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Aliases for FAM166B Gene

Aliases for FAM166B Gene

  • Family With Sequence Similarity 166 Member B 2 3 5
  • Family With Sequence Similarity 166, Member B 2

External Ids for FAM166B Gene

Summaries for FAM166B Gene

GeneCards Summary for FAM166B Gene

FAM166B (Family With Sequence Similarity 166 Member B) is a Protein Coding gene.

Additional gene information for FAM166B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM166B Gene

Genomics for FAM166B Gene

GeneHancer (GH) Regulatory Elements for FAM166B Gene

Promoters and enhancers for FAM166B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I035560 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 557.2 +0.3 264 7.2 DRAP1 ELF3 GATAD2A CTCF FOXA2 SAP130 SP5 HLF TEAD3 NFIL3 FAM166B CCDC107 RN7SL22P ARHGEF39 CD72 RGP1 PIR61372 RUSC2
GH09I035515 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 17.3 +44.8 44774 8 PKNOX1 FOXA2 MLX ARID4B NEUROD1 SIN3A DMAP1 BRCA1 ETS1 ATF7 FAM166B RUSC2 OR13J1 CCDC107 ARHGEF39 CREB3 VCP STOML2 RPL36AP33 PIR61372
GH09I035487 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.4 +73.4 73404 5.5 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 ZNF766 ZNF213 E2F8 ZNF143 RUSC2 LOC105376026 PIGO RGP1 FANCG ARHGEF39 TMEM8B FAM214B SPAG8 FAM166B
GH09I035537 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 17.7 +25.1 25069 3.5 MXI1 POLR2A SIN3A CTBP2 REST CHD2 RUSC2 FAM166B OR13J1 PIR61372 RPL36AP33
GH09I035616 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 11 -55.4 -55355 6.4 HDGF PKNOX1 ATF1 SMAD1 RB1 SIN3A BATF RFX5 ETS1 SCRT2 CD72 CCDC107 RN7SL22P ARHGEF39 SIT1 CA9 FAM166B TLN1 CREB3 GBA2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM166B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM166B gene promoter:

Genomic Locations for FAM166B Gene

Genomic Locations for FAM166B Gene
chr9:35,561,830-35,563,899
(GRCh38/hg38)
Size:
2,070 bases
Orientation:
Minus strand
chr9:35,561,827-35,563,896
(GRCh37/hg19)

Genomic View for FAM166B Gene

Genes around FAM166B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM166B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM166B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM166B Gene

Proteins for FAM166B Gene

  • Protein details for FAM166B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MTA8-F166B_HUMAN
    Recommended name:
    Protein FAM166B
    Protein Accession:
    A8MTA8
    Secondary Accessions:
    • A1L3B2
    • B7ZBJ0

    Protein attributes for FAM166B Gene

    Size:
    275 amino acids
    Molecular mass:
    30575 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM166B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM166B Gene

Post-translational modifications for FAM166B Gene

No Post-translational modifications

Other Protein References for FAM166B Gene

No data available for DME Specific Peptides for FAM166B Gene

Domains & Families for FAM166B Gene

Gene Families for FAM166B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM166B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM166B Gene

Graphical View of Domain Structure for InterPro Entry

A8MTA8

UniProtKB/Swiss-Prot:

F166B_HUMAN :
  • Belongs to the UPF0605 family.
Family:
  • Belongs to the UPF0605 family.
genes like me logo Genes that share domains with FAM166B: view

Function for FAM166B Gene

Phenotypes From GWAS Catalog for FAM166B Gene

Phenotypes for FAM166B Gene

genes like me logo Genes that share phenotypes with FAM166B: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM166B Gene

Localization for FAM166B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM166B gene
Compartment Confidence
mitochondrion 2
extracellular 1
peroxisome 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for FAM166B Gene

Pathways & Interactions for FAM166B Gene

SuperPathways for FAM166B Gene

No Data Available

Interacting Proteins for FAM166B Gene

Gene Ontology (GO) - Biological Process for FAM166B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM166B Gene

Drugs & Compounds for FAM166B Gene

No Compound Related Data Available

Transcripts for FAM166B Gene

mRNA/cDNA for FAM166B Gene

(5) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM166B Gene

Family with sequence similarity 166, member B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM166B Gene

No ASD Table

Relevant External Links for FAM166B Gene

GeneLoc Exon Structure for
FAM166B
ECgene alternative splicing isoforms for
FAM166B

Expression for FAM166B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM166B Gene

mRNA differential expression in normal tissues according to GTEx for FAM166B Gene

This gene is overexpressed in Adrenal Gland (x30.1) and Muscle - Skeletal (x13.0).

Protein differential expression in normal tissues from HIPED for FAM166B Gene

This gene is overexpressed in Neutrophil (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM166B Gene



Protein tissue co-expression partners for FAM166B Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM166B Gene:

FAM166B

SOURCE GeneReport for Unigene cluster for FAM166B Gene:

Hs.98959

Evidence on tissue expression from TISSUES for FAM166B Gene

  • Adrenal gland(2.4)
genes like me logo Genes that share expression patterns with FAM166B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM166B Gene

Orthologs for FAM166B Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM166B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM166B 34
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM166B 33 34
  • 84.86 (n)
dog
(Canis familiaris)
Mammalia FAM166B 33 34
  • 84.61 (n)
mouse
(Mus musculus)
Mammalia Fam166b 33 16 34
  • 81.15 (n)
rat
(Rattus norvegicus)
Mammalia Fam166b 33
  • 78.35 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM166B 34
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM166B 34
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM166B 34
  • 37 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii fam166b 34
  • 36 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG18335 34
  • 25 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 27 (a)
OneToMany
-- 34
  • 25 (a)
OneToMany
Species where no ortholog for FAM166B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM166B Gene

ENSEMBL:
Gene Tree for FAM166B (if available)
TreeFam:
Gene Tree for FAM166B (if available)

Paralogs for FAM166B Gene

No data available for Paralogs for FAM166B Gene

Variants for FAM166B Gene

Sequence variations from dbSNP and Humsavar for FAM166B Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000305348 -- 35,562,549(-) G/A coding_sequence_variant, intron_variant, synonymous_variant
rs1000624189 -- 35,562,475(-) G/A/C coding_sequence_variant, missense_variant, stop_gained, synonymous_variant
rs1000636325 -- 35,563,021(-) C/T coding_sequence_variant, missense_variant
rs1001237657 -- 35,561,354(-) G/A downstream_transcript_variant
rs1001507875 -- 35,562,138(-) /TA intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM166B Gene

Variant ID Type Subtype PubMed ID
esv3620379 CNV gain 21293372
nsv1125318 OTHER inversion 24896259
nsv527028 CNV loss 19592680
nsv528256 CNV loss 19592680
nsv951701 CNV deletion 24416366

Variation tolerance for FAM166B Gene

Residual Variation Intolerance Score: 85.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.54; 77.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM166B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM166B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM166B Gene

Disorders for FAM166B Gene

Additional Disease Information for FAM166B

No disorders were found for FAM166B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM166B Gene

Publications for FAM166B Gene

  1. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo MF … Soares MB (Genome research 1996) 3 58

Products for FAM166B Gene

Sources for FAM166B Gene

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