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Aliases for FAM168A Gene

Aliases for FAM168A Gene

  • Family With Sequence Similarity 168 Member A 2 3 5
  • Tongue Cancer Chemotherapy Resistance-Associated Protein 1 2 3 4
  • KIAA0280 2 3 4
  • TCRP1 3 4
  • Family With Sequence Similarity 168, Member A 2
  • Protein FAM168A 3

External Ids for FAM168A Gene

Previous HGNC Symbols for FAM168A Gene

  • KIAA0280

Previous GeneCards Identifiers for FAM168A Gene

  • GC11U901028
  • GC11M072795
  • GC11M073117
  • GC11M069412
  • GC11M073111

Summaries for FAM168A Gene

GeneCards Summary for FAM168A Gene

FAM168A (Family With Sequence Similarity 168 Member A) is a Protein Coding gene. Diseases associated with FAM168A include Tongue Cancer and Oral Squamous Cell Carcinoma. An important paralog of this gene is FAM168B.

UniProtKB/Swiss-Prot for FAM168A Gene

  • In cancer context, protects cells from induced-DNA damage and apoptosis. Acts, at least in part, through PI3K/AKT/NFKB signaling pathway and by preventing POLB degradation. Decreases POLB ubiquitation and stabilizes its protein levels.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM168A Gene

Genomics for FAM168A Gene

Regulatory Elements for FAM168A Gene

Enhancers for FAM168A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F073461 1.2 Ensembl ENCODE 17.3 +135.0 134960 4.1 TBP ELF3 ATF1 ARID4B DMAP1 RAD21 YY1 RARA FOS ETV6 FAM168A ARHGEF17 ENSG00000256448 RELT ENSG00000255786 GC11M073483
GH11F073413 1.2 FANTOM5 Ensembl ENCODE 16.6 +183.2 183189 2.4 PKNOX1 CBX3 MTA2 CBX5 IKZF1 SP7 TCF7L2 RELT FAM168A ARHGEF17 ENSG00000255928 PIR54238 PIR45238
GH11F073537 1.1 Ensembl ENCODE 17.9 +59.5 59489 3.0 PKNOX1 ESRRA BACH1 RAD21 ZNF316 CTBP1 GATA3 POLR2A FOS RCOR1 ARHGEF17 FAM168A RELT PLEKHB1 ENSG00000256448 MRPL48 ENSG00000255928 GC11M073518 HMGN2P38
GH11F073428 1.2 Ensembl ENCODE 15.9 +168.7 168678 1.3 ELF3 PKNOX1 ARID4B RAD21 YY1 RARA ZNF335 CREM THAP11 ZHX1 FAM168A ENSG00000256448 RELT ARHGEF17 PIR52508 ENSG00000255786
GH11F073527 1.1 Ensembl ENCODE 17.3 +69.7 69689 1.8 DDX20 ZMYM3 ZNF175 PTRF BACH1 PYGO2 NFXL1 RELA ZFHX2 EGR2 ARHGEF17 FAM168A RELT ENSG00000255928 GC11M073518 HMGN2P38
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM168A on UCSC Golden Path with GeneCards custom track

Promoters for FAM168A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000565242 -111 2201 HDGF PKNOX1 MLX CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2

Genomic Location for FAM168A Gene

Chromosome:
11
Start:
73,400,478 bp from pter
End:
73,598,189 bp from pter
Size:
197,712 bases
Orientation:
Minus strand

Genomic View for FAM168A Gene

Genes around FAM168A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM168A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM168A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM168A Gene

Proteins for FAM168A Gene

  • Protein details for FAM168A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92567-F168A_HUMAN
    Recommended name:
    Protein FAM168A
    Protein Accession:
    Q92567
    Secondary Accessions:
    • A2ICY2
    • A2ID81
    • Q86UG2

    Protein attributes for FAM168A Gene

    Size:
    244 amino acids
    Molecular mass:
    26184 Da
    Quaternary structure:
    • Interacts with POLB (PubMed:25260657). Interacts with AKT1 and MT1X (PubMed:23251525). May interact with FAM168B (PubMed:22771904).
    SequenceCaution:
    • Sequence=BAA13408.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM168A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM168A Gene

Post-translational modifications for FAM168A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM168A Gene

No data available for DME Specific Peptides for FAM168A Gene

Domains & Families for FAM168A Gene

Protein Domains for FAM168A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM168A Gene

Graphical View of Domain Structure for InterPro Entry

Q92567

UniProtKB/Swiss-Prot:

F168A_HUMAN :
  • Belongs to the FAM168 family.
Family:
  • Belongs to the FAM168 family.
genes like me logo Genes that share domains with FAM168A: view

No data available for Gene Families for FAM168A Gene

Function for FAM168A Gene

Molecular function for FAM168A Gene

UniProtKB/Swiss-Prot Function:
In cancer context, protects cells from induced-DNA damage and apoptosis. Acts, at least in part, through PI3K/AKT/NFKB signaling pathway and by preventing POLB degradation. Decreases POLB ubiquitation and stabilizes its protein levels.

