family with sequence similarity 168, member B:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM168B Gene

No ASD Table

Relevant External Links for FAM168B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM168B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM168B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM168B Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM168B Gene:


SOURCE GeneReport for Unigene cluster for FAM168B Gene:


mRNA Expression by UniProt/SwissProt for FAM168B Gene:

Tissue specificity: Expressed in the brain, within neuronal axonal fibers and associated with myelin sheets (at protein level). Expression tends to be lower in the brain of Alzheimer disease patients compared to healthy individuals (at protein level).
genes like me logo Genes that share expression patterns with FAM168B: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Protein tissue co-expression partners for FAM168B Gene

Orthologs for FAM168B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM168B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM168B 34 35
  • 99.83 (n)
(Monodelphis domestica)
Mammalia FAM168B 35
  • 97 (a)
(Bos Taurus)
Mammalia FAM168B 34 35
  • 93.41 (n)
(Canis familiaris)
Mammalia FAM168B 34 35
  • 93.33 (n)
(Mus musculus)
Mammalia Fam168b 34 16 35
  • 91.58 (n)
(Rattus norvegicus)
Mammalia Fam168b 34
  • 91.24 (n)
(Ornithorhynchus anatinus)
Mammalia FAM168B 35
  • 79 (a)
(Gallus gallus)
Aves FAM168B 34 35
  • 84.44 (n)
(Anolis carolinensis)
Reptilia FAM168B 35
  • 96 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam168b 34
  • 80.34 (n)
(Danio rerio)
Actinopterygii fam168b 34 35
  • 76.98 (n)
Species where no ortholog for FAM168B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM168B Gene

Gene Tree for FAM168B (if available)
Gene Tree for FAM168B (if available)

Paralogs for FAM168B Gene

Paralogs for FAM168B Gene

(1) SIMAP similar genes for FAM168B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM168B: view

Variants for FAM168B Gene

Sequence variations from dbSNP and Humsavar for FAM168B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10167343 -- 131,055,869(+) TGTGT(A/G)CGTGT intron-variant
rs10201624 -- 131,050,896(+) CCGCT(C/G)AAAGG intron-variant, utr-variant-3-prime
rs10206085 -- 131,048,325(+) TGCAC(A/G)GGGAC intron-variant, utr-variant-3-prime
rs10208629 -- 131,078,706(+) ATTCT(A/G)ggccg intron-variant
rs10496683 -- 131,071,065(+) GGAAA(C/T)GAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM168B Gene

Variant ID Type Subtype PubMed ID
dgv2032n106 OTHER inversion 24896259
dgv4074n100 CNV gain 25217958
dgv4075n100 CNV gain 25217958
dgv616e201 CNV deletion 23290073
dgv731e199 CNV deletion 23128226
esv2157663 CNV deletion 18987734
esv2497466 CNV deletion 19546169
esv2576731 CNV deletion 19546169
esv2670824 CNV deletion 23128226
esv2720778 CNV deletion 23290073
esv2759092 CNV gain+loss 17122850
esv2760576 CNV gain+loss 21179565
esv3560142 CNV deletion 23714750
esv3831 CNV loss 18987735
esv3893337 CNV loss 25118596
nsv1000507 CNV gain 25217958
nsv1005040 CNV gain 25217958
nsv1005763 CNV gain 25217958
nsv1014723 CNV loss 25217958
nsv10179 CNV loss 18304495
nsv1072455 CNV deletion 25765185
nsv1118882 CNV deletion 24896259
nsv1147463 OTHER inversion 26484159
nsv214458 CNV deletion 16902084
nsv428404 CNV loss 18775914
nsv524021 CNV loss 19592680
nsv583135 CNV loss 21841781
nsv7327 OTHER inversion 18451855
nsv953168 CNV deletion 24416366

Variation tolerance for FAM168B Gene

Residual Variation Intolerance Score: 32.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.71; 15.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM168B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM168B Gene

Disorders for FAM168B Gene

Relevant External Links for FAM168B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM168B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM168B Gene

Publications for FAM168B Gene

  1. The novel protein MANI modulates neurogenesis and neurite-cone growth. (PMID: 20716133) Mishra M. … Heese K. (J. Cell. Mol. Med. 2011) 2 3 4 64
  2. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3 64
  3. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  4. Characterizing the neurite outgrowth inhibitory effect of Mani. (PMID: 22771904) Mishra M. … Heese K. (FEBS Lett. 2012) 4 64
  5. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PMID: 19413330) Gauci S. … Mohammed S. (Anal. Chem. 2009) 4 64

Products for FAM168B Gene

Sources for FAM168B Gene

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