Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FAM162A Gene

Aliases for FAM162A Gene

  • Family With Sequence Similarity 162 Member A 2 3 5
  • Growth And Transformation-Dependent Protein 3 4
  • E2-Induced Gene 5 Protein 3 4
  • C3orf28 3 4
  • HGTD-P 3 4
  • E2IG5 3 4
  • Family With Sequence Similarity 162, Member A 2
  • HIF-1 Alpha-Responsive Proapoptotic Molecule 3
  • Chromosome 3 Open Reading Frame 28 2
  • Protein FAM162A 3

External Ids for FAM162A Gene

Previous HGNC Symbols for FAM162A Gene

  • C3orf28

Previous GeneCards Identifiers for FAM162A Gene

  • GC03P123587
  • GC03P122103
  • GC03P119476

Summaries for FAM162A Gene

GeneCards Summary for FAM162A Gene

FAM162A (Family With Sequence Similarity 162 Member A) is a Protein Coding gene. An important paralog of this gene is FAM162B.

UniProtKB/Swiss-Prot for FAM162A Gene

  • Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM162A Gene

Genomics for FAM162A Gene

Regulatory Elements for FAM162A Gene

Enhancers for FAM162A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around FAM162A on UCSC Golden Path with GeneCards custom track

Promoters for FAM162A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for FAM162A Gene

Chromosome:
3
Start:
122,384,176 bp from pter
End:
122,412,334 bp from pter
Size:
28,159 bases
Orientation:
Plus strand

Genomic View for FAM162A Gene

Genes around FAM162A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM162A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM162A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM162A Gene

Proteins for FAM162A Gene

  • Protein details for FAM162A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A26-F162A_HUMAN
    Recommended name:
    Protein FAM162A
    Protein Accession:
    Q96A26
    Secondary Accessions:
    • Q9NRN6
    • Q9UJX8

    Protein attributes for FAM162A Gene

    Size:
    154 amino acids
    Molecular mass:
    17342 Da
    Quaternary structure:
    • Interacts with HSP90AB1; HSP90AB1 is essential for FAM162A mitochondrial localization and pro-apoptotic activity. Interacts with VDAC2; the interaction is probably involved in inducing mitochondrial permability transition.
    SequenceCaution:
    • Sequence=AAF09484.1; Type=Frameshift; Positions=147; Evidence={ECO:0000305};

neXtProt entry for FAM162A Gene

Post-translational modifications for FAM162A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM162A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM162A Gene

Domains & Families for FAM162A Gene

Protein Domains for FAM162A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM162A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96A26

UniProtKB/Swiss-Prot:

F162A_HUMAN :
  • Belongs to the UPF0389 family.
Family:
  • Belongs to the UPF0389 family.
genes like me logo Genes that share domains with FAM162A: view

No data available for Gene Families for FAM162A Gene

Function for FAM162A Gene

Molecular function for FAM162A Gene

UniProtKB/Swiss-Prot Function:
Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly.
UniProtKB/Swiss-Prot Induction:
By 17-beta-estradiol. By hypoxia.

Gene Ontology (GO) - Molecular Function for FAM162A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15082785
genes like me logo Genes that share ontologies with FAM162A: view

Phenotypes for FAM162A Gene

GenomeRNAi human phenotypes for FAM162A:
genes like me logo Genes that share phenotypes with FAM162A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM162A Gene

Localization for FAM162A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM162A Gene

Membrane; Single-pass membrane protein. Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM162A Gene COMPARTMENTS Subcellular localization image for FAM162A gene
Compartment Confidence
extracellular 5
mitochondrion 5
cytosol 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for FAM162A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IEA,IDA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with FAM162A: view

Pathways & Interactions for FAM162A Gene

SuperPathways for FAM162A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM162A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IDA 15082785
GO:0006927 obsolete transformed cell apoptotic process IDA --
GO:0043065 positive regulation of apoptotic process IEA,IDA 15082785
GO:0051402 neuron apoptotic process IEA --
GO:0071456 cellular response to hypoxia IEA,IDA 15082785
genes like me logo Genes that share ontologies with FAM162A: view

No data available for Pathways by source and SIGNOR curated interactions for FAM162A Gene

Drugs & Compounds for FAM162A Gene

No Compound Related Data Available

Transcripts for FAM162A Gene

mRNA/cDNA for FAM162A Gene

Unigene Clusters for FAM162A Gene

Family with sequence similarity 162, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM162A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: -
SP2: - -
SP3: -

