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FAM168B Gene

protein-coding   GIFtS: 45
GCID: GC02M131805

Family With Sequence Similarity 168, Member B

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 168, Member B1 2     Protein FAM168B2
MANI2 3     KIAA0280L3
p202 3     Mani3
Myelin-Associated Neurite-Outgrowth Inhibitor2     

External Ids:    HGNC: 270161   Entrez Gene: 1300742   Ensembl: ENSG000001521027   UniProtKB: A1KXE43   

Export aliases for FAM168B gene to outside databases

Previous GC identifers: GC02M131524 GC02M123873


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM168B Gene:
FAM168B (family with sequence similarity 168, member B) is a protein-coding gene. Diseases associated with FAM168B include alzheimer's disease, and neuronitis. An important paralog of this gene is FAM168A.

UniProtKB/Swiss-Prot: F168B_HUMAN, A1KXE4
Function: Modulates neuronal axonal outgrowth by acting as a negative regulator of CDC42 and STAT3 and a positive
regulator of STMN2. Positive regulator of CDC27 (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAM168B gene promoter:
         AhR   E4BP4   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM168B promoter sequence
   Search Chromatin IP Primers for FAM168B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM168B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q21.1   Ensembl cytogenetic band:  2q21.1   HGNC cytogenetic band: 2q21.1

FAM168B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM168B gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M131805:  view genomic region     (about GC identifiers)

Start:
131,805,449 bp from pter      End:
131,851,033 bp from pter
Size:
45,585 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: F168B_HUMAN, A1KXE4 (See protein sequence)
Recommended Name: Myelin-associated neurite-outgrowth inhibitor  
Size: 195 amino acids; 20324 Da
Subunit: May form homodimers. May interact with DAZAP2, FAM168A, PRDX6, RBM6, TMTC1 and YPEL2. Interacts with
CDC27
Secondary accessions: Q2TAZ6 Q6NZ40
Alternative splicing: 2 isoforms:  A1KXE4-1   A1KXE4-2   

Explore the universe of human proteins at neXtProt for FAM168B: NX_A1KXE4

Explore proteomics data for FAM168B at MOPED

Post-translational modifications: 

  • N-glycosylated (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FAM168B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001009993.2  
    ENSEMBL proteins: 
     ENSP00000387051   ENSP00000374565  

    FAM168B Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for FAM168B

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    FAM168B Assay Products:

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    Cloud-Clone Corp. ELISAs for FAM168B
    Cloud-Clone Corp. CLIAs for FAM168B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: A1KXE4

    UniProtKB/Swiss-Prot: F168B_HUMAN, A1KXE4
    Similarity: Belongs to the FAM168 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: F168B_HUMAN, A1KXE4
    Function: Modulates neuronal axonal outgrowth by acting as a negative regulator of CDC42 and STAT3 and a positive
    regulator of STMN2. Positive regulator of CDC27 (By similarity)

    Animal Models:

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAM168B
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FAM168B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FAM168B

    miRNA
    Products:
        
    miRTarBase miRNAs that target FAM168B:
    hsa-mir-92a-3p (MIRT049312), hsa-mir-26b-5p (MIRT029136), hsa-mir-330-3p (MIRT043832), hsa-mir-421 (MIRT039434), hsa-mir-1226-3p (MIRT036535), hsa-mir-23b-3p (MIRT046272), hsa-mir-331-3p (MIRT043304)

    Block miRNA regulation of human, mouse, rat FAM168B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FAM168B (see all 135):
    hsa-miR-640 hsa-miR-1245 hsa-miR-134 hsa-miR-3653 hsa-miR-519a hsa-miR-149 hsa-miR-208b hsa-miR-200b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FAM168B

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for FAM168B (see all 7)
    OriGene ORF clones in mouse, rat for FAM168B
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    GenScript: all cDNA clones in your preferred vector: FAM168B (NM_001009993)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM168B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM168B

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM168B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    F168B_HUMAN, A1KXE4: Cytoplasm, perinuclear region (By similarity). Cell membrane; Multi-pass membrane protein
    (By similarity). Cell projection, axon (By similarity). Note=Expressed in neuronal cell bodies and axonal fibers
    (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    mitochondrion2
    cytosol1
    extracellular1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--
    GO:0030424axon IEA--
    GO:0048471perinuclear region of cytoplasm IEA--

    FAM168B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM168B
    Interactions:

        Search GeneGlobe Interaction Network for FAM168B

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for FAM168B (A1KXE42, 3 ENSP000003745654) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PARP2Q9UGN52, 3, ENSP000002504164MINT-8202046 I2D: score=1 STRING: ENSP00000250416
    --P031882MINT-6770231
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM168B (F168B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FAM168B gene: 
    NM_001009993.2  

    Unigene Cluster for FAM168B:

    Family with sequence similarity 168, member B
    Hs.534679  [show with all ESTs]
    Unigene Representative Sequence: NM_001009993
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409185(uc002tsd.3) ENST00000389915

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FAM168B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FAM168B (see all 135):
    hsa-miR-640 hsa-miR-1245 hsa-miR-134 hsa-miR-3653 hsa-miR-519a hsa-miR-149 hsa-miR-208b hsa-miR-200b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for FAM168B
    Predesigned siRNA for gene silencing in human, mouse, rat FAM168B
    Clone
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    OriGene clones in human, mouse for FAM168B (see all 7)
    OriGene ORF clones in mouse, rat for FAM168B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FAM168B (NM_001009993)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM168B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM168B
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for FAM168B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FAM168B
      QuantiTect SYBR Green Assays in human, mouse, rat FAM168B
      QuantiFast Probe-based Assays in human, mouse, rat FAM168B

