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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAM162A Gene

protein-coding   GIFtS: 49
GCID: GC03P122103

family with sequence similarity 162, member A

(Previous name: chromosome 3 open reading frame 28 )
(Previous symbol: C3orf28)
 Explore 6 diseases affiliated with
FAM162A via our new
 Human Malady Compendium 
Biological research products
for FAM162A
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Family With Sequence Similarity 162, Member A1 2     E2-Induced Gene 5 Protein2 3
C3orf281 2 3 5     Chromosome 3 Open Reading Frame 281
E2IG51 2 3 5     HIF-1 Alpha-Responsive Proapoptotic Molecule2
Growth And Transformation-Dependent Protein2 3     Protein FAM162A2
HGTD-P2 3     

External Ids:    HGNC: 178651   Entrez Gene: 263552   Ensembl: ENSG000001140237   OMIM: 6080175   UniProtKB: Q96A263   

Export aliases for FAM162A gene to outside databases

Previous GC identifers: GC03P123587 GC03P119476


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: F162A_HUMAN, Q96A26
Function: Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell
types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and
caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in
hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and
its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FAM162A gene promoter:
         AML1a   STAT5A   CUTL1   Arnt   POU2F1   USF-1   FOXJ2 (long isoform)   POU2F1a   ARP-1   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM162A promoter sequence
   Search SABiosciences Chromatin IP Primers for FAM162A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM162A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21.1   Ensembl cytogenetic band:  3q21.1   HGNC cytogenetic band: 3q21.1

FAM162A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM162A gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P122103:  view genomic region     (about GC identifiers)

Start:
122,103,023 bp from pter      End:
122,131,181 bp from pter
Size:
28,159 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: F162A_HUMAN, Q96A26 (See protein sequence)
Recommended Name: Protein FAM162A  
Size: 154 amino acids; 17342 Da
Subunit: Interacts with HSP90AB1; HSP90AB1 is essential for FAM162A mitochondrial localization and pro-apoptotic
activity. Interacts with VDAC2; the interaction is probably involved in inducing mitochondrial permability transition
Subcellular location: Membrane; Single-pass membrane protein (Potential). Mitochondrion
Sequence caution: Sequence=AAF09484.1; Type=Frameshift; Positions=147;
Secondary accessions: Q9NRN6 Q9UJX8

Explore the universe of human proteins at neXtProt for FAM162A: NX_Q96A26

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96A26

  • FAM162A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_055182.3  
    ENSEMBL proteins: 
     ENSP00000232125   ENSP00000419088   ENSP00000419491  

    Human Recombinant Protein Products: 
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    Novus Biologicals FAM162A Lysate
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for FAM162A

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0016021integral to membrane IEA--


    FAM162A for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for FAM162A


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    FAM162A for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR009432 DUF1075

    Graphical View of Domain Structure for InterPro Entry Q96A26

    ProtoNet protein and cluster: Q96A26

    UniProtKB/Swiss-Prot: F162A_HUMAN, Q96A26
    Similarity: Belongs to the UPF0389 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: F162A_HUMAN, Q96A26
    Function: Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell
    types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and
    caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in
    hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and
    its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly
    Induction: By 17-beta-estradiol. By hypoxia

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate FAM162A:
    hsa-miR-3658
    SwitchGear 3'UTR luciferase reporter plasmidFAM162A 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: FAM162A
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15082785


    FAM162A for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM162A

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/6 Interacting proteins for FAM162A (Q96A261, 2, 3 ENSP000004190884) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSP90AB1P082382, 3, ENSP000003258754MINT-2567397 MINT-2567472 MINT-2567511 I2D: score=1 STRING: ENSP00000325875
    HSP90AA1P079003, ENSP000003351534I2D: score=1 STRING: ENSP00000335153
    VDAC2P458801, ENSP000003616864EBI-6123466,EBI-354022 STRING: ENSP00000361686
    SQSTM1Q135013I2D: score=1 
    IKBKEENSP000003560874STRING: ENSP00000356087
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process IDA15082785
    GO:0006927transformed cell apoptotic process IDA15082785
    GO:0043065positive regulation of apoptotic process IDA15082785
    GO:0051402neuron apoptotic process IEA--
    GO:0071456cellular response to hypoxia IDA15082785


    FAM162A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FAM162A
    Search CenterWatch for drugs/clinical trials and news about FAM162A / F162A 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FAM162A gene: 
    NM_014367.3  

    Unigene Cluster for FAM162A:

    Family with sequence similarity 162, member A
    Hs.584881  [show with all ESTs]
    Unigene Representative Sequence: AK125835
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000232125 ENST00000477892(uc003eez.3) ENST00000469967(uc011bjq.1)


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    1 QIAGEN miScript miRNA Assays for microRNA that regulate FAM162A:
    hsa-miR-3658
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    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM162A
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    Additional cDNA sequence: 

    AF107495.1 AF191020.1 AF201944.1 AK026030.1 AK125835.1 AK293994.1 BC010896.1 BC015060.1 

    9 DOTS entries:

    DT.418501  DT.418503  DT.100825396  DT.95117732  DT.100825400  DT.95117747  DT.120865950  DT.92430374 
    DT.99943747 

    24/263 AceView cDNA sequences (see all 263):

