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Aliases for FAM162A Gene

Aliases for FAM162A Gene

  • Family With Sequence Similarity 162 Member A 2 3 5
  • Growth And Transformation-Dependent Protein 3 4
  • E2-Induced Gene 5 Protein 3 4
  • C3orf28 3 4
  • HGTD-P 3 4
  • E2IG5 3 4
  • Family With Sequence Similarity 162, Member A 2
  • HIF-1 Alpha-Responsive Proapoptotic Molecule 3
  • Chromosome 3 Open Reading Frame 28 2
  • Protein FAM162A 3

External Ids for FAM162A Gene

Previous HGNC Symbols for FAM162A Gene

  • C3orf28

Previous GeneCards Identifiers for FAM162A Gene

  • GC03P123587
  • GC03P122103
  • GC03P119476

Summaries for FAM162A Gene

GeneCards Summary for FAM162A Gene

FAM162A (Family With Sequence Similarity 162 Member A) is a Protein Coding gene. An important paralog of this gene is FAM162B.

UniProtKB/Swiss-Prot for FAM162A Gene

  • Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly.

Additional gene information for FAM162A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM162A Gene

Genomics for FAM162A Gene

Regulatory Elements for FAM162A Gene

Enhancers for FAM162A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H122073 1.7 FANTOM5 Ensembl ENCODE dbSUPER 9.9 -306.7 -306747 7 HDGF PKNOX1 FOXA2 TBL1XR1 SIN3A BMI1 BATF RFX5 ZNF143 ATF7 CD86 ENSG00000202388 DTX3L PARP9 CCDC58 FAM162A IQCB1 EAF2 CSTA HCLS1
GH03H122414 1.3 ENCODE dbSUPER 10.6 +32.0 31983 2 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 FOS WDR5B LOC102723582 FAM162A CCDC58
GH03H122313 1.1 FANTOM5 ENCODE dbSUPER 10.7 -69.5 -69505 1 HLF MNT CSTA WDR5B CCDC58 FAM162A PARP14 PARP9 DTX3L DIRC2 CD86 KPNA1
GH03H122482 1.1 Ensembl ENCODE 10.3 +99.0 98992 1 HDGF TBL1XR1 BATF RFX5 GTF3C2 SMARCC2 FOS ATF7 ETV6 RUNX3 LOC102723582 WDR5B GOLGB1 IQCB1 KPNA1 RPL7AP11 SEC22A CCDC58 FAM162A ENSG00000275348
GH03H122081 1.1 FANTOM5 dbSUPER 9.8 -302.4 -302449 0 PKNOX1 BACH1 BATF RELA EED ATF7 ETV6 RUNX3 IKZF2 CREM ILDR1 ENSG00000202388 CSTA CCDC58 FAM162A CD86 EAF2 CASR
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM162A on UCSC Golden Path with GeneCards custom track

Promoters for FAM162A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000157315 -276 3001 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 CBX5

Genomic Location for FAM162A Gene

Chromosome:
3
Start:
122,384,176 bp from pter
End:
122,412,334 bp from pter
Size:
28,159 bases
Orientation:
Plus strand

Genomic View for FAM162A Gene

Genes around FAM162A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM162A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM162A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM162A Gene

Proteins for FAM162A Gene

  • Protein details for FAM162A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A26-F162A_HUMAN
    Recommended name:
    Protein FAM162A
    Protein Accession:
    Q96A26
    Secondary Accessions:
    • Q9NRN6
    • Q9UJX8

    Protein attributes for FAM162A Gene

    Size:
    154 amino acids
    Molecular mass:
    17342 Da
    Quaternary structure:
    • Interacts with HSP90AB1; HSP90AB1 is essential for FAM162A mitochondrial localization and pro-apoptotic activity. Interacts with VDAC2; the interaction is probably involved in inducing mitochondrial permability transition.
    SequenceCaution:
    • Sequence=AAF09484.1; Type=Frameshift; Positions=147; Evidence={ECO:0000305};

neXtProt entry for FAM162A Gene

Post-translational modifications for FAM162A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM162A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM162A Gene

Domains & Families for FAM162A Gene

Gene Families for FAM162A Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for FAM162A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM162A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96A26

UniProtKB/Swiss-Prot:

F162A_HUMAN :
  • Belongs to the UPF0389 family.
Family:
  • Belongs to the UPF0389 family.
genes like me logo Genes that share domains with FAM162A: view

Function for FAM162A Gene

Molecular function for FAM162A Gene

UniProtKB/Swiss-Prot Function:
Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly.
UniProtKB/Swiss-Prot Induction:
By 17-beta-estradiol. By hypoxia.

