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FAM161B Gene

protein-coding   GIFtS: 46
GCID: GC14M074400

Family With Sequence Similarity 161, Member B

(Previous name: chromosome 14 open reading frame 44)
(Previous symbol: C14orf44)
  See FAM161B-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 161, Member B1 2
C14orf441 2 3
Chromosome 14 Open Reading Frame 441
c14_55472
Protein FAM161B2

External Ids:    HGNC: 198541   Entrez Gene: 1454832   Ensembl: ENSG000001560507   UniProtKB: Q96MY73   

Export aliases for FAM161B gene to outside databases

Previous GC identifers: GC14M073471 GC14M054567


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM161B Gene:
FAM161B (family with sequence similarity 161, member B) is a protein-coding gene. Diseases associated with FAM161B include retinitis pigmentosa 28. An important paralog of this gene is FAM161A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAM161B gene promoter:
         TBP   AML1a   Pax-5   IRF-1   E47   Evi-1   GATA-1   CP1A   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM161B promoter sequence
   Search Chromatin IP Primers for FAM161B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM161B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3   Ensembl cytogenetic band:  14q24.3   HGNC cytogenetic band: 14q24.2

FAM161B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM161B gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M074400:  view genomic region     (about GC identifiers)

Start:
74,398,204 bp from pter      End:
74,417,117 bp from pter
Size:
18,914 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: F161B_HUMAN, Q96MY7 (See protein sequence)
Recommended Name: Protein FAM161B  
Size: 647 amino acids; 73647 Da
Subunit: Interacts with FAM161A
Secondary accessions: B7Z882 J3KNA2
Alternative splicing: 2 isoforms:  Q96MY7-1   Q96MY7-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FAM161B: NX_Q96MY7

Explore proteomics data for FAM161B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FAM161B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_689658.2  
    ENSEMBL proteins: 
     ENSP00000450889   ENSP00000286544   ENSP00000445326  

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    antibodies-online proteins for FAM161B (2 products) 

     
    antibodies-online peptides for FAM161B

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    antibodies-online antibodies for FAM161B (15 products) 

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    Cloud-Clone Corp. CLIAs for FAM161B
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    antibodies-online kits for FAM161B (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR019579 UPF0564

    Graphical View of Domain Structure for InterPro Entry Q96MY7

    ProtoNet protein and cluster: Q96MY7

    UniProtKB/Swiss-Prot: F161B_HUMAN, Q96MY7
    Similarity: Belongs to the FAM161 family


    Find genes that share domains with FAM161B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAM161B
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FAM161B
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    hsa-miR-595 hsa-miR-3662 hsa-miR-2278 hsa-miR-630 hsa-miR-4275
    SwitchGear 3'UTR luciferase reporter plasmidFAM161B 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FAM161B

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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM161B

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM161B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    cytoskeleton1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM161B
    Interactions:

        Search GeneGlobe Interaction Network for FAM161B

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for FAM161B (Q96MY72, 3 ENSP000002865444) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD2Q157962, 3MINT-61602 I2D: score=2 
    USO1ENSP000004116984STRING: ENSP00000411698
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM161B (F161B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FAM161B gene: 
    NM_152445.2  

    Unigene Cluster for FAM161B:

    Family with sequence similarity 161, member B
    Hs.550547  [show with all ESTs]
    Unigene Representative Sequence: NM_152445
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000556794 ENST00000286544(uc001xpd.2) ENST00000534936
    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate FAM161B:
    hsa-miR-595 hsa-miR-3662 hsa-miR-2278 hsa-miR-630 hsa-miR-4275
    SwitchGear 3'UTR luciferase reporter plasmidFAM161B 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FAM161B
    Predesigned siRNA for gene silencing in human, mouse, rat FAM161B
    Clone
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    GenScript: all cDNA clones in your preferred vector: FAM161B (NM_152445)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM161B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM161B
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for FAM161B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FAM161B
      QuantiTect SYBR Green Assays in human, mouse, rat FAM161B
      QuantiFast Probe-based Assays in human, mouse, rat FAM161B

    Additional mRNA sequence: 

    AK056259.1 AK302982.1 BC053909.1 

    6 DOTS entries:

    DT.40126076  DT.120749963  DT.435519  DT.440234  DT.100744564  DT.120749800 

    Selected AceView cDNA sequences (see all 53):

