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FAM166A Gene

protein-coding   GIFtS: 37
GCID: GC09M140138

Family With Sequence Similarity 166, Member A

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Aliases
for FAM166A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Family With Sequence Similarity 166, Member A1 2
Protein FAM166A2

External Ids:    HGNC: 338181   Entrez Gene: 4015652   Ensembl: ENSG000001881637   UniProtKB: Q6J2723   
ORGUL members:         

Export aliases for FAM166A gene to outside databases

Previous GC identifers: GC09M139258 GC09M109597


Summaries
for FAM166A gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM166A Gene:
FAM166A (family with sequence similarity 166, member A) is a protein-coding gene.


Genomic Views
for FAM166A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAM166A gene promoter:
         SRF   RFX1   GATA-3   p53   CP2   Pbx1a   Pax-5   SRF (504 AA)   XBP-1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FAM166A promoter sequence
   Search Chromatin IP Primers for FAM166A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM166A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.3   Ensembl cytogenetic band:  9q34.3   HGNC cytogenetic band: 9q34.3

FAM166A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM166A gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M140138:  view genomic region     (about GC identifiers)

Start:
 140,138,036 bp from pter      End:
 140,142,222 bp from pter
Size:
 4,187 bases      Orientation:
 minus strand

Proteins
for FAM166A gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: F166A_HUMAN, Q6J272 (See protein sequence)
Recommended Name: Protein FAM166A  
Size: 317 amino acids; 36165 Da
Secondary accessions: A6NND9 Q8N830
Alternative splicing: 2 isoforms:  Q6J272-1   Q6J272-2   

Explore the universe of human proteins at neXtProt for FAM166A: NX_Q6J272

Explore proteomics data for FAM166A at MOPED


See FAM166A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001001710.1  
ENSEMBL proteins: 
 ENSP00000419151   ENSP00000344729   ENSP00000420741   ENSP00000373584  

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antibodies-online antibodies for FAM166A (15 products) 

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antibodies-online kits for FAM166A (6 products) 

Domains /
Families
for FAM166A gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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TryGeneCards Plus		 1 InterPro protein domain:
 IPR018902 UPF0573/UPF0605

Graphical View of Domain Structure for InterPro Entry Q6J272

ProtoNet protein and cluster: Q6J272

UniProtKB/Swiss-Prot: F166A_HUMAN, Q6J272
Similarity: Belongs to the UPF0605 family


Find genes that share domains with FAM166A           About GenesLikeMe


Function
for FAM166A gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Phenotypes:
     1 GenomeRNAi human phenotype for FAM166A:
 Decreased homologous recombina 

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for FAM166A

miRNA
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2 qRT-PCR Assays for microRNAs that regulate FAM166A:
hsa-let-7g* hsa-let-7a-2*
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Inhib. RNA
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Localization
for FAM166A gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol2
nucleus2
extracellular1
mitochondrion1

Pathways & Interactions
for FAM166A gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Interactions:

    Search GeneGlobe Interaction Network for FAM166A

Drugs & Compounds
for FAM166A gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for FAM166A (F166A)



Transcripts
for FAM166A gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for FAM166A gene: 
NM_001001710.2  

Unigene Cluster for FAM166A:

Family with sequence similarity 166, member A
Hs.522530  [show with all ESTs]
Unigene Representative Sequence: AK097419
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000471784 ENST00000344774(uc004cmi.1) ENST00000484720 ENST00000388932

miRNA
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2 qRT-PCR Assays for microRNAs that regulate FAM166A:
hsa-let-7g* hsa-let-7a-2*
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat FAM166A
Clone
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM166A
Primer
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Additional mRNA sequence: 

AK097419.1 AY604177.1 BC132916.1 BC132918.1 

14 DOTS entries:

DT.95361033  DT.100059985  DT.100893018  DT.121210450  DT.100059989  DT.121210387  DT.87002174  DT.95360983 
DT.121307030  DT.91779006  DT.91779055  DT.91994133  DT.92009164  DT.95361034 

Selected AceView cDNA sequences (see all 86):

NM_001001710 BF838536 AI001929 AY604177 T12649 BQ360314 BF838538 AK097419 
CD621885 AI026681 AW242362 AA352446 CD621898 BE926604 BG938763 BX445177 
CD621903 BX411826 BQ375830 BF870534 BE698093 BE940286 CD621878 BQ940167 

GeneLoc Exon Structure


Expression
for FAM166A gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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FAM166A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GATGTGGACA
FAM166A Expression
About this image

FAM166A Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

FAM166A Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.522530
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Primer
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In Situ
Assay Products: 
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM166A

