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FAM162B Gene

protein-coding   GIFtS: 42
GCID: GC06M117073

Family With Sequence Similarity 162, Member B

(Previous name: chromosome 6 open reading frame 189)
(Previous symbol: C6orf189)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 162, Member B1 2
C6orf1891 2 3
Chromosome 6 Open Reading Frame 1891
bA86F4.22
Protein FAM162B2

External Ids:    HGNC: 215491   Entrez Gene: 2213032   Ensembl: ENSG000001838077   UniProtKB: Q5T6X43   

Export aliases for FAM162B gene to outside databases

Previous GC identifers: GC06M117182 GC06M114652


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM162B Gene:
FAM162B (family with sequence similarity 162, member B) is a protein-coding gene. An important paralog of this gene is FAM162A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAM162B gene promoter:
         FOXJ2 (long isoform)   ATF-2   FOXJ2   E4BP4   Hlf   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for FAM162B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM162B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22.1   Ensembl cytogenetic band:  6q22.1   HGNC cytogenetic band: 6q22.31

FAM162B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM162B gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M117073:  view genomic region     (about GC identifiers)

Start:
117,073,360 bp from pter      End:
117,086,886 bp from pter
Size:
13,527 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: F162B_HUMAN, Q5T6X4 (See protein sequence)
Recommended Name: Protein FAM162B  
Size: 162 amino acids; 17685 Da
Sequence caution: Sequence=AAH38997.1; Type=Erroneous initiation;
Secondary accessions: Q8IXW8

Explore the universe of human proteins at neXtProt for FAM162B: NX_Q5T6X4

Explore proteomics data for FAM162B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FAM162B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001078949.1  
    ENSEMBL proteins: 
     ENSP00000357545  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR009432 DUF1075

    Graphical View of Domain Structure for InterPro Entry Q5T6X4

    ProtoNet protein and cluster: Q5T6X4

    UniProtKB/Swiss-Prot: F162B_HUMAN, Q5T6X4
    Similarity: Belongs to the UPF0389 family


    Find genes that share domains with FAM162B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         1 GenomeRNAi human phenotype for FAM162B:
     Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAM162B
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    F162B_HUMAN, Q5T6X4: Membrane; Single-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion3
    cytosol2
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with FAM162B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM162B
    Interactions:

        Search GeneGlobe Interaction Network for FAM162B

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM162B (F162B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FAM162B gene: 
    NM_001085480.2  

    Unigene Cluster for FAM162B:

    Family with sequence similarity 162, member B
    Hs.126712  [show with all ESTs]
    Unigene Representative Sequence: NM_001085480
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000368557(uc003pxi.2)
    miRNA
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    hsa-miR-142-5p hsa-miR-410 hsa-miR-340 hsa-miR-548aa
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat FAM162B

    Additional mRNA sequence: BC038997.1 

    2 DOTS entries:

    DT.206054  DT.100867854 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for FAM162B    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4
    SP1:                                    
    SP2:              -                     


    ECgene alternative splicing isoforms for FAM162B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM162B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATTCAAAAA
    FAM162B Expression
    About this image


    FAM162B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Lung (Respiratory System)
    FAM162B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM162B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.126712
        Custom PCR Arrays for FAM162B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM162B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FAM162B gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam162b1 , 5 family with sequence similarity 162, member B1, 5 74.6(n)1
    68.03(a)1
      10 (25.62 cM)5
    772961  NM_029894.11  NP_084170.11 
     515854505 
    chicken
    (Gallus gallus)
    Aves FAM162B1 family with sequence similarity 162, member B 65.31(n)
    66.67(a)
      100857953  XM_003641034.2  XP_003641082.1 
    lizard
    (Anolis carolinensis)
    Reptilia FAM162B6
    family with sequence similarity 162, member B
    58(a)
    1 ↔ 1
    1(185919674-185934975)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1017340271 protein FAM162B-like 66.99(n)
    67.31(a)
      101734027  XM_004914868.1  XP_004914925.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fam162a6
    family with sequence similarity 162, member A
    42(a)
    1 ↔ 1
    24(21535587-21543118) ENSDARG00000063344
    fruit fly
    (Drosophila melanogaster)
    Insecta CG92316
    --
    25(a)
    1 → many
    3L(19578193-19579070)


    ENSEMBL Gene Tree for FAM162B (if available)
    TreeFam Gene Tree for FAM162B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM162B gene
    FAM162A2  
    1 SIMAP similar gene for FAM162B using alignment to 1 protein entry:     F162B_HUMAN:
    FAM162A

    Find genes that share paralogs with FAM162B           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for FAM162B
    PGOHUM00000242378


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM162B (see all 336)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1904218371,2
    --117072878(+) TGAGAA/TATGTA 1 -- int10--------
    rs6459601,2
    C,F,A,H--117072921(-) TGATCG/ATCAAA 1 -- int116Minor allele frequency- A:0.28NS EA NA WA 1514
    rs1460120211,2
    C--117072934(+) AATGTA/GTACCA 1 -- int10--------
    rs1819267151,2
    --117072941(+) ACCATC/TTTTTT 1 -- int10--------
    rs1144294471,2
    C,F--117073379(+) ATTTAT/CATAAA 1 -- ut311Minor allele frequency- C:0.01WA 118
    rs1399108401,2
    --117073493(+) TGCCAA/GTATTC 1 -- ut310--------
    rs784456271,2
    C,F--117073502(+) TCTACA/GTCTTC 1 -- ut311Minor allele frequency- G:0.01WA 118
    rs1498066731,2
    --117073536(+) GTTCAC/TGACAT 1 -- ut310--------
    rs1447197511,2
    --117073542(+) GACATA/CAATAT 1 -- ut310--------
    rs1485126081,2
    --117073589(+) TGCATA/GGTATA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for FAM162B (117073360 - 117086886 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FAM162B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv523972CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FAM162B
    DNA2.0 Custom Variant and Variant Library Synthesis for FAM162B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with FAM162B           About GenesLikeMe

    Genetic Association Database (GAD): FAM162B
    Human Genome Epidemiology (HuGE) Navigator: FAM162B (1 document)

    Export disorders for FAM162B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM162B gene integrated from 10 sources:
    (articles sorted by number of sources associating them with FAM162B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A genome-wide association study identifies a locus on chromosome 14q21 as a predictor of leukocyte telomere length and as a marker of susceptibility for bladder cancer. (PubMed id 21460395)1, 4 Gu J....Wu X. (Cancer Prev Res (Phila) 2011)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    6. Generation and analysis of 280,000 human expressed sequence tags. (PubMed id 8889549)1 Hillier L.D....Marra M. (Genome Res. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 221303 HGNC: 21549 Ensembl:ENSG00000183807 euGenes: HUgn221303 ECgene: FAM162B
    H-InvDB: FAM162B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM162B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for FAM162B gene:
    Search GeneIP for patents involving FAM162B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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