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Aliases for FAM159A Gene

Aliases for FAM159A Gene

  • Family With Sequence Similarity 159 Member A 2 3 5
  • Family With Sequence Similarity 159, Member A 2
  • Membrane Protein FAM159A 3
  • WWLS2783 3
  • PRO7171 3

External Ids for FAM159A Gene

Previous GeneCards Identifiers for FAM159A Gene

  • GC01P052872
  • GC01P053099
  • GC01P051214

Summaries for FAM159A Gene

GeneCards Summary for FAM159A Gene

FAM159A (Family With Sequence Similarity 159 Member A) is a Protein Coding gene. An important paralog of this gene is FAM159B.

Additional gene information for FAM159A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM159A Gene

Genomics for FAM159A Gene

Regulatory Elements for FAM159A Gene

Enhancers for FAM159A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H052631 1.9 FANTOM5 Ensembl ENCODE dbSUPER 7.1 +3.9 3914 8.1 HDGF PKNOX1 SIN3A YBX1 ZNF766 ZNF207 ATF7 RUNX3 CAVIN1 JUNB ZCCHC11 GPX7 MAGOH PRPF38A ENSG00000230953 ENSG00000272100 CC2D1B ECHDC2 FAM159A GC01P052637
GH01H052601 0.8 ENCODE 12.4 -28.1 -28140 4.3 SOX13 PKNOX1 BACH1 ZNF644 ZNF316 POLR2A SCRT2 ATF7 PRDM10 NR2F6 GPX7 CC2D1B FAM159A ZCCHC11 GC01P052619
GH01H052640 1.2 FANTOM5 ENCODE dbSUPER 4 +9.7 9719 1.2 HDGF PKNOX1 RFX1 RELA IKZF1 NBN ATF7 IKZF2 GPX7 FAM159A ZCCHC11 PRPF38A CC2D1B GC01P052637 PIR34624
GH01H052674 0.9 ENCODE 5.3 +45.7 45730 5.7 HDGF FOXA2 PKNOX1 ATF1 YY1 TCF12 GATA2 FOS ATF7 NCOA1 GPX7 ZCCHC11 ZYG11B COA7 SCP2 FAM159A PIR34624 GC01P052685
GH01H053416 1 Ensembl ENCODE dbSUPER 4.3 +785.9 785912 0.8 ZFHX2 IKZF1 ZIC2 IKZF2 EGR2 LINC01771 LRP8 ENSG00000232762 FAM159A LOC105378733 ENSG00000230138
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM159A on UCSC Golden Path with GeneCards custom track

Promoters for FAM159A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000006412 1861 601 RING1 ZNF687 MAZ SUZ12 MAX ZBTB33 RUNX3 EZH2

Genomic Locations for FAM159A Gene

Genomic Locations for FAM159A Gene
chr1:52,631,439-52,669,683
(GRCh38/hg38)
Size:
38,245 bases
Orientation:
Plus strand
chr1:53,099,016-53,135,355
(GRCh37/hg19)

Genomic View for FAM159A Gene

Genes around FAM159A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM159A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM159A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM159A Gene

Proteins for FAM159A Gene

  • Protein details for FAM159A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWV7-F159A_HUMAN
    Recommended name:
    Membrane protein FAM159A
    Protein Accession:
    Q6UWV7
    Secondary Accessions:
    • Q6ZRG4

    Protein attributes for FAM159A Gene

    Size:
    190 amino acids
    Molecular mass:
    20306 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ88984.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM159A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM159A Gene

Post-translational modifications for FAM159A Gene

No Post-translational modifications

Other Protein References for FAM159A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM159A Gene

Domains & Families for FAM159A Gene

Gene Families for FAM159A Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for FAM159A Gene

ProtoNet:

Suggested Antigen Peptide Sequences for FAM159A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UWV7

UniProtKB/Swiss-Prot:

