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Aliases for FAM160A2 Gene

Aliases for FAM160A2 Gene

  • Family With Sequence Similarity 160 Member A2 2 3 5
  • C11orf56 3 4
  • FHIP 3 4
  • Family With Sequence Similarity 160, Member A2 2
  • Chromosome 11 Open Reading Frame 56 2
  • FTS And Hook Interacting Protein 2
  • FTS And Hook-Interacting Protein 3
  • Protein FAM160A2 4
  • KIAA1759 4

External Ids for FAM160A2 Gene

Previous HGNC Symbols for FAM160A2 Gene

  • C11orf56

Previous GeneCards Identifiers for FAM160A2 Gene

  • GC11M006192
  • GC11M005892

Summaries for FAM160A2 Gene

Entrez Gene Summary for FAM160A2 Gene

  • The protein encoded by this gene is part of the FTS/Hook/FHIP (FHF) complex, which can interact with members of the homotypic vesicular protein sorting (HOPS) complex. This interaction suggests that the encoded protein is involved in vesicle trafficking. [provided by RefSeq, Dec 2016]

GeneCards Summary for FAM160A2 Gene

FAM160A2 (Family With Sequence Similarity 160 Member A2) is a Protein Coding gene. An important paralog of this gene is FAM160A1.

UniProtKB/Swiss-Prot for FAM160A2 Gene

  • Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex).

Gene Wiki entry for FAM160A2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM160A2 Gene

Genomics for FAM160A2 Gene

Regulatory Elements for FAM160A2 Gene

Enhancers for FAM160A2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G006202 1.6 FANTOM5 Ensembl ENCODE dbSUPER 18.7 +31.3 31344 1.5 HDGF ETV1 TAL1 BMI1 TCF12 GATA2 NCOR1 TRIM24 RELB IKZF2 FAM160A2 TPP1 ENSG00000267940 C11orf42
GH11G006233 1.1 ENCODE 21.6 -0.1 -139 2.5 HDGF PKNOX1 MLX CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 FAM160A2 CNGA4 CCKBR TRIM34 GC11M006236
GH11G006218 1.1 FANTOM5 Ensembl ENCODE 16.7 +15.4 15366 1.5 GATA2 NFYB FOS FAM160A2 OR52B2 CAVIN3 TPP1 C11orf42
GH11G006479 1.3 ENCODE dbSUPER 10.9 -246.7 -246722 3.6 HDGF PKNOX1 MLX CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 SP3 TIMM10B FAM160A2 APBB1 SMPD1 TRIM34 TRIM3
GH11G006250 1 Ensembl ENCODE 13.8 -17.6 -17629 2.8 CTCF FOXA2 TAL1 ZNF175 RAD21 TCF12 POLR2A NCOR1 EGR1 ZNF143 FAM160A2 CCKBR C11orf42 OR52W1 OR56A1 GC11M006236
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM160A2 on UCSC Golden Path with GeneCards custom track

Promoters for FAM160A2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000036265 -189 1801 HDGF PKNOX1 MLX CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for FAM160A2 Gene

Chromosome:
11
Start:
6,211,334 bp from pter
End:
6,234,711 bp from pter
Size:
23,378 bases
Orientation:
Minus strand

Genomic View for FAM160A2 Gene

Genes around FAM160A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM160A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM160A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM160A2 Gene

Proteins for FAM160A2 Gene

  • Protein details for FAM160A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N612-F16A2_HUMAN
    Recommended name:
    FTS and Hook-interacting protein
    Protein Accession:
    Q8N612
    Secondary Accessions:
    • Q9C0A4
    • Q9H0N3
    • Q9H624

    Protein attributes for FAM160A2 Gene

    Size:
    972 amino acids
    Molecular mass:
    105568 Da
    Quaternary structure:
    • Component of the FTS/Hook/FHIP complex (FHF complex), composed of AKTIP/FTS, FAM160A2, and one or more members of the Hook family of proteins HOOK1, HOOK2, and HOOK3. The FHF complex associates with the homotypic vesicular sorting complex (the HOPS complex).
    SequenceCaution:
    • Sequence=BAB21850.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM160A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM160A2 Gene

Post-translational modifications for FAM160A2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM160A2 Gene

No data available for DME Specific Peptides for FAM160A2 Gene

Domains & Families for FAM160A2 Gene

Protein Domains for FAM160A2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM160A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N612

UniProtKB/Swiss-Prot:

F16A2_HUMAN :
  • Belongs to the UPF0518 family.
Family:
  • Belongs to the UPF0518 family.
genes like me logo Genes that share domains with FAM160A2: view

No data available for Gene Families for FAM160A2 Gene

Function for FAM160A2 Gene

Molecular function for FAM160A2 Gene

UniProtKB/Swiss-Prot Function:
Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex).