    Additional mRNA sequence: 

    AK022529.1 AK023868.1 AL137406.1 AL137413.1 AL833819.1 AY253283.1 BC035115.1 BC066347.1 
    BC110642.1 BC127804.1 BX647486.1 

    23 DOTS entries:

    DT.92053523  DT.101955989  DT.95155687  DT.99969272  DT.120980780  DT.95207827  DT.100667079  DT.120981186 
    DT.101969909  DT.120981368  DT.91846690  DT.120981245  DT.120981392  DT.92034728  DT.100667080  DT.91760223 
    DT.91842552  DT.100667076  DT.102837983  DT.120980723  DT.120981333  DT.91783289  DT.91808163 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM168B expression in normal human tissues (normalized intensities)      FAM168B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAAGGAATG
    FAM168B Expression
    About this image


    FAM168B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Ovary (Reproductive System)
    FAM168B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM168B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.534679

    UniProtKB/Swiss-Prot: F168B_HUMAN, A1KXE4
    Tissue specificity: Expressed in the brain, within neuronal axonal fibers and associated with myelin sheets (at
    protein level). Expression tends to be lower in the brain of Alzheimer disease patients compared to healthy
    individuals (at protein level)

        Custom PCR Arrays for FAM168B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM168B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FAM168B gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam168b1 , 5 family with sequence similarity 168, member B1, 5 91.58(n)1
    97.94(a)1
      1 (13.34 cM)5
    2144691  NM_001160236.11  NP_001153708.11 
     348132215 
    chicken
    (Gallus gallus)
    Aves FAM168B1 family with sequence similarity 168, member B 84.44(n)
    97.95(a)
      424759  XM_422581.4  XP_422581.1 
    lizard
    (Anolis carolinensis)
    Reptilia FAM168B6
    family with sequence similarity 168, member B
    96(a)
    1 ↔ 1
    3(37505000-37510515)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fam168b1 family with sequence similarity 168, member B 80.34(n)
    92.31(a)
      779648  NM_001078734.1  NP_001072202.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fam168b1 family with sequence similarity 168, member B 76.98(n)
    86.6(a)
      561051  NM_001076569.1  NP_001070037.1 


    ENSEMBL Gene Tree for FAM168B (if available)
    TreeFam Gene Tree for FAM168B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM168B gene
    FAM168A2  
    1 SIMAP similar gene for FAM168B using alignment to 1 protein entry:     F168B_HUMAN:
    FAM168A

    FAM168B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM168B (see all 946)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1143671081,2
    F--131805399(+) GGCCAT/CGCTAC 1 -- int11Minor allele frequency- C:0.03WA 118
    rs788674231,2
    C,F--131805402(+) CATGCT/CACCTC 1 -- int11Minor allele frequency- C:0.03WA 118
    rs1819029421,2
    --131805577(+) AATAGC/TATCAA 1 -- ut310--------
    rs1387705351,2
    C--131805602(+) AACTGA/GCTCAG 1 -- ut310--------
    rs1489576111,2
    --131805625(+) ATTCCA/TTGGCA 1 -- ut310--------
    rs1861282061,2
    --131805815(+) TCTCCA/GTGTGG 1 -- ut310--------
    rs102060851,2
    C,F,H--131805898(+) TGCACA/GGGGAC 1 -- ut31 ese35Minor allele frequency- G:0.01NS EA CSA 394
    rs1905014611,2
    --131805982(+) CCCGGG/TGGGGG 1 -- ut310--------
    rs115412201,2
    C,F--131805984(+) CGGGGC/G/TGGGGT 2 -- ut317MN WA NA CSA EA 547
    rs1813430011,2
    --131806091(+) TTCTTC/GAAATA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for FAM168B (131805449 - 131851033 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FAM168B (see all 19):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2576731CNV Deletion19546169
    esv2670824CNV Deletion23128226
    dgv659e201CNV Deletion23290073
    dgv731e199CNV Deletion23128226
    esv2157663CNV Deletion18987734
    esv2497466CNV Deletion19546169
    esv3831CNV Deletion18987735
    esv2720778CNV Deletion23290073
    nsv428404CNV Loss18775914
    nsv10179CNV Loss18304495

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FAM168B
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for FAM168B:    About MalaCards
    alzheimer's disease    neuronitis


    FAM168B for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Export disorders for FAM168B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM168B gene integrated from 10 sources:
    (articles sorted by number of sources associating them with FAM168B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The novel protein MANI modulates neurogenesis and neurite-cone growth. (PubMed id 20716133)1, 2 Mishra M.... Heese K. (J. Cell. Mol. Med. 2011)
    2. Characterizing the neurite outgrowth inhibitory effect of Mani. (PubMed id 22771904)2 Mishra M.... Heese K. (FEBS Lett. 2012)
    3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    4. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 130074 HGNC: 27016 Ensembl:ENSG00000152102 euGenes: HUgn130074 ECgene: FAM168B
    H-InvDB: FAM168B

    (According to HUGE)
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    HUGE: KIAA0280L

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM168B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM168B gene:
    Search GeneIP for patents involving FAM168B

    GeneCards and IP:
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