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FAM166A Gene

protein-coding GIFtS: 37
GCID: GC09M140138

Family With Sequence Similarity 166, Member A

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MalaCards

disease database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Family With Sequence Similarity 166, Member A¹ ²
Protein FAM166A²

External Ids:	HGNC: 33818¹	Entrez Gene: 401565²	Ensembl: ENSG00000188163⁷	UniProtKB: Q6J272³

ORGUL members:

Export aliases for FAM166A gene to outside databases

Previous GC identifers: GC09M139258 GC09M109597

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FAM166A Gene:

FAM166A (family with sequence similarity 166, member A) is a protein-coding gene.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000009.11 NT_008470.20 NC_018920.2

Regulatory elements:

Regulatory transcription factor binding sites in the FAM166A gene promoter:
SRF RFX1 GATA-3 p53 CP2 Pbx1a Pax-5 SRF (504 AA) XBP-1 C/EBPalpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FAM166A promoter sequence

Search Chromatin IP Primers for FAM166A

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM166A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.3 Ensembl cytogenetic band: 9q34.3 HGNC cytogenetic band: 9q34.3

FAM166A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM166A gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M140138: view genomic region (about GC identifiers)

Start:	140,138,036 bp from pter	End:	140,142,222 bp from pter
Size:	4,187 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
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About This Section

UniProtKB/Swiss-Prot: F166A_HUMAN, Q6J272 (See protein sequence)

Recommended Name: Protein FAM166A

Size: 317 amino acids; 36165 Da

Secondary accessions: A6NND9 Q8N830

Alternative splicing: 2 isoforms: Q6J272-1 Q6J272-2

Explore the universe of human proteins at neXtProt for FAM166A: NX_Q6J272

Explore proteomics data for FAM166A at MOPED

See FAM166A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001001710.1

ENSEMBL proteins:

ENSP00000419151 ENSP00000344729 ENSP00000420741 ENSP00000373584

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

1 InterPro protein domain:

IPR018902 UPF0573/UPF0605

Graphical View of Domain Structure for InterPro Entry Q6J272

ProtoNet protein and cluster: Q6J272

UniProtKB/Swiss-Prot: F166A_HUMAN, Q6J272

Similarity: Belongs to the UPF0605 family

Find genes that share domains with FAM166A About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Phenotypes:
1 GenomeRNAi human phenotype for FAM166A:

Decreased homologous recombina

Animal Models:

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytosol	2
nucleus	2
extracellular	1
mitochondrion	1

About this image

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

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Interactions:

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Browse Small Molecules at EMD Millipore

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

REFSEQ mRNAs for FAM166A gene (3 alternative transcripts):

NM_001001710.2 XM_005266088.1 XM_006717108.1

Unigene Cluster for FAM166A:

Family with sequence similarity 166, member A

Hs.522530 [show with all ESTs]

Unigene Representative Sequence: AK097419

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000471784 ENST00000344774(uc004cmi.1) ENST00000484720 ENST00000388932

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Additional mRNA sequence:

AK097419.1 AY604177.1 BC132916.1 BC132918.1

14 DOTS entries:

DT.95361033 DT.100059985 DT.100893018 DT.121210450 DT.100059989 DT.121210387 DT.87002174 DT.95360983

DT.121307030 DT.91779006 DT.91779055 DT.91994133 DT.92009164 DT.95361034

Selected AceView cDNA sequences (see all 86):

NM_001001710 BF838536 AI001929 AY604177 T12649 BQ360314 BF838538 AK097419

CD621885 AI026681 AW242362 AA352446 CD621898 BE926604 BG938763 BX445177

CD621903 BX411826 BQ375830 BF870534 BE698093 BE940286 CD621878 BQ940167

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FAM166A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GATGTGGACA

About this image

FAM166A Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

FAM166A Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.522530

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for FAM166A gene from Selected species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Fam166a^{1 , 5}	family with sequence similarity 166, member A^{1, 5}	80.79(n)¹ 78.98(a)¹		2 (17.08 cM)⁵ 68222¹ NM_026624.3¹ NP_080900.1¹ 25218745⁵
chicken (Gallus gallus)	Aves	FAM166A¹	family with sequence similarity 166, member A	57.01(n) 46.13(a)		771210 XM_001234502.3 XP_001234503.3
lizard (Anolis carolinensis)	Reptilia	FAM166A⁶	family with sequence similarity 166, member A	49(a)	1 ↔ 1	GL344097.1(55348-62249)

ENSEMBL Gene Tree for FAM166A (if available)
TreeFam Gene Tree for FAM166A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

Paralogs for FAM166A gene

Find genes that share paralogs with FAM166A About GenesLikeMe

Selected Pseudogenes.org Pseudogenes for FAM166A (see all 15)
PGOHUM00000238663 PGOHUM00000239410 PGOHUM00000239737 PGOHUM00000234966 PGOHUM00000243875

