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Aliases for FAM163B Gene

Aliases for FAM163B Gene

  • Family With Sequence Similarity 163 Member B 2 3 5
  • C9orf166 3 4
  • Family With Sequence Similarity 163, Member B 2
  • Chromosome 9 Open Reading Frame 166 2
  • Protein FAM163B 3

External Ids for FAM163B Gene

Previous HGNC Symbols for FAM163B Gene

  • C9orf166

Previous GeneCards Identifiers for FAM163B Gene

  • GC09M135436
  • GC09M136444
  • GC09M105944

Summaries for FAM163B Gene

GeneCards Summary for FAM163B Gene

FAM163B (Family With Sequence Similarity 163 Member B) is a Protein Coding gene. An important paralog of this gene is FAM163A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM163B Gene

Genomics for FAM163B Gene

Regulatory Elements for FAM163B Gene

Enhancers for FAM163B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F133557 1.3 Ensembl ENCODE 11.7 +51.3 51291 2.5 INSM2 SIN3A KLF17 FOS JUNB MEF2D ZFP69B SMARCA4 IKZF1 ZNF341 ENSG00000273249 TSC1 ADAMTSL2 TMEM8C FAM163B DBH
GH09F133564 0.6 ENCODE 11.6 +44.5 44477 1.5 HIC1 ZFHX2 KLF1 ZNF366 ZNF169 ZBTB33 PRDM1 EGR2 ADAMTSL2 TMEM8C FAM163B DBH
GH09F133563 0.5 Ensembl 11.6 +46.5 46519 0.8 KLF1 ZNF76 KLF17 ZIC2 ZNF121 ZFHX2 GLIS2 ZBTB48 SCRT2 KLF7 ADAMTSL2 TMEM8C FAM163B DBH
GH09F133659 0.4 Ensembl 11 -49.0 -48953 1.3 ARID4B FEZF1 ZNF48 YY1 GLIS2 KLF7 PAF1 SP3 SP5 MIER2 SARDH FAM163B ADAMTSL2 TMEM8C DBH-AS1 GC09M133655
GH09F133676 1.2 FANTOM5 ENCODE 10.9 -67.4 -67431 1.9 CTCF SREBF2 NR2F2 HIC1 GLIS2 POLR2A SCRT2 GLIS1 ZBTB33 DBH FAM163B DBH-AS1 RPL7A GC09P133683 LOC105376308
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FAM163B on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM163B Gene

Chromosome:
9
Start:
133,577,076 bp from pter
End:
133,609,920 bp from pter
Size:
32,845 bases
Orientation:
Minus strand

Genomic View for FAM163B Gene

Genes around FAM163B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM163B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM163B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM163B Gene

Proteins for FAM163B Gene

  • Protein details for FAM163B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C2L3-F163B_HUMAN
    Recommended name:
    Protein FAM163B
    Protein Accession:
    P0C2L3
    Secondary Accessions:
    • B2RUZ5

    Protein attributes for FAM163B Gene

    Size:
    166 amino acids
    Molecular mass:
    18190 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM163B Gene

Post-translational modifications for FAM163B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM163B Gene

Domains & Families for FAM163B Gene

Protein Domains for FAM163B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM163B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0C2L3

UniProtKB/Swiss-Prot:

F163B_HUMAN :
  • Belongs to the FAM163 family.
Family:
  • Belongs to the FAM163 family.
genes like me logo Genes that share domains with FAM163B: view

No data available for Gene Families for FAM163B Gene

Function for FAM163B Gene

Phenotypes for FAM163B Gene

GenomeRNAi human phenotypes for FAM163B:
genes like me logo Genes that share phenotypes with FAM163B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for FAM163B

miRNA for FAM163B Gene

miRTarBase miRNAs that target FAM163B

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM163B Gene

Localization for FAM163B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM163B Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM163B Gene COMPARTMENTS Subcellular localization image for FAM163B gene
Compartment Confidence
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FAM163B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM163B: view

