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Aliases for FAM167A Gene

Aliases for FAM167A Gene

  • Family With Sequence Similarity 167 Member A 2 3 5
  • Family With Sequence Similarity 167, Member A 2 3
  • C8orf13 3 4
  • Chromosome 8 Open Reading Frame 13 2
  • D8S265 3

External Ids for FAM167A Gene

Previous HGNC Symbols for FAM167A Gene

  • C8orf13

Previous GeneCards Identifiers for FAM167A Gene

  • GC08M011317
  • GC08M010209
  • GC08M011278

Summaries for FAM167A Gene

GeneCards Summary for FAM167A Gene

FAM167A (Family With Sequence Similarity 167 Member A) is a Protein Coding gene. Diseases associated with FAM167A include keratolytic winter erythema. An important paralog of this gene is FAM167B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM167A Gene

Genomics for FAM167A Gene

Regulatory Elements for FAM167A Gene

Promoters for FAM167A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAM167A on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM167A Gene

Chromosome:
8
Start:
11,421,463 bp from pter
End:
11,475,915 bp from pter
Size:
54,453 bases
Orientation:
Minus strand

Genomic View for FAM167A Gene

Genes around FAM167A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM167A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM167A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM167A Gene

Proteins for FAM167A Gene

  • Protein details for FAM167A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96KS9-F167A_HUMAN
    Recommended name:
    Protein FAM167A
    Protein Accession:
    Q96KS9
    Secondary Accessions:
    • A8K3T9
    • Q3SXY1
    • Q3SXY3
    • Q8N3M3
    • Q9NSR0

    Protein attributes for FAM167A Gene

    Size:
    214 amino acids
    Molecular mass:
    24182 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM167A Gene

Proteomics data for FAM167A Gene at MOPED

Post-translational modifications for FAM167A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM167A Gene

No data available for DME Specific Peptides for FAM167A Gene

Domains & Families for FAM167A Gene

Protein Domains for FAM167A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM167A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96KS9

UniProtKB/Swiss-Prot:

F167A_HUMAN :
  • Belongs to the FAM167 (SEC) family.
Family:
  • Belongs to the FAM167 (SEC) family.
genes like me logo Genes that share domains with FAM167A: view

No data available for Gene Families for FAM167A Gene

Function for FAM167A Gene

genes like me logo Genes that share phenotypes with FAM167A: view

Animal Model Products

CRISPR Products

miRNA for FAM167A Gene

miRTarBase miRNAs that target FAM167A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM167A Gene

Localization for FAM167A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM167A Gene COMPARTMENTS Subcellular localization image for FAM167A gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM167A Gene

Pathways & Interactions for FAM167A Gene

SuperPathways for FAM167A Gene

No Data Available

Interacting Proteins for FAM167A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000284486%0d%0a9606.ENSP00000282570%0d%0a
Selected Interacting proteins: ENSP00000284486 Q96KS9-F167A_HUMAN for FAM167A Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for FAM167A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM167A Gene

Drugs & Compounds for FAM167A Gene

No Compound Related Data Available

Transcripts for FAM167A Gene

Unigene Clusters for FAM167A Gene

Family with sequence similarity 167, member A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM167A Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7
SP1: - - -
SP2: -
SP3: - - -
SP4:

Relevant External Links for FAM167A Gene

GeneLoc Exon Structure for
FAM167A
ECgene alternative splicing isoforms for
FAM167A

Expression for FAM167A Gene

mRNA expression in normal human tissues for FAM167A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM167A Gene

This gene is overexpressed in Thyroid (x4.6) and Pituitary (x4.1).

Protein differential expression in normal tissues from HIPED for FAM167A Gene

This gene is overexpressed in Heart (37.8) and Rectum (27.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM167A Gene



SOURCE GeneReport for Unigene cluster for FAM167A Gene Hs.124299

mRNA Expression by UniProt/SwissProt for FAM167A Gene

Q96KS9-F167A_HUMAN
Tissue specificity: Expressed in skin, including primary keratinocytes, spleen, kidney, leukocytes, testis, lung, small intestine and prostate.
genes like me logo Genes that share expression patterns with FAM167A: view

