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Aliases for FAM160A2 Gene

Aliases for FAM160A2 Gene

  • Family With Sequence Similarity 160, Member A2 2 3
  • C11orf56 3 4
  • FHIP 3 4
  • Chromosome 11 Open Reading Frame 56 2
  • Protein FAM160A2 4
  • KIAA1759 4

External Ids for FAM160A2 Gene

Previous HGNC Symbols for FAM160A2 Gene

  • C11orf56

Previous GeneCards Identifiers for FAM160A2 Gene

  • GC11M006192
  • GC11M005892

Summaries for FAM160A2 Gene

GeneCards Summary for FAM160A2 Gene

FAM160A2 (Family With Sequence Similarity 160, Member A2) is a Protein Coding gene. An important paralog of this gene is FAM160A1.

UniProtKB/Swiss-Prot for FAM160A2 Gene

  • Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex).

Gene Wiki entry for FAM160A2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM160A2 Gene

Genomics for FAM160A2 Gene

Regulatory Elements for FAM160A2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM160A2 Gene

Chromosome:
11
Start:
6,211,334 bp from pter
End:
6,234,711 bp from pter
Size:
23,378 bases
Orientation:
Minus strand

Genomic View for FAM160A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM160A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM160A2 Gene

Proteins for FAM160A2 Gene

  • Protein details for FAM160A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N612-F16A2_HUMAN
    Recommended name:
    FTS and Hook-interacting protein
    Protein Accession:
    Q8N612
    Secondary Accessions:
    • Q9C0A4
    • Q9H0N3
    • Q9H624

    Protein attributes for FAM160A2 Gene

    Size:
    972 amino acids
    Molecular mass:
    105568 Da
    Quaternary structure:
    • Component of the FTS/Hook/FHIP complex (FHF complex), composed of AKTIP/FTS, FAM160A2, and one or more members of the Hook family of proteins HOOK1, HOOK2, and HOOK3. The FHF complex associates with the homotypic vesicular sorting complex (the HOPS complex).
    SequenceCaution:
    • Sequence=BAB21850.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM160A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM160A2 Gene

Proteomics data for FAM160A2 Gene at MOPED

Post-translational modifications for FAM160A2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM160A2 Gene

No data available for DME Specific Peptides for FAM160A2 Gene

Domains & Families for FAM160A2 Gene

Protein Domains for FAM160A2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM160A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N612

UniProtKB/Swiss-Prot:

F16A2_HUMAN :
  • Belongs to the UPF0518 family.
Family:
  • Belongs to the UPF0518 family.
genes like me logo Genes that share domains with FAM160A2: view

No data available for Gene Families for FAM160A2 Gene

Function for FAM160A2 Gene

Molecular function for FAM160A2 Gene

UniProtKB/Swiss-Prot Function:
Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex).

Gene Ontology (GO) - Molecular Function for FAM160A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with FAM160A2: view
genes like me logo Genes that share phenotypes with FAM160A2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM160A2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM160A2 Gene

Localization for FAM160A2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM160A2 Gene COMPARTMENTS Subcellular localization image for FAM160A2 gene
Compartment Confidence
endosome 1

Gene Ontology (GO) - Cellular Components for FAM160A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070695 FHF complex IDA 18799622
genes like me logo Genes that share ontologies with FAM160A2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAM160A2 Gene

Pathways & Interactions for FAM160A2 Gene

SuperPathways for FAM160A2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM160A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007032 endosome organization IMP 18799622
GO:0007040 lysosome organization IMP 18799622
GO:0008333 endosome to lysosome transport IMP 18799622
GO:0015031 protein transport IEA --
GO:0045022 early endosome to late endosome transport IMP 18799622
genes like me logo Genes that share ontologies with FAM160A2: view

No data available for Pathways by source and SIGNOR curated interactions for FAM160A2 Gene

Drugs & Compounds for FAM160A2 Gene

No Compound Related Data Available

Transcripts for FAM160A2 Gene

Unigene Clusters for FAM160A2 Gene

Family with sequence similarity 160, member A2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM160A2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM160A2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b ^ 15
SP1:
SP2: - -
SP3: -
SP4: -
SP5:
SP6: -
SP7:
SP8: -

Relevant External Links for FAM160A2 Gene

GeneLoc Exon Structure for
FAM160A2
ECgene alternative splicing isoforms for
FAM160A2

Expression for FAM160A2 Gene

mRNA expression in normal human tissues for FAM160A2 Gene

mRNA differential expression in normal tissues according to GTEx for FAM160A2 Gene

This gene is overexpressed in Whole Blood (x4.6).

Protein differential expression in normal tissues from HIPED for FAM160A2 Gene

This gene is overexpressed in Monocytes (31.4), Blymphocyte (7.9), and Fetal gut (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM160A2 Gene



SOURCE GeneReport for Unigene cluster for FAM160A2 Gene Hs.501793

genes like me logo Genes that share expression patterns with FAM160A2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FAM160A2 Gene

Orthologs for FAM160A2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM160A2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAM160A2 35
  • 92.63 (n)
  • 94.44 (a)
FAM160A2 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM160A2 35
  • 92.41 (n)
  • 95.47 (a)
FAM160A2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam160a2 35
  • 90.53 (n)
  • 93.82 (a)
Fam160a2 16
Fam160a2 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM160A2 35
  • 96.42 (n)
  • 95.52 (a)
FAM160A2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam160a2 35
  • 91.13 (n)
  • 94.01 (a)
oppossum
(Monodelphis domestica)
Mammalia FAM160A2 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM160A2 36
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM160A2 35
  • 67.94 (n)
  • 67.55 (a)
FAM160A2 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM160A2 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam160a2 35
  • 66.23 (n)
  • 67.45 (a)
Str.17354 35
zebrafish
(Danio rerio)
Actinopterygii fam160a2 35
  • 62.16 (n)
  • 63.76 (a)
fam160a2 36
  • 45 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG3558 36
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C05D11.8 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10656 36
  • 35 (a)
OneToMany
Species with no ortholog for FAM160A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM160A2 Gene

ENSEMBL:
Gene Tree for FAM160A2 (if available)
TreeFam:
Gene Tree for FAM160A2 (if available)

Paralogs for FAM160A2 Gene

Paralogs for FAM160A2 Gene

(1) SIMAP similar genes for FAM160A2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FAM160A2: view

Variants for FAM160A2 Gene

Sequence variations from dbSNP and Humsavar for FAM160A2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs35716832 -- 6,232,095(+) TACAT(-/G)CATCA intron-variant, upstream-variant-2KB
rs73395024 -- 6,232,144(+) CTATA(C/T)GATAC intron-variant, upstream-variant-2KB
rs73395025 -- 6,232,339(+) ATCCA(A/G)GTATT intron-variant
rs78584212 -- 6,232,356(+) ACCTG(C/T)TCCAA intron-variant
rs79765556 -- 6,232,218(+) AGCTT(A/G)CCAAA intron-variant

Variation tolerance for FAM160A2 Gene

Residual Variation Intolerance Score: 52.86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.56; 82.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM160A2 Gene

HapMap Linkage Disequilibrium report
FAM160A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FAM160A2 Gene

Disorders for FAM160A2 Gene

Relevant External Links for FAM160A2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM160A2
genes like me logo Genes that share disorders with FAM160A2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM160A2 Gene

Publications for FAM160A2 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 67
  2. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67

Products for FAM160A2 Gene

Sources for FAM160A2 Gene

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