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Aliases for FAM159A Gene

Aliases for FAM159A Gene

  • Family With Sequence Similarity 159 Member A 2 3 5
  • Family With Sequence Similarity 159, Member A 2
  • Membrane Protein FAM159A 3
  • WWLS2783 3
  • PRO7171 3

External Ids for FAM159A Gene

Previous GeneCards Identifiers for FAM159A Gene

  • GC01P052872
  • GC01P053099
  • GC01P051214

Summaries for FAM159A Gene

GeneCards Summary for FAM159A Gene

FAM159A (Family With Sequence Similarity 159 Member A) is a Protein Coding gene. An important paralog of this gene is FAM159B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM159A Gene

Genomics for FAM159A Gene

Regulatory Elements for FAM159A Gene

Enhancers for FAM159A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around FAM159A on UCSC Golden Path with GeneCards custom track

Promoters for FAM159A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for FAM159A Gene

Chromosome:
1
Start:
52,631,439 bp from pter
End:
52,669,683 bp from pter
Size:
38,245 bases
Orientation:
Plus strand

Genomic View for FAM159A Gene

Genes around FAM159A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM159A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM159A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM159A Gene

Proteins for FAM159A Gene

  • Protein details for FAM159A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWV7-F159A_HUMAN
    Recommended name:
    Membrane protein FAM159A
    Protein Accession:
    Q6UWV7
    Secondary Accessions:
    • Q6ZRG4

    Protein attributes for FAM159A Gene

    Size:
    190 amino acids
    Molecular mass:
    20306 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ88984.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM159A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM159A Gene

Post-translational modifications for FAM159A Gene

No Post-translational modifications

Other Protein References for FAM159A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM159A Gene

Domains & Families for FAM159A Gene

Protein Domains for FAM159A Gene

ProtoNet:

Suggested Antigen Peptide Sequences for FAM159A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UWV7

UniProtKB/Swiss-Prot:

F159A_HUMAN :
  • Belongs to the FAM159 family.
Family:
  • Belongs to the FAM159 family.
genes like me logo Genes that share domains with FAM159A: view

No data available for Gene Families for FAM159A Gene

Function for FAM159A Gene

genes like me logo Genes that share phenotypes with FAM159A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for FAM159A

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM159A Gene

Localization for FAM159A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM159A Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for FAM159A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM159A: view

No data available for Subcellular locations from COMPARTMENTS for FAM159A Gene

Pathways & Interactions for FAM159A Gene

SuperPathways for FAM159A Gene

No Data Available

Interacting Proteins for FAM159A Gene

Gene Ontology (GO) - Biological Process for FAM159A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM159A Gene

Drugs & Compounds for FAM159A Gene

No Compound Related Data Available

Transcripts for FAM159A Gene

mRNA/cDNA for FAM159A Gene

Unigene Clusters for FAM159A Gene

Family with sequence similarity 159, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM159A Gene

No ASD Table

Relevant External Links for FAM159A Gene

GeneLoc Exon Structure for
FAM159A
ECgene alternative splicing isoforms for
FAM159A

Expression for FAM159A Gene

mRNA expression in normal human tissues for FAM159A Gene

mRNA differential expression in normal tissues according to GTEx for FAM159A Gene

This gene is overexpressed in Whole Blood (x17.0), Spleen (x6.1), and Small Intestine - Terminal Ileum (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of FAM159A Gene:

FAM159A

SOURCE GeneReport for Unigene cluster for FAM159A Gene:

Hs.424589
genes like me logo Genes that share expression patterns with FAM159A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for FAM159A Gene

Orthologs for FAM159A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM159A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAM159A 34
  • 84.22 (n)
  • 79.26 (a)
FAM159A 35
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM159A 34
  • 84.39 (n)
  • 75.79 (a)
FAM159A 35
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam159a 34
  • 81.83 (n)
  • 75.13 (a)
Fam159a 16
Fam159a 35
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM159A 34
  • 99.3 (n)
  • 98.95 (a)
FAM159A 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam159a 34
  • 82.19 (n)
  • 77.78 (a)
chicken
(Gallus gallus)
Aves FAM159A 34
  • 71.2 (n)
  • 68 (a)
FAM159A 35
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM159A 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam159a 34
  • 60.04 (n)
  • 58.43 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100536524 34
  • 59.8 (n)
  • 50.91 (a)
Species where no ortholog for FAM159A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM159A Gene

ENSEMBL:
Gene Tree for FAM159A (if available)
TreeFam:
Gene Tree for FAM159A (if available)

Paralogs for FAM159A Gene

Paralogs for FAM159A Gene

(1) SIMAP similar genes for FAM159A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM159A: view

Variants for FAM159A Gene

Sequence variations from dbSNP and Humsavar for FAM159A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs492606 -- 52,642,554(-) caccc(A/G)ctcgg intron-variant
rs494030 -- 52,636,855(+) GTCTG(A/G)ATCTC intron-variant
rs546662 -- 52,635,208(+) TGGTA(A/T)TCACT intron-variant
rs447837 -- 52,662,578(-) AGGTC(C/T)GGAGT intron-variant
rs269318 -- 52,669,543(-) gttta(C/T)aggca downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for FAM159A Gene

Variant ID Type Subtype PubMed ID
esv1918082 CNV deletion 18987734
esv2672204 CNV deletion 23128226
esv2748129 CNV deletion 23290073
esv2748141 CNV deletion 23290073
esv3586053 CNV loss 21293372
nsv1001535 CNV gain 25217958

Variation tolerance for FAM159A Gene

Residual Variation Intolerance Score: 74.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.56; 30.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM159A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM159A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM159A Gene

Disorders for FAM159A Gene

Relevant External Links for FAM159A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM159A

No disorders were found for FAM159A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM159A Gene

Publications for FAM159A Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 65
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 65
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4 65
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 65

Products for FAM159A Gene

Sources for FAM159A Gene

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