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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAM159B Gene

protein-coding   GIFtS: 34
GCID: GC05P064023

Family With Sequence Similarity 159, Member B

  Search for FAM159B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Family With Sequence Similarity 159, Member B1 2
Membrane Protein FAM159B2

External Ids:    HGNC: 342361   Entrez Gene: 1001329162   Ensembl: ENSG000001456427   UniProtKB: A6NKW63   

Export aliases for FAM159B gene to outside databases

Previous GC identifer: GC05P060940


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FAM159B Gene: 
FAM159B (family with sequence similarity 159, member B) is a protein-coding gene. An important paralog of this gene is FAM159A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_006713.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FAM159B gene promoter:
         COUP-TF1   HTF   COUP   POU3F2 (N-Oct-5a)   HNF-4alpha2   POU3F2   HNF-4alpha1   MEF-2A   COUP-TF   aMEF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for FAM159B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM159B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q12.3   Ensembl cytogenetic band:  5q12.3   HGNC cytogenetic band: 5q12.3

FAM159B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM159B gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P064023:  view genomic region     (about GC identifiers)

Start:
63,986,135 bp from pter      End:
64,014,017 bp from pter
Size:
27,883 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: F159B_HUMAN, A6NKW6 (See protein sequence)
Recommended Name: Membrane protein FAM159B  
Size: 160 amino acids; 17663 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)

Explore the universe of human proteins at neXtProt for FAM159B: NX_A6NKW6

Explore proteomics data for FAM159B at MOPED 

FAM159B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

FAM159B Protein Expression

REFSEQ proteins: NP_001157914.1  
ENSEMBL proteins: 
 ENSP00000373726   ENSP00000426194   ENSP00000426145  

Human Recombinant Protein Products for FAM159B: 
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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral to membrane IEA--

FAM159B for ontologies           About GeneDecksing



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Cloud-Clone Corp. CLIAs for FAM159B


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro protein domain:
 IPR026910 Shisa

Graphical View of Domain Structure for InterPro Entry A6NKW6

ProtoNet protein and cluster: A6NKW6

UniProtKB/Swiss-Prot: F159B_HUMAN, A6NKW6
Similarity: Belongs to the FAM159 family


FAM159B for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Animal Models:
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM159B

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FAM159B (F159B)

Search CenterWatch for drugs/clinical trials and news about FAM159B / F159B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FAM159B gene: 
NM_001164442.1  

Unigene Cluster for FAM159B:

Family with sequence similarity 159, member B
Hs.591776  [show with all ESTs]
Unigene Representative Sequence: NM_001164442
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000389074(uc021xzg.1) ENST00000509189 ENST00000506473 ENST00000512767
ENST00000513930
miRNA
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Primer
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6 DOTS entries:

DT.100811592  DT.104076  DT.100036303  DT.97829572  DT.97815525  DT.100000037 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for FAM159B    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3
SP1:                        
SP2:              -         


ECgene alternative splicing isoforms for FAM159B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FAM159B expression in normal human tissues (normalized intensities)      FAM159B embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
FAM159B Expression
About this image


FAM159B expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/5 selected tissues (see all 5) fully expand
 
 Primitive Streak (Early Embryonic Tissues)
         Definitive endoderm-like cells ( Generation and expansion of endodermal progenitor...
 
 Gut Tube (Gastrointestinal Tract)
         Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
 
 Endothelium (Cardiovascular System)
         blood vessel   
 
 Inner Cell Mass (Early Embryonic Tissues)
         Line H9 (WA09)
 
 Pancreas (Endocrine System)

See FAM159B Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.591776
    SABiosciences Custom PCR Arrays for FAM159B
Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM159B

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for FAM159B gene from 1/7 species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Fam159b1 , 5 family with sequence similarity 159, member B1, 5 87.05(n)1
85.99(a)1
  13 (56.87 cM)5
778031  NM_029984.11  NP_084260.11 
 1048452835 


ENSEMBL Gene Tree for FAM159B (if available)
TreeFam Gene Tree for FAM159B (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for FAM159B gene
FAM159A2  
1 SIMAP similar gene for FAM159B using alignment to 2 protein entries:     F159B_HUMAN (see all proteins):
FAM159A

FAM159B for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/462 SNPs in FAM159B are shown (see all 462)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 5 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1408622961,2
--63984140(+) CAGAAC/TTGTGA 1 -- us2k10--------
rs1813582591,2
--63984182(+) TCTGCA/GGTACT 1 -- us2k10--------
rs1860230001,2
--63984217(+) AATACA/GCTAAT 1 -- us2k10--------
rs613469651,2
C,F--63984251(+) TATAAA/GGAATA 1 -- us2k15Minor allele frequency- G:0.12WA CSA NA 244
rs104713051,2
C,A,H--63984299(+) tatttC/Acatat 1 -- us2k1 tfbs37Minor allele frequency- A:0.46NA WA EA 366
rs1916884481,2
--63984374(+) GCTATA/CAATCA 1 -- us2k10--------
rs1446969021,2
--63984377(+) ATAAAC/TCACTG 1 -- us2k10--------
rs68699871,2
C,F,A,H--63984386(+) tgtggA/Tgtgac 1 -- us2k1 tfbs315Minor allele frequency- T:0.40NS EA NA WA CSA 787
rs1818004181,2
--63984441(+) ATACAA/CACCCT 1 -- us2k10--------
rs1166848281,2
C,F--63984542(+) GTGGTA/GGCTGT 1 -- us2k11Minor allele frequency- G:0.02NA 120

HapMap Linkage Disequilibrium report for FAM159B (63986135 - 64014017 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for FAM159B:    About this table     
Variant IDTypeSubtypePubMed ID
nsv881748CNV Gain21882294
esv2752074CNV Gain17911159
dgv6083n71CNV Gain21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed article for FAM159B gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM159B)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)1, 2 Schmutz J.... Rubin E.M. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 100132916 HGNC: 34236 Ensembl:ENSG00000145642 euGenes: HUgn100132916 ECgene: FAM159B
H-InvDB: FAM159B

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for FAM159B Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for FAM159B gene:
Search GeneIP for patents involving FAM159B

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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