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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAM168A Gene

protein-coding   GIFtS: 42
GCID: GC11M073111

Family With Sequence Similarity 168, Member A

(Previous name: KIAA0280)
(Previous symbol: KIAA0280)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Family With Sequence Similarity 168, Member A1 2
KIAA02801 2 3
Tongue Cancer Chemotherapy Resistance-Associated Protein 11 2 3
TCRP12 3
Protein FAM168A2

External Ids:    HGNC: 289991   Entrez Gene: 232012   Ensembl: ENSG000000549657   UniProtKB: Q925673   

Export aliases for FAM168A gene to outside databases

Previous GC identifers: GC11U901028 GC11M072795 GC11M073117 GC11M069412


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FAM168A Gene: 
FAM168A (family with sequence similarity 168, member A) is a protein-coding gene. Diseases associated with FAM168A include tongue cancer, and oral squamous cell carcinoma. An important paralog of this gene is FAM168B.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FAM168A gene promoter:
         AhR   E2F-3a   E2F-4   E2F-5   E2F-2   NF-kappaB   E2F-1   E2F   FOXC1   NF-kappaB1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for FAM168A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM168A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.4   Ensembl cytogenetic band:  11q13.4   HGNC cytogenetic band: 11q13.4

FAM168A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM168A gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M073111:  view genomic region     (about GC identifiers)

Start:
73,111,532 bp from pter      End:
73,309,234 bp from pter
Size:
197,703 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: F168A_HUMAN, Q92567 (See protein sequence)
Recommended Name: Protein FAM168A  
Size: 244 amino acids; 26184 Da
Subunit: May interact with FAM168B
Sequence caution: Sequence=BAA13408.1; Type=Erroneous initiation;
Secondary accessions: A2ICY2 A2ID81 Q86UG2
Alternative splicing: 3 isoforms:  Q92567-1   Q92567-2   Q92567-3   

Explore the universe of human proteins at neXtProt for FAM168A: NX_Q92567

Explore proteomics data for FAM168A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q92567

  • FAM168A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FAM168A Protein Expression
    REFSEQ proteins: NP_055974.1  
    ENSEMBL proteins: 
     ENSP00000064778   ENSP00000390501   ENSP00000348852  

    Human Recombinant Protein Products for FAM168A: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q92567

    UniProtKB/Swiss-Prot: F168A_HUMAN, Q92567
    Similarity: Belongs to the FAM168 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         3 GenomeRNAi human phenotypes for FAM168A:
     Decreased cell number  Decreased viability of wild-ty  Increased cell size 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FAM168A 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM168A

    3 Interacting proteins for FAM168A (Q925672, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FBXW5Q969U63I2D: score=1 
    SS18L1O751773I2D: score=1 
    --D4AEP32MINT-8383573
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FAM168A (F168A)

    Search CenterWatch for drugs/clinical trials and news about FAM168A / F168A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FAM168A gene: 
    NM_015159.1  

    Unigene Cluster for FAM168A:

    Family with sequence similarity 168, member A
    Hs.475334  [show with all ESTs]
    Unigene Representative Sequence: D87470
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000064778(uc001otz.1) ENST00000450446 ENST00000356467(uc001oty.1 uc009ytp.1)
    ENST00000432223
    miRNA
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    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate FAM168A (see all 28):
    hsa-miR-579 hsa-miR-142-5p hsa-miR-448 hsa-miR-520d-5p hsa-miR-106a hsa-miR-1244 hsa-miR-499-5p hsa-miR-93
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FAM168A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM168A
    Clone
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    OriGene clones in human, mouse for FAM168A (see all 6)
    OriGene ORF clones in mouse, rat for FAM168A
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    GenScript: all cDNA clones in your preferred vector: FAM168A (NM_015159)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM168A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM168A
    Sirion Biotech Customized lentivirus for stable overexpression of FAM168A 
                         Customized lentivirus expression plasmids for stable overexpression of FAM168A 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM168A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM168A

    Additional mRNA sequence: 

    AK292054.1 BC014932.1 BC052341.1 D87470.1 EF197985.1 EF363480.1 

    9 DOTS entries:

    DT.452639  DT.95165154  DT.100779225  DT.95153821  DT.95165156  DT.91655226  DT.91754879  DT.91898471 
    DT.91989642 

    24/254 AceView cDNA sequences (see all 254):

    BM466565 BE304367 AA401045 AV703145 AW193292 AA401014 BQ059958 BX113950 
    BC052341 AA400949 R87483 F12242 T32809 BU634205 BX956934 AA402209 
    BM693487 BX479837 BU624583 Z40501 AI393713 Z44208 AW294058 AI672411 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for FAM168A    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
    SP1:                          -                                       
    SP2:                          -     -                                 
    SP3:                                                                  


    ECgene alternative splicing isoforms for FAM168A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FAM168A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTTGCCTG
    FAM168A Expression
    About this image


