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Aliases for FAM160B2 Gene

Aliases for FAM160B2 Gene

  • Family With Sequence Similarity 160 Member B2 2 3 5
  • Family With Sequence Similarity 160, Member B2 2 3
  • Retinoic Acid-Induced Protein 16 3 4
  • Retinoic Acid Induced 16 2 3
  • RAI16 3 4

External Ids for FAM160B2 Gene

Previous HGNC Symbols for FAM160B2 Gene

  • RAI16

Previous GeneCards Identifiers for FAM160B2 Gene

  • GC08P022003
  • GC08P020466
  • GC08P021947

Summaries for FAM160B2 Gene

GeneCards Summary for FAM160B2 Gene

FAM160B2 (Family With Sequence Similarity 160 Member B2) is a Protein Coding gene. An important paralog of this gene is FAM160B1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM160B2 Gene

Genomics for FAM160B2 Gene

Regulatory Elements for FAM160B2 Gene

Promoters for FAM160B2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAM160B2 on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM160B2 Gene

Chromosome:
8
Start:
22,089,159 bp from pter
End:
22,104,898 bp from pter
Size:
15,740 bases
Orientation:
Plus strand

Genomic View for FAM160B2 Gene

Genes around FAM160B2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM160B2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM160B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM160B2 Gene

Proteins for FAM160B2 Gene

  • Protein details for FAM160B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86V87-F16B2_HUMAN
    Recommended name:
    Protein FAM160B2
    Protein Accession:
    Q86V87
    Secondary Accessions:
    • B2RDQ5
    • B3KNX1
    • Q2M211
    • Q71JB5
    • Q7L3J6
    • Q969T0
    • Q9H6W4

    Protein attributes for FAM160B2 Gene

    Size:
    743 amino acids
    Molecular mass:
    82340 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH52237.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI12148.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAI12148.2; Type=Frameshift; Positions=291; Evidence={ECO:0000305}; Sequence=AAQ06676.1; Type=Frameshift; Positions=258, 727; Evidence={ECO:0000305}; Sequence=BAB15137.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG38002.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG51483.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for FAM160B2 Gene

Proteomics data for FAM160B2 Gene at MOPED

Post-translational modifications for FAM160B2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM160B2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM160B2 Gene

Domains & Families for FAM160B2 Gene

Protein Domains for FAM160B2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM160B2 Gene

Graphical View of Domain Structure for InterPro Entry

Q86V87

UniProtKB/Swiss-Prot:

F16B2_HUMAN :
  • Belongs to the UPF0518 family.
Family:
  • Belongs to the UPF0518 family.
genes like me logo Genes that share domains with FAM160B2: view

No data available for Gene Families for FAM160B2 Gene

Function for FAM160B2 Gene

Phenotypes for FAM160B2 Gene

GenomeRNAi human phenotypes for FAM160B2:
genes like me logo Genes that share phenotypes with FAM160B2: view

Animal Model Products

CRISPR Products

miRNA for FAM160B2 Gene

miRTarBase miRNAs that target FAM160B2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM160B2 Gene

Localization for FAM160B2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM160B2 Gene COMPARTMENTS Subcellular localization image for FAM160B2 gene
Compartment Confidence
cytosol 3
nucleus 3
extracellular 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM160B2 Gene

Pathways & Interactions for FAM160B2 Gene

SuperPathways for FAM160B2 Gene

No Data Available

Interacting Proteins for FAM160B2 Gene

Gene Ontology (GO) - Biological Process for FAM160B2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM160B2 Gene

Drugs & Compounds for FAM160B2 Gene

No Compound Related Data Available

Transcripts for FAM160B2 Gene

Unigene Clusters for FAM160B2 Gene

Family with sequence similarity 160, member B2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM160B2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c ^ 17a ·
SP1: - - -
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9: -
SP10:

ExUns: 17b · 17c · 17d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for FAM160B2 Gene

GeneLoc Exon Structure for
FAM160B2
ECgene alternative splicing isoforms for
FAM160B2

Expression for FAM160B2 Gene

mRNA expression in normal human tissues for FAM160B2 Gene

Protein differential expression in normal tissues from HIPED for FAM160B2 Gene

This gene is overexpressed in Bone (62.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for FAM160B2 Gene



