Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FAM159A Gene

Aliases for FAM159A Gene

  • Family With Sequence Similarity 159 Member A 2 3 5
  • Family With Sequence Similarity 159, Member A 2
  • Membrane Protein FAM159A 3
  • WWLS2783 3
  • PRO7171 3

External Ids for FAM159A Gene

Previous GeneCards Identifiers for FAM159A Gene

  • GC01P052872
  • GC01P053099
  • GC01P051214

Summaries for FAM159A Gene

GeneCards Summary for FAM159A Gene

FAM159A (Family With Sequence Similarity 159 Member A) is a Protein Coding gene. An important paralog of this gene is FAM159B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM159A Gene

Genomics for FAM159A Gene

Regulatory Elements for FAM159A Gene

Enhancers for FAM159A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F052601 0.5 ENCODE 12.4 -28.1 -28140 4.3 HDAC1 SOX13 PKNOX1 TAL1 CEBPG ZNF644 ZNF664 ZNF316 POLR2A SCRT2 GPX7 CC2D1B FAM159A ZCCHC11 GC01P052619
GH01F052588 0.6 Ensembl 11.5 -42.9 -42939 1.0 SMARCA5 ZMYM3 MAX ZNF121 IKZF1 NR2F6 ZNF24 SPI1 GPX7 ZCCHC11 FAM159A EEF1GP7
GH01F052631 1.2 FANTOM5 ENCODE 7.2 +3.9 3914 8.1 HDGF PKNOX1 WRNIP1 YBX1 ELK1 JUNB TBX21 CREB3 GLIS1 NBN GPX7 ZCCHC11 ENSG00000272100 MAGOH CC2D1B ENSG00000230953 FAM159A PRPF38A GC01P052637
GH01F052629 0.6 Ensembl 7.1 -1.9 -1939 0.6 BCOR SMARCA5 ELF3 ESRRA SAP130 ZMYM3 CBX1 POLR2A HDAC2 ZNF341 FAM159A GC01P052619
GH01F052640 0.8 FANTOM5 Ensembl ENCODE 7 +9.7 9734 1.3 HDGF PKNOX1 RFX1 HLF RELA RAD51 JUND ZGPAT SMARCA4 IKZF1 GPX7 FAM159A ZCCHC11 PRPF38A CC2D1B GC01P052637 PIR34624
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FAM159A on UCSC Golden Path with GeneCards custom track

Promoters for FAM159A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001744914 1961 1201 RING1 RNF2 SUZ12 MAX ZNF274 ZNF707 POLR2A ZBTB33 EZH2 SALL1

Genomic Location for FAM159A Gene

52,631,439 bp from pter
52,669,683 bp from pter
38,245 bases
Plus strand

Genomic View for FAM159A Gene

Genes around FAM159A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM159A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM159A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM159A Gene

Proteins for FAM159A Gene

  • Protein details for FAM159A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Membrane protein FAM159A
    Protein Accession:
    Secondary Accessions:
    • Q6ZRG4

    Protein attributes for FAM159A Gene

    190 amino acids
    Molecular mass:
    20306 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAQ88984.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM159A Gene


neXtProt entry for FAM159A Gene

Post-translational modifications for FAM159A Gene

No Post-translational modifications

Other Protein References for FAM159A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM159A Gene

Domains & Families for FAM159A Gene

Protein Domains for FAM159A Gene


Suggested Antigen Peptide Sequences for FAM159A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM159 family.
  • Belongs to the FAM159 family.
genes like me logo Genes that share domains with FAM159A: view

No data available for Gene Families for FAM159A Gene

Function for FAM159A Gene

genes like me logo Genes that share phenotypes with FAM159A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for FAM159A

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM159A Gene

Localization for FAM159A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM159A Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for FAM159A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM159A: view

No data available for Subcellular locations from COMPARTMENTS for FAM159A Gene

Pathways & Interactions for FAM159A Gene

SuperPathways for FAM159A Gene

No Data Available

Interacting Proteins for FAM159A Gene

Gene Ontology (GO) - Biological Process for FAM159A Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM159A Gene

Transcripts for FAM159A Gene

mRNA/cDNA for FAM159A Gene

Unigene Clusters for FAM159A Gene

Family with sequence similarity 159, member A:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM159A Gene

No ASD Table

Relevant External Links for FAM159A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM159A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM159A Gene

mRNA differential expression in normal tissues according to GTEx for FAM159A Gene

This gene is overexpressed in Whole Blood (x17.0), Spleen (x6.1), and Small Intestine - Terminal Ileum (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of FAM159A Gene:


SOURCE GeneReport for Unigene cluster for FAM159A Gene:

genes like me logo Genes that share expression patterns with FAM159A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for FAM159A Gene

Orthologs for FAM159A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM159A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM159A 34 35
  • 99.3 (n)
(Canis familiaris)
Mammalia FAM159A 34 35
  • 84.39 (n)
(Bos Taurus)
Mammalia FAM159A 34 35
  • 84.22 (n)
(Rattus norvegicus)
Mammalia Fam159a 34
  • 82.19 (n)
(Mus musculus)
Mammalia Fam159a 34 16 35
  • 81.83 (n)
(Gallus gallus)
Aves FAM159A 34 35
  • 71.2 (n)
(Anolis carolinensis)
Reptilia FAM159A 35
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam159a 34
  • 60.04 (n)
(Danio rerio)
Actinopterygii LOC100536524 34
  • 59.8 (n)
Species where no ortholog for FAM159A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM159A Gene

Gene Tree for FAM159A (if available)
Gene Tree for FAM159A (if available)

Paralogs for FAM159A Gene

Paralogs for FAM159A Gene

(1) SIMAP similar genes for FAM159A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM159A: view

Variants for FAM159A Gene

Sequence variations from dbSNP and Humsavar for FAM159A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1038226 -- 52,648,738(-) GACAC(A/G)TGTTT intron-variant
rs10493169 -- 52,638,366(-) TCTAG(C/G)AGAAT intron-variant
rs10676753 -- 52,666,584(+) GCGCG(-/CGTG/TG)TGTGT intron-variant
rs10714496 -- 52,658,045(+) AAGAC(-/T)TTTTT intron-variant
rs10788940 -- 52,648,478(+) TCACC(A/G)AATGA intron-variant, nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for FAM159A Gene

Variant ID Type Subtype PubMed ID
esv1918082 CNV deletion 18987734
esv2672204 CNV deletion 23128226
esv2748129 CNV deletion 23290073
esv2748141 CNV deletion 23290073
esv3586053 CNV loss 21293372
nsv1001535 CNV gain 25217958

Variation tolerance for FAM159A Gene

Residual Variation Intolerance Score: 74.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.56; 30.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM159A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM159A Gene

Disorders for FAM159A Gene

Relevant External Links for FAM159A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM159A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM159A Gene

Publications for FAM159A Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64

Products for FAM159A Gene

Sources for FAM159A Gene

Loading form....