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FAM159A Gene

protein-coding   GIFtS: 35
GCID: GC01P053099

Family With Sequence Similarity 159, Member A

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Family With Sequence Similarity 159, Member A1 2
PRO71712
WWLS27832
Membrane Protein FAM159A2

External Ids:    HGNC: 287571   Entrez Gene: 3483782   Ensembl: ENSG000001821837   UniProtKB: Q6UWV73   
ORGUL members:         

Export aliases for FAM159A gene to outside databases

Previous GC identifers: GC01P052872 GC01P051214


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM159A Gene:
FAM159A (family with sequence similarity 159, member A) is a protein-coding gene. An important paralog of this gene is FAM159B.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAM159A gene promoter:
         AML1a   FOXD1   NF-kappaB   MZF-1   NF-kappaB2   Msx-1   LyF-1   NF-kappaB1   Pax-4a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM159A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32.3   Ensembl cytogenetic band:  1p32.3   HGNC cytogenetic band: 1p32.3

FAM159A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM159A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P053099:  view genomic region     (about GC identifiers)

Start:
53,099,016 bp from pter      End:
53,135,355 bp from pter
Size:
36,340 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: F159A_HUMAN, Q6UWV7 (See protein sequence)
Recommended Name: Membrane protein FAM159A  
Size: 190 amino acids; 20306 Da
Sequence caution: Sequence=AAQ88984.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q6ZRG4
Alternative splicing: 2 isoforms:  Q6UWV7-1   Q6UWV7-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for FAM159A: NX_Q6UWV7

REFSEQ proteins: NP_001036158.1  
ENSEMBL proteins: 
 ENSP00000429726  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q6UWV7

UniProtKB/Swiss-Prot: F159A_HUMAN, Q6UWV7
Similarity: Belongs to the FAM159 family


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Phenotypes:
     1 GenomeRNAi human phenotype for FAM159A:
 Decreased viability of wild-ty 

     1 MGI phenotypic allele for Fam159a (no phenotypes)

Find genes that share phenotypes with FAM159A           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Fam159atm1Lex for FAM159A

   genOway: Develop your customized and physiologically relevant rodent model for FAM159A

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
F159A_HUMAN, Q6UWV7: Membrane; Multi-pass membrane protein (Potential)

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral component of membrane IEA--

Find genes that share ontologies with FAM159A           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM159A
Interactions:

    Search GeneGlobe Interaction Network for FAM159A

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for FAM159A (F159A)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for FAM159A gene (2 alternative transcripts): 
NM_182621.1  NM_001042693.1  

Unigene Cluster for FAM159A:

Family with sequence similarity 159, member A
Hs.424589  [show with all ESTs]
Unigene Representative Sequence: AK128236
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000517870(uc001cuf.3) ENST00000440303(uc001cug.1) ENST00000401050(uc001cuh.3)
ENST00000424164
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Additional mRNA sequence: 

AK128236.1 AY358621.1 

5 DOTS entries:

DT.101969570  DT.101979993  DT.424221  DT.75109583  DT.75113710 

22 AceView cDNA sequences:

BX094562 AK128236 AI638840 BG218665 BG213356 BG192125 AI824994 BF056053 
NM_182621 AI202832 BG211778 AY358621 BC041608 BG199282 AA455726 BM561575 
AW768338 AI671007 AW003254 AJ573663 BG201848 AA455669 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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FAM159A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TGGTGGCTCA
FAM159A Expression
About this image

FAM159A Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

SOURCE GeneReport for Unigene cluster: Hs.424589
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for FAM159A gene from Selected species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Fam159a1 , 5 family with sequence similarity 159, member A1, 5 81.83(n)1
75.13(a)1
  4 (50.47 cM)5
5456671  NM_001099303.21  NP_001092773.11 
 1083677775 
chicken
(Gallus gallus)
Aves FAM159A1 family with sequence similarity 159, member A 71.2(n)
68(a)
  424644  XM_004936793.1  XP_004936850.1 
lizard
(Anolis carolinensis)
Reptilia FAM159A6
family with sequence similarity 159, member A
78(a)
1 ↔ 1
4(114708126-114721299)
tropical clawed frog
(Xenopus tropicalis)
Amphibia fam159a1 family with sequence similarity 159, member A 60.04(n)
58.43(a)
  100496818  XM_002931421.2  XP_002931467.1 
zebrafish
(Danio rerio)
Actinopterygii LOC1005365241 membrane protein FAM159A-like 59.8(n)
50.91(a)
  100536524  XM_003201238.2  XP_003201286.1 


ENSEMBL Gene Tree for FAM159A (if available)
TreeFam Gene Tree for FAM159A (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for FAM159A gene
FAM159B2  
1 SIMAP similar gene for FAM159A using alignment to 1 protein entry:     F159A_HUMAN:
FAM159B

Find genes that share paralogs with FAM159A           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for FAM159A (see all 502)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1431588451,2
--53097106(+) GAGCCA/GAGATT 1 -- us2k10--------
rs2006680841,2
--53097168(+) AAAAC-/AAAAAA 1 -- us2k10--------
rs569240071,2
--53097177(+) AAAAAA/CCCCAC 1 -- us2k10--------
rs1884153761,2
--53097178(+) AAAAAA/CCCACT 1 -- us2k10--------
rs1461938221,2
--53097182(+) ACCCAC/TTATTC 1 -- us2k10--------
rs20506941,2
C,F,A,H--53097205(-) tgaagC/Gctatg 1 -- us2k111Minor allele frequency- G:0.25NS EA NA CSA WA 786
rs729075191,2
C,F--53097228(+) GGGGGA/CCATGG 1 -- us2k12Minor allele frequency- C:0.04WA 120
rs795709061,2
C,F--53097317(+) CCCTGC/TGTGGC 1 -- us2k11Minor allele frequency- T:0.05WA 118
rs1391011741,2
--53097318(+) CCTGCA/GTGGCT 1 -- us2k10--------
rs729075201,2
C,F--53097399(+) CTTTCT/GAGTTT 1 -- us2k12Minor allele frequency- G:0.04WA 120

HapMap Linkage Disequilibrium report for FAM159A (53099016 - 53135355 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for FAM159A:    About this table    
Variant IDTypeSubtypePubMed ID
esv2672204CNV Deletion23128226
esv2748141CNV Deletion23290073
esv2748129CNV Deletion23290073
esv1918082CNV Deletion18987734

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for FAM159A gene integrated from 10 sources:
(articles sorted by number of sources associating them with FAM159A)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 348378 HGNC: 28757 AceView: MGC52498 Ensembl:ENSG00000182183 euGenes: HUgn348378
ECgene: FAM159A H-InvDB: FAM159A

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for FAM159A Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for FAM159A gene:
Search GeneIP for patents involving FAM159A

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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  eBioscience FlowRNA Probe Sets
 genOway: Develop your customized and physiologically relevant rodent model for FAM159A
 antibodies-online antibodies for FAM159A (3 products)
 antibodies-online kits for FAM159A (4 products)
  Search antibodies-online for peptides for FAM159A
  Search antibodies-online for proteins for FAM159A
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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