Protein tissue co-expression partners for FAM167A Gene

Primer Products

In Situ Assay Products

Orthologs for FAM167A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM167A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM167A 35
  • 99.07 (n)
  • 99.07 (a)
FAM167A 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM167A 36
  • 77 (a)
OneToOne
FAM167A 35
  • 83.01 (n)
  • 82.69 (a)
dog
(Canis familiaris)
Mammalia FAM167A 35
  • 84.62 (n)
  • 84.13 (a)
FAM167A 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam167a 16
Fam167a 35
  • 83.49 (n)
  • 83.18 (a)
Fam167a 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM167A 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam167a 35
  • 82.71 (n)
  • 82.71 (a)
chicken
(Gallus gallus)
Aves FAM167A 35
  • 72.3 (n)
  • 71.5 (a)
FAM167A 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM167A 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam167a 35
  • 67.31 (n)
  • 68.6 (a)
zebrafish
(Danio rerio)
Actinopterygii fam167ab 36
  • 59 (a)
OneToOne
Dr.15778 35
fam167ab 35
  • 63.48 (n)
  • 64.32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
ManyToMany
CSA.10625 36
  • 38 (a)
ManyToMany
Species with no ortholog for FAM167A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM167A Gene

ENSEMBL:
Gene Tree for FAM167A (if available)
TreeFam:
Gene Tree for FAM167A (if available)

Paralogs for FAM167A Gene

Paralogs for FAM167A Gene

(1) SIMAP similar genes for FAM167A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FAM167A: view

Variants for FAM167A Gene

Sequence variations from dbSNP and Humsavar for FAM167A Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs3021513 - 11,444,244(+) CAGGT(A/C)TGCTC reference, missense
rs3021512 - 11,444,092(+) TGCCA(C/G)TGGAC reference, missense
rs899363 -- 11,475,273(-) GGCCC(A/G)TAGGG intron-variant
rs1478886 -- 11,475,888(-) GATAA(C/T)CAAGA utr-variant-5-prime
rs1986630 -- 11,461,216(+) GGCTG(C/T)GGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM167A Gene

Variant ID Type Subtype PubMed ID
esv34097 CNV Loss 18971310
nsv470183 CNV Loss 18288195
nsv465465 CNV Loss 19166990
nsv522860 CNV Loss 19592680
nsv509252 CNV Insertion 20534489
nsv890357 CNV Loss 21882294
esv259887 OTHER Complex 20981092
nsv824538 CNV Loss 20364138
esv22493 CNV Loss 19812545
esv2736602 CNV Deletion 23290073
esv2736603 CNV Deletion 23290073
esv3628 CNV Deletion 18987735
esv2736604 CNV Deletion 23290073
esv1058919 CNV Insertion 17803354
esv2736605 CNV Deletion 23290073

Variation tolerance for FAM167A Gene

Residual Variation Intolerance Score: 79.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.65; 45.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM167A Gene

HapMap Linkage Disequilibrium report
FAM167A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM167A Gene

Disorders for FAM167A Gene

MalaCards: The human disease database

(1) MalaCards diseases for FAM167A Gene - From: GeneCards

Disorder Aliases PubMed IDs
keratolytic winter erythema
  • erythrokeratolysis hiemalis ichthyosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for FAM167A

Genetic Association Database (GAD)
FAM167A
Human Genome Epidemiology (HuGE) Navigator
FAM167A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM167A
genes like me logo Genes that share disorders with FAM167A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAM167A Gene

Publications for FAM167A Gene

  1. A genome-wide association study identifies three new risk loci for Kawasaki disease. (PMID: 22446962) Onouchi Y. … . (Nat. Genet. 2012) 3 48 67
  2. Single nucleotide polymorphisms in the FAM167A-BLK gene are associated with polymyositis/dermatomyositis in the Han Chinese population. (PMID: 25846585) Chen S. … Li Y. (Immunol. Res. 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Possible single-nucleotide polymorphism loci associated with systemic sclerosis susceptibility: a genetic association study in a Chinese Han population. (PMID: 25470816) Shu C. … Sun Q. (PLoS ONE 2014) 3
  5. Association between a C8orf13-BLK polymorphism and polymyositis/dermatomyositis in the Japanese population: an additive effect with STAT4 on disease susceptibility. (PMID: 24632671) Sugiura T. … Yamanaka H. (PLoS ONE 2014) 3

Products for FAM167A Gene

Sources for FAM167A Gene

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