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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAM162B Gene

protein-coding   GIFtS: 39
GCID: GC06M117073

family with sequence similarity 162, member B

(Previous name: chromosome 6 open reading frame 189 )
(Previous symbol: C6orf189)
  Search for FAM162B
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FAM162B    

Aliases
for FAM162B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Family With Sequence Similarity 162, Member B1 2
C6orf1891 2 3
BA86F4.21
Chromosome 6 Open Reading Frame 1891
Protein FAM162B2

External Ids:    HGNC: 215491   Entrez Gene: 2213032   Ensembl: ENSG000001838077   UniProtKB: Q5T6X43   

Export aliases for FAM162B gene to outside databases

Previous GC identifers: GC06M117182 GC06M114652


Summaries
for FAM162B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for FAM162B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FAM162B gene promoter:
         FOXJ2 (long isoform)   ATF-2   FOXJ2   E4BP4   Hlf   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for FAM162B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM162B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22.1   Ensembl cytogenetic band:  6q22.1   HGNC cytogenetic band: 6q22.31

FAM162B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM162B gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M117073:  view genomic region     (about GC identifiers)

Start:
 117,073,360 bp from pter      End:
 117,086,886 bp from pter
Size:
 13,527 bases      Orientation:
 minus strand

Proteins
for FAM162B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: F162B_HUMAN, Q5T6X4 (See protein sequence)
Recommended Name: Protein FAM162B  
Size: 162 amino acids; 17685 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Sequence caution: Sequence=AAH38997.1; Type=Erroneous initiation;
Secondary accessions: Q8IXW8

Explore the universe of human proteins at neXtProt for FAM162B: NX_Q5T6X4

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q5T6X4

    • FAM162B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001078949.1  
    ENSEMBL proteins: 
     ENSP00000357545  

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    Uscn Proteins for FAM162B

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--


    FAM162B for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for FAM162B

    Protein Domains /
    Families
    for FAM162B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FAM162B for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR009432 DUF1075

    Graphical View of Domain Structure for InterPro Entry Q5T6X4

    ProtoNet protein and cluster: Q5T6X4

    UniProtKB/Swiss-Prot: F162B_HUMAN, Q5T6X4
    Similarity: Belongs to the UPF0389 family


    Function
    for FAM162B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    Inhib. RNA
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    Gene Editing
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    1 GenomeRNAi human phenotype for FAM162B:
     Increased G1 DNA content 


    Pathways & Interactions
    for FAM162B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM162B

    Drugs & Compounds
    for FAM162B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FAM162B
    Search CenterWatch for drugs/clinical trials and news about FAM162B / F162B 

    Transcripts
    for FAM162B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section
    REFSEQ mRNAs for FAM162B gene: 
    NM_001085480.2  

    Unigene Cluster for FAM162B:

    Family with sequence similarity 162, member B
    Hs.126712  [show with all ESTs]
    Unigene Representative Sequence: NM_001085480
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000368557(uc003pxi.2)

    miRNA
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    hsa-miR-142-5p hsa-miR-410 hsa-miR-340 hsa-miR-548aa
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    Inhib. RNA
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    OriGene shRNA RFP: FAM162B
    OriGene siRNA: FAM162B
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    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM162B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM162B

    Additional cDNA sequence: BC038997.1 

    2 DOTS entries:

    DT.206054  DT.100867854 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for FAM162B    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4
    SP1:                                    
    SP2:              -                     


    ECgene alternative splicing isoforms for FAM162B

    Expression
    for FAM162B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FAM162B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CATTCAAAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    FAM162B expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierEndothelial CellsBlood Brain Barrier, Endothelium
    BrainBlood Brain BarrierPostnatal Endothelial CellsBlood Brain Barrier, Endothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)

    See FAM162B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FAM162B

    SOURCE GeneReport for Unigene cluster: Hs.126712
        SABiosciences Custom PCR Arrays for FAM162B
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM162B

    Orthologs
    for FAM162B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for FAM162B gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LOC1008579531 protein FAM162B-like 64.91(n)
    66.17(a)    		   100857953  XM_003641034.1  XP_003641082.1 
    lizard
    (Anolis carolinensis)    		 Reptilia FAM162B6
    		 --
    		 60(a)
    		 1 ↔ 1
    		 1(185920610-185934975)
    zebrafish
    (Danio rerio)    		 Actinopterygii fam162a6
    		 family with sequence similarity 162, member A
    		 43(a)
    		 1 ↔ 1
    		 24(21535587-21543118)
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG92316
    		 --
    		 28(a)
    		 1 → many
    		 3L(19578193-19579070)


    ENSEMBL Gene Tree for FAM162B (if available)
    TreeFam Gene Tree for FAM162B (if available) 

    Paralogs
    for FAM162B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FAM162B gene
    FAM162A2  
    1 SIMAP similar gene for FAM162B using alignment to 1 protein entry:     F162B_HUMAN:
    FAM162A

    FAM162B for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for FAM162B
    PGOHUM00000242378


    Genomic Variants
    for FAM162B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/275 NCBI SNPs in FAM162B are shown (see all 275)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1904218371,2
    		--117072878(+) TGAGAA/TATGTA 1 -- int10--------
    rs6459601,2
    		C,F,A,H,--117072921(-) TGATCG/ATCAAA 1 -- int116Minor allele frequency- A:0.28NS EA NA WA 1514
    rs1460120211,2
    		--117072934(+) AATGTA/GTACCA 1 -- int10--------
    rs1819267151,2
    		--117072941(+) ACCATC/TTTTTT 1 -- int10--------
    rs1144294471,2
    		--117073379(+) ATTTAT/CATAAA 1 -- ut311Minor allele frequency- C:0.01WA 118
    rs1399108401,2
    		--117073493(+) TGCCAA/GTATTC 1 -- ut310--------
    rs784456271,2
    		--117073502(+) TCTACA/GTCTTC 1 -- ut311Minor allele frequency- G:0.01WA 118
    rs1498066731,2
    		--117073536(+) GTTCAC/TGACAT 1 -- ut310--------
    rs1447197511,2
    		--117073542(+) GACATA/CAATAT 1 -- ut310--------
    rs1485126081,2
    		--117073589(+) TGCATA/GGTATA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for FAM162B (117073360 - 117086886 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for FAM162B: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for FAM162B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FAM162B for disorders           About MalaCards

    FAM162B for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: FAM162B (1 document)

    Export disorders for FAM162B gene to outside databases

    Publications
    for FAM162B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FAM162B gene integrated from 9 sources:
    (articles sorted by number of sources associating them with FAM162B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    3. A genome-wide association study identifies a locus on chromosome 14q21 as a predictor of leukocyte telomere length and as a marker o f susceptibility for bladder cancer. (PubMed id 21460395)1 Gu J....Wu X. (2011)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    6. Generation and analysis of 280,000 human expressed sequence tags. (PubMed id 8889549)1 Hillier L.D....Marra M. (1996)

    External Searches for FAM162B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing FAM162B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 221303 HGNC: 21549 Ensembl:ENSG00000183807 euGenes: HUgn221303 ECgene: FAM162B
    H-InvDB: FAM162B

    Other Databases showing FAM162B gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FAM162B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FAM162B Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for FAM162B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FAM162B gene:
    Search GeneIP for patents involving FAM162B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for FAM162B gene

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    About This Section

     
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