Gene Ontology (GO) - Molecular Function for FAM160A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with FAM160A2: view
genes like me logo Genes that share phenotypes with FAM160A2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM160A2 Gene

Localization for FAM160A2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM160A2 gene
Compartment Confidence
cytosol 3
nucleus 2
mitochondrion 1
peroxisome 1
endosome 1

Gene Ontology (GO) - Cellular Components for FAM160A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
GO:0070695 FHF complex IDA 18799622
genes like me logo Genes that share ontologies with FAM160A2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAM160A2 Gene

Pathways & Interactions for FAM160A2 Gene

SuperPathways for FAM160A2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM160A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0007032 endosome organization IMP 18799622
GO:0007040 lysosome organization IMP 18799622
GO:0008333 endosome to lysosome transport IMP 18799622
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with FAM160A2: view

No data available for Pathways by source and SIGNOR curated interactions for FAM160A2 Gene

Transcripts for FAM160A2 Gene

Unigene Clusters for FAM160A2 Gene

Family with sequence similarity 160, member A2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM160A2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b ^ 15
SP1:
SP2: - -
SP3: -
SP4: -
SP5:
SP6: -
SP7:
SP8: -

Relevant External Links for FAM160A2 Gene

GeneLoc Exon Structure for
FAM160A2
ECgene alternative splicing isoforms for
FAM160A2

Expression for FAM160A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM160A2 Gene

mRNA differential expression in normal tissues according to GTEx for FAM160A2 Gene

This gene is overexpressed in Whole Blood (x4.6).

Protein differential expression in normal tissues from HIPED for FAM160A2 Gene

This gene is overexpressed in Monocytes (31.4), Blymphocyte (7.9), and Fetal gut (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FAM160A2 Gene



NURSA nuclear receptor signaling pathways regulating expression of FAM160A2 Gene:

FAM160A2

SOURCE GeneReport for Unigene cluster for FAM160A2 Gene:

Hs.501793

Evidence on tissue expression from TISSUES for FAM160A2 Gene

  • Nervous system(4.5)
  • Liver(4.3)
  • Intestine(4.2)
  • Kidney(4.2)
genes like me logo Genes that share expression patterns with FAM160A2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM160A2 Gene

Orthologs for FAM160A2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM160A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM160A2 34 35
  • 96.42 (n)
cow
(Bos Taurus)
Mammalia FAM160A2 34 35
  • 92.63 (n)
dog
(Canis familiaris)
Mammalia FAM160A2 34 35
  • 92.41 (n)
rat
(Rattus norvegicus)
Mammalia Fam160a2 34
  • 91.13 (n)
mouse
(Mus musculus)
Mammalia Fam160a2 34 16 35
  • 90.53 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM160A2 35
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM160A2 35
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM160A2 34 35
  • 67.94 (n)
lizard
(Anolis carolinensis)
Reptilia FAM160A2 35
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam160a2 34
  • 66.23 (n)
Str.17354 34
zebrafish
(Danio rerio)
Actinopterygii fam160a2 34 35
  • 62.16 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG3558 35
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C05D11.8 35
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10656 35
  • 35 (a)
OneToMany
Species where no ortholog for FAM160A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM160A2 Gene

ENSEMBL:
Gene Tree for FAM160A2 (if available)
TreeFam:
Gene Tree for FAM160A2 (if available)

Paralogs for FAM160A2 Gene

Paralogs for FAM160A2 Gene

(1) SIMAP similar genes for FAM160A2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FAM160A2: view

Variants for FAM160A2 Gene

Sequence variations from dbSNP and Humsavar for FAM160A2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs117940741 Uncertain significance 6,214,426(+) AGAAC(A/G)GCGTG intron-variant, nc-transcript-variant, downstream-variant-500B, reference, missense
rs1000024554 -- 6,219,523(+) GGGAA(A/G)TAGGT intron-variant
rs1000324883 -- 6,225,223(+) CTACA(C/T)AATCT intron-variant
rs1000366143 -- 6,231,463(+) TGATA(C/T)ATTTT intron-variant, upstream-variant-2KB
rs1000438109 -- 6,219,228(+) ATGAT(C/G)ACACG intron-variant

Variation tolerance for FAM160A2 Gene

Residual Variation Intolerance Score: 52.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.56; 82.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM160A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM160A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FAM160A2 Gene

Disorders for FAM160A2 Gene

Relevant External Links for FAM160A2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM160A2

No disorders were found for FAM160A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM160A2 Gene

Publications for FAM160A2 Gene

  1. An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex. (PMID: 18799622) Xu L. … Harper J.W. (Mol. Biol. Cell 2008) 2 3 4 64
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 64
  3. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for FAM160A2 Gene

Sources for FAM160A2 Gene

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