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Aliases for FAM160A1 Gene

Aliases for FAM160A1 Gene

  • Family With Sequence Similarity 160 Member A1 2 3 5
  • Family With Sequence Similarity 160, Member A1 2

External Ids for FAM160A1 Gene

Previous GeneCards Identifiers for FAM160A1 Gene

  • GC04P152549
  • GC04P152330
  • GC04P148055

Summaries for FAM160A1 Gene

GeneCards Summary for FAM160A1 Gene

FAM160A1 (Family With Sequence Similarity 160 Member A1) is a Protein Coding gene. An important paralog of this gene is FAM160A2.

Additional gene information for FAM160A1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM160A1 Gene

Genomics for FAM160A1 Gene

Regulatory Elements for FAM160A1 Gene

Enhancers for FAM160A1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H151322 1.7 FANTOM5 Ensembl ENCODE 28.9 -84.3 -84326 4.5 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 FOS SP3 SP5 FAM160A1 ENSG00000251455 SH3D19 GC04P151316
GH04H151312 0.9 Ensembl ENCODE 13.5 -94.0 -93986 5.2 SAP130 JUN ZNF10 CEBPG EP300 ZNF781 JUND GATA3 ATF3 CEBPA FAM160A1 PRSS48 ENSG00000250350 GATB ENSG00000251455 GC04P151316 RNU6-1282P
GH04H151483 0.8 Ensembl ENCODE 10.7 +75.9 75858 3.5 PRDM6 JUND TEAD1 POLR2A POU5F1 FOS HNF4A ENSG00000251603 FAM160A1-DT FAM160A1 GC04M151467
GH04H151097 1.2 ENCODE 6.2 -309.1 -309106 4.5 MLX FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC ZNF610 ZNF585B NBN ENSG00000249708 ENSG00000249818 RPS3A FAM160A1 SH3D19 ENSG00000270681 GC04P151105 GC04P151106 GC04P151107 SNORD73B
GH04H151339 0.5 ENCODE 14.2 -68.6 -68627 2.4 ELF3 GATAD2A HNF4A ZNF7 FAM160A1 ENSG00000251455 SH3D19 ENSG00000270265
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM160A1 on UCSC Golden Path with GeneCards custom track

Promoters for FAM160A1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000174776 44 1601 PKNOX1 ATF1 FOXA2 MLX ARNT ARID4B ZNF2 YY1 GLIS2 KAT8

Genomic Locations for FAM160A1 Gene

Genomic Locations for FAM160A1 Gene
chr4:151,409,156-151,670,503
(GRCh38/hg38)
Size:
261,348 bases
Orientation:
Plus strand
chr4:152,330,368-152,584,784
(GRCh37/hg19)

Genomic View for FAM160A1 Gene

Genes around FAM160A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM160A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM160A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM160A1 Gene

Proteins for FAM160A1 Gene

  • Protein details for FAM160A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q05DH4-F16A1_HUMAN
    Recommended name:
    Protein FAM160A1
    Protein Accession:
    Q05DH4
    Secondary Accessions:
    • Q6ZUS2

    Protein attributes for FAM160A1 Gene

    Size:
    1040 amino acids
    Molecular mass:
    116621 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH14937.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH14937.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAC86147.1; Type=Frameshift; Positions=859, 986; Evidence={ECO:0000305}; Sequence=BAC86147.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

neXtProt entry for FAM160A1 Gene

Post-translational modifications for FAM160A1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM160A1 Gene

Domains & Families for FAM160A1 Gene

Gene Families for FAM160A1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM160A1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM160A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q05DH4

UniProtKB/Swiss-Prot:

F16A1_HUMAN :
  • Belongs to the UPF0518 family.
Family:
  • Belongs to the UPF0518 family.
genes like me logo Genes that share domains with FAM160A1: view

Function for FAM160A1 Gene

Phenotypes From GWAS Catalog for FAM160A1 Gene

Phenotypes for FAM160A1 Gene

genes like me logo Genes that share phenotypes with FAM160A1: view

Animal Models for FAM160A1 Gene

MGI Knock Outs for FAM160A1:

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FAM160A1 Gene

Localization for FAM160A1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM160A1 gene
Compartment Confidence
cytosol 3
nucleus 2
plasma membrane 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM160A1 Gene

Pathways & Interactions for FAM160A1 Gene

SuperPathways for FAM160A1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM160A1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM160A1 Gene

Drugs & Compounds for FAM160A1 Gene

No Compound Related Data Available

Transcripts for FAM160A1 Gene

mRNA/cDNA for FAM160A1 Gene

(9) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM160A1 Gene

Family with sequence similarity 160, member A1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM160A1 Gene

No ASD Table

Relevant External Links for FAM160A1 Gene

GeneLoc Exon Structure for
FAM160A1
ECgene alternative splicing isoforms for
FAM160A1

Expression for FAM160A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM160A1 Gene

mRNA differential expression in normal tissues according to GTEx for FAM160A1 Gene

This gene is overexpressed in Muscle - Skeletal (x7.4), Skin - Sun Exposed (Lower leg) (x5.0), Skin - Not Sun Exposed (Suprapubic) (x4.9), and Esophagus - Mucosa (x4.6).