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs113210630^1,2	C,F	--	140137768(+)	`GCCACC/G/TTTCAT`	3	T	syn¹		2		CSA NA	4548
rs139069738^1,2	F	--	140174667(+)	`GAGGTG/AGATGA`	1	--	int¹		1		NA	4548
rs9330200^1,2	C,H	--	140174670(+)	`GTGGAT/AGAGCA`	1	--	int¹		5		NS EA NA	408
rs201909594^1,2		--	140174724(+)	`TGGATC/TCCCAA`	1	--	int¹		0	--	--	--	--
rs147118736^1,2	C,F	--	140174733(+)	`AACAAT/CGTGAA`	1	--	int¹		1		NA	4550
rs201286727^1,2	C	--	140174784(+)	`TCCGCC/TACCTT`	1	--	int¹		0	--	--	--	--
rs149615824^1,2	F	--	140174835(+)	`ATCTCC/TGAGCA`	1	--	int¹		1		NA	4534
rs143919939^1,2	F	--	140174886(+)	`TACACG/AGGCGA`	1	--	int¹		1		NA	4538
rs148635740^1,2	C,F	--	140174889(+)	`ACGGGC/TGAGGG`	1	--	int¹		2		NA EU	5857
rs201737567^1,2	C	--	140174979(+)	`ACAGCC/G/TGAGGA`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for FAM166A (140138036 - 140142222 bp)

Structural Variations
Database of Genomic Variants (DGV) Selected variations for FAM166A (see all 27): About this table

Variant ID	Type	Subtype	PubMed ID
esv2422220	CNV	Deletion	17116639
nsv894640	CNV	Loss	21882294
dgv8416n71	CNV	Loss	21882294
dgv8445n71	CNV	Loss	21882294
nsv894521	CNV	Loss	21882294
dgv8450n71	CNV	Loss	21882294
nsv894642	CNV	Loss	21882294
dgv8423n71	CNV	Loss	21882294
dgv8451n71	CNV	Loss	21882294
dgv8446n71	CNV	Loss	21882294

Human Gene Mutation Database (HGMD): FAM166A

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

Find genes that share disorders with FAM166A About GenesLikeMe

Export disorders for FAM166A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FAM166A gene integrated from 10 sources:
(articles sorted by number of sources associating them with FAM166A)

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)² Humphray S.J.... Dunham I. (Nature 2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S.... Malek J. (Genome Res. 2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 401565	HGNC: 33818	AceView: LOC401565	Ensembl:ENSG00000188163	euGenes: HUgn401565
ECgene: FAM166A	H-InvDB: FAM166A

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FAM166A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FAM166A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for FAM166A gene:
Search GeneIP for patents involving FAM166A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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About This Section


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FAM166A Gene

Family With Sequence Similarity 166, Member A

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GeneCards Suite

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Export list of displayed genes

FAM166A Gene

Family With Sequence Similarity 166, Member A

Aliasesfor FAM166A gene

Summariesfor FAM166A gene

Genomic Viewsfor FAM166A gene

Proteinsfor FAM166A gene

FAM166A Human Recombinant Protein Products:

FAM166A Antibody Products:

FAM166A Assay Products:

Domains /Familiesfor FAM166A gene

Functionfor FAM166A gene

Localizationfor FAM166A gene

Pathways & Interactionsfor FAM166A gene

Drugs & Compoundsfor FAM166A gene

Transcriptsfor FAM166A gene

Expression for FAM166A gene

Orthologsfor FAM166A gene

Paralogsfor FAM166A gene

Genomic Variantsfor FAM166A gene

Disorders / Diseasesfor FAM166A gene

Publicationsfor FAM166A gene

External Searches for FAM166A gene

Genome Databases showing FAM166A gene

Other Databases showing FAM166A gene

Specialized Databases showing FAM166A gene

Intellectual Propertyfor FAM166A gene

Productsfor FAM166A gene

View Random Gene

Aliases
for FAM166A gene

Summaries
for FAM166A gene

Genomic Views
for FAM166A gene

Proteins
for FAM166A gene

Domains /
Families
for FAM166A gene

Function
for FAM166A gene

Localization
for FAM166A gene

Pathways & Interactions
for FAM166A gene

Drugs & Compounds
for FAM166A gene

Transcripts
for FAM166A gene

Expression
for FAM166A gene

Orthologs
for FAM166A gene

Paralogs
for FAM166A gene

Genomic Variants
for FAM166A gene

Disorders / Diseases
for FAM166A gene

Publications
for FAM166A gene

Intellectual Property
for FAM166A gene

Products
for FAM166A gene