F159A_HUMAN :
  • Belongs to the FAM159 family.
Family:
  • Belongs to the FAM159 family.
genes like me logo Genes that share domains with FAM159A: view

Function for FAM159A Gene

genes like me logo Genes that share phenotypes with FAM159A: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM159A Gene

Localization for FAM159A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM159A Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for FAM159A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM159A: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for FAM159A Gene

Pathways & Interactions for FAM159A Gene

SuperPathways for FAM159A Gene

No Data Available

Interacting Proteins for FAM159A Gene

Gene Ontology (GO) - Biological Process for FAM159A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM159A Gene

Drugs & Compounds for FAM159A Gene

No Compound Related Data Available

Transcripts for FAM159A Gene

mRNA/cDNA for FAM159A Gene

Unigene Clusters for FAM159A Gene

Family with sequence similarity 159, member A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM159A Gene

No ASD Table

Relevant External Links for FAM159A Gene

GeneLoc Exon Structure for
FAM159A
ECgene alternative splicing isoforms for
FAM159A

Expression for FAM159A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM159A Gene

mRNA differential expression in normal tissues according to GTEx for FAM159A Gene

This gene is overexpressed in Whole Blood (x17.0), Spleen (x6.1), and Small Intestine - Terminal Ileum (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of FAM159A Gene:

FAM159A

SOURCE GeneReport for Unigene cluster for FAM159A Gene:

Hs.424589
genes like me logo Genes that share expression patterns with FAM159A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM159A Gene

Orthologs for FAM159A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM159A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM159A 33 34
  • 99.3 (n)
dog
(Canis familiaris)
Mammalia FAM159A 33 34
  • 84.39 (n)
cow
(Bos Taurus)
Mammalia FAM159A 33 34
  • 84.22 (n)
rat
(Rattus norvegicus)
Mammalia Fam159a 33
  • 82.19 (n)
mouse
(Mus musculus)
Mammalia Fam159a 34 16 33
  • 81.83 (n)
OneToOne
chicken
(Gallus gallus)
Aves FAM159A 33 34
  • 71.2 (n)
lizard
(Anolis carolinensis)
Reptilia FAM159A 34
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam159a 33
  • 60.04 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100536524 33
  • 59.8 (n)
Species where no ortholog for FAM159A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM159A Gene

ENSEMBL:
Gene Tree for FAM159A (if available)
TreeFam:
Gene Tree for FAM159A (if available)

Paralogs for FAM159A Gene

Paralogs for FAM159A Gene

(1) SIMAP similar genes for FAM159A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM159A: view

Variants for FAM159A Gene

Sequence variations from dbSNP and Humsavar for FAM159A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000069463 -- 52,643,831(+) CTGGG(C/T)GACAG intron-variant
rs1000082835 -- 52,642,199(+) GCAGT(A/T)TGGGG intron-variant
rs1000085896 -- 52,650,226(+) AAGCA(C/G)GGGGA intron-variant
rs1000283563 -- 52,631,461(+) AGTGA(G/T)ACTCC nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000311991 -- 52,667,521(+) CATCA(C/T)TGTCA nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM159A Gene

Variant ID Type Subtype PubMed ID
nsv1001535 CNV gain 25217958
esv3586053 CNV loss 21293372
esv2748141 CNV deletion 23290073
esv2748129 CNV deletion 23290073
esv2672204 CNV deletion 23128226
esv1918082 CNV deletion 18987734

Variation tolerance for FAM159A Gene

Residual Variation Intolerance Score: 74.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.56; 30.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM159A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM159A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM159A Gene

Disorders for FAM159A Gene

Relevant External Links for FAM159A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM159A

No disorders were found for FAM159A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM159A Gene

Publications for FAM159A Gene

  1. Unexpected diversity in Shisa-like proteins suggests the importance of their roles as transmembrane adaptors. (PMID: 22120523) Pei J … Grishin NV (Cellular signalling 2012) 2 3 60
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 60
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 60

Products for FAM159A Gene

Sources for FAM159A Gene

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