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Aliases for FAM161B Gene

Aliases for FAM161B Gene

  • Family With Sequence Similarity 161 Member B 2 3 5
  • C14orf44 3 4
  • Family With Sequence Similarity 161, Member B 2
  • Chromosome 14 Open Reading Frame 44 2
  • Protein FAM161B 3
  • C14_5547 3

External Ids for FAM161B Gene

Previous HGNC Symbols for FAM161B Gene

  • C14orf44

Previous GeneCards Identifiers for FAM161B Gene

  • GC14M073471
  • GC14M074400
  • GC14M054567

Summaries for FAM161B Gene

GeneCards Summary for FAM161B Gene

FAM161B (Family With Sequence Similarity 161 Member B) is a Protein Coding gene. Diseases associated with FAM161B include Retinitis Pigmentosa 28 and Retinitis Pigmentosa. An important paralog of this gene is FAM161A.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM161B Gene

Genomics for FAM161B Gene

Regulatory Elements for FAM161B Gene

Enhancers for FAM161B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G073994 1.2 ENCODE dbSUPER 11.6 -46.9 -46927 6.2 HNRNPUL1 FOXA2 ATF1 MLX ARID4B FEZF1 ZNF48 YY1 SP5 PPARG PTGR2 LIN52 LOC100506476 FAM161B COQ6 ALDH6A1 ENSG00000223300 ENTPD5 BBOF1 RPL41P4
GH14G073456 1.4 ENCODE dbSUPER 9.9 +490.1 490076 7.9 HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZBTB7B YY1 ZNF302 PNMA1 ENSG00000258695 ENSG00000258944 RBM25 ACOT1 ELMSAN1 FAM161B LOC100420966 NUMB LOC105370561
GH14G074425 1.2 Ensembl ENCODE dbSUPER 9.9 -475.6 -475550 1.1 CTCF SAP130 KLF6 RBBP5 MIER2 REST ZNF48 RARA ZNF664 MXD3 PNMA1 FAM161B LIN52 SYNDIG1L GC14M074406
GH14G074293 1.1 ENCODE 9.9 -345.1 -345064 3.2 HDGF MLX CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ENSG00000258559 PNMA1 SYNDIG1L FAM161B PTGR2 ABCD4
GH14G074027 0.6 ENCODE 16.8 -78.2 -78188 1.3 ELF3 FOXA2 CEBPG PPARG JUND CEBPA NR2F6 SMAD4 HNF4A MAFK FAM161B LIN52 ALDH6A1 COQ6 LINC02274 ENTPD5 GC14P074048
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM161B on UCSC Golden Path with GeneCards custom track

Promoters for FAM161B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000070691 214 1601 HDGF PKNOX1 FOXA2 MLX CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF2

Genomic Location for FAM161B Gene

Chromosome:
14
Start:
73,931,501 bp from pter
End:
73,950,414 bp from pter
Size:
18,914 bases
Orientation:
Minus strand

Genomic View for FAM161B Gene

Genes around FAM161B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM161B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM161B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM161B Gene

Proteins for FAM161B Gene

  • Protein details for FAM161B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MY7-F161B_HUMAN
    Recommended name:
    Protein FAM161B
    Protein Accession:
    Q96MY7
    Secondary Accessions:
    • B7Z882
    • J3KNA2

    Protein attributes for FAM161B Gene

    Size:
    647 amino acids
    Molecular mass:
    73647 Da
    Quaternary structure:
    • Interacts with FAM161A.

    Alternative splice isoforms for FAM161B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM161B Gene

Post-translational modifications for FAM161B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM161B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM161B Gene

Domains & Families for FAM161B Gene

Protein Domains for FAM161B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM161B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96MY7

UniProtKB/Swiss-Prot:

F161B_HUMAN :
  • Belongs to the FAM161 family.
Family:
  • Belongs to the FAM161 family.
genes like me logo Genes that share domains with FAM161B: view

No data available for Gene Families for FAM161B Gene

Function for FAM161B Gene

Phenotypes for FAM161B Gene

genes like me logo Genes that share phenotypes with FAM161B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM161B Gene

Localization for FAM161B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM161B gene
Compartment Confidence
nucleus 4
cytosol 3
cytoskeleton 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM161B Gene