    AA026844 AA428461 CA392234 AA976020 AW105118 CB153578 AA883616 BG250126 
    BU686485 BC053909 BI254210 AI334807 BX281864 AA368338 NM_152445 BP363738 
    AA429550 BP362242 BI918434 CO403815 CR749537 AW274700 AK056259 BM968096 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for FAM161B    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7
    SP1:                                                                  
    SP2:                    -                                             
    SP3:                                                                  
    SP4:                                                                  


    ECgene alternative splicing isoforms for FAM161B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM161B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTACTGTTA
    FAM161B Expression
    About this image


    FAM161B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Adipose (Muscoskeletal System)
             Mesenchymal Stem Cells Subcutaneous White Adipose
     
     Mesenchymal Stem Cells
             Mesenchymal Stem Cells Subcutaneous White Adipose
    FAM161B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM161B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.550547

    UniProtKB/Swiss-Prot: F161B_HUMAN, Q96MY7
    Tissue specificity: Ubiquitously expressed

        Custom PCR Arrays for FAM161B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM161B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FAM161B gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam161b1 , 5 family with sequence similarity 161, member B1, 5 81.77(n)1
    78.36(a)1
      12 (39.17 cM)5
    2177051  NM_172581.21  NP_766169.11 
     843453095 
    chicken
    (Gallus gallus)
    Aves FAM161B1 family with sequence similarity 161, member B 61.49(n)
    52.62(a)
      423341  XM_004941784.1  XP_004941841.1 
    lizard
    (Anolis carolinensis)
    Reptilia FAM161B6
    family with sequence similarity 161, member B
    47(a)
    1 ↔ 1
    1(23798291-23810661)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fam161b1 family with sequence similarity 161, member B 49.85(n)
    42.12(a)
      100492844  XM_002938594.2  XP_002938640.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fam161b6
    family with sequence similarity 161, member B
    33(a)
    1 ↔ 1
    17(45147199-45176144) ENSDARG00000089467


    ENSEMBL Gene Tree for FAM161B (if available)
    TreeFam Gene Tree for FAM161B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM161B gene
    FAM161A2  

    Find genes that share paralogs with FAM161B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM161B (see all 386)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs357261421,2
    C--54574685(+) CTATC-/T/T   
       T
    /TTT
    TTTTT
    1 -- int12NA 4
    rs1473050701,2
    C--74399504(+) TGTGG-/TTTTTT 1 -- int10--------
    rs1503876771,2
    --74399550(+) TTGAAC/TGCCTG 1 -- int10--------
    rs1931720481,2
    --74399633(+) GAATAC/TCCAAT 1 -- int10--------
    rs1846435571,2
    --74399675(+) TTCACC/GTACTA 1 -- int10--------
    rs1380244221,2
    --74399777(+) CGGGAA/GAGAAT 1 -- ut310--------
    rs1425669011,2
    --74399896(+) CATTTA/CTATTA 1 -- ut310--------
    rs1886809911,2
    --74400039(+) ACATTC/TTACAA 1 -- ut310--------
    rs1912569211,2
    --74400114(+) ACTGAA/GGATAA 1 -- ut310--------
    rs676027111,2
    C,F--74400175(+) TGATAC/G/TGCAGA 2 -- ut315NA EA 246

    HapMap Linkage Disequilibrium report for FAM161B (74398204 - 74417117 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FAM161B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv274934CNV Gain+Loss21479260

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FAM161B
    DNA2.0 Custom Variant and Variant Library Synthesis for FAM161B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for FAM161B:    
    About MalaCards
    retinitis pigmentosa 28


    Find genes that share disorders with FAM161B           About GenesLikeMe

    Genetic Association Database (GAD): FAM161B

    Export disorders for FAM161B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM161B gene integrated from 10 sources:
    (articles sorted by number of sources associating them with FAM161B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The retinitis pigmentosa 28 protein FAM161A is a novel ciliary protein involved in intermolecular protein interaction and microtubule association. (PubMed id 22791751)2 Zach F.... Stohr H. (Hum. Mol. Genet. 2012)
    4. Functional proteomics mapping of a human signaling pathway. (PubMed id 15231748)1 Colland F....Gauthier J.M. (Genome Res. 2004)
    5. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)2 Heilig R.... Weissenbach J. (Nature 2003)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    7. Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. (PubMed id 7566098)1 Adams M.D.... White O. (Nature 1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 145483 HGNC: 19854 AceView: C14orf44 Ensembl:ENSG00000156050 euGenes: HUgn145483
    ECgene: FAM161B H-InvDB: FAM161B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM161B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM161B gene:
    Search GeneIP for patents involving FAM161B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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