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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FAM159A Gene

protein-coding GIFtS: 34
GCID: GC01P053099

family with sequence similarity 159, member A

Search for FAM159A
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Family With Sequence Similarity 159, Member A¹ ²
MGC52498¹
PRO7171²
WWLS2783²
Membrane Protein FAM159A²

External Ids:	HGNC: 28757¹	Entrez Gene: 348378²	Ensembl: ENSG00000182183⁷	UniProtKB: Q6UWV7³

Export aliases for FAM159A gene to outside databases

Previous GC identifers: GC01P052872 GC01P051214

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FAM159A gene promoter:
AML1a FOXD1 NF-kappaB MZF-1 NF-kappaB2 Msx-1 LyF-1 NF-kappaB1 Pax-4a
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for FAM159A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM159A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32.3 Ensembl cytogenetic band: 1p32.3 HGNC cytogenetic band: 1p32.3

FAM159A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM159A gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P053099: view genomic region (about GC identifiers)

Start:	53,099,016 bp from pter	End:	53,135,355 bp from pter
Size:	36,340 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: F159A_HUMAN, Q6UWV7 (See protein sequence)

Recommended Name: Membrane protein FAM159A

Size: 190 amino acids; 20306 Da

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Sequence caution: Sequence=AAQ88984.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Secondary accessions: Q6ZRG4

Alternative splicing: 2 isoforms: Q6UWV7-1 Q6UWV7-2 (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for FAM159A: NX_Q6UWV7

FAM159A Protein expression data from MOPED and PaxDb: --

REFSEQ proteins: NP_001036158.1

ENSEMBL proteins:

ENSP00000429726

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

FAM159A for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q6UWV7

UniProtKB/Swiss-Prot: F159A_HUMAN, Q6UWV7

Similarity: Belongs to the FAM159 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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1 GenomeRNAi human phenotype for FAM159A:

Decreased viability of wild-ty

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for FAM159A

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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Search CenterWatch for drugs/clinical trials and news about FAM159A / F159A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for FAM159A gene (2 alternative transcripts):

NM_182621.1 NM_001042693.1

Unigene Cluster for FAM159A:

Family with sequence similarity 159, member A

Hs.424589 [show with all ESTs]

Unigene Representative Sequence: AK128236

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000517870(uc001cuf.3) ENST00000440303(uc001cug.1) ENST00000401050(uc001cuh.3)

ENST00000424164

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Additional cDNA sequence:

AK128236.1 AY358621.1

5 DOTS entries:

DT.101969570 DT.101979993 DT.424221 DT.75109583 DT.75113710

22 AceView cDNA sequences:

BX094562 AK128236 BG192125 BG213356 AI824994 BC041608 AA455726 NM_182621

BM561575 BG218665 AY358621 AI638840 BG199282 AI202832 BG211778 BF056053

AW768338 AI671007 AW003254 AJ573663 BG201848 AA455669

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FAM159A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGTGGCTCA

About this image

FAM159A expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Genevestigator expression for FAM159A

SOURCE GeneReport for Unigene cluster: Hs.424589

SABiosciences Custom PCR Arrays for FAM159A

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for FAM159A gene from 3/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	FAM159A¹	family with sequence similarity 159, member A	76.64(n) 75.7(a)		424644 XM_422478.3 XP_422478.1
lizard (Anolis carolinensis)	Reptilia	FAM159A⁶	--	78(a)	1 ↔ 1	4(114708133-114721299)
zebrafish (Danio rerio)	Actinopterygii	LOC100536524¹	membrane protein FAM159A-like	62.53(n) 54.04(a)		100536524 XM_003201238.1 XP_003201286.1

ENSEMBL Gene Tree for FAM159A (if available)
TreeFam Gene Tree for FAM159A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FAM159A gene

FAM159B²

1 SIMAP similar gene for FAM159A using alignment to 1 protein entry: F159A_HUMAN:

FAM159B

FAM159A for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs143158845^1,2		--	53097106(+)	`GAGCCA/GAGATT`	1	--	us2k¹		0	--	--	--	--
rs200668084^1,2		--	53097168(+)	`AAAAC-/AAAAAA`	1	--	us2k¹		0	--	--	--	--
rs56924007^1,2		--	53097177(+)	`AAAAAA/CCCCAC`	1	--	us2k¹		0	--	--	--	--
rs188415376^1,2		--	53097178(+)	`AAAAAA/CCCACT`	1	--	us2k¹		0	--	--	--	--
rs146193822^1,2		--	53097182(+)	`ACCCAC/TTATTC`	1	--	us2k¹		0	--	--	--	--
rs2050694^1,2	C,F,A,H,	--	53097205(-)	`TGAAGC/GCTATG`	1	--	us2k¹		11		NS EA NA CSA WA	786
rs72907519^1,2	C,	--	53097228(+)	`GGGGGA/CCATGG`	1	--	us2k¹		2		WA	120
rs79570906^1,2	C,F,	--	53097317(+)	`CCCTGC/TGTGGC`	1	--	us2k¹		1		WA	118
rs139101174^1,2		--	53097318(+)	`CCTGCA/GTGGCT`	1	--	us2k¹		0	--	--	--	--
rs72907520^1,2	C,	--	53097399(+)	`CTTTCT/GAGTTT`	1	--	us2k¹		2		WA	120

HapMap Linkage Disequilibrium report for FAM159A (53099016 - 53135355 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FAM159A: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FAM159A gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM159A)

Utopia: connect your pdf to the dynamic
world of online information

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)² Gregory S.G.... Bentley D.R. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 348378	HGNC: 28757	AceView: MGC52498	Ensembl:ENSG00000182183	euGenes: HUgn348378
ECgene: FAM159A	H-InvDB: FAM159A

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FAM159A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FAM159A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for FAM159A gene:
Search GeneIP for patents involving FAM159A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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FAM159A Gene

family with sequence similarity 159, member A

Aliases
for FAM159A gene

Summaries
for FAM159A gene

Genomic Views
for FAM159A gene

Proteins
for FAM159A gene

Protein Domains /
Families
for FAM159A gene

Function
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FAM159A Gene

family with sequence similarity 159, member A

Aliasesfor FAM159A gene

Summariesfor FAM159A gene

Genomic Viewsfor FAM159A gene

Proteinsfor FAM159A gene

Protein Domains /Familiesfor FAM159A gene

Functionfor FAM159A gene

Pathways & Interactionsfor FAM159A gene

Drugs & Compoundsfor FAM159A gene

Transcriptsfor FAM159A gene

Expression for FAM159A gene

Orthologsfor FAM159A gene

Paralogsfor FAM159A gene

Genomic Variantsfor FAM159A gene

Disorders / Diseasesfor FAM159A gene

Publicationsfor FAM159A gene

External Searches for FAM159A gene

Genome Databases showing FAM159A gene

Other Databases showing FAM159A gene

Specialized Databases showing FAM159A gene

Intellectual Propertyfor FAM159A gene

Productsfor FAM159A gene

View Random Gene

Aliases
for FAM159A gene

Summaries
for FAM159A gene

Genomic Views
for FAM159A gene

Proteins
for FAM159A gene

Protein Domains /
Families
for FAM159A gene

Function
for FAM159A gene

Pathways & Interactions
for FAM159A gene

Drugs & Compounds
for FAM159A gene

Transcripts
for FAM159A gene

Expression
for FAM159A gene

Orthologs
for FAM159A gene

Paralogs
for FAM159A gene

Genomic Variants
for FAM159A gene

Disorders / Diseases
for FAM159A gene

Publications
for FAM159A gene

Intellectual Property
for FAM159A gene

Products
for FAM159A gene