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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAM163A Gene

protein-coding   GIFtS: 44
GCID: GC01P179712

family with sequence similarity 163, member A

(Previous name: chromosome 1 open reading frame 76 )
(Previous symbol: C1orf76)
 Explore 1 disease affiliated with
FAM163A via our new
 Human Malady Compendium 
Biological research products
for FAM163A
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Family With Sequence Similarity 163, Member A1 2     RP11-12M5.22
C1orf761 2 3 5     Cebelin3
NDSP2 3 5     Neuroblastoma Derived Secretory Protein2
Neuroblastoma-Derived Secretory Protein2 3     Protein FAM163A2
MGC166641     Cebelin3
Chromosome 1 Open Reading Frame 761     

External Ids:    HGNC: 282741   Entrez Gene: 1487532   Ensembl: ENSG000001433407   OMIM: 6117275   UniProtKB: Q96GL93   

Export aliases for FAM163A gene to outside databases

Previous GC identifers: GC01P177980 GC01P150944


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FAM163A gene promoter:
         AP-1   AML1a   SREBP-1c   POU6F1 (c2)   SREBP-1b   AREB6   SREBP-1a   POU2F1   POU2F1a   MRF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for FAM163A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM163A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25.2   Ensembl cytogenetic band:  1q25.2   HGNC cytogenetic band: 1q25.2

FAM163A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM163A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P179712:  view genomic region     (about GC identifiers)

Start:
179,712,298 bp from pter      End:
179,785,333 bp from pter
Size:
73,036 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: F163A_HUMAN, Q96GL9 (See protein sequence)
Recommended Name: Protein FAM163A  
Size: 167 amino acids; 17641 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Secondary accessions: A8K8R7

Explore the universe of human proteins at neXtProt for FAM163A: NX_Q96GL9

FAM163A Protein expression data from MOPED and PaxDb:    About this image 
FAM163A Protein Expression

REFSEQ proteins: NP_775780.1  
ENSEMBL proteins: 
 ENSP00000354891  

Human Recombinant Protein Products for FAM163A: 
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Uscn Proteins for FAM163A

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral to membrane IEA--

FAM163A for ontologies           About GeneDecksing



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Uscn ELISAs and CLIAs for FAM163A


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q96GL9

UniProtKB/Swiss-Prot: F163A_HUMAN, Q96GL9
Similarity: Belongs to the FAM163 family


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Animal Models:
   inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for FAM163A 

miRNA
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SwitchGear 3'UTR luciferase reporter plasmidFAM163A 3' UTR sequence
Inhib. RNA
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM163A


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM163A

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/25 Interacting proteins for FAM163A (ENSP000003548914) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
InteractantInteraction Details
GeneCardExternal ID(s)
ARHGEF10LENSP000003550604STRING: ENSP00000355060
ASPMENSP000003563794STRING: ENSP00000356379
ATPAF1ENSP000003610054STRING: ENSP00000361005
C1orf146ENSP000003594014STRING: ENSP00000359401
DEPDC1ENSP000004122924STRING: ENSP00000412292
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FAM163A
Search CenterWatch for drugs/clinical trials and news about FAM163A / F163A 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FAM163A gene: 
NM_173509.2  

Unigene Cluster for FAM163A:

Family with sequence similarity 163, member A
Hs.729631  [show with all ESTs]
Unigene Representative Sequence: NM_173509
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000341785(uc009wxj.3 uc001gnj.3 uc009wxk.3)

miRNA
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SwitchGear 3'UTR luciferase reporter plasmidFAM163A 3' UTR sequence
Inhib. RNA
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Sirion Biotech Custom design and validation of potent shRNA sequences against FAM163A 
Clone
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OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector: FAM163A (NM_173509)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM163A
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM163A 
Primer
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM163A

Additional cDNA sequence: 

AB299025.1 AK292432.1 AK302665.1 AK310711.1 AK313887.1 AY902195.1 BC009382.2 

4 DOTS entries:

DT.95273753  DT.121457333  DT.121457356  DT.80100835 

24 AceView cDNA sequences:

CR594925 AI917686 AI187962 BF059281 NM_173509 AI222080 BC009382 AI932320 
AI652060 BX375650 AI018400 AI148944 AI214979 BX451365 AA911242 AI028301 
BX328941 AW450345 BX353533 BQ186887 AI341171 BF310420 BQ187822 BQ716595 

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for FAM163A (see all 10)    About this scheme

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11
SP1:        -     -     -                 -                                                                     
SP2:        -     -     -     -     -     -                       -                                             
SP3:        -     -     -     -     -     -                       -     -     -     -     -     -               
SP4:        -     -     -     -     -     -                             -     -     -                           
SP5:                    -     -     -     -                       -                                             


ECgene alternative splicing isoforms for FAM163A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FAM163A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCAGACAGCG
FAM163A Expression
About this image

FAM163A expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells 
Tissue Anatomical Compartment CellCategory (developmental path)
EyeInner Nuclear LayerType1 Off Cone Bipolar CellsBipolar, Retina
HeartEndocardiumCushion Mesenchymal CellsEndocardium
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell 
NameCategory
Primordial germ cell-like cells (Reconstitution of mo...)

