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Aliases for FAM166A Gene

Aliases for FAM166A Gene

  • Family With Sequence Similarity 166 Member A 2 3 5
  • Family With Sequence Similarity 166, Member A 2
  • Protein FAM166A 3
  • HSD46 3

External Ids for FAM166A Gene

Previous GeneCards Identifiers for FAM166A Gene

  • GC09M139258
  • GC09M140138
  • GC09M109597

Summaries for FAM166A Gene

GeneCards Summary for FAM166A Gene

FAM166A (Family With Sequence Similarity 166 Member A) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM166A Gene

Genomics for FAM166A Gene

Regulatory Elements for FAM166A Gene

Enhancers for FAM166A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G136514 1.3 Ensembl ENCODE dbSUPER 5.7 +732.7 732737 7.2 BCOR TFAP4 SAP130 ARID4B MAX ZMYM3 ZIC2 RAD21 BCL11B RARA SNAPC4 NALT1 FAM166A SEC16A SLC34A3 MIR4673
GH09G137386 1.2 Ensembl ENCODE dbSUPER 4.9 -136.8 -136801 2.7 TFAP4 SAP130 NR2F1 ZFHX2 NCOR1 ZBTB48 EGR1 POLR2A PATZ1 KLF9 LOC101928932 FAM166A EXD3 GC09M137332
GH09G137417 1.2 FANTOM5 Ensembl dbSUPER 3.1 -166.5 -166509 1.0 MXI1 USF1 BHLHE40 MAX USF2 GATAD2B POLR2A KDM6A MYC RBFOX2 FAM166A STPG3 ABCA2 LCNL1 EXD3 GC09M137332
GH09G137369 0.5 ENCODE 5.8 -119.4 -119449 1.3 POLR2A SMARCA4 SCRT2 EZH2 FAM166A GC09M137332 EXD3
GH09G137569 0.5 FANTOM5 3.7 -318.2 -318187 0.4 ZFHX2 ZNF366 ZNF670 EGR2 EHMT1 FAM166A STPG3 DPH7 MRPL41
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM166A on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM166A Gene

137,243,583 bp from pter
137,251,193 bp from pter
7,611 bases
Minus strand

Genomic View for FAM166A Gene

Genes around FAM166A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM166A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM166A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM166A Gene

Proteins for FAM166A Gene

  • Protein details for FAM166A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM166A
    Protein Accession:
    Secondary Accessions:
    • A6NND9
    • Q8N830

    Protein attributes for FAM166A Gene

    317 amino acids
    Molecular mass:
    36165 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM166A Gene


neXtProt entry for FAM166A Gene

Post-translational modifications for FAM166A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM166A Gene

No data available for DME Specific Peptides for FAM166A Gene

Domains & Families for FAM166A Gene

Protein Domains for FAM166A Gene


Suggested Antigen Peptide Sequences for FAM166A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPF0605 family.
  • Belongs to the UPF0605 family.
genes like me logo Genes that share domains with FAM166A: view

No data available for Gene Families for FAM166A Gene

Function for FAM166A Gene

genes like me logo Genes that share phenotypes with FAM166A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM166A Gene

Localization for FAM166A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM166A gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for FAM166A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
genes like me logo Genes that share ontologies with FAM166A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAM166A Gene

Pathways & Interactions for FAM166A Gene

SuperPathways for FAM166A Gene

No Data Available

Interacting Proteins for FAM166A Gene

Gene Ontology (GO) - Biological Process for FAM166A Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM166A Gene

Drugs & Compounds for FAM166A Gene

No Compound Related Data Available

Transcripts for FAM166A Gene

Unigene Clusters for FAM166A Gene

Family with sequence similarity 166, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM166A Gene

No ASD Table

Relevant External Links for FAM166A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM166A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM166A Gene

mRNA differential expression in normal tissues according to GTEx for FAM166A Gene

This gene is overexpressed in Testis (x39.3).

NURSA nuclear receptor signaling pathways regulating expression of FAM166A Gene:


SOURCE GeneReport for Unigene cluster for FAM166A Gene:


Evidence on tissue expression from TISSUES for FAM166A Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with FAM166A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM166A Gene

Orthologs for FAM166A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM166A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM166A 34 35
  • 98.21 (n)
(Canis familiaris)
Mammalia FAM166A 34 35
  • 83.49 (n)
(Bos Taurus)
Mammalia FAM166A 34 35
  • 82.49 (n)
(Mus musculus)
Mammalia Fam166a 34 16 35
  • 80.79 (n)
(Rattus norvegicus)
Mammalia Fam166a 34
  • 80.49 (n)
(Monodelphis domestica)
Mammalia FAM166A 35
  • 58 (a)
(Ornithorhynchus anatinus)
Mammalia FAM166A 35
  • 48 (a)
(Gallus gallus)
Aves FAM166A 34 35
  • 57.01 (n)
(Anolis carolinensis)
Reptilia FAM166A 35
  • 49 (a)
Species where no ortholog for FAM166A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM166A Gene

Gene Tree for FAM166A (if available)
Gene Tree for FAM166A (if available)

Paralogs for FAM166A Gene

No data available for Paralogs for FAM166A Gene

Variants for FAM166A Gene

Sequence variations from dbSNP and Humsavar for FAM166A Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000357207 -- 137,250,582(+) GCTCC(A/G)GAGAC nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000801398 -- 137,249,230(+) CATAC(A/G)TGCTG intron-variant, upstream-variant-2KB
rs1001148781 -- 137,249,393(+) GAAGC(C/T)GTCTG intron-variant, upstream-variant-2KB
rs1001153927 -- 137,243,959(+) CTTGG(C/G)GCTCG intron-variant, downstream-variant-500B
rs1001431152 -- 137,247,210(+) AACCT(C/G)GGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM166A Gene

Variant ID Type Subtype PubMed ID
dgv13009n54 CNV loss 21841781
dgv13011n54 CNV loss 21841781
esv2422220 CNV deletion 17116639
nsv1161918 CNV duplication 26073780
nsv524322 CNV loss 19592680
nsv951207 CNV deletion 24416366

Variation tolerance for FAM166A Gene

Residual Variation Intolerance Score: 82.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.82; 58.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM166A Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM166A Gene

Disorders for FAM166A Gene

Relevant External Links for FAM166A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM166A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM166A Gene

Publications for FAM166A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S. … Oliva R. (Proteomics 2011) 3 64
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for FAM166A Gene

Sources for FAM166A Gene

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