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FAM163B Gene

protein-coding   GIFtS: 30
GCID: GC09M136444

Family With Sequence Similarity 163, Member B

(Previous name: chromosome 9 open reading frame 166)
(Previous symbol: C9orf166)
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Aliases
for FAM163B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 163, Member B1 2
C9orf1661 2 3
Chromosome 9 Open Reading Frame 1661
Protein FAM163B2

External Ids:    HGNC: 332771   Entrez Gene: 6429682   Ensembl: ENSG000001969907   UniProtKB: P0C2L33   

Export aliases for FAM163B gene to outside databases

Previous GC identifers: GC09M135436 GC09M105944


Summaries
for FAM163B gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM163B Gene:
FAM163B (family with sequence similarity 163, member B) is a protein-coding gene. An important paralog of this gene is ENSG00000215611.


Genomic Views
for FAM163B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus		 Regulatory elements:
   Regulatory transcription factor binding sites in the FAM163B gene promoter:
         Tal-1   MyoD   Tal-1beta   AP-2gamma   E47   Arnt   AP-2beta   AP-2alpha   AP-2alphaA   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for FAM163B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM163B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.2   Ensembl cytogenetic band:  9q34.2   HGNC cytogenetic band: 9q34.2

FAM163B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM163B gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M136444:  view genomic region     (about GC identifiers)

Start:
 136,443,537 bp from pter      End:
 136,451,319 bp from pter
Size:
 7,783 bases      Orientation:
 minus strand

Proteins
for FAM163B gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: F163B_HUMAN, P0C2L3 (See protein sequence)
Recommended Name: Protein FAM163B  
Size: 166 amino acids; 18190 Da
Secondary accessions: B2RUZ5

Explore the universe of human proteins at neXtProt for FAM163B: NX_P0C2L3

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
    • REFSEQ proteins: NP_001073984.1  
    ENSEMBL proteins: 
     ENSP00000419867   ENSP00000349336  

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    Domains /
    Families
    for FAM163B gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: P0C2L3

    UniProtKB/Swiss-Prot: F163B_HUMAN, P0C2L3
    Similarity: Belongs to the FAM163 family


    Function
    for FAM163B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for FAM163B

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    Localization
    for FAM163B gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    F163B_HUMAN, P0C2L3: Membrane; Single-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with FAM163B           About GenesLikeMe


    Pathways & Interactions
    for FAM163B gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Interactions:

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    Drugs & Compounds
    for FAM163B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM163B (F163B)



    Transcripts
    for FAM163B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FAM163B gene: 
    NM_001080515.2  

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000496132 ENST00000356873(uc011mdm.2)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat FAM163B

    GeneLoc Exon Structure


    Expression
    for FAM163B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM163B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGGGAGGCCT
    FAM163B Expression
    About this image

    FAM163B Protein expression data from MOPED1, PaxDb2 and MaxQB3:  --
        Custom PCR Arrays for FAM163B
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    In Situ
    Assay Products:     
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    Orthologs
    for FAM163B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FAM163B gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Fam163b1 , 5 family with sequence similarity 163, member B1, 5 86.95(n)1
    90.36(a)1    		   2 (19.25 cM)5
    1093491  NM_175427.41  NP_780636.11 
     271103805 
    chicken
    (Gallus gallus)    		 Aves LOC1008583261 protein FAM163B-like 80.62(n)
    78.75(a)    		   100858326  XM_003642289.2  XP_003642337.1 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 Uncharacterized protein
    		 76(a)
    		 1 → many
    		 GL343999.1(77085-82682)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia fam163b1 family with sequence similarity 163, member B 72.04(n)
    74.19(a)    		   779655  NM_001078741.1  NP_001072209.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1005379201 protein FAM163B-like 64.56(n)
    60.76(a)    		   100537920  XM_005155610.1  XP_005155667.1 


    ENSEMBL Gene Tree for FAM163B (if available)
    TreeFam Gene Tree for FAM163B (if available)

    Paralogs
    for FAM163B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM163B gene
    ENSG000002156112  FAM163A2  
    1 SIMAP similar gene for FAM163B using alignment to 1 protein entry:     F163B_HUMAN:
    FAM163A

    Find genes that share paralogs with FAM163B           About GenesLikeMe



    Genomic Variants
    for FAM163B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM163B (see all 57)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 9 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1488349261,2
    		C--136443089(+) CTCCTA/GGGTCC 1 -- ds50010--------
    rs1406039291,2
    		C--136443127(+) CTGCAA/GCTCTG 1 -- ds50010--------
    rs1486800751,2
    		C--136443165(+) GAGACC/TCACAG 1 -- ds50010--------
    rs1440083211,2
    		C--136443259(+) TCTCAC/TGGGGA 1 -- ds50010--------
    rs1406390871,2
    		C--136443301(+) CTGCC-/CCACCTGA 1 -- cds10--------
    rs2005291491,2
    		C--136443302(+) TGCCC-/ACCCTGAC 1 -- cds10--------
    rs1489908911,2
    		C--136443382(+) TTTCCA/GCGTTG 1 -- ds50010--------
    rs1397038691,2
    		C--136443469(+) AGGGCA/GGAGCA 1 -- ds50010--------
    rs1436864371,2
    		C--136443522(+) GCAGCC/TGGTCC 1 -- ds50010--------
    rs1472195861,2
    		C--136443568(+) CAGACA/GCTTGG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for FAM163B (136443537 - 136451319 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FAM163B (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2656927CNV Deletion23128226
    esv2739138CNV Deletion23290073
    nsv894081CNV Loss21882294
    dgv8330n71CNV Loss21882294
    nsv894102CNV Loss21882294
    nsv894101CNV Loss21882294
    dgv8328n71CNV Loss21882294
    dgv8325n71CNV Loss21882294
    nsv428225CNV Loss18775914
    nsv894094CNV Loss21882294

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    Disorders / Diseases
    for FAM163B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with FAM163B           About GenesLikeMe

    Genetic Association Database (GAD): FAM163B

    Export disorders for FAM163B gene to outside databases

    Publications
    for FAM163B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM163B gene integrated from 10 sources:
    (articles sorted by number of sources associating them with FAM163B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    2. Genome-wide meta-analyses identify multiple loci associated with smoking behavior. (PubMed id 20418890)4 (Nat. Genet. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)1 Dias Neto E....Simpson A.J.G. (Proc. Natl. Acad. Sci. U.S.A. 2000)

    External Searches for FAM163B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing FAM163B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 642968 HGNC: 33277 Ensembl:ENSG00000196990 euGenes: HUgn642968 ECgene: FAM163B
    H-InvDB: FAM163B

    Other Databases showing FAM163B gene

    (According to HUGE)
    About This Section

    TryGeneCards Plus    		   --

    Specialized Databases showing FAM163B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FAM163B Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for FAM163B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus    		Patent Information for FAM163B gene:
    Search GeneIP for patents involving FAM163B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    for FAM163B gene

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    About This Section

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