Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FAM162A Gene

Aliases for FAM162A Gene

  • Family With Sequence Similarity 162, Member A 2 3
  • C3orf28 3 4 6
  • E2IG5 3 4 6
  • Growth And Transformation-Dependent Protein 3 4
  • E2-Induced Gene 5 Protein 3 4
  • HGTD-P 3 4
  • HIF-1 Alpha-Responsive Proapoptotic Molecule 3
  • Chromosome 3 Open Reading Frame 28 2
  • Protein FAM162A 3

External Ids for FAM162A Gene

Previous HGNC Symbols for FAM162A Gene

  • C3orf28

Previous GeneCards Identifiers for FAM162A Gene

  • GC03P123587
  • GC03P122103
  • GC03P119476

Summaries for FAM162A Gene

GeneCards Summary for FAM162A Gene

FAM162A (Family With Sequence Similarity 162, Member A) is a Protein Coding gene. An important paralog of this gene is FAM162B.

UniProtKB/Swiss-Prot for FAM162A Gene

  • Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM162A Gene

Genomics for FAM162A Gene

Regulatory Elements for FAM162A Gene

Genomic Location for FAM162A Gene

Start:
122,384,176 bp from pter
End:
122,412,334 bp from pter
Size:
28,159 bases
Orientation:
Plus strand

Genomic View for FAM162A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM162A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM162A Gene

Proteins for FAM162A Gene

  • Protein details for FAM162A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A26-F162A_HUMAN
    Recommended name:
    Protein FAM162A
    Protein Accession:
    Q96A26
    Secondary Accessions:
    • Q9NRN6
    • Q9UJX8

    Protein attributes for FAM162A Gene

    Size:
    154 amino acids
    Molecular mass:
    17342 Da
    Quaternary structure:
    • Interacts with HSP90AB1; HSP90AB1 is essential for FAM162A mitochondrial localization and pro-apoptotic activity. Interacts with VDAC2; the interaction is probably involved in inducing mitochondrial permability transition.
    SequenceCaution:
    • Sequence=AAF09484.1; Type=Frameshift; Positions=147; Evidence={ECO:0000305};

neXtProt entry for FAM162A Gene

Proteomics data for FAM162A Gene at MOPED

Post-translational modifications for FAM162A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM162A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM162A Gene

Domains for FAM162A Gene

Protein Domains for FAM162A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM162A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96A26

UniProtKB/Swiss-Prot:

F162A_HUMAN :
  • Q96A26
Family:
  • Belongs to the UPF0389 family.
genes like me logo Genes that share domains with FAM162A: view

No data available for Gene Families for FAM162A Gene

Function for FAM162A Gene

Molecular function for FAM162A Gene

UniProtKB/Swiss-Prot Function: Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly.
UniProtKB/Swiss-Prot Induction: By 17-beta-estradiol. By hypoxia.

Gene Ontology (GO) - Molecular Function for FAM162A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15082785
genes like me logo Genes that share ontologies with FAM162A: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM162A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FAM162A Gene

Localization for FAM162A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM162A Gene

Membrane; Single-pass membrane protein. Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM162A Gene COMPARTMENTS Subcellular localization image for FAM162A gene
Compartment Confidence
mitochondrion 5
extracellular 2
plasma membrane 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for FAM162A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IDA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with FAM162A: view

Pathways for FAM162A Gene

SuperPathways for FAM162A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM162A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IDA 15082785
GO:0006927 transformed cell apoptotic process IDA 15082785
GO:0043065 positive regulation of apoptotic process IDA 15082785
GO:0051402 neuron apoptotic process IEA --
GO:0071456 cellular response to hypoxia IDA 15082785
genes like me logo Genes that share ontologies with FAM162A: view

No data available for Pathways by source for FAM162A Gene

Transcripts for FAM162A Gene

mRNA/cDNA for FAM162A Gene

Unigene Clusters for FAM162A Gene

Family with sequence similarity 162, member A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM162A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM162A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: -
SP2: - -
SP3: -