Pathways & Interactions for FAM163B Gene

SuperPathways for FAM163B Gene

No Data Available

Interacting Proteins for FAM163B Gene

Gene Ontology (GO) - Biological Process for FAM163B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM163B Gene

Transcripts for FAM163B Gene

mRNA/cDNA for FAM163B Gene

(8) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM163B Gene

Family with sequence similarity 163, member B:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM163B Gene

No ASD Table

Relevant External Links for FAM163B Gene

GeneLoc Exon Structure for
FAM163B
ECgene alternative splicing isoforms for
FAM163B

Expression for FAM163B Gene

mRNA expression in normal human tissues for FAM163B Gene

mRNA differential expression in normal tissues according to GTEx for FAM163B Gene

This gene is overexpressed in Brain - Cortex (x13.0), Brain - Frontal Cortex (BA9) (x10.5), Brain - Anterior cingulate cortex (BA24) (x9.5), and Brain - Amygdala (x4.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM163B Gene



Protein tissue co-expression partners for FAM163B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM163B Gene:

FAM163B

SOURCE GeneReport for Unigene cluster for FAM163B Gene:

Hs.741379
genes like me logo Genes that share expression patterns with FAM163B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM163B Gene

Orthologs for FAM163B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM163B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM163B 34
  • 99.4 (n)
-- 35
  • 98 (a)
OneToMany
dog
(Canis familiaris)
Mammalia FAM163B 34
  • 90.65 (n)
-- 35
  • 90 (a)
OneToMany
cow
(Bos Taurus)
Mammalia FAM163B 34
  • 89.71 (n)
-- 35
  • 88 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Fam163b 34 16 35
  • 86.95 (n)
rat
(Rattus norvegicus)
Mammalia Fam163b 34
  • 86.55 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 86 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 66 (a)
OneToMany
chicken
(Gallus gallus)
Aves LOC100858326 34
  • 80.62 (n)
-- 35
  • 78 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 76 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia fam163b 34
  • 72.04 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100537920 34
  • 64.56 (n)
fam163b 35
  • 51 (a)
OneToMany
Species where no ortholog for FAM163B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM163B Gene

ENSEMBL:
Gene Tree for FAM163B (if available)
TreeFam:
Gene Tree for FAM163B (if available)

Paralogs for FAM163B Gene

Paralogs for FAM163B Gene

(1) SIMAP similar genes for FAM163B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM163B: view

Variants for FAM163B Gene

Sequence variations from dbSNP and Humsavar for FAM163B Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10046828 -- 133,593,959(+) CAGAT(A/C)CATGG intron-variant
rs10114817 -- 133,577,362(+) GGCCC(A/G)GGGGG nc-transcript-variant, utr-variant-3-prime
rs10115001 -- 133,610,971(+) GTTCT(C/T)TTCCA upstream-variant-2KB
rs10115651 -- 133,578,347(+) AGGGC(A/G)GAGCA nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs10122343 -- 133,578,043(+) GAGAC(C/T)CACAG nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FAM163B Gene

Variant ID Type Subtype PubMed ID
dgv4157n106 CNV deletion 24896259
esv2656927 CNV deletion 23128226
esv2739138 CNV deletion 23290073
esv2759719 CNV gain+loss 17122850
nsv1075278 CNV deletion 25765185
nsv1125319 OTHER inversion 24896259
nsv428225 CNV loss 18775914
nsv951799 CNV deletion 24416366

Variation tolerance for FAM163B Gene

Gene Damage Index Score: 0.68; 14.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM163B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM163B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM163B Gene

Disorders for FAM163B Gene

Relevant External Links for FAM163B

Genetic Association Database (GAD)
FAM163B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM163B

No disorders were found for FAM163B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM163B Gene

Publications for FAM163B Gene

  1. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64
  2. Genome-wide meta-analyses identify multiple loci associated with smoking behavior. (PMID: 20418890) (Nat. Genet. 2010) 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64
  5. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PMID: 10737800) Dias Neto E. … Simpson A.J.G. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 64

Products for FAM163B Gene

Sources for FAM163B Gene

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