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Aliases for FAM159B Gene

Aliases for FAM159B Gene

  • Family With Sequence Similarity 159 Member B 2 3 5
  • Family With Sequence Similarity 159, Member B 2

External Ids for FAM159B Gene

Previous GeneCards Identifiers for FAM159B Gene

  • GC05P064023
  • GC05P060940
  • GC05P063989

Summaries for FAM159B Gene

GeneCards Summary for FAM159B Gene

FAM159B (Family With Sequence Similarity 159 Member B) is a Protein Coding gene. An important paralog of this gene is FAM159A.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM159B Gene

Genomics for FAM159B Gene

Regulatory Elements for FAM159B Gene

Enhancers for FAM159B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G065072 0.8 FANTOM5 dbSUPER 37.2 +382.8 382778 0.4 USF1 POLR2A SMARCA4 EED REST FAM159B GC05M065036 GC05P065124
GH05G065125 1.5 FANTOM5 Ensembl ENCODE dbSUPER 9.8 +437.2 437152 4.0 CTCF PKNOX1 TEAD4 FEZF1 FOSL1 FOS EGR2 ZNF10 ZFP37 ZNF501 ADAMTS6 FAM159B ENSG00000207439 LOC100419140
GH05G064665 0.6 ENCODE 12 -24.2 -24227 0.7 CBX2 USF2 RBBP5 REST FOSL1 RAD51 NFYB FOS EZH2 FAM159B RGS7BP MRPL49P1 GC05P064585
GH05G065075 1.7 FANTOM5 Ensembl ENCODE dbSUPER 4 +386.2 386199 1.8 HDAC1 PKNOX1 CBX3 TBL1XR1 ARNT SIN3A RAD21 CHAMP1 ZNF766 GATA2 FAM159B GC05M065036 GC05P065124
GH05G064653 0.6 ENCODE 11.1 -36.2 -36237 1.9 HNRNPUL1 FOXA2 ZNF384 HNF1A NCOR1 CEBPA BCL6 HNF4A FAM159B MRPL49P1 GC05P064585
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM159B on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM159B Gene

Chromosome:
5
Start:
64,690,308 bp from pter
End:
64,718,190 bp from pter
Size:
27,883 bases
Orientation:
Plus strand

Genomic View for FAM159B Gene

Genes around FAM159B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM159B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM159B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM159B Gene

Proteins for FAM159B Gene

  • Protein details for FAM159B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NKW6-F159B_HUMAN
    Recommended name:
    Membrane protein FAM159B
    Protein Accession:
    A6NKW6

    Protein attributes for FAM159B Gene

    Size:
    160 amino acids
    Molecular mass:
    17663 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM159B Gene

Post-translational modifications for FAM159B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM159B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM159B Gene

Domains & Families for FAM159B Gene

Protein Domains for FAM159B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM159B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NKW6

UniProtKB/Swiss-Prot:

F159B_HUMAN :
  • Belongs to the FAM159 family.
Family:
  • Belongs to the FAM159 family.
genes like me logo Genes that share domains with FAM159B: view

No data available for Gene Families for FAM159B Gene

Function for FAM159B Gene

Phenotypes for FAM159B Gene

GenomeRNAi human phenotypes for FAM159B:
genes like me logo Genes that share phenotypes with FAM159B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for FAM159B

CRISPR Products

miRNA for FAM159B Gene

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM159B Gene

Localization for FAM159B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM159B Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM159B gene
Compartment Confidence
plasma membrane 3
extracellular 2

Gene Ontology (GO) - Cellular Components for FAM159B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM159B: view

Pathways & Interactions for FAM159B Gene

SuperPathways for FAM159B Gene

No Data Available

Interacting Proteins for FAM159B Gene

Gene Ontology (GO) - Biological Process for FAM159B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM159B Gene

Drugs & Compounds for FAM159B Gene

No Compound Related Data Available

Transcripts for FAM159B Gene

mRNA/cDNA for FAM159B Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM159B Gene

Family with sequence similarity 159, member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM159B Gene

ExUns: 1a · 1b ^ 2 ^ 3
SP1:
SP2: -

Relevant External Links for FAM159B Gene

GeneLoc Exon Structure for
FAM159B
ECgene alternative splicing isoforms for
FAM159B

Expression for FAM159B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM159B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM159B Gene

This gene is overexpressed in Pancreas (x21.5) and Brain - Hypothalamus (x13.6).

NURSA nuclear receptor signaling pathways regulating expression of FAM159B Gene:

FAM159B

SOURCE GeneReport for Unigene cluster for FAM159B Gene:

Hs.591776

Evidence on tissue expression from TISSUES for FAM159B Gene

  • Pancreas(2.9)
genes like me logo Genes that share expression patterns with FAM159B: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM159B Gene

Orthologs for FAM159B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM159B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM159B 34 35
  • 99.58 (n)
cow
(Bos Taurus)
Mammalia FAM159B 34 35
  • 91.04 (n)
rat
(Rattus norvegicus)
Mammalia Fam159b 34
  • 88.61 (n)
mouse
(Mus musculus)
Mammalia Fam159b 34 16 35
  • 87.05 (n)
dog
(Canis familiaris)
Mammalia FAM159B 34 35
  • 85.83 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM159B 35
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM159B 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam159b 34
  • 63.49 (n)
Species where no ortholog for FAM159B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM159B Gene

ENSEMBL:
Gene Tree for FAM159B (if available)
TreeFam:
Gene Tree for FAM159B (if available)

Paralogs for FAM159B Gene

Paralogs for FAM159B Gene

(1) SIMAP similar genes for FAM159B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FAM159B: view

Variants for FAM159B Gene

Sequence variations from dbSNP and Humsavar for FAM159B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000170529 -- 64,688,467(+) TACAG(C/T)ATTTC upstream-variant-2KB
rs1000289536 -- 64,695,850(+) TGAAG(A/G)AAAAA intron-variant
rs1000620794 -- 64,694,383(+) TTAAT(C/T)AGAAC intron-variant
rs1000728644 -- 64,715,588(+) GGGTG(A/G)ACTGA intron-variant
rs1000739943 -- 64,715,436(+) CCTGA(-/AGG)AGAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM159B Gene

Variant ID Type Subtype PubMed ID
dgv5692n100 CNV gain 25217958
esv2752074 CNV gain 17911159
nsv1124912 CNV duplication 24896259
nsv598390 CNV gain 21841781

Variation tolerance for FAM159B Gene

Gene Damage Index Score: 6.26; 76.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM159B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM159B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM159B Gene

Disorders for FAM159B Gene

Relevant External Links for FAM159B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM159B

No disorders were found for FAM159B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM159B Gene

Publications for FAM159B Gene

  1. Unexpected diversity in Shisa-like proteins suggests the importance of their roles as transmembrane adaptors. (PMID: 22120523) Pei J. … Grishin N.V. (Cell. Signal. 2012) 2 3 64
  2. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 3 4 64

Products for FAM159B Gene

Sources for FAM159B Gene

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