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Aliases for FAM163B Gene

Aliases for FAM163B Gene

  • Family With Sequence Similarity 163, Member B 2 3
  • C9orf166 3 4
  • Chromosome 9 Open Reading Frame 166 2

External Ids for FAM163B Gene

Previous HGNC Symbols for FAM163B Gene

  • C9orf166

Previous GeneCards Identifiers for FAM163B Gene

  • GC09M135436
  • GC09M136444
  • GC09M105944

Summaries for FAM163B Gene

GeneCards Summary for FAM163B Gene

FAM163B (Family With Sequence Similarity 163, Member B) is a Protein Coding gene. An important paralog of this gene is FAM163A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM163B Gene

Genomics for FAM163B Gene

Regulatory Elements for FAM163B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM163B Gene

133,577,076 bp from pter
133,609,920 bp from pter
32,845 bases
Minus strand

Genomic View for FAM163B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM163B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM163B Gene

Proteins for FAM163B Gene

  • Protein details for FAM163B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM163B
    Protein Accession:
    Secondary Accessions:
    • B2RUZ5

    Protein attributes for FAM163B Gene

    166 amino acids
    Molecular mass:
    18190 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM163B Gene

Proteomics data for FAM163B Gene at MOPED

Post-translational modifications for FAM163B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM163B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM163B Gene

Domains & Families for FAM163B Gene

Protein Domains for FAM163B Gene


Suggested Antigen Peptide Sequences for FAM163B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM163 family.
  • Belongs to the FAM163 family.
genes like me logo Genes that share domains with FAM163B: view

No data available for Gene Families for FAM163B Gene

Function for FAM163B Gene

Phenotypes for FAM163B Gene

GenomeRNAi human phenotypes for FAM163B:
genes like me logo Genes that share phenotypes with FAM163B: view

Animal Model Products

CRISPR Products

miRNA for FAM163B Gene

miRTarBase miRNAs that target FAM163B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM163B

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM163B Gene

Localization for FAM163B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM163B Gene

Membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for FAM163B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM163B: view

No data available for Subcellular locations from COMPARTMENTS for FAM163B Gene

Pathways & Interactions for FAM163B Gene

SuperPathways for FAM163B Gene

No Data Available

Interacting Proteins for FAM163B Gene

Gene Ontology (GO) - Biological Process for FAM163B Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM163B Gene

Drugs & Compounds for FAM163B Gene

No Compound Related Data Available

Transcripts for FAM163B Gene

mRNA/cDNA for FAM163B Gene

(7) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM163B Gene

Family with sequence similarity 163, member B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM163B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM163B Gene

No ASD Table

Relevant External Links for FAM163B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM163B Gene

mRNA expression in normal human tissues for FAM163B Gene

mRNA differential expression in normal tissues according to GTEx for FAM163B Gene

This gene is overexpressed in Brain - Cortex (x13.0), Brain - Frontal Cortex (BA9) (x10.5), Brain - Anterior cingulate cortex (BA24) (x9.5), and Brain - Amygdala (x4.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM163B Gene

SOURCE GeneReport for Unigene cluster for FAM163B Gene Hs.741379

genes like me logo Genes that share expression patterns with FAM163B: view

Protein tissue co-expression partners for FAM163B Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM163B Gene

Orthologs for FAM163B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM163B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM163B 35
  • 89.71 (n)
  • 88.27 (a)
-- 36
  • 88 (a)
(Canis familiaris)
Mammalia FAM163B 35
  • 90.65 (n)
  • 90.24 (a)
-- 36
  • 90 (a)
(Mus musculus)
Mammalia Fam163b 35
  • 86.95 (n)
  • 90.36 (a)
Fam163b 16
Fam163b 36
  • 89 (a)
(Pan troglodytes)
Mammalia FAM163B 35
  • 99.4 (n)
  • 98.19 (a)
-- 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Fam163b 35
  • 86.55 (n)
  • 89.76 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 66 (a)
(Gallus gallus)
Aves LOC100858326 35
  • 80.62 (n)
  • 78.75 (a)
-- 36
  • 78 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam163b 35
  • 72.04 (n)
  • 74.19 (a)
(Danio rerio)
Actinopterygii LOC100537920 35
  • 64.56 (n)
  • 60.76 (a)
fam163b 36
  • 51 (a)
Species with no ortholog for FAM163B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM163B Gene

Gene Tree for FAM163B (if available)
Gene Tree for FAM163B (if available)

Paralogs for FAM163B Gene

Paralogs for FAM163B Gene

(1) SIMAP similar genes for FAM163B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM163B: view

Variants for FAM163B Gene

Sequence variations from dbSNP and Humsavar for FAM163B Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs739444 -- 133,590,623(-) CGAGG(C/G)CTTTA intron-variant
rs739445 -- 133,590,683(-) TCCAG(C/G)CGTGT intron-variant
rs739446 -- 133,590,752(-) GGCCA(C/T)GCTGC intron-variant
rs753659 -- 133,590,934(-) TCCCC(A/G)GAAGC intron-variant
rs756771 -- 133,599,386(+) CGGGA(C/G)CCCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM163B Gene

Variant ID Type Subtype PubMed ID
esv2739138 CNV Deletion 23290073
dgv8325n71 CNV Loss 21882294
nsv894081 CNV Loss 21882294
dgv8328n71 CNV Loss 21882294
nsv894086 CNV Gain 21882294
nsv894094 CNV Loss 21882294
dgv8330n71 CNV Loss 21882294
nsv894100 CNV Gain 21882294
nsv894101 CNV Loss 21882294
nsv894102 CNV Loss 21882294
esv2656927 CNV Deletion 23128226
dgv2425e1 CNV Complex 17122850
nsv428225 CNV Loss 18775914

Variation tolerance for FAM163B Gene

Gene Damage Index Score: 0.68; 14.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM163B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM163B Gene

Disorders for FAM163B Gene

Relevant External Links for FAM163B

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FAM163B: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM163B Gene

Publications for FAM163B Gene

  1. Genome-wide meta-analyses identify multiple loci associated with smoking behavior. (PMID: 20418890) (Nat. Genet. 2010) 67
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 67
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 67
  5. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PMID: 10737800) Dias Neto E. … Simpson A.J.G. (Proc. Natl. Acad. Sci. U.S.A. 2000) 67

Products for FAM163B Gene

Sources for FAM163B Gene

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