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Aliases for FAM159B Gene

Aliases for FAM159B Gene

  • Family With Sequence Similarity 159 Member B 2 3 5
  • Family With Sequence Similarity 159, Member B 2

External Ids for FAM159B Gene

Previous GeneCards Identifiers for FAM159B Gene

  • GC05P064023
  • GC05P060940
  • GC05P063989

Summaries for FAM159B Gene

GeneCards Summary for FAM159B Gene

FAM159B (Family With Sequence Similarity 159 Member B) is a Protein Coding gene. An important paralog of this gene is FAM159A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM159B Gene

Genomics for FAM159B Gene

Regulatory Elements for FAM159B Gene

Promoters for FAM159B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAM159B on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM159B Gene

64,690,308 bp from pter
64,718,190 bp from pter
27,883 bases
Plus strand

Genomic View for FAM159B Gene

Genes around FAM159B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM159B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM159B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM159B Gene

Proteins for FAM159B Gene

  • Protein details for FAM159B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Membrane protein FAM159B
    Protein Accession:

    Protein attributes for FAM159B Gene

    160 amino acids
    Molecular mass:
    17663 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM159B Gene

Proteomics data for FAM159B Gene at MOPED

Post-translational modifications for FAM159B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM159B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM159B Gene

Domains & Families for FAM159B Gene

Protein Domains for FAM159B Gene


Suggested Antigen Peptide Sequences for FAM159B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM159 family.
  • Belongs to the FAM159 family.
genes like me logo Genes that share domains with FAM159B: view

No data available for Gene Families for FAM159B Gene

Function for FAM159B Gene

Phenotypes for FAM159B Gene

GenomeRNAi human phenotypes for FAM159B:
genes like me logo Genes that share phenotypes with FAM159B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for FAM159B

CRISPR Products

miRNA for FAM159B Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM159B Gene

Localization for FAM159B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM159B Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for FAM159B Gene COMPARTMENTS Subcellular localization image for FAM159B gene
Compartment Confidence
plasma membrane 3
extracellular 2

No data available for Gene Ontology (GO) - Cellular Components for FAM159B Gene

Pathways & Interactions for FAM159B Gene

SuperPathways for FAM159B Gene

No Data Available

Interacting Proteins for FAM159B Gene

Gene Ontology (GO) - Biological Process for FAM159B Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM159B Gene

Drugs & Compounds for FAM159B Gene

No Compound Related Data Available

Transcripts for FAM159B Gene

mRNA/cDNA for FAM159B Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM159B Gene

Family with sequence similarity 159, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM159B Gene

ExUns: 1a · 1b ^ 2 ^ 3
SP2: -

Relevant External Links for FAM159B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM159B Gene

mRNA expression in normal human tissues for FAM159B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM159B Gene

This gene is overexpressed in Pancreas (x21.5) and Brain - Hypothalamus (x13.6).

SOURCE GeneReport for Unigene cluster for FAM159B Gene Hs.591776

genes like me logo Genes that share expression patterns with FAM159B: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FAM159B Gene

Orthologs for FAM159B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM159B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM159B 35
  • 91.04 (n)
  • 90.62 (a)
FAM159B 36
  • 90 (a)
(Canis familiaris)
Mammalia FAM159B 35
  • 85.83 (n)
  • 80 (a)
FAM159B 36
  • 80 (a)
(Mus musculus)
Mammalia Fam159b 35
  • 87.05 (n)
  • 85.99 (a)
Fam159b 16
Fam159b 36
  • 85 (a)
(Pan troglodytes)
Mammalia FAM159B 35
  • 99.58 (n)
  • 100 (a)
FAM159B 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Fam159b 35
  • 88.61 (n)
  • 88.61 (a)
(Monodelphis domestica)
Mammalia FAM159B 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia FAM159B 36
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam159b 35
  • 63.49 (n)
  • 61.9 (a)
Species with no ortholog for FAM159B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM159B Gene

Gene Tree for FAM159B (if available)
Gene Tree for FAM159B (if available)

Paralogs for FAM159B Gene

Paralogs for FAM159B Gene

(1) SIMAP similar genes for FAM159B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FAM159B: view

Variants for FAM159B Gene

Sequence variations from dbSNP and Humsavar for FAM159B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs16893053 - 64,690,636(+) AGGCC(A/C)GCCGA reference, missense
rs2305962 - 64,695,646(-) AGAAG(C/G)CTCTA reference, missense
rs192456 -- 64,711,343(+) attta(C/T)tgatt intron-variant
rs182149 -- 64,697,362(-) AATCT(A/G)GTCAA intron-variant
rs183917 -- 64,716,253(-) CAAAT(A/G)ATGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM159B Gene

Variant ID Type Subtype PubMed ID
dgv6083n71 CNV Gain 21882294
nsv881748 CNV Gain 21882294
esv2752074 CNV Gain 17911159

Variation tolerance for FAM159B Gene

Gene Damage Index Score: 6.26; 76.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM159B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM159B Gene

Disorders for FAM159B Gene

Relevant External Links for FAM159B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM159B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM159B Gene

Publications for FAM159B Gene

  1. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 3 4 67

Products for FAM159B Gene

Sources for FAM159B Gene

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