Relevant External Links for FAM162A Gene

GeneLoc Exon Structure for
FAM162A
ECgene alternative splicing isoforms for
FAM162A

Expression for FAM162A Gene

mRNA expression in normal human tissues for FAM162A Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM162A Gene

SOURCE GeneReport for Unigene cluster for FAM162A Gene Hs.584881

genes like me logo Genes that share expressions with FAM162A: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM162A Gene

Orthologs for FAM162A Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM162A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM162A 35
  • 99.41 (n)
  • 99.12 (a)
FAM162A 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM162A 35
  • 87.88 (n)
  • 85.06 (a)
FAM162A 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM162A 35
  • 87.45 (n)
  • 81.17 (a)
FAM162A 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam162a 35
  • 83.55 (n)
  • 79.22 (a)
Fam162a 16
Fam162a 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM162A 36
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam162a 35
  • 80.66 (n)
  • 78.63 (a)
chicken
(Gallus gallus)
Aves FAM162A 35
  • 64.81 (n)
  • 61.11 (a)
FAM162A 36
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM162A 36
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490517 35
  • 63.21 (n)
  • 61.32 (a)
zebrafish
(Danio rerio)
Actinopterygii fam162a 35
  • 60.49 (n)
  • 50.93 (a)
wufb08c12 35
fruit fly
(Drosophila melanogaster)
Insecta CG9231 36
  • 30 (a)
OneToMany
Species with no ortholog for FAM162A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM162A Gene

ENSEMBL:
Gene Tree for FAM162A (if available)
TreeFam:
Gene Tree for FAM162A (if available)

Paralogs for FAM162A Gene

Paralogs for FAM162A Gene

Selected SIMAP similar genes for FAM162A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FAM162A: view

Variants for FAM162A Gene

Sequence variations from dbSNP and Humsavar for FAM162A Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1127343 -- 122,409,547(+) CTTGA(A/G)TGGAT intron-variant
rs1138418 -- 122,410,408(+) CCCAG(C/T)GTCAT downstream-variant-500B
rs1801418 -- 122,409,864(+) GAAAA(C/T)CCAGG utr-variant-3-prime
rs1961957 -- 122,385,275(+) TATCT(A/G)GTGTT intron-variant
rs1986617 -- 122,397,710(+) TCTGa(A/T)tttaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM162A Gene

Variant ID Type Subtype PubMed ID
nsv3973 CNV Loss 18451855
esv2660557 CNV Deletion 23128226

Relevant External Links for FAM162A Gene

HapMap Linkage Disequilibrium report
FAM162A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM162A Gene

Disorders for FAM162A Gene

Relevant External Links for FAM162A

Genetic Association Database (GAD)
FAM162A
Human Genome Epidemiology (HuGE) Navigator
FAM162A
genes like me logo Genes that share disorders with FAM162A: view

No data available for UniProtKB/Swiss-Prot for FAM162A Gene

Publications for FAM162A Gene

  1. Effects of estrogen on global gene expression: identification of novel targets of estrogen action. (PMID: 11085516) Charpentier A.H. … Aldaz C.M. (Cancer Res. 2000) 2 3 4
  2. Proapoptotic role of human growth and transformation-dependent protein in the developing rat brain after hypoxia-ischemia. (PMID: 19520982) Qu Y. … Mu D. (Stroke 2009) 3 23
  3. Identification of the hypoxia-inducible factor 1 alpha-responsive HGTD-P gene as a mediator in the mitochondrial apoptotic pathway. (PMID: 15082785) Lee M.J. … Park J.H. (Mol. Cell. Biol. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Interaction of pro-apoptotic protein HGTD-P with heat shock protein 90 is required for induction of mitochondrial apoptotic cascades. (PMID: 16698020) Kim J.Y. … Park J.H. (FEBS Lett. 2006) 3 4

Products for FAM162A Gene

Sources for FAM162A Gene

Back to Top

Content