FAM163B Gene
protein-coding GIFtS: 30
GCID: GC09M136444
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Family With Sequence Similarity 163, Member B(Previous name: chromosome 9 open reading frame 166)
(Previous symbol: C9orf166)
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Aliases
for FAM163B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
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| Aliases |
|---|
| Family With Sequence Similarity 163, Member B1 2 | | C9orf1661 2 3 | | Chromosome 9 Open Reading Frame 1661 | | Protein FAM163B2 |
Export aliases for FAM163B gene to outside databasesPrevious GC identifers: GC09M135436 GC09M105944 |
Summaries
for FAM163B gene(According to Entrez Gene,
GeneCards,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
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GeneCards Summary for FAM163B Gene:
FAM163B (family with sequence similarity 163, member B) is a protein-coding gene. An important paralog of this gene is ENSG00000215611.
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Genomic Views
for FAM163B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 75),
Regulatory elements and Epigenetics data according to
QIAGEN, and/or
SwitchGear Genomics)
About This Section
TryGeneCards Plus | Regulatory elements:
 Regulatory transcription factor binding sites in the FAM163B gene promoter:
Tal-1 MyoD Tal-1beta AP-2gamma E47 Arnt AP-2beta AP-2alpha AP-2alphaA
Other transcription factors
Search Chromatin IP Primers for FAM163B
Epigenetics:
| | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM163B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q34.2 Ensembl cytogenetic band: 9q34.2 HGNC cytogenetic band: 9q34.2FAM163B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M136444: view genomic region
(about GC identifiers)
Start:
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136,443,537 bp from pter |
End:
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136,451,319 bp from pter |
Size:
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7,783 bases |
Orientation:
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minus strand |
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Proteins
for FAM163B gene
(According to
1UniProtKB,
HORDE,
2neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Antibodies by
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: F163B_HUMAN, P0C2L3 (See
protein sequence)Recommended Name: Protein FAM163B Size: 166 amino acids; 18190 Da
Secondary accessions: B2RUZ5Explore the universe of human proteins at neXtProt for FAM163B: NX_P0C2L3
Post-translational modifications:  Modification sites at neXtProt Modification sites at PhosphoSitePlusREFSEQ proteins: NP_001073984.1
ENSEMBL proteins: ENSP00000419867 ENSP00000349336
FAM163B Human Recombinant
Protein Products:FAM163B Antibody
Products:FAM163B Assay Products: |
Domains /
Families
for FAM163B gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
TryGeneCards Plus | ProtoNet protein and cluster: P0C2L3 UniProtKB/Swiss-Prot: F163B_HUMAN, P0C2L3Similarity: Belongs to the FAM163 family |
Function
for FAM163B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
genOway,
transcription factor targeting from QIAGEN
and/or HOMER,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
SwitchGear Genomics,
Gene Editing from DNA2.0,
Clones from OriGene,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
ESI BIO,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
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Animal Models:
Inhib. RNA
Products: |  | OriGene RNAi products in human, mouse, rat for FAM163B
| | | Predesigned siRNA for gene silencing in human, mouse, rat FAM163B |
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for FAM163B | |  | Browse ESI BIO Cell Lines and PureStem Progenitors for FAM163B  | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM163B |
Localization
for FAM163B gene
(According to UniProtKB, COMPARTMENTS Subcellular localization database,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot F163B_HUMAN, P0C2L3: Membrane; Single-pass membrane protein (Potential)Subcellular locations from COMPARTMENTS:
| Compartment | Confidence |
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| extracellular | 1 | | plasma membrane | 1 |
Gene Ontology (GO): 1 cellular component term: About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0016021 | integral component of membrane |
IEA | -- |
FAM163B for ontologies About GeneDecksing
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Pathways & Interactions
for FAM163B gene
(SuperPaths according to PathCards,
Pathways according to
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
QIAGEN,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene).
