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FAM167B Gene

protein-coding   GIFtS: 41
GCID: GC01P032712

Family With Sequence Similarity 167, Member B

(Previous name: chromosome 1 open reading frame 90)
(Previous symbol: C1orf90)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 167, Member B1 2
C1orf901 2 3
Chromosome 1 Open Reading Frame 901
Protein FAM167B2

External Ids:    HGNC: 281331   Entrez Gene: 847342   Ensembl: ENSG000001836157   UniProtKB: Q9BTA03   

Export aliases for FAM167B gene to outside databases

Previous GC identifers: GC01P032487 GC01P030829


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM167B Gene:
FAM167B (family with sequence similarity 167, member B) is a protein-coding gene. An important paralog of this gene is FAM167A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAM167B gene promoter:
         STAT1   Sp1   AP-1   ATF-2   STAT1beta   STAT3   c-Jun   NF-kappaB1   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM167B promoter sequence
   Search Chromatin IP Primers for FAM167B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM167B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35.1   Ensembl cytogenetic band:  1p35.1   HGNC cytogenetic band: 1p35.1

FAM167B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM167B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P032712:  view genomic region     (about GC identifiers)

Start:
32,712,818 bp from pter      End:
32,714,461 bp from pter
Size:
1,644 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: F167B_HUMAN, Q9BTA0 (See protein sequence)
Recommended Name: Protein FAM167B  
Size: 163 amino acids; 18414 Da
Secondary accessions: Q5TDH6

Explore the universe of human proteins at neXtProt for FAM167B: NX_Q9BTA0

Explore proteomics data for FAM167B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FAM167B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_116037.2  
    ENSEMBL proteins: 
     ENSP00000362684  

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    antibodies-online proteins for FAM167B (2 products) 

     
    antibodies-online peptides for FAM167B

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    antibodies-online kits for FAM167B (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR024280 FAM167

    Graphical View of Domain Structure for InterPro Entry Q9BTA0

    ProtoNet protein and cluster: Q9BTA0

    UniProtKB/Swiss-Prot: F167B_HUMAN, Q9BTA0
    Similarity: Belongs to the FAM167 (SEC) family


    Find genes that share domains with FAM167B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for FAM167B

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate FAM167B:
    hsa-miR-330-5p hsa-miR-326
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular2
    cytosol1
    mitochondrion1
    nucleus1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM167B
    Interactions:

        Search GeneGlobe Interaction Network for FAM167B

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM167B (F167B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FAM167B gene: 
    NM_032648.2  

    Unigene Cluster for FAM167B:

    Family with sequence similarity 167, member B
    Hs.18449  [show with all ESTs]
    Unigene Representative Sequence: NM_032648
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000373582(uc001buw.3)
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate FAM167B:
    hsa-miR-330-5p hsa-miR-326
    SwitchGear 3'UTR luciferase reporter plasmidFAM167B 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat FAM167B

    Additional mRNA sequence: BC004269.1 

    2 DOTS entries:

    DT.311364  DT.121433015 

    7 AceView cDNA sequences:

    NM_032648 BC004269 BG913527 T98752 BE386717 BX091465 T98751 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM167B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACATCAGCG
    FAM167B Expression
    About this image


    FAM167B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Endothelium (Cardiovascular System)
             Mature Endothelial Cells Blood Brain Barrier
     
     Bone (Muscoskeletal System)
             Zeugopod Periosteum
     
     Kidney (Urinary System)
             S-shaped Body
     
     Brain (Nervous System)
             Mature Endothelial Cells Blood Brain Barrier
    FAM167B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM167B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.18449
        Custom PCR Arrays for FAM167B
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM167B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FAM167B gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam167b1 , 5 family with sequence similarity 167, member B1, 5 84.16(n)1
    86.42(a)1
      4 (63.26 cM)5
    2307661  NM_182783.21  NP_877584.21 
     1295768155 
    chicken
    (Gallus gallus)
    Aves FAM167B1 family with sequence similarity 167, member B 66.05(n)
    54.94(a)
      770783  XM_001234110.2  XP_001234111.1 
    lizard
    (Anolis carolinensis)
    Reptilia FAM167B6
    family with sequence similarity 167, member B
    51(a)
    1 ↔ 1
    GL343706.1(75609-79865)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004975021 protein FAM167A-like 55.62(n)
    52.76(a)
      100497502  XM_002939294.2  XP_002939340.1 
    zebrafish
    (Danio rerio)
    Actinopterygii FAM167B6
    family with sequence similarity 167, member B
    45(a)
    1 ↔ 1
    17(25182442-25237123) ENSDARG00000022454


    ENSEMBL Gene Tree for FAM167B (if available)
    TreeFam Gene Tree for FAM167B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM167B gene
    FAM167A2  
    1 SIMAP similar gene for FAM167B using alignment to 1 protein entry:     F167B_HUMAN:
    FAM167A

    Find genes that share paralogs with FAM167B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM167B (see all 82)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1809430341,2
    --32710850(+) TCACCA/GTGTTA 1 -- us2k10--------
    rs1511229701,2
    --32710870(+) GTCTCA/GATCTC 1 -- us2k10--------
    rs1850472841,2
    --32710934(+) TGAACA/CACCGC 1 -- us2k10--------
    rs1132466941,2
    C--32711002(+) AACTT-/A/AA  
            
    AAAAA
    1 -- us2k11CSA 2
    rs1142252561,2
    F--32711070(+) TCAAGC/GAAGAG 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1154962861,2
    F--32711147(+) CAACAA/GAGCAA 1 -- us2k11Minor allele frequency- G:0.02NA 120
    rs1893596201,2
    --32711349(+) GTGAAC/TCACTA 1 -- us2k10--------
    rs6695381,2
    C,F,A,H--32711360(+) GAAGGT/CATATA 1 -- us2k1 tfbs325Minor allele frequency- C:0.34NS EA NA WA CSA 2764
    rs1135481021,2
    C--32711409(+) CCCTTAGG/-AGATT 1 -- cds11Minor allele frequency- -:0.50CSA 2
    rs1819285321,2
    --32711465(+) TGCTGA/GTAATA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FAM167B (32712818 - 32714461 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for FAM167B: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FAM167B
    DNA2.0 Custom Variant and Variant Library Synthesis for FAM167B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with FAM167B           About GenesLikeMe

    Genetic Association Database (GAD): FAM167B
    Human Genome Epidemiology (HuGE) Navigator: FAM167B (3 documents)

    Export disorders for FAM167B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM167B gene integrated from 10 sources:
    (articles sorted by number of sources associating them with FAM167B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84734 HGNC: 28133 AceView: MGC10820 Ensembl:ENSG00000183615 euGenes: HUgn84734
    ECgene: FAM167B H-InvDB: FAM167B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM167B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM167B gene:
    Search GeneIP for patents involving FAM167B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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