FAM160A2 Gene
protein-coding GIFtS: 45
GCID: GC11M006232
|
|
family with sequence similarity 160, member A2(Previous name: chromosome 11 open reading frame 56 )
(Previous symbol: C11orf56)
| |
Aliases
for FAM160A2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Family With Sequence Similarity 160, Member A21 2 | | FLJ226651 | | C11orf561 2 3 | | Chromosome 11 Open Reading Frame 561 | | KIAA17591 3 | | FTS And Hook-Interacting Protein2 | | FHIP2 3 | | Protein FAM160A23 | | DKFZP566M10461 | | |
Export aliases for FAM160A2 gene to outside databasesPrevious GC identifers: GC11M006192 GC11M005892 |
Summaries
for FAM160A2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: F16A2_HUMAN, Q8N612Function: Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicletrafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex)
Gene Wiki entry for FAM160A2 (C11orf56)
|
Genomic Views
for FAM160A2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_009237.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FAM160A2 gene promoter:
GR GR-beta STAT3 GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM160A2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM160A2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p15.4 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15.4FAM160A2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M006232: view genomic region
(about GC identifiers)
Start:
|
6,232,564 bp from pter |
End:
|
6,255,941 bp from pter |
Size:
|
23,378 bases |
Orientation:
|
minus strand |
|
Proteins
for FAM160A2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: F16A2_HUMAN, Q8N612 (See
protein sequence)Recommended Name: FTS and Hook-interacting protein Size: 972 amino acids; 105568 Da
Subunit: Component of the FTS/Hook/FHIP complex (FHF complex), composed of AKTIP/FTS, FAM160A2, and one or more membersof the Hook family of proteins HOOK1, HOOK2, and HOOK3. The FHF complex associates with the homotypic vesicularsorting complex (the HOPS complex)
Sequence caution: Sequence=BAB21850.1; Type=Erroneous initiation;
Secondary accessions: Q9C0A4 Q9H0N3 Q9H624Alternative splicing: 3 isoforms: Q8N612-1 Q8N612-2 Q8N612-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for FAM160A2: NX_Q8N612
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N612
FAM160A2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001092264.1 NP_115503.2
ENSEMBL proteins: ENSP00000416918 ENSP00000265978 ENSP00000431773
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
FAM160A2 for ontologies About GeneDecksing
FAM160A2 Antibody Products:
Assay Products for FAM160A2: |
Protein
Domains /
Families
for FAM160A2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FAM160A2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8N612ProtoNet protein and cluster: Q8N612 UniProtKB/Swiss-Prot: F16A2_HUMAN, Q8N612Similarity: Belongs to the UPF0518 family |
Function
for FAM160A2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: F16A2_HUMAN, Q8N612Function: Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicletrafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex)
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM160A2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for FAM160A2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM160A2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM160A2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
FAM160A2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for FAM160A2:
|
Pathways & Interactions
for FAM160A2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM160A2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 9)
5/11 Interacting proteins for FAM160A2 (Q8N6122, 3 ENSP000002659784) via UniProtKB, MINT, STRING, and/or I2D (see all 11)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
FAM160A2 for ontologies About GeneDecksing
|
Drugs & Compounds
for FAM160A2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM160A2
Search CenterWatch for drugs/clinical trials and news about FAM160A2 / F16A2
|
Transcripts
for FAM160A2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAM160A2 gene (2 alternative transcripts): NM_001098794.1 NM_032127.3 Unigene Cluster for FAM160A2: Family with sequence similarity 160, member A2 Hs.501793 [show with all ESTs]Unigene Representative Sequence: NM_0321275 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000449352 ENST00000529360 ENST00000265978(uc001mck.4 uc001mcl.4)
ENST00000524416(uc001mcm.2) ENST00000532797
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM160A2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM160A2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): FAM160A2 (NM_032127) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM160A2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM160A2 |
Additional cDNA sequence: AB051546.1 AK291702.1 AL136723.1 BC030825.1 8 DOTS entries: DT.75140934 DT.91706569 DT.100749827 DT.100749826 DT.120700854 DT.120700831 DT.120700846 DT.91925625 24/157 AceView cDNA sequences (see all 157): CA414352 AA627470 AW515197 BM916561 BU736731 BM911752 F04566 BI711276 AI445962 Z39671 CA843685 AI673531 BM974940 AW206001 CK903290 F03319 CK820543 CA414340 CA430780 BE796166 AI825955 BM695243 CK299857 AL048985
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for FAM160A2 (see all 8) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13a | · | 13b | · | 13c | ^ | 14a | · | 14b | ^ | 15 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FAM160A2
|
Expression
for FAM160A2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAM160A2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGTGGCCCGG
About this image
See FAM160A2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM160A2
SOURCE GeneReport for Unigene cluster: Hs.501793
SABiosciences Custom PCR Arrays for FAM160A2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM160A2
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM160A2 |
Orthologs
for FAM160A2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FAM160A2 gene from 6/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
FAM160A21 |
family with sequence similarity 160, member A2 |
68.2(n)
67.74(a) |
|
425130 XM_003640616.1 XP_003640664.1 |
lizard
(Anolis carolinensis) |
Reptilia |
FAM160A26 |
-- |
60(a) |
1 ↔ 1 |
GL344039.1(64751-93562) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.173542 |
Transcribed sequence with moderate similarity to protein refNP_115503.1 (H.sapiens) hypothetical protein DKFZp566M1046 [Homo sapiens] less |
77.53(n) |
|
AL774965.2 |
zebrafish
(Danio rerio) |
Actinopterygii |
fam160a21 |
family with sequence similarity 160, member A2 |
60.99(n)
61.94(a) |
|
100001896 NM_001130857.1 NP_001124329.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG35586 |
-- |
27(a) |
1 → many |
2L(2992870-2998726) |
worm
(Caenorhabditis elegans) |
Secernentea |
C05D11.86 |
UPF0518 protein C05D11.8 |
22(a) |
1 → many |
III(6422406-6427252) |
ENSEMBL Gene Tree for FAM160A2 (if available)
TreeFam Gene Tree for FAM160A2 (if available) |
Paralogs
for FAM160A2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAM160A2 gene
- FAM160B22 FAM160A12 FAM160B12
1 SIMAP similar gene for FAM160A2 using alignment to 2 protein entries: F16A2_HUMAN (see all proteins):FAM160A1
FAM160A2 for paralogs About GeneDecksing
|
Genomic Variants
for FAM160A2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM160A2 (6232564 - 6255941 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FAM160A2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM160A2 |
|
Disorders
/ Diseases
for FAM160A2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for FAM160A2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM160A2 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with FAM160A2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
- Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2, 3 Nagase T.... Ohara O. (2000)
- An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex. (PubMed id 18799622)1, 2 Xu L....Harper J.W. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
|
External Searches for FAM160A2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FAM160A2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM160A2 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing FAM160A2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAM160A2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FAM160A2 gene:
Search GeneIP for patents involving FAM160A2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM160A2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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 |
 |
 |
 | | | FAM160A2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM160A2 |
|  |  |  | | | | Search ThermoFisher Antibodies for FAM160A2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM160A2 |
|
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|