    BM128453 BF034502 CA413798 AV713133 BM693062 AA441798 BG656426 BM980190 
    AI367861 AI087202 BP429425 CB068805 AI074487 BM781567 BG057258 BP429571 
    CA952618 N64447 N98224 BQ937560 CA952819 AA662361 CR605172 CA941090 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for FAM162A    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
    SP1:                                      -               
    SP2:              -                       -               
    SP3:              -                                       


    ECgene alternative splicing isoforms for FAM162A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FAM162A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTTATTGAGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    FAM162A expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor SK17 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See FAM162A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FAM162A

    SOURCE GeneReport for Unigene cluster: Hs.584881
        SABiosciences Custom PCR Arrays for FAM162A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM162A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FAM162A gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam162a1 , 5 family with sequence similarity 162, member A1, 5 83.55(n)1
    79.22(a)1
      16 (25.43 cM)5
    701861  NM_027342.11  NP_081618.11 
     360438445 
    chicken
    (Gallus gallus)
    Aves FAM162A1 family with sequence similarity 162, member A 61.07(n)
    54.74(a)
      418270  XM_416495.3  XP_416495.3 
    lizard
    (Anolis carolinensis)
    Reptilia FAM162A6
    --
    47(a)
    1 ↔ 1
    GL343473.1(100186-108968)
    zebrafish
    (Danio rerio)
    Actinopterygii wufb08c122 Transcribed sequence with weak similarity to protein more 75.35(n)    57076751 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG92316
    --
    30(a)
    1 → many
    3L(19578193-19579070)


    ENSEMBL Gene Tree for FAM162A (if available)
    TreeFam Gene Tree for FAM162A (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FAM162A gene
    FAM162B2  
    1 SIMAP similar gene for FAM162A using alignment to 3 protein entries:     F162A_HUMAN (see all proteins):
    FAM162B

    FAM162A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/430 NCBI SNPs in FAM162A are shown (see all 430    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1839638521,2
    --122101442(+) TCAGGG/TGTTAA 2 -- us2k1 int10--------
    rs771106841,2
    F,--122101508(+) TACATC/TTTCTC 2 -- us2k1 int11Minor allele frequency- T:0.02NA 120
    rs587589981,2
    F,--122101545(+) ACTATA/GATTAA 2 -- int1 us2k11Minor allele frequency- G:0.13WA 118
    rs1467764251,2
    --122101570(+) TTCCAC/TACGTC 2 -- us2k1 int10--------
    rs1485040891,2
    --122101625(+) CTAAAA/TAGCTC 2 -- us2k1 int10--------
    rs67712011,2
    C,F,H,--122101721(+) TGCTAA/C/G/
            
    AAGAT
    2 -- int1 us2k119NS EA NA CSA WA 2347
    rs1146014221,2
    F,--122101810(+) GCGGAG/AAGAAC 2 -- us2k1 int11Minor allele frequency- A:0.02WA 118
    rs1887371551,2
    --122101858(+) CGCTCC/TCTAAG 2 -- int1 us2k10--------
    rs1806931141,2
    --122101879(+) CGCCCC/TCCATG 2 -- us2k1 int10--------
    rs1861327931,2
    C,--122102014(+) AAACCC/TCATCA 2 -- int1 us2k10--------

    HapMap Linkage Disequilibrium report for FAM162A (122103023 - 122131181 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for FAM162A: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM162A
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    FAM162A for disorders           About GeneDecksing

    OMIM gene information: 608017    OMIM disorders: --

    6 diseases for FAM162A:    About MalaCards
    ischemia    adenoma    hypoxia    cervicitis
    carcinoma    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: FAM162A (1 document)

    Export disorders for FAM162A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FAM162A gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with FAM162A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Effects of estrogen on global gene expression: identification of novel targets of estrogen action. (PubMed id 11085516)1, 2, 3 Charpentier A.H.... Aldaz C.M. (2000)
    2. Interaction of pro-apoptotic protein HGTD-P with heat shock protein 90 is required for induction of mitochondrial apoptotic cascades. (PubMed id 16698020)1, 2 Kim J.Y....Park J.H. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Identification of the hypoxia-inducible factor 1 alpha-responsive HGTD-P gene as a mediator in the mitochondrial apoptotic pathway. (PubMed id 15082785)1, 2 Lee M.J....Park J.H. (2004)
    5. Proapoptotic role of human growth and transformation- dependent protein in the developing rat brain after hypoxia-ischemia. (PubMed id 19520982)1, 9 Qu Y....Mu D. (2009)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. Expression and clinicopathological significance of hu man growth and transformation-dependent protein (HGTD-P) in uterine cervical ca ncer. (PubMed id 20840676)1 Cho Y.E....Park J.H. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26355 HGNC: 17865 AceView: E2IG5 Ensembl:ENSG00000114023 euGenes: HUgn26355
    ECgene: FAM162A H-InvDB: FAM162A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FAM162A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FAM162A gene:
    Search GeneIP for patents involving FAM162A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
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