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Aliases for FAM163A Gene

Aliases for FAM163A Gene

  • Family With Sequence Similarity 163, Member A 2 3
  • Neuroblastoma-Derived Secretory Protein 3 4
  • Cebelin 3 4
  • C1orf76 3 4
  • NDSP 3 4
  • Neuroblastoma Derived Secretory Protein 3
  • Chromosome 1 Open Reading Frame 76 2

External Ids for FAM163A Gene

Previous HGNC Symbols for FAM163A Gene

  • C1orf76

Previous GeneCards Identifiers for FAM163A Gene

  • GC01P177980
  • GC01P150944

Summaries for FAM163A Gene

GeneCards Summary for FAM163A Gene

FAM163A (Family With Sequence Similarity 163, Member A) is a Protein Coding gene. Diseases associated with FAM163A include neuroblastoma. An important paralog of this gene is FAM163B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM163A Gene

Genomics for FAM163A Gene

Regulatory Elements for FAM163A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM163A Gene

179,727,763 bp from pter
179,816,198 bp from pter
88,436 bases
Plus strand

Genomic View for FAM163A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM163A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM163A Gene

Proteins for FAM163A Gene

  • Protein details for FAM163A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM163A
    Protein Accession:
    Secondary Accessions:
    • A8K8R7

    Protein attributes for FAM163A Gene

    167 amino acids
    Molecular mass:
    17641 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM163A Gene

Proteomics data for FAM163A Gene at MOPED

Post-translational modifications for FAM163A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM163A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM163A Gene

Domains & Families for FAM163A Gene

Protein Domains for FAM163A Gene


Suggested Antigen Peptide Sequences for FAM163A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM163 family.
  • Belongs to the FAM163 family.
genes like me logo Genes that share domains with FAM163A: view

No data available for Gene Families for FAM163A Gene

Function for FAM163A Gene

Phenotypes for FAM163A Gene

GenomeRNAi human phenotypes for FAM163A:
genes like me logo Genes that share phenotypes with FAM163A: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM163A Gene

Localization for FAM163A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM163A Gene

Membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for FAM163A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM163A: view

No data available for Subcellular locations from COMPARTMENTS for FAM163A Gene

Pathways & Interactions for FAM163A Gene

SuperPathways for FAM163A Gene

No Data Available

Interacting Proteins for FAM163A Gene

Gene Ontology (GO) - Biological Process for FAM163A Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM163A Gene

Drugs & Compounds for FAM163A Gene

No Compound Related Data Available

Transcripts for FAM163A Gene

Unigene Clusters for FAM163A Gene

Family with sequence similarity 163, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM163A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM163A Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11
SP1: - - - -
SP2: - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - -
SP6: - -
SP7: - - - - - - - - - - - -
SP8: - -
SP9: - -

Relevant External Links for FAM163A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM163A Gene

mRNA expression in normal human tissues for FAM163A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM163A Gene

This gene is overexpressed in Pituitary (x25.2) and Testis (x9.3).

Protein differential expression in normal tissues from HIPED for FAM163A Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM163A Gene

SOURCE GeneReport for Unigene cluster for FAM163A Gene Hs.729631

mRNA Expression by UniProt/SwissProt for FAM163A Gene

Tissue specificity: Highly expressed in neuroblastoma compared to other tissues, suggesting that it may be used as a marker for metastasis in bone marrow.
genes like me logo Genes that share expression patterns with FAM163A: view

Protein tissue co-expression partners for FAM163A Gene

Primer Products

In Situ Assay Products

Orthologs for FAM163A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM163A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM163A 35
  • 91.82 (n)
  • 91.02 (a)
FAM163A 36
  • 88 (a)
(Canis familiaris)
Mammalia FAM163A 35
  • 88.34 (n)
  • 88.96 (a)
FAM163A 36
  • 87 (a)
(Mus musculus)
Mammalia Fam163a 35
  • 88.55 (n)
  • 86.14 (a)
Fam163a 16
Fam163a 36
  • 83 (a)
(Pan troglodytes)
Mammalia FAM163A 35
  • 99.61 (n)
  • 98.82 (a)
FAM163A 36
  • 96 (a)
(Rattus norvegicus)
Mammalia Fam163a 35
  • 89.56 (n)
  • 89.16 (a)
(Monodelphis domestica)
Mammalia FAM163A 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia FAM163A 36
  • 63 (a)
(Gallus gallus)
Aves FAM163A 35
  • 70.09 (n)
  • 66.03 (a)
FAM163A 36
  • 60 (a)
(Anolis carolinensis)
Reptilia FAM163A 36
  • 56 (a)
(Danio rerio)
Actinopterygii si:dkey-193b15.8 35
  • 61.31 (n)
  • 60.84 (a)
FAM163A (1 of 2) 36
  • 53 (a)
FAM163A (2 of 2) 36
  • 62 (a)
Species with no ortholog for FAM163A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM163A Gene

Gene Tree for FAM163A (if available)
Gene Tree for FAM163A (if available)

Paralogs for FAM163A Gene

Paralogs for FAM163A Gene

(1) SIMAP similar genes for FAM163A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM163A: view

Variants for FAM163A Gene

Sequence variations from dbSNP and Humsavar for FAM163A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs867440 -- 179,793,651(-) TGAAC(C/G)AAAGG intron-variant
rs904272 -- 179,810,663(+) ACTCT(A/G)GTCTG intron-variant
rs1052447 -- 179,742,514(+) ACAGG(G/T)AAACG upstream-variant-2KB, splice-donor-variant, intron-variant
rs1148822 -- 179,811,006(+) ccact(G/T)cactc intron-variant
rs1148823 -- 179,809,297(+) AGCTC(C/T)CACAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM163A Gene

Variant ID Type Subtype PubMed ID
esv2552928 CNV Deletion 19546169
esv33942 CNV Loss 17666407
dgv19n21 CNV Loss 19592680
nsv522044 CNV Loss 19592680

Variation tolerance for FAM163A Gene

Residual Variation Intolerance Score: 74.78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.27; 25.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM163A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM163A Gene

Disorders for FAM163A Gene

MalaCards: The human disease database

(1) MalaCards diseases for FAM163A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • neuroblastoma 1
- elite association

Relevant External Links for FAM163A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FAM163A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAM163A Gene

Publications for FAM163A Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 67
  3. Neuroblastoma-derived secretory protein is a novel secreted factor overexpressed in neuroblastoma. (PMID: 19671756) Vasudevan S.A. … Nuchtern J.G. (Mol. Cancer Ther. 2009) 67
  4. Neuroblastoma-derived secretory protein messenger RNA levels correlate with high-risk neuroblastoma. (PMID: 17208556) Vasudevan S.A. … Nuchtern J.G. (J. Pediatr. Surg. 2007) 67
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 67

Products for FAM163A Gene

Sources for FAM163A Gene

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