Orthologs
for FAM166A gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for FAM166A gene from Selected species (see all 9)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
mouse
(Mus musculus)		 Mammalia Fam166a1 , 5 family with sequence similarity 166, member A1, 5 80.79(n)1
78.98(a)1		   2 (17.08 cM)5
682221  NM_026624.31  NP_080900.11 
 252187455 
chicken
(Gallus gallus)		 Aves FAM166A1 family with sequence similarity 166, member A 57.01(n)
46.13(a)		   771210  XM_001234502.3  XP_001234503.3 
lizard
(Anolis carolinensis)		 Reptilia FAM166A6
 family with sequence similarity 166, member A
 49(a)
 1 ↔ 1
 GL344097.1(55348-62249)


ENSEMBL Gene Tree for FAM166A (if available)
TreeFam Gene Tree for FAM166A (if available)

Paralogs
for FAM166A gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for FAM166A gene

Find genes that share paralogs with FAM166A           About GenesLikeMe


Selected Pseudogenes.org Pseudogenes for FAM166A (see all 15)
PGOHUM00000238663 PGOHUM00000239410 PGOHUM00000239737 PGOHUM00000234966 PGOHUM00000243875


Genomic Variants
for FAM166A gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for FAM166A (see all 318)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance		Chr 9 posSequence#AA
Chg		TypeMore#Allele
freq		PopTotal
sample		More
----------
rs1132106301,2
C,F--140137768(+) GCCACC/G/TTTCAT 3 T syn12CSA NA 4548
rs1390697381,2
F--140174667(+) GAGGTG/AGATGA 1 -- int11Minor allele frequency- A:0.00NA 4548
rs93302001,2
C,H--140174670(+) GTGGAT/AGAGCA 1 -- int15Minor allele frequency- A:0.00NS EA NA 408
rs2019095941,2
--140174724(+) TGGATC/TCCCAA 1 -- int10--------
rs1471187361,2
C,F--140174733(+) AACAAT/CGTGAA 1 -- int11Minor allele frequency- C:0.00NA 4550
rs2012867271,2
C--140174784(+) TCCGCC/TACCTT 1 -- int10--------
rs1496158241,2
F--140174835(+) ATCTCC/TGAGCA 1 -- int11Minor allele frequency- T:0.00NA 4534
rs1439199391,2
F--140174886(+) TACACG/AGGCGA 1 -- int11Minor allele frequency- A:0.00NA 4538
rs1486357401,2
C,F--140174889(+) ACGGGC/TGAGGG 1 -- int12Minor allele frequency- T:0.00NA EU 5857
rs2017375671,2
C--140174979(+) ACAGCC/G/TGAGGA 1 -- int10--------

HapMap Linkage Disequilibrium report for FAM166A (140138036 - 140142222 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for FAM166A (see all 27):    About this table    
Variant IDTypeSubtypePubMed ID
esv2422220CNV Deletion17116639
nsv894640CNV Loss21882294
dgv8416n71CNV Loss21882294
dgv8445n71CNV Loss21882294
nsv894521CNV Loss21882294
dgv8450n71CNV Loss21882294
nsv894642CNV Loss21882294
dgv8423n71CNV Loss21882294
dgv8451n71CNV Loss21882294
dgv8446n71CNV Loss21882294

Human Gene Mutation Database (HGMD): FAM166A
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing FAM166A
DNA2.0 Custom Variant and Variant Library Synthesis for FAM166A

Disorders / Diseases
for FAM166A gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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Find genes that share disorders with FAM166A           About GenesLikeMe


Export disorders for FAM166A gene to outside databases

Publications
for FAM166A gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for FAM166A gene integrated from 10 sources:
(articles sorted by number of sources associating them with FAM166A)		    Utopia: connect your pdf to the dynamic
world of online information

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  2. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (Nature 2004)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

External Searches for FAM166A gene

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing FAM166A gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 401565 HGNC: 33818 AceView: LOC401565 Ensembl:ENSG00000188163 euGenes: HUgn401565
ECgene: FAM166A H-InvDB: FAM166A

Other Databases showing FAM166A gene

(According to HUGE)
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Specialized Databases showing FAM166A gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for FAM166A Pharmacogenomics, SNPs, Pathways

Intellectual Property
for FAM166A gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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TryGeneCards Plus		Patent Information for FAM166A gene:
Search GeneIP for patents involving FAM166A

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
for FAM166A gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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 Browse ProSpec Recombinant Proteins
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 Browse ESI BIO Cell Lines and PureStem Progenitors for FAM166A
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 Browse SwitchGear 3'UTR luciferase reporter plasmids for FAM166A
 SwitchGear Promoter luciferase reporter plasmids for FAM166A
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 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM166A
 Browse compounds at ApexBio
 Search Addgene for plasmids for FAM166A
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 genOway: Develop your customized and physiologically relevant rodent model for FAM166A
 antibodies-online antibodies for FAM166A (15 products)
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