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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAM167B Gene

protein-coding   GIFtS: 39
GCID: GC01P032712

family with sequence similarity 167, member B

(Previous name: chromosome 1 open reading frame 90 )
(Previous symbol: C1orf90)
  Search for FAM167B
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FAM167B    

Aliases
for FAM167B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Family With Sequence Similarity 167, Member B1 2
C1orf901 2 3
MGC108201
Chromosome 1 Open Reading Frame 901
Protein FAM167B2

External Ids:    HGNC: 281331   Entrez Gene: 847342   Ensembl: ENSG000001836157   UniProtKB: Q9BTA03   

Export aliases for FAM167B gene to outside databases

Previous GC identifers: GC01P032487 GC01P030829


Summaries
for FAM167B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for FAM167B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FAM167B gene promoter:
         STAT1   Sp1   AP-1   ATF-2   STAT1beta   STAT3   c-Jun   NF-kappaB1   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FAM167B promoter sequence
   Search SABiosciences Chromatin IP Primers for FAM167B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM167B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35.1   Ensembl cytogenetic band:  1p35.1   HGNC cytogenetic band: 1p35.1

FAM167B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM167B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P032712:  view genomic region     (about GC identifiers)

Start:
 32,712,818 bp from pter      End:
 32,714,461 bp from pter
Size:
 1,644 bases      Orientation:
 plus strand

Proteins
for FAM167B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: F167B_HUMAN, Q9BTA0 (See protein sequence)
Recommended Name: Protein FAM167B  
Size: 163 amino acids; 18414 Da
Secondary accessions: Q5TDH6

Explore the universe of human proteins at neXtProt for FAM167B: NX_Q9BTA0

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BTA0

    • FAM167B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_116037.2  
    ENSEMBL proteins: 
     ENSP00000362684  

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    Protein Domains /
    Families
    for FAM167B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FAM167B for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR024280 FAM167

    Graphical View of Domain Structure for InterPro Entry Q9BTA0

    ProtoNet protein and cluster: Q9BTA0

    UniProtKB/Swiss-Prot: F167B_HUMAN, Q9BTA0
    Similarity: Belongs to the FAM167 (SEC) family


    Function
    for FAM167B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    Pathways & Interactions
    for FAM167B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM167B

    Drugs & Compounds
    for FAM167B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FAM167B
    Search CenterWatch for drugs/clinical trials and news about FAM167B / F167B 

    Transcripts
    for FAM167B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FAM167B gene: 
    NM_032648.2  

    Unigene Cluster for FAM167B:

    Family with sequence similarity 167, member B
    Hs.18449  [show with all ESTs]
    Unigene Representative Sequence: NM_032648
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000373582(uc001buw.3)

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    hsa-miR-330-5p hsa-miR-326
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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: BC004269.1 

    2 DOTS entries:

    DT.311364  DT.121433015 

    7 AceView cDNA sequences:

    NM_032648 BC004269 BG913527 T98752 BE386717 BX091465 T98751 

    GeneLoc Exon Structure


    Expression
    for FAM167B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FAM167B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AACATCAGCG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    FAM167B expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneZeugopod PeriosteumBone
    KidneyS-shaped BodyKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See FAM167B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FAM167B

    SOURCE GeneReport for Unigene cluster: Hs.18449
        SABiosciences Custom PCR Arrays for FAM167B
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    In Situ
    Assay Products:     
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    Orthologs
    for FAM167B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for FAM167B gene from 2/10 species (see all 10)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves FAM167B1 family with sequence similarity 167, member B 68.52(n)
    58.64(a)    		   770783  XM_001234110.1  XP_001234111.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1001510501 protein FAM167A-like 60.34(n)
    56.33(a)    		   100151050  XM_001923369.2  XP_001923404.1 


    ENSEMBL Gene Tree for FAM167B (if available)
    TreeFam Gene Tree for FAM167B (if available) 

    Paralogs
    for FAM167B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FAM167B gene
    FAM167A2  
    1 SIMAP similar gene for FAM167B using alignment to 1 protein entry:     F167B_HUMAN:
    FAM167A

    FAM167B for paralogs           About GeneDecksing



    Genomic Variants
    for FAM167B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/62 NCBI SNPs in FAM167B are shown (see all 62)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1809430341,2
    		--32710850(+) TCACCA/GTGTTA 1 -- us2k10--------
    rs1511229701,2
    		--32710870(+) GTCTCA/GATCTC 1 -- us2k10--------
    rs1850472841,2
    		--32710934(+) TGAACA/CACCGC 1 -- us2k10--------
    rs1142252561,2
    		F,--32711070(+) TCAAGC/GAAGAG 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1154962861,2
    		F,--32711147(+) CAACAA/GAGCAA 1 -- us2k11Minor allele frequency- G:0.02NA 120
    rs1893596201,2
    		--32711349(+) GTGAAC/TCACTA 1 -- us2k10--------
    rs6695381,2
    		C,F,A,H,--32711360(+) GAAGGT/CATATA 1 -- us2k1 tfbs325Minor allele frequency- C:0.34NS EA NA WA CSA 2764
    rs1135481021,2
    		C,--32711409(+) CCCTTAGG/-AGATT 1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs1819285321,2
    		--32711465(+) TGCTGA/GTAATA 1 -- us2k10--------
    rs1870638811,2
    		--32711574(+) TGAGAC/TGGAGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FAM167B (32712818 - 32714461 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for FAM167B: --

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    Disorders / Diseases
    for FAM167B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FAM167B for disorders           About MalaCards

    FAM167B for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: FAM167B (3 documents)

    Export disorders for FAM167B gene to outside databases

    Publications
    for FAM167B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FAM167B gene integrated from 9 sources:
    (articles sorted by number of sources associating them with FAM167B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    4. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
    5. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)

    External Searches for FAM167B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing FAM167B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84734 HGNC: 28133 AceView: MGC10820 Ensembl:ENSG00000183615 euGenes: HUgn84734
    ECgene: FAM167B H-InvDB: FAM167B

    Other Databases showing FAM167B gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FAM167B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FAM167B Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for FAM167B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FAM167B gene:
    Search GeneIP for patents involving FAM167B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for FAM167B gene

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    About This Section

     
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    von Willebrand factor
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