FAM168A Gene
protein-coding GIFtS: 45
GCID: GC11M073111
|
|
family with sequence similarity 168, member A(Previous name: KIAA0280 )
(Previous symbol: KIAA0280)
| |
Aliases
for FAM168A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Family With Sequence Similarity 168, Member A1 2 | | KIAA02801 2 3 | | TCRP11 2 3 | | Tongue Cancer Chemotherapy Resistance-Associated Protein 12 3 | | Protein FAM168A2 |
Export aliases for FAM168A gene to outside databasesPrevious GC identifers: GC11U901028 GC11M072795 GC11M073117 GC11M069412 |
Summaries
for FAM168A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FAM168A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FAM168A gene promoter:
AhR E2F-3a E2F-4 E2F-5 E2F-2 NF-kappaB E2F-1 E2F FOXC1 NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM168A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM168A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13.4 Ensembl cytogenetic band: 11q13.4 HGNC cytogenetic band: 11q13.4FAM168A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M073111: view genomic region
(about GC identifiers)
Start:
|
73,111,532 bp from pter |
End:
|
73,309,234 bp from pter |
Size:
|
197,703 bases |
Orientation:
|
minus strand |
|
Proteins
for FAM168A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: F168A_HUMAN, Q92567 (See
protein sequence)Recommended Name: Protein FAM168A Size: 244 amino acids; 26184 Da
Subunit: May interact with FAM168B
Sequence caution: Sequence=BAA13408.1; Type=Erroneous initiation;
Secondary accessions: A2ICY2 A2ID81 Q86UG2Alternative splicing: 3 isoforms: Q92567-1 Q92567-2 Q92567-3 Explore the universe of human proteins at neXtProt for FAM168A: NX_Q92567
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q92567
FAM168A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055974.1
ENSEMBL proteins: ENSP00000064778 ENSP00000390501 ENSP00000348852
Human Recombinant Protein Products:
FAM168A Antibody Products:
Assay Products for FAM168A: |
Protein
Domains /
Families
for FAM168A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q92567 UniProtKB/Swiss-Prot: F168A_HUMAN, Q92567Similarity: Belongs to the FAM168 protein family |
Function
for FAM168A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM168A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM168A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FAM168A (NM_015159) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM168A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM168A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM168A |
3 GenomeRNAi human phenotypes for FAM168A:
|
Pathways & Interactions
for FAM168A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM168A
3 Interacting proteins for FAM168A (Q925672, 3) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for FAM168A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM168A
Search CenterWatch for drugs/clinical trials and news about FAM168A / F168A
|
Transcripts
for FAM168A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAM168A gene: NM_015159.1 Unigene Cluster for FAM168A: Family with sequence similarity 168, member A Hs.475334 [show with all ESTs]Unigene Representative Sequence: D874704 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000064778(uc001otz.1) ENST00000450446 ENST00000356467(uc001oty.1 uc009ytp.1)
ENST00000432223
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM168A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM168A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FAM168A (NM_015159) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM168A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM168A |
Additional cDNA sequence: AK292054.1 BC014932.1 BC052341.1 D87470.1 EF197985.1 EF363480.1 9 DOTS entries: DT.452639 DT.95165154 DT.100779225 DT.95153821 DT.95165156 DT.91655226 DT.91754879 DT.91898471 DT.91989642 24/254 AceView cDNA sequences (see all 254): BF112244 BM683205 AL135208 BE858044 AI423371 BE220833 BG820745 AA402756 AI567484 AI272232 AI672411 AI393713 Z44208 AW294058 BU624583 BX479837 AA402209 T32809 BU634205 BX956934 BM693487 Z40501 F12242 R87483
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for FAM168A About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 |
|---|
|
| SP1: | | | | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FAM168A
|
Expression
for FAM168A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAM168A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCTTGCCTG
About this image
See FAM168A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM168A
SOURCE GeneReport for Unigene cluster: Hs.475334
SABiosciences Custom PCR Arrays for FAM168A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM168A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FAM168A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM168A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM168A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM168A |
Orthologs
for FAM168A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for FAM168A gene from 4/12 species (see all 12) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
FAM168A1 |
family with sequence similarity 168, member A |
81.28(n)
94.89(a) |
|
419066 XM_417256.3 XP_417256.1 |
lizard
(Anolis carolinensis) |
Reptilia |
FAM168A6 |
-- |
93(a) |
1 ↔ 1 |
GL343489.1(207296-228423) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.131762 |
Xenopus laevis transcribed sequences |
81.69(n) |
|
BX846189.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufc28c052 |
Transcribed sequences |
74.52(n) |
|
57048198 |
ENSEMBL Gene Tree for FAM168A (if available)
TreeFam Gene Tree for FAM168A (if available) |
Paralogs
for FAM168A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAM168A gene
- FAM168B2
1 SIMAP similar gene for FAM168A using alignment to 1 protein entry: F168A_HUMAN:FAM168B
FAM168A for paralogs About GeneDecksing
|
Genomic Variants
for FAM168A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM168A (73111532 - 73309234 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for FAM168A
2 CNVs: 65991 48879
3 Indels: 75700 85850 75699 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM168A |
|
Disorders
/ Diseases
for FAM168A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FAM168A for disorders About GeneDecksing
4  diseases for FAM168A: About MalaCardstongue cancer oral squamous cell carcinoma squamous cell carcinoma carcinoma
1 disease from the University of Copenhagen DISEASES database for FAM168A:Tongue cancer Export disorders for FAM168A gene to outside databases
|
Publications
for FAM168A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM168A gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM168A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1, 2 Nagase T....Nomura N. (1996)
- Characterizing the neurite outgrowth inhibitory effect of Mani. (PubMed id 22771904)2 Mishra M.... Heese K. (2012)
- TCRP1 promotes radioresistance of oral squamous cell carcinoma cells via Akt signal pathway. (PubMed id 21603883)1 Gu Y....He Z. (2011)
- Cloning and functional characterization of TCRP1, a n ovel gene mediating resistance to cisplatin in an oral squamous cell carcinoma cell line. (PubMed id 21334329)1 Gu Y....He Z. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for FAM168A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FAM168A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM168A gene
(According to HUGE)
About This Section
| |
Specialized Databases showing FAM168A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAM168A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FAM168A gene:
Search GeneIP for patents involving FAM168A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM168A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FAM168A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM168A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM168A | | | OriGene Protein Over-expression Lysate for FAM168A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FAM168A | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM168A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM168A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FAM168A | | OriGene Custom Protein Services for FAM168A | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM168A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM168A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM168A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM168A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM168A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM168A |
| |
 |  |  |  | |
| | | | Search Tocris compounds for FAM168A |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | FAM168A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM168A |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM168A |
|
|
|
|