Protein differential expression in normal tissues from HIPED for FAM160A1 Gene

This gene is overexpressed in Monocytes (25.9), Neutrophil (13.5), Tlymphocyte (9.9), and Fetal gut (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FAM160A1 Gene



NURSA nuclear receptor signaling pathways regulating expression of FAM160A1 Gene:

FAM160A1

SOURCE GeneReport for Unigene cluster for FAM160A1 Gene:

Hs.633810
genes like me logo Genes that share expression patterns with FAM160A1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM160A1 Gene

Orthologs for FAM160A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM160A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM160A1 33 34
  • 99.46 (n)
dog
(Canis familiaris)
Mammalia FAM160A1 33 34
  • 85.87 (n)
cow
(Bos Taurus)
Mammalia FAM160A1 33 34
  • 83.64 (n)
mouse
(Mus musculus)
Mammalia Fam160a1 33 16 34
  • 83.28 (n)
rat
(Rattus norvegicus)
Mammalia Fam160a1 33
  • 81.22 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM160A1 34
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM160A1 34
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM160A1 34
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM160A1 34
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam160a1 33
  • 65.98 (n)
zebrafish
(Danio rerio)
Actinopterygii fam160a1 33 34
  • 60.59 (n)
FAM160A1 (2 of 2) 34
  • 48 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG3558 34
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C05D11.8 34
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10656 34
  • 32 (a)
OneToMany
Species where no ortholog for FAM160A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM160A1 Gene

ENSEMBL:
Gene Tree for FAM160A1 (if available)
TreeFam:
Gene Tree for FAM160A1 (if available)

Paralogs for FAM160A1 Gene

Paralogs for FAM160A1 Gene

(1) SIMAP similar genes for FAM160A1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FAM160A1: view

Variants for FAM160A1 Gene

Sequence variations from dbSNP and Humsavar for FAM160A1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000011589 -- 151,474,321(+) TGCTC(A/G)TTATG intron-variant
rs10000281 -- 151,599,338(+) CAAGG(C/G)TGAAT intron-variant
rs1000039283 -- 151,541,486(+) CCAAT(A/G)ATATT intron-variant
rs1000040417 -- 151,500,276(+) TTCTA(C/G)GCCTC intron-variant
rs1000064233 -- 151,427,882(+) TGGGC(A/G)TTCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM160A1 Gene

Variant ID Type Subtype PubMed ID
nsv955629 CNV deletion 24416366
nsv830114 CNV loss 17160897
nsv822774 CNV gain 20364138
nsv508321 CNV deletion 20534489
nsv474145 CNV novel sequence insertion 20440878
nsv4551 CNV deletion 18451855
nsv1147606 CNV deletion 26484159
nsv1074228 CNV deletion 25765185
nsv1028814 CNV gain 25217958
esv3948 CNV loss 18987735
esv3602690 CNV loss 21293372
esv3602688 CNV gain 21293372
esv3602687 CNV loss 21293372
esv3602685 CNV loss 21293372
esv3564797 CNV deletion 23714750
esv3564796 CNV deletion 23714750
esv2728538 CNV deletion 23290073
esv2728537 CNV deletion 23290073
esv2670825 CNV deletion 23128226
esv2611953 CNV deletion 19546169
esv2051581 CNV deletion 18987734
dgv2919n106 CNV deletion 24896259

Variation tolerance for FAM160A1 Gene

Gene Damage Index Score: 3.84; 58.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM160A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM160A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM160A1 Gene

Disorders for FAM160A1 Gene

Relevant External Links for FAM160A1

Genetic Association Database (GAD)
FAM160A1
Human Genome Epidemiology (HuGE) Navigator
FAM160A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM160A1

No disorders were found for FAM160A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM160A1 Gene

Publications for FAM160A1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 60
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 4 60

Products for FAM160A1 Gene

Sources for FAM160A1 Gene

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