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Aliases for FAM162B Gene

Aliases for FAM162B Gene

  • Family With Sequence Similarity 162 Member B 2 3 5
  • Family With Sequence Similarity 162, Member B 2 3
  • C6orf189 3 4
  • Chromosome 6 Open Reading Frame 189 2
  • BA86F4.2 3

External Ids for FAM162B Gene

Previous HGNC Symbols for FAM162B Gene

  • C6orf189

Previous GeneCards Identifiers for FAM162B Gene

  • GC06M117182
  • GC06M117073
  • GC06M114652

Summaries for FAM162B Gene

GeneCards Summary for FAM162B Gene

FAM162B (Family With Sequence Similarity 162 Member B) is a Protein Coding gene. An important paralog of this gene is FAM162A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM162B Gene

Genomics for FAM162B Gene

Regulatory Elements for FAM162B Gene

Promoters for FAM162B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAM162B on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM162B Gene

116,752,197 bp from pter
116,765,723 bp from pter
13,527 bases
Minus strand

Genomic View for FAM162B Gene

Genes around FAM162B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM162B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM162B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM162B Gene

Proteins for FAM162B Gene

  • Protein details for FAM162B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM162B
    Protein Accession:
    Secondary Accessions:
    • Q8IXW8

    Protein attributes for FAM162B Gene

    162 amino acids
    Molecular mass:
    17685 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH38997.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for FAM162B Gene

Proteomics data for FAM162B Gene at MOPED

Post-translational modifications for FAM162B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM162B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM162B Gene

Domains & Families for FAM162B Gene

Protein Domains for FAM162B Gene


Suggested Antigen Peptide Sequences for FAM162B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPF0389 family.
  • Belongs to the UPF0389 family.
genes like me logo Genes that share domains with FAM162B: view

No data available for Gene Families for FAM162B Gene

Function for FAM162B Gene

Phenotypes for FAM162B Gene

GenomeRNAi human phenotypes for FAM162B:
genes like me logo Genes that share phenotypes with FAM162B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM162B Gene

Localization for FAM162B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM162B Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for FAM162B Gene COMPARTMENTS Subcellular localization image for FAM162B gene
Compartment Confidence
mitochondrion 3
cytosol 2
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for FAM162B Gene

Pathways & Interactions for FAM162B Gene

SuperPathways for FAM162B Gene

No Data Available

Interacting Proteins for FAM162B Gene

Gene Ontology (GO) - Biological Process for FAM162B Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM162B Gene

Drugs & Compounds for FAM162B Gene

No Compound Related Data Available

Transcripts for FAM162B Gene

mRNA/cDNA for FAM162B Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM162B Gene

Family with sequence similarity 162, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM162B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4
SP2: -

Relevant External Links for FAM162B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM162B Gene

mRNA expression in normal human tissues for FAM162B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAM162B Gene

This gene is overexpressed in Placenta (42.5), Fetal heart (20.3), and Fetal ovary (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM162B Gene

SOURCE GeneReport for Unigene cluster for FAM162B Gene Hs.126712

genes like me logo Genes that share expression patterns with FAM162B: view

Protein tissue co-expression partners for FAM162B Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM162B Gene

Orthologs for FAM162B Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM162B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM162B 35
  • 80.48 (n)
  • 75.66 (a)
FAM162B 36
  • 75 (a)
(Canis familiaris)
Mammalia FAM162B 35
  • 87.53 (n)
  • 82.11 (a)
FAM162B 36
  • 77 (a)
(Mus musculus)
Mammalia Fam162b 35
  • 74.6 (n)
  • 68.03 (a)
Fam162b 16
Fam162b 36
  • 68 (a)
(Pan troglodytes)
Mammalia FAM162B 35
  • 99.79 (n)
  • 100 (a)
FAM162B 36
  • 100 (a)
(Gallus gallus)
Aves FAM162B 35
  • 65.31 (n)
  • 66.67 (a)
FAM162B 36
  • 69 (a)
(Anolis carolinensis)
Reptilia FAM162B 36
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734027 35
  • 66.99 (n)
  • 67.31 (a)
(Danio rerio)
Actinopterygii fam162a 36
  • 42 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9231 36
  • 25 (a)
Species with no ortholog for FAM162B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM162B Gene

Gene Tree for FAM162B (if available)
Gene Tree for FAM162B (if available)

Paralogs for FAM162B Gene

Paralogs for FAM162B Gene

(1) SIMAP similar genes for FAM162B Gene using alignment to 1 proteins: Pseudogenes for FAM162B Gene

genes like me logo Genes that share paralogs with FAM162B: view

Variants for FAM162B Gene

Sequence variations from dbSNP and Humsavar for FAM162B Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_053782 -
rs548101 -- 116,762,557(-) GCATG(C/T)GAAGG intron-variant
rs590572 -- 116,763,598(-) ATAAT(G/T)TAATT intron-variant
rs647689 -- 116,760,067(-) gtagt(A/T)gggaa intron-variant
rs590991 -- 116,761,419(-) AACTC(A/G)ATTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM162B Gene

Variant ID Type Subtype PubMed ID
nsv523972 CNV Gain 19592680

Variation tolerance for FAM162B Gene

Residual Variation Intolerance Score: 81.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.69; 66.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM162B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM162B Gene

Disorders for FAM162B Gene

Relevant External Links for FAM162B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM162B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM162B Gene

Publications for FAM162B Gene

  1. A genome-wide association study identifies a locus on chromosome 14q21 as a predictor of leukocyte telomere length and as a marker of susceptibility for bladder cancer. (PMID: 21460395) Gu J. … Wu X. (Cancer Prev Res (Phila) 2011) 3 48 67
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for FAM162B Gene

Sources for FAM162B Gene

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