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Aliases for FAM163A Gene

Aliases for FAM163A Gene

  • Family With Sequence Similarity 163 Member A 2 3 5
  • Neuroblastoma-Derived Secretory Protein 3 4
  • Cebelin 3 4
  • C1orf76 3 4
  • NDSP 3 4
  • Family With Sequence Similarity 163, Member A 2
  • Neuroblastoma Derived Secretory Protein 3
  • Chromosome 1 Open Reading Frame 76 2
  • Protein FAM163A 3

External Ids for FAM163A Gene

Previous HGNC Symbols for FAM163A Gene

  • C1orf76

Previous GeneCards Identifiers for FAM163A Gene

  • GC01P177980
  • GC01P150944

Summaries for FAM163A Gene

GeneCards Summary for FAM163A Gene

FAM163A (Family With Sequence Similarity 163 Member A) is a Protein Coding gene. Diseases associated with FAM163A include Neuroblastoma. An important paralog of this gene is FAM163B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM163A Gene

Genomics for FAM163A Gene

Regulatory Elements for FAM163A Gene

Enhancers for FAM163A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around FAM163A on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM163A Gene

179,727,763 bp from pter
179,816,198 bp from pter
88,436 bases
Plus strand

Genomic View for FAM163A Gene

Genes around FAM163A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM163A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM163A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM163A Gene

Proteins for FAM163A Gene

  • Protein details for FAM163A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM163A
    Protein Accession:
    Secondary Accessions:
    • A8K8R7

    Protein attributes for FAM163A Gene

    167 amino acids
    Molecular mass:
    17641 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM163A Gene

Post-translational modifications for FAM163A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM163A Gene

Domains & Families for FAM163A Gene

Protein Domains for FAM163A Gene


Suggested Antigen Peptide Sequences for FAM163A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM163 family.
  • Belongs to the FAM163 family.
genes like me logo Genes that share domains with FAM163A: view

No data available for Gene Families for FAM163A Gene

Function for FAM163A Gene

Phenotypes for FAM163A Gene

GenomeRNAi human phenotypes for FAM163A:
genes like me logo Genes that share phenotypes with FAM163A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM163A Gene

Localization for FAM163A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM163A Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for FAM163A Gene COMPARTMENTS Subcellular localization image for FAM163A gene
Compartment Confidence
extracellular 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for FAM163A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM163A: view

Pathways & Interactions for FAM163A Gene

SuperPathways for FAM163A Gene

No Data Available

Interacting Proteins for FAM163A Gene

Gene Ontology (GO) - Biological Process for FAM163A Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM163A Gene

Drugs & Compounds for FAM163A Gene

No Compound Related Data Available

Transcripts for FAM163A Gene

Unigene Clusters for FAM163A Gene

Family with sequence similarity 163, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM163A Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11
SP1: - - - -
SP2: - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - -
SP6: - -
SP7: - - - - - - - - - - - -
SP8: - -
SP9: - -

Relevant External Links for FAM163A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM163A Gene

mRNA expression in normal human tissues for FAM163A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM163A Gene

This gene is overexpressed in Pituitary (x25.2) and Testis (x9.3).

Protein differential expression in normal tissues from HIPED for FAM163A Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM163A Gene

Protein tissue co-expression partners for FAM163A Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM163A Gene:


SOURCE GeneReport for Unigene cluster for FAM163A Gene:


mRNA Expression by UniProt/SwissProt for FAM163A Gene:

Tissue specificity: Highly expressed in neuroblastoma compared to other tissues, suggesting that it may be used as a marker for metastasis in bone marrow.
genes like me logo Genes that share expression patterns with FAM163A: view

Primer Products

Orthologs for FAM163A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM163A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM163A 34
  • 91.82 (n)
  • 91.02 (a)
FAM163A 35
  • 88 (a)
(Canis familiaris)
Mammalia FAM163A 34
  • 88.34 (n)
  • 88.96 (a)
FAM163A 35
  • 87 (a)
(Mus musculus)
Mammalia Fam163a 34
  • 88.55 (n)
  • 86.14 (a)
Fam163a 16
Fam163a 35
  • 83 (a)
(Pan troglodytes)
Mammalia FAM163A 34
  • 99.61 (n)
  • 98.82 (a)
FAM163A 35
  • 96 (a)
(Rattus norvegicus)
Mammalia Fam163a 34
  • 89.56 (n)
  • 89.16 (a)
(Monodelphis domestica)
Mammalia FAM163A 35
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia FAM163A 35
  • 63 (a)
(Gallus gallus)
Aves FAM163A 34
  • 70.09 (n)
  • 66.03 (a)
FAM163A 35
  • 60 (a)
(Anolis carolinensis)
Reptilia FAM163A 35
  • 56 (a)
(Danio rerio)
Actinopterygii si:dkey-193b15.8 34
  • 61.31 (n)
  • 60.84 (a)
FAM163A (1 of 2) 35
  • 53 (a)
FAM163A (2 of 2) 35
  • 62 (a)
Species where no ortholog for FAM163A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM163A Gene

Gene Tree for FAM163A (if available)
Gene Tree for FAM163A (if available)

Paralogs for FAM163A Gene

Paralogs for FAM163A Gene

(1) SIMAP similar genes for FAM163A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM163A: view

Variants for FAM163A Gene

Sequence variations from dbSNP and Humsavar for FAM163A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1052447 -- 179,742,514(+) ACAGG(G/T)AAACG intron-variant, upstream-variant-2KB, splice-donor-variant
rs867440 -- 179,793,651(-) TGAAC(C/G)AAAGG intron-variant
rs1148822 -- 179,811,006(+) ccact(G/T)cactc intron-variant
rs1148823 -- 179,809,297(+) AGCTC(C/T)CACAC intron-variant
rs1148824 -- 179,808,847(+) AGGAG(A/T)TATTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM163A Gene

Variant ID Type Subtype PubMed ID
dgv19n21 CNV loss 19592680
dgv472n100 CNV gain 25217958
dgv473n100 CNV gain 25217958
dgv64e214 CNV gain 21293372
esv2552928 CNV deletion 19546169
esv33942 CNV loss 17666407
nsv1140428 CNV tandem duplication 24896259
nsv522044 CNV loss 19592680
nsv548339 CNV gain 21841781

Variation tolerance for FAM163A Gene

Residual Variation Intolerance Score: 74.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.27; 25.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM163A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM163A Gene

Disorders for FAM163A Gene

MalaCards: The human disease database

(1) MalaCards diseases for FAM163A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • neuroblastoma 1
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for FAM163A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FAM163A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAM163A Gene

Publications for FAM163A Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  2. Neuroblastoma-derived secretory protein messenger RNA levels correlate with high-risk neuroblastoma. (PMID: 17208556) Vasudevan S.A. … Nuchtern J.G. (J. Pediatr. Surg. 2007) 3 4 65
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 65
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 65

Products for FAM163A Gene

Sources for FAM163A Gene

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