    See FAM168A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FAM168A

    SOURCE GeneReport for Unigene cluster: Hs.475334
        SABiosciences Custom PCR Arrays for FAM168A
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM168A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM168A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FAM168A gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam168a1 , 5 family with sequence similarity 168, member A1, 5 94.89(n)1
    100(a)1
      7 (54.39 cM)5
    3196041  NM_178764.31  NP_848879.11 
     1007067025 
    chicken
    (Gallus gallus)
    Aves FAM168A1 family with sequence similarity 168, member A 81.28(n)
    94.89(a)
      419066  XM_417256.3  XP_417256.1 
    lizard
    (Anolis carolinensis)
    Reptilia FAM168A6
    family with sequence similarity 168, member A
    93(a)
    1 ↔ 1
    GL343489.1(46081-228441)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.131762 Xenopus laevis transcribed sequences 81.69(n)    BX846189.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc28c052 Transcribed sequences 74.52(n)    57048198 


    ENSEMBL Gene Tree for FAM168A (if available)
    TreeFam Gene Tree for FAM168A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FAM168A gene
    FAM168B2  
    1 SIMAP similar gene for FAM168A using alignment to 1 protein entry:     F168A_HUMAN:
    FAM168B

    FAM168A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3643 SNPs in FAM168A are shown (see all 3643)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1857013851,2
    --73116543(+) TTACTC/GTAAGG 1 -- int10--------
    rs122774101,2
    F,H--73116547(+) tgtaaG/Cgtcta 1 -- int1 ese35Minor allele frequency- C:0.07NS EA WA 536
    rs1905598701,2
    --73116554(+) TCTAGA/GGAAGT 1 -- int10--------
    rs1176874301,2
    C,F--73116610(+) GAAATG/TGATGA 1 -- int11Minor allele frequency- T:0.03NA 120
    rs1399486891,2
    --73116657(+) TGAAAC/TGTTTA 1 -- int10--------
    rs1925099401,2
    --73116692(+) CCTCAC/GCTTCA 1 -- int10--------
    rs1498269901,2
    --73116726(+) TGTGGA/TTCCTT 1 -- int10--------
    rs1129553201,2
    C--73117115(+) AGCACC/TGCTCC 1 -- ut310--------
    rs1835933661,2
    --73117134(+) TCCCTC/TTCCTT 1 -- ut310--------
    rs1468477321,2
    --73117221(+) TTAAGC/TTGCTA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for FAM168A (73111532 - 73309234 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for FAM168A:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2677115CNV Deletion23128226
    nsv389CNV Insertion18451855
    esv271125CNV Insertion20981092
    nsv38888CNV Insertion16902084
    esv22737CNV Loss19812545
    nsv508641CNV Loss20534489
    nsv520130CNV Gain19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    3 diseases for FAM168A:    About MalaCards
    tongue cancer    oral squamous cell carcinoma    squamous cell carcinoma

    1 disease from the University of Copenhagen DISEASES database for FAM168A:
    Tongue cancer

    FAM168A for disorders           About GeneDecksing


    Export disorders for FAM168A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FAM168A gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with FAM168A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1, 2 Nagase T....Nomura N. (1996)
    3. Bcl2-associated Athanogene 3 Interactome Analysis Reve als a New Role in Modulating Proteasome Activity. (PubMed id 23824909)1 Chen Y....Ge F. (2013)
    4. Microarray-assisted pathway analysis identifies MT1X & amp; NFkB as mediators of TCRP1-associated resistance to cisplatin in oral squam ous cell carcinoma. (PubMed id 23251525)1 Peng B....He Z. (2012)
    5. Genome-wide joint meta-analysis of SNP and SNP-by-smok ing interaction identifies novel loci for pulmonary function. (PubMed id 23284291)1 Hancock D.B....London S.J. (2012)
    6. Purification and biochemical characterization of a nov el protein-tongue cancer chemotherapy resistance-associated protein1 (TCRP1). (PubMed id 22365988)1 Peng B....He Z. (2012)
    7. Characterizing the neurite outgrowth inhibitory effect of Mani. (PubMed id 22771904)2 Mishra M.... Heese K. (2012)
    8. TCRP1 promotes radioresistance of oral squamous cell carcinoma cells via Akt signal pathway. (PubMed id 21603883)1 Gu Y....He Z. (2011)
    9. Cloning and functional characterization of TCRP1, a n ovel gene mediating resistance to cisplatin in an oral squamous cell carcinoma cell line. (PubMed id 21334329)1 Gu Y....He Z. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23201 HGNC: 28999 AceView: KIAA0280 Ensembl:ENSG00000054965 euGenes: HUgn23201
    ECgene: FAM168A H-InvDB: FAM168A

    (According to HUGE)
    About This Section
    HUGE: KIAA0280

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FAM168A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FAM168A gene:
    Search GeneIP for patents involving FAM168A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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