See FAM163A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM163A

SOURCE GeneReport for Unigene cluster: Hs.729631

UniProtKB/Swiss-Prot: F163A_HUMAN, Q96GL9
Tissue specificity: Highly expressed in neuroblastoma compared to other tissues, suggesting that it may be used as a
marker for metastasis in bone marrow

    SABiosciences Custom PCR Arrays for FAM163A
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM163A

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for FAM163A gene from 4/11 species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves FAM163A1 family with sequence similarity 163, member A 70.51(n)
66.03(a)
  771080  XM_001234381.1  XP_001234382.1 
lizard
(Anolis carolinensis)
Reptilia FAM163A6
--
59(a)
1 ↔ 1
4(70775911-70779980)
tropical clawed frog
(Xenopus tropicalis)
Amphibia AL846929.22   -- 79.39(n)    AL846929.2 
zebrafish
(Danio rerio)
Actinopterygii si:dkey-193b15.81 si:dkey-193b15.8 59.41(n)
60.54(a)
  100321107  XM_002660854.1  XP_002660900.1 


ENSEMBL Gene Tree for FAM163A (if available)
TreeFam Gene Tree for FAM163A (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for FAM163A gene
LOC1009963902  FAM163B2  
1 SIMAP similar gene for FAM163A using alignment to 1 protein entry:     F163A_HUMAN:
FAM163B

FAM163A for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/1357 NCBI SNPs in FAM163A are shown (see all 1357    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs801397481,2
C,F--150942341(+) AAAGAT/CTGCAC 2 -- int1 us2k11Minor allele frequency- C:0.07WA 118
rs798946431,2
--150942586(+) GCAATA/GTTATT 2 -- us2k1 int11Minor allele frequency- G:0.01NA 120
rs779422941,2
F--150942786(+) TGACCT/CGGGTG 2 -- int1 us2k11Minor allele frequency- C:0.03WA 118
rs556868841,2
C--150942825(+) GAAGGT/CACGTT 2 -- int1 us2k13Minor allele frequency- C:0.09WA NA 240
rs1125910401,2
--150942871(+) TCACAC/TGTCCT 2 -- us2k1 int11Minor allele frequency- T:0.50CSA 2
rs796328321,2
F--150943383(+) AAGAGA/GAAGAT 2 -- nc-transcript-variant1Minor allele frequency- G:0.02WA 118
rs741322461,2
C--150943643(+) CCCTTC/ACTGCC 2 -- ds50012Minor allele frequency- A:0.05WA 120
rs1390048791,2
--179710353(+) TGAAAC/TGAAGA 3 -- us2k1 int10--------
rs38560451,2
C,F,A,H--179710420(+) AATATT/CATATT 3 -- us2k1 int19Minor allele frequency- C:0.38NA WA CSA EA 371
rs1423918311,2
--179710421(+) ATATTA/GTATTT 3 -- us2k1 int10--------

HapMap Linkage Disequilibrium report for FAM163A (179712298 - 179785333 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for FAM163A
     2 CNVs: 6801 97569

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FAM163A for disorders           About GeneDecksing

OMIM gene information: 611727    OMIM disorders: --

1 disease for FAM163A:    About MalaCards
neuroblastoma

Human Genome Epidemiology (HuGE) Navigator: FAM163A (1 document)

Export disorders for FAM163A gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for FAM163A gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM163A)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Neuroblastoma-derived secretory protein messenger RNA levels correlate with high-risk neuroblastoma. (PubMed id 17208556)1, 2 Vasudevan S.A.... Nuchtern J.G. (2007)
  2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
  6. Neuroblastoma-derived secretory protein is a novel se creted factor overexpressed in neuroblastoma. (PubMed id 19671756)1 Vasudevan S.A....Nuchtern J.G. (2009)
  7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 148753 HGNC: 28274 AceView: MGC16664 Ensembl:ENSG00000143340 euGenes: HUgn148753
ECgene: FAM163A H-InvDB: FAM163A

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for FAM163A Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for FAM163A gene:
Search GeneIP for patents involving FAM163A

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section

 
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 Browse OriGene Antibodies   OriGene shRNA RFP for FAM163A  
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Sirion Biotech Customized:
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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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