SOURCE GeneReport for Unigene cluster for FAM160B2 Gene Hs.491223

genes like me logo Genes that share expression patterns with FAM160B2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FAM160B2 Gene

Orthologs for FAM160B2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM160B2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAM160B2 35
  • 85.98 (n)
  • 84.53 (a)
FAM160B2 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM160B2 35
  • 84.93 (n)
  • 84.63 (a)
FAM160B2 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam160b2 35
  • 83.89 (n)
  • 86.27 (a)
Fam160b2 16
Fam160b2 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM160B2 35
  • 99.46 (n)
  • 98.98 (a)
FAM160B2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam160b2 35
  • 83.49 (n)
  • 85.33 (a)
oppossum
(Monodelphis domestica)
Mammalia FAM160B2 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM160B2 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM160B2 36
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM160B2 36
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam160b2 35
  • 58.36 (n)
  • 52.97 (a)
zebrafish
(Danio rerio)
Actinopterygii fam160b2 35
  • 55.9 (n)
  • 52.05 (a)
fam160b2 36
  • 49 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5399 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToMany
Species with no ortholog for FAM160B2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM160B2 Gene

ENSEMBL:
Gene Tree for FAM160B2 (if available)
TreeFam:
Gene Tree for FAM160B2 (if available)

Paralogs for FAM160B2 Gene

Paralogs for FAM160B2 Gene

(1) SIMAP similar genes for FAM160B2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FAM160B2: view

Variants for FAM160B2 Gene

Sequence variations from dbSNP and Humsavar for FAM160B2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs35497596 - 22,098,597(-) TAAGG(C/T)GGCAA nc-transcript-variant, reference, missense
rs7822461 - 22,102,534(+) TGATC(A/G)GGGAC nc-transcript-variant, downstream-variant-500B, reference, missense
rs7490 -- 22,104,323(+) ACTTT(A/C/G/T)GCATT nc-transcript-variant, utr-variant-3-prime
rs11352 -- 22,097,605(+) AGCGT(C/T)CACAG nc-transcript-variant, reference, synonymous-codon
rs1456 -- 22,094,715(-) CCGGC(A/G)GCTAA intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for FAM160B2 Gene

Variant ID Type Subtype PubMed ID
essv19243 CNV CNV 17122850
essv21913 CNV CNV 17122850
dgv7756n71 CNV Loss 21882294
nsv831263 CNV Loss 17160897
nsv528590 CNV Loss 19592680
dgv7757n71 CNV Loss 21882294
nsv890654 CNV Loss 21882294
nsv465613 CNV Loss 19166990
dgv7758n71 CNV Loss 21882294
nsv890657 CNV Loss 21882294
esv1008033 CNV Deletion 20482838
nsv831264 CNV Gain+Loss 17160897
dgv450n21 CNV Loss 19592680
dgv881n27 CNV Loss 19166990
nsv470204 CNV Loss 18288195
esv2736745 CNV Deletion 23290073

Variation tolerance for FAM160B2 Gene

Residual Variation Intolerance Score: 55.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.00; 90.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM160B2 Gene

HapMap Linkage Disequilibrium report
FAM160B2
Human Gene Mutation Database (HGMD)
FAM160B2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM160B2 Gene

Disorders for FAM160B2 Gene

Relevant External Links for FAM160B2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM160B2

No disorders were found for FAM160B2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM160B2 Gene

Publications for FAM160B2 Gene

  1. Retinoic acid induced 16 enhances tumorigenesis and serves as a novel tumor marker for hepatocellular carcinoma. (PMID: 22971576) Wang W. … Qi Z.T. (Carcinogenesis 2012) 2 3 67
  2. Are gene expression microarray analyses reliable? A review of studies of retinoic acid responsive genes. (PMID: 15626329) van der Spek P.J. … Walker M.G. (Genomics Proteomics Bioinformatics 2003) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. Loss-of-function mutations of an inhibitory upstream ORF in the human hairless transcript cause Marie Unna hereditary hypotrichosis. (PMID: 19122663) Wen Y. … Zhang X. (Nat. Genet. 2009) 3

Products for FAM160B2 Gene

Sources for FAM160B2 Gene

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