Gene Ontology (GO) - Molecular Function for FAM168A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with FAM168A: view
genes like me logo Genes that share phenotypes with FAM168A: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM168A Gene

Localization for FAM168A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM168A gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM168A Gene

Pathways & Interactions for FAM168A Gene

SuperPathways for FAM168A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM168A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1905053 positive regulation of base-excision repair IDA 25260657
genes like me logo Genes that share ontologies with FAM168A: view

No data available for Pathways by source and SIGNOR curated interactions for FAM168A Gene

Transcripts for FAM168A Gene

Unigene Clusters for FAM168A Gene

Family with sequence similarity 168, member A:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM168A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1: -
SP2: - -
SP3:

Relevant External Links for FAM168A Gene

GeneLoc Exon Structure for
FAM168A
ECgene alternative splicing isoforms for
FAM168A

Expression for FAM168A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM168A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAM168A Gene

This gene is overexpressed in Fetal Brain (24.9), Retina (16.8), Prostate (12.3), and Frontal cortex (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FAM168A Gene



Protein tissue co-expression partners for FAM168A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM168A Gene:

FAM168A

SOURCE GeneReport for Unigene cluster for FAM168A Gene:

Hs.475334
genes like me logo Genes that share expression patterns with FAM168A: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM168A Gene

Orthologs for FAM168A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM168A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM168A 34 35
  • 99.73 (n)
dog
(Canis familiaris)
Mammalia FAM168A 34 35
  • 95.63 (n)
cow
(Bos Taurus)
Mammalia FAM168A 34 35
  • 95.32 (n)
rat
(Rattus norvegicus)
Mammalia Fam168a 34
  • 94.95 (n)
mouse
(Mus musculus)
Mammalia Fam168a 34 16 35
  • 94.89 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FAM168A 35
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM168A 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM168A 34 35
  • 81.28 (n)
lizard
(Anolis carolinensis)
Reptilia FAM168A 35
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam168a 34
  • 80.43 (n)
Str.4204 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.13176 34
zebrafish
(Danio rerio)
Actinopterygii fam168a 34 35
  • 75.21 (n)
wufc28c05 34
Species where no ortholog for FAM168A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM168A Gene

ENSEMBL:
Gene Tree for FAM168A (if available)
TreeFam:
Gene Tree for FAM168A (if available)

Paralogs for FAM168A Gene

Paralogs for FAM168A Gene

(1) SIMAP similar genes for FAM168A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM168A: view

Variants for FAM168A Gene

Sequence variations from dbSNP and Humsavar for FAM168A Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10047427 -- 73,473,325(+) TCTCT(A/G)GTCAG intron-variant
rs10047442 -- 73,475,819(+) ACTGC(A/T)ACCAG intron-variant
rs10082565 -- 73,432,717(+) gacca(A/G)cctga intron-variant
rs10128665 -- 73,597,933(+) AGCAG(C/T)TGCAG utr-variant-5-prime
rs10501411 -- 73,581,040(+) AGGTA(A/C)ATTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM168A Gene

Variant ID Type Subtype PubMed ID
esv22737 CNV loss 19812545
esv2677115 CNV deletion 23128226
esv3306849 CNV mobile element insertion 20981092
nsv975202 CNV duplication 23825009
nsv951041 CNV deletion 24416366
nsv555412 CNV loss 21841781
nsv520130 CNV gain 19592680
nsv508641 CNV deletion 20534489
nsv389 CNV insertion 18451855
nsv38888 CNV insertion 16902084
nsv1069609 CNV deletion 25765185
nsv1048171 CNV gain 25217958
esv3626814 CNV loss 21293372
esv3373743 CNV insertion 20981092

Variation tolerance for FAM168A Gene

Residual Variation Intolerance Score: 20.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.50; 10.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM168A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM168A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM168A Gene

Disorders for FAM168A Gene

MalaCards: The human disease database

(2) MalaCards diseases for FAM168A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
tongue cancer
  • malignant neoplasm of anterior 2/3 of tongue unspecified
oral squamous cell carcinoma
  • mouth squamous cell carcinoma
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

F168A_HUMAN
  • Note=Associated with cisplatin (DDP)-resistance and radioresistance in the treatment of lung cancer as well as oral squamous cell carcinoma and poor clinical outcome in patients. {ECO:0000269 PubMed:21334329, ECO:0000269 PubMed:21603883, ECO:0000269 PubMed:23251525, ECO:0000269 PubMed:25260657}.

Relevant External Links for FAM168A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM168A
genes like me logo Genes that share disorders with FAM168A: view

No data available for Genatlas for FAM168A Gene

Publications for FAM168A Gene

  1. TCRP1 contributes to cisplatin resistance by preventing Pol I^ degradation in lung cancer cells. (PMID: 25260657) Liu X. … He Z. (Mol. Cell. Biochem. 2015) 3 4 64
  2. Microarray-assisted pathway analysis identifies MT1X & NFI_B as mediators of TCRP1-associated resistance to cisplatin in oral squamous cell carcinoma. (PMID: 23251525) Peng B. … He Z. (PLoS ONE 2012) 3 4 64
  3. Cloning and functional characterization of TCRP1, a novel gene mediating resistance to cisplatin in an oral squamous cell carcinoma cell line. (PMID: 21334329) Gu Y. … He Z. (FEBS Lett. 2011) 3 4 64
  4. TCRP1 promotes radioresistance of oral squamous cell carcinoma cells via Akt signal pathway. (PMID: 21603883) Gu Y. … He Z. (Mol. Cell. Biochem. 2011) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for FAM168A Gene

Sources for FAM168A Gene

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