Relevant External Links for FAM162A Gene

GeneLoc Exon Structure for
FAM162A
ECgene alternative splicing isoforms for
FAM162A

Expression for FAM162A Gene

mRNA expression in normal human tissues for FAM162A Gene

Protein differential expression in normal tissues from HIPED for FAM162A Gene

This gene is overexpressed in Nasal epithelium (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM162A Gene



Protein tissue co-expression partners for FAM162A Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM162A Gene:

FAM162A

SOURCE GeneReport for Unigene cluster for FAM162A Gene:

Hs.584881
genes like me logo Genes that share expression patterns with FAM162A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM162A Gene

Orthologs for FAM162A Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM162A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAM162A 34
  • 87.88 (n)
  • 85.06 (a)
FAM162A 35
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM162A 34
  • 87.45 (n)
  • 81.17 (a)
FAM162A 35
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam162a 34
  • 83.55 (n)
  • 79.22 (a)
Fam162a 16
Fam162a 35
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM162A 34
  • 99.41 (n)
  • 99.12 (a)
FAM162A 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam162a 34
  • 80.66 (n)
  • 78.63 (a)
oppossum
(Monodelphis domestica)
Mammalia FAM162A 35
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM162A 34
  • 64.81 (n)
  • 61.11 (a)
FAM162A 35
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM162A 35
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490517 34
  • 63.21 (n)
  • 61.32 (a)
zebrafish
(Danio rerio)
Actinopterygii fam162a 34
  • 60.49 (n)
  • 50.93 (a)
wufb08c12 34
fruit fly
(Drosophila melanogaster)
Insecta CG9231 35
  • 30 (a)
OneToMany
Species where no ortholog for FAM162A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM162A Gene

ENSEMBL:
Gene Tree for FAM162A (if available)
TreeFam:
Gene Tree for FAM162A (if available)

Paralogs for FAM162A Gene

Paralogs for FAM162A Gene

(1) SIMAP similar genes for FAM162A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FAM162A: view

Variants for FAM162A Gene

Sequence variations from dbSNP and Humsavar for FAM162A Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs17850692 - 122,402,874(+) CGGAG(C/T)TCCAT reference, missense
rs2332181 -- 122,396,019(+) ccttt(C/T)cacag intron-variant
rs4677949 -- 122,398,044(+) TCCCA(A/G)TGGGA intron-variant
rs4678190 -- 122,398,191(+) ctgca(C/T)ggttt intron-variant
rs4678191 -- 122,402,391(+) TTGGT(G/T)ACCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM162A Gene

Variant ID Type Subtype PubMed ID
esv2660557 CNV deletion 23128226
esv3597608 CNV loss 21293372
esv3597609 CNV gain 21293372
nsv3973 CNV deletion 18451855

Variation tolerance for FAM162A Gene

Residual Variation Intolerance Score: 79.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.49; 55.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM162A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM162A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM162A Gene

Disorders for FAM162A Gene

Relevant External Links for FAM162A

Genetic Association Database (GAD)
FAM162A
Human Genome Epidemiology (HuGE) Navigator
FAM162A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM162A

No disorders were found for FAM162A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM162A Gene

Publications for FAM162A Gene

  1. Effects of estrogen on global gene expression: identification of novel targets of estrogen action. (PMID: 11085516) Charpentier A.H. … Aldaz C.M. (Cancer Res. 2000) 2 3 4 65
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 65
  3. Proapoptotic role of human growth and transformation-dependent protein in the developing rat brain after hypoxia-ischemia. (PMID: 19520982) Qu Y. … Mu D. (Stroke 2009) 3 22 65
  4. Interaction of pro-apoptotic protein HGTD-P with heat shock protein 90 is required for induction of mitochondrial apoptotic cascades. (PMID: 16698020) Kim J.Y. … Park J.H. (FEBS Lett. 2006) 3 4 65
  5. Identification of the hypoxia-inducible factor 1 alpha-responsive HGTD-P gene as a mediator in the mitochondrial apoptotic pathway. (PMID: 15082785) Lee M.J. … Park J.H. (Mol. Cell. Biol. 2004) 3 4 65

Products for FAM162A Gene

Sources for FAM162A Gene

Content
Loading form....