Pathways & Interactions for FAM161B Gene

SuperPathways for FAM161B Gene

No Data Available

Interacting Proteins for FAM161B Gene

Gene Ontology (GO) - Biological Process for FAM161B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM161B Gene

Transcripts for FAM161B Gene

mRNA/cDNA for FAM161B Gene

Unigene Clusters for FAM161B Gene

Family with sequence similarity 161, member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM161B Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7
SP1:
SP2: -
SP3:
SP4:

Relevant External Links for FAM161B Gene

GeneLoc Exon Structure for
FAM161B
ECgene alternative splicing isoforms for
FAM161B

Expression for FAM161B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM161B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAM161B Gene

This gene is overexpressed in Monocytes (33.2), Peripheral blood mononuclear cells (18.5), and Ovary (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM161B Gene



NURSA nuclear receptor signaling pathways regulating expression of FAM161B Gene:

FAM161B

SOURCE GeneReport for Unigene cluster for FAM161B Gene:

Hs.550547

mRNA Expression by UniProt/SwissProt for FAM161B Gene:

Q96MY7-F161B_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for FAM161B Gene

  • Nervous system(3.6)
genes like me logo Genes that share expression patterns with FAM161B: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM161B Gene

Orthologs for FAM161B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM161B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM161B 34 35
  • 99.15 (n)
dog
(Canis familiaris)
Mammalia FAM161B 34 35
  • 85.57 (n)
cow
(Bos Taurus)
Mammalia FAM161B 34 35
  • 83.98 (n)
mouse
(Mus musculus)
Mammalia Fam161b 34 16 35
  • 81.77 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM161B 35
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM161B 34 35
  • 61.49 (n)
lizard
(Anolis carolinensis)
Reptilia FAM161B 35
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam161b 34
  • 49.85 (n)
zebrafish
(Danio rerio)
Actinopterygii fam161b 35
  • 33 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 29 (a)
OneToMany
Species where no ortholog for FAM161B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM161B Gene

ENSEMBL:
Gene Tree for FAM161B (if available)
TreeFam:
Gene Tree for FAM161B (if available)

Paralogs for FAM161B Gene

Paralogs for FAM161B Gene

genes like me logo Genes that share paralogs with FAM161B: view

Variants for FAM161B Gene

Sequence variations from dbSNP and Humsavar for FAM161B Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs863223938 Uncertain significance 73,950,447(+) ACGTG(A/G)TGGTG intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs111833521 Benign 73,950,129(+) TTGGC(G/T)TCTGG upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs17094161 Benign 73,950,133(+) CGTCT(A/G)GTTGG upstream-variant-2KB, reference, missense, stop-gained, utr-variant-5-prime
rs190881382 Benign 73,950,079(+) AGCGG(C/G/T)GGCAG upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs60369619 Benign 73,950,506(+) CCCTT(C/T)TCCAG intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for FAM161B Gene

Variant ID Type Subtype PubMed ID
dgv1936n100 CNV gain 25217958
dgv1937n100 CNV gain 25217958
dgv663e212 CNV loss 25503493
esv274934 CNV gain+loss 21479260
nsv1053281 CNV gain 25217958

Variation tolerance for FAM161B Gene

Residual Variation Intolerance Score: 82.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.62; 93.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM161B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM161B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM161B Gene

Disorders for FAM161B Gene

MalaCards: The human disease database

(2) MalaCards diseases for FAM161B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
retinitis pigmentosa 28
  • rp28
retinitis pigmentosa
  • retinitis pigmentosa 1
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for FAM161B

Genetic Association Database (GAD)
FAM161B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM161B
genes like me logo Genes that share disorders with FAM161B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAM161B Gene

Publications for FAM161B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The retinitis pigmentosa 28 protein FAM161A is a novel ciliary protein involved in intermolecular protein interaction and microtubule association. (PMID: 22791751) Zach F. … Stohr H. (Hum. Mol. Genet. 2012) 4 64
  4. Functional proteomics mapping of a human signaling pathway. (PMID: 15231748) Colland F. … Gauthier J.M. (Genome Res. 2004) 3 64
  5. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 4 64

Products for FAM161B Gene

Sources for FAM161B Gene

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