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Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM163B
Interactions:
Search GeneGlobe Interaction Network for FAM163B
|
Drugs & Compounds
for FAM163B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience,
ApexBio,
HMDB,
BitterDB, and/or
Novoseek,
Ligands according to IUPHAR,
and Drugs according to DrugBank,
Enzo Life Sciences, and/or
PharmGKB)
About This Section
TryGeneCards Plus |  Browse compounds at ApexBio
 Browse Tocris compounds for FAM163B (F163B)
|
Transcripts
for FAM163B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
SwitchGear Genomics,
Tagged/untagged cDNA clones from
OriGene,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene, and/or
QIAGEN
)
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REFSEQ mRNAs for FAM163B gene: NM_001080515.2 2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000496132 ENST00000356873(uc011mdm.2)
Inhib. RNA
Products: | | OriGene RNAi products in human, mouse, rat for FAM163B
| |
| | Predesigned siRNA for gene silencing in human, mouse, rat FAM163B |
GeneLoc Exon Structure
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Expression
for FAM163B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MaxQB,
plus additional links to
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
QIAGEN,
Primers from
OriGene, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
TryGeneCards Plus | FAM163B expression in normal human tissues
(normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CGGGAGGCCT
About this image FAM163B Protein expression data from MOPED1, PaxDb2 and
MaxQB3: --
Custom PCR Arrays for FAM163B
Primer
Products: | | OriGene qSTAR qPCR primer pairs in human, mouse for FAM163B
| | | Search Pre-validated RT2 qPCR
Primer Assays in human, mouse, rat FAM163B | | | Search QuantiTect SYBR Green Assays in human, mouse, rat FAM163B | | | QuantiFast Probe-based Assays in human, mouse, rat FAM163B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM163B |
Orthologs
for FAM163B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
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This gene was present in the common ancestor of chordates.
Orthologs for FAM163B gene from Selected species (see all 11) About this table
ENSEMBL Gene Tree for FAM163B (if available)
TreeFam Gene Tree for FAM163B (if available) |
Paralogs
for FAM163B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
TryGeneCards Plus | Paralogs for FAM163B gene
- ENSG000002156112 FAM163A2
1 SIMAP similar gene for FAM163B using alignment to 1 protein entry: F163B_HUMAN:FAM163A
FAM163B for paralogs About GeneDecksing
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Genomic Variants
for FAM163B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD), the Human Cytochrome P450 Allele
Nomenclature Database, and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for FAM163B (136443537 - 136451319 bp)
Structural Variations
Database of Genomic Variants (DGV) Selected variations for FAM163B (see all 13): About this table
| | Site Specific Mutation Identification with PCR Assays |
| | SeqTarget long-range PCR primers for resequencing FAM163B |
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Disorders
/ Diseases
for FAM163B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
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FAM163B for disorders About GeneDecksing
Genetic Association Database (GAD): FAM163B
Export disorders for FAM163B gene to outside databases
|
Publications
for FAM163B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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PubMed articles for FAM163B gene integrated from 10 sources:
(articles sorted by number of sources associating them with FAM163B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
- Genome-wide meta-analyses identify multiple loci associated with smoking behavior. (PubMed id 20418890)4 (Nat. Genet. 2010)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
- Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)1 Dias Neto E....Simpson A.J.G. (Proc. Natl. Acad. Sci. U.S.A. 2000)
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External Searches for FAM163B gene (in PubMed,
OMIM, and NCBI Bookshelf)
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|
Genome Databases showing FAM163B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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|
Other Databases showing FAM163B gene
(According to HUGE)
About This Section
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Specialized Databases showing FAM163B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for FAM163B | Pharmacogenomics, SNPs, Pathways |
|
| | |
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TryGeneCards Plus | Patent Information for FAM163B gene:
Search GeneIP for patents involving FAM163B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM163B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or
ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory,
genOway)
About This Section
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|  | Block miRNA regulation of human, mouse, rat FAM163B using miScript Target Protectors | | SeqTarget long-range PCR primers for resequencing FAM163B | | | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM163B | | Predesigned siRNA for gene silencing in human, mouse, rat FAM163B | | | QuantiFast Probe-based Assays in human, mouse, rat FAM163B | | Search QuantiTect SYBR Green Assays in human, mouse, rat FAM163B | | | Custom PCR Arrays for FAM163B | | Search Chromatin IP Primers for FAM163B | | | Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat FAM163B | | Search GeneGlobe Interaction Network for FAM163B | | | Regulatory tfbs in FAM163B promoter |
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 |  | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM163B |
| |  |  |  |  | | | Search ThermoFisher Antibodies for FAM163B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM163B |
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