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Aliases for FAM161B Gene

Aliases for FAM161B Gene

  • Family With Sequence Similarity 161 Member B 2 3 5
  • Family With Sequence Similarity 161, Member B 2 3
  • C14orf44 3 4
  • Chromosome 14 Open Reading Frame 44 2
  • C14_5547 3

External Ids for FAM161B Gene

Previous HGNC Symbols for FAM161B Gene

  • C14orf44

Previous GeneCards Identifiers for FAM161B Gene

  • GC14M073471
  • GC14M074400
  • GC14M054567

Summaries for FAM161B Gene

GeneCards Summary for FAM161B Gene

FAM161B (Family With Sequence Similarity 161 Member B) is a Protein Coding gene. An important paralog of this gene is FAM161A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM161B Gene

Genomics for FAM161B Gene

Regulatory Elements for FAM161B Gene

Enhancers for FAM161B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FAM161B on UCSC Golden Path with GeneCards custom track

Promoters for FAM161B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAM161B on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM161B Gene

73,931,501 bp from pter
73,950,414 bp from pter
18,914 bases
Minus strand

Genomic View for FAM161B Gene

Genes around FAM161B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM161B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM161B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM161B Gene

Proteins for FAM161B Gene

  • Protein details for FAM161B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM161B
    Protein Accession:
    Secondary Accessions:
    • B7Z882
    • J3KNA2

    Protein attributes for FAM161B Gene

    647 amino acids
    Molecular mass:
    73647 Da
    Quaternary structure:
    • Interacts with FAM161A.

    Alternative splice isoforms for FAM161B Gene


neXtProt entry for FAM161B Gene

Proteomics data for FAM161B Gene at MOPED

Post-translational modifications for FAM161B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM161B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM161B Gene

Domains & Families for FAM161B Gene

Protein Domains for FAM161B Gene


Suggested Antigen Peptide Sequences for FAM161B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM161 family.
  • Belongs to the FAM161 family.
genes like me logo Genes that share domains with FAM161B: view

No data available for Gene Families for FAM161B Gene

Function for FAM161B Gene

Phenotypes for FAM161B Gene

GenomeRNAi human phenotypes for FAM161B:
genes like me logo Genes that share phenotypes with FAM161B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM161B Gene

Localization for FAM161B Gene

Subcellular locations from

Jensen Localization Image for FAM161B Gene COMPARTMENTS Subcellular localization image for FAM161B gene
Compartment Confidence
nucleus 4
cytosol 3
cytoskeleton 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM161B Gene

Pathways & Interactions for FAM161B Gene

SuperPathways for FAM161B Gene

No Data Available

Interacting Proteins for FAM161B Gene

Selected Interacting proteins: Q96MY7-F161B_HUMAN for FAM161B Gene via MINT I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for FAM161B Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM161B Gene

Drugs & Compounds for FAM161B Gene

No Compound Related Data Available

Transcripts for FAM161B Gene

mRNA/cDNA for FAM161B Gene

Unigene Clusters for FAM161B Gene

Family with sequence similarity 161, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM161B Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7
SP2: -

Relevant External Links for FAM161B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM161B Gene

mRNA expression in normal human tissues for FAM161B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAM161B Gene

This gene is overexpressed in Monocytes (33.2), Peripheral blood mononuclear cells (18.5), and Ovary (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM161B Gene

SOURCE GeneReport for Unigene cluster for FAM161B Gene Hs.550547

mRNA Expression by UniProt/SwissProt for FAM161B Gene

Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with FAM161B: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for FAM161B Gene

Orthologs for FAM161B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM161B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM161B 35
  • 83.98 (n)
  • 77.59 (a)
FAM161B 36
  • 76 (a)
(Canis familiaris)
Mammalia FAM161B 35
  • 85.57 (n)
  • 78.21 (a)
FAM161B 36
  • 76 (a)
(Mus musculus)
Mammalia Fam161b 35
  • 81.77 (n)
  • 78.36 (a)
Fam161b 16
Fam161b 36
  • 77 (a)
(Pan troglodytes)
Mammalia FAM161B 35
  • 99.15 (n)
  • 99.01 (a)
FAM161B 36
  • 99 (a)
(Monodelphis domestica)
Mammalia FAM161B 36
  • 56 (a)
(Gallus gallus)
Aves FAM161B 35
  • 61.49 (n)
  • 52.62 (a)
FAM161B 36
  • 52 (a)
(Anolis carolinensis)
Reptilia FAM161B 36
  • 47 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam161b 35
  • 49.85 (n)
  • 42.12 (a)
(Danio rerio)
Actinopterygii fam161b 36
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
Species with no ortholog for FAM161B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM161B Gene

Gene Tree for FAM161B (if available)
Gene Tree for FAM161B (if available)

Paralogs for FAM161B Gene

Paralogs for FAM161B Gene

genes like me logo Genes that share paralogs with FAM161B: view

Variants for FAM161B Gene

Sequence variations from dbSNP and Humsavar for FAM161B Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_027963 -
rs17094077 - 73,934,335(+) GTTCT(A/G)GAGAT reference, missense
rs28927675 - 73,938,053(+) TCTTT(C/T)TGTGT reference, missense
rs7142206 -- 73,940,359(+) CTCAT(A/C)TTTGC intron-variant
rs8019443 -- 73,936,147(+) CTAAA(C/T)TACTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM161B Gene

Variant ID Type Subtype PubMed ID
esv274934 CNV Gain+Loss 21479260

Variation tolerance for FAM161B Gene

Residual Variation Intolerance Score: 82.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.62; 93.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM161B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM161B Gene

Disorders for FAM161B Gene

Relevant External Links for FAM161B

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM161B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM161B Gene

Publications for FAM161B Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  3. Functional proteomics mapping of a human signaling pathway. (PMID: 15231748) Colland F. … Gauthier J.M. (Genome Res. 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. (PMID: 7566098) Adams M.D. … White O. (Nature 1995) 3

Products for FAM161B Gene

Sources for FAM161B Gene