Phenotypes From GWAS Catalog for FAM162A Gene

Gene Ontology (GO) - Molecular Function for FAM162A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15082785
genes like me logo Genes that share ontologies with FAM162A: view

Phenotypes for FAM162A Gene

GenomeRNAi human phenotypes for FAM162A:
genes like me logo Genes that share phenotypes with FAM162A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FAM162A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM162A Gene

Localization for FAM162A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM162A Gene

Membrane; Single-pass membrane protein. Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM162A gene
Compartment Confidence
extracellular 5
mitochondrion 5
cytosol 5
plasma membrane 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (4)
  • Cytosol (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FAM162A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005829 cytosol IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with FAM162A: view

Pathways & Interactions for FAM162A Gene

SuperPathways for FAM162A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM162A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IDA 15082785
GO:0043065 positive regulation of apoptotic process IEA,IDA 15082785
GO:0051402 neuron apoptotic process IEA --
GO:0071456 cellular response to hypoxia IDA,IEA 15082785
genes like me logo Genes that share ontologies with FAM162A: view

No data available for Pathways by source and SIGNOR curated interactions for FAM162A Gene

Drugs & Compounds for FAM162A Gene

No Compound Related Data Available

Transcripts for FAM162A Gene

mRNA/cDNA for FAM162A Gene

Unigene Clusters for FAM162A Gene

Family with sequence similarity 162, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FAM162A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for FAM162A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: -
SP2: - -
SP3: -

Relevant External Links for FAM162A Gene

GeneLoc Exon Structure for
FAM162A
ECgene alternative splicing isoforms for
FAM162A

Expression for FAM162A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM162A Gene

Protein differential expression in normal tissues from HIPED for FAM162A Gene

This gene is overexpressed in Nasal epithelium (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FAM162A Gene



Protein tissue co-expression partners for FAM162A Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM162A Gene:

FAM162A

SOURCE GeneReport for Unigene cluster for FAM162A Gene:

Hs.584881

Evidence on tissue expression from TISSUES for FAM162A Gene

  • Liver(4.4)
  • Nervous system(4.4)
  • Lymph node(4.3)
  • Spleen(4.3)
  • Blood(4.2)
genes like me logo Genes that share expression patterns with FAM162A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM162A Gene

Orthologs for FAM162A Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM162A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM162A 33 34
  • 99.41 (n)
cow
(Bos Taurus)
Mammalia FAM162A 33 34
  • 87.88 (n)
dog
(Canis familiaris)
Mammalia FAM162A 33 34
  • 87.45 (n)
mouse
(Mus musculus)
Mammalia Fam162a 33 16 34
  • 83.55 (n)
rat
(Rattus norvegicus)
Mammalia Fam162a 33
  • 80.66 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM162A 34
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM162A 33 34
  • 64.81 (n)
lizard
(Anolis carolinensis)
Reptilia FAM162A 34
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490517 33
  • 63.21 (n)
zebrafish
(Danio rerio)
Actinopterygii fam162a 33
  • 60.49 (n)
wufb08c12 33
fruit fly
(Drosophila melanogaster)
Insecta CG9231 34
  • 30 (a)
OneToMany
Species where no ortholog for FAM162A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM162A Gene

ENSEMBL:
Gene Tree for FAM162A (if available)
TreeFam:
Gene Tree for FAM162A (if available)

Paralogs for FAM162A Gene

Paralogs for FAM162A Gene

(1) SIMAP similar genes for FAM162A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FAM162A: view

Variants for FAM162A Gene

Sequence variations from dbSNP and Humsavar for FAM162A Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000111323 -- 122,384,564(+) TTCTC(A/C)CCACC intron-variant, upstream-variant-2KB
rs1000434523 -- 122,409,959(+) TTTCC(A/G)TATTT utr-variant-3-prime
rs1000500148 -- 122,385,661(+) TTCTG(A/T)TGTGT intron-variant
rs1000544319 -- 122,384,250(+) TCGGC(A/G)GAGTA upstream-variant-2KB, utr-variant-5-prime
rs1000592807 -- 122,404,979(+) ATCCC(C/T)GGCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM162A Gene

Variant ID Type Subtype PubMed ID
esv2660557 CNV deletion 23128226
esv3597608 CNV loss 21293372
esv3597609 CNV gain 21293372
nsv3973 CNV deletion 18451855

Variation tolerance for FAM162A Gene

Residual Variation Intolerance Score: 79.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.49; 55.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM162A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM162A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM162A Gene

Disorders for FAM162A Gene

Relevant External Links for FAM162A

Genetic Association Database (GAD)
FAM162A
Human Genome Epidemiology (HuGE) Navigator
FAM162A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM162A

No disorders were found for FAM162A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM162A Gene

Publications for FAM162A Gene

  1. Effects of estrogen on global gene expression: identification of novel targets of estrogen action. (PMID: 11085516) Charpentier AH … Aldaz CM (Cancer research 2000) 2 3 4 60
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 45 60
  3. Proapoptotic role of human growth and transformation-dependent protein in the developing rat brain after hypoxia-ischemia. (PMID: 19520982) Qu Y … Mu D (Stroke 2009) 3 22 60
  4. Interaction of pro-apoptotic protein HGTD-P with heat shock protein 90 is required for induction of mitochondrial apoptotic cascades. (PMID: 16698020) Kim JY … Park JH (FEBS letters 2006) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for FAM162A Gene

Sources for FAM162A Gene

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