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Aliases for FAM159A Gene

Aliases for FAM159A Gene

  • Family With Sequence Similarity 159, Member A 2 3
  • Membrane Protein FAM159A 3
  • WWLS2783 3
  • PRO7171 3

External Ids for FAM159A Gene

Previous GeneCards Identifiers for FAM159A Gene

  • GC01P052872
  • GC01P053099
  • GC01P051214

Summaries for FAM159A Gene

GeneCards Summary for FAM159A Gene

FAM159A (Family With Sequence Similarity 159, Member A) is a Protein Coding gene. An important paralog of this gene is FAM159B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM159A Gene

Genomics for FAM159A Gene

Regulatory Elements for FAM159A Gene

Genomic Location for FAM159A Gene

52,633,344 bp from pter
52,669,683 bp from pter
36,340 bases
Plus strand

Genomic View for FAM159A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM159A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM159A Gene

Proteins for FAM159A Gene

  • Protein details for FAM159A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Membrane protein FAM159A
    Protein Accession:
    Secondary Accessions:
    • Q6ZRG4

    Protein attributes for FAM159A Gene

    190 amino acids
    Molecular mass:
    20306 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAQ88984.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM159A Gene


neXtProt entry for FAM159A Gene

Proteomics data for FAM159A Gene at MOPED

Post-translational modifications for FAM159A Gene

No Post-translational modifications

Other Protein References for FAM159A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM159A Gene

Domains for FAM159A Gene

Protein Domains for FAM159A Gene


Suggested Antigen Peptide Sequences for FAM159A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q6UWV7
  • Belongs to the FAM159 family.
genes like me logo Genes that share domains with FAM159A: view

No data available for Gene Families for FAM159A Gene

Function for FAM159A Gene

Phenotypes for FAM159A Gene

genes like me logo Genes that share phenotypes with FAM159A: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FAM159A Gene

Localization for FAM159A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM159A Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for FAM159A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM159A: view

No data available for Subcellular locations from COMPARTMENTS for FAM159A Gene

Pathways for FAM159A Gene

SuperPathways for FAM159A Gene

No Data Available

Interacting Proteins for FAM159A Gene

Gene Ontology (GO) - Biological Process for FAM159A Gene


No data available for Pathways by source for FAM159A Gene

Transcripts for FAM159A Gene

mRNA/cDNA for FAM159A Gene

Unigene Clusters for FAM159A Gene

Family with sequence similarity 159, member A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM159A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM159A Gene

No ASD Table

Relevant External Links for FAM159A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM159A Gene

mRNA expression in normal human tissues for FAM159A Gene

mRNA differential expression in normal tissues according to GTEx for FAM159A Gene

This gene is overexpressed in Whole Blood (17.0), Spleen (6.1), and Small Intestine - Terminal Ileum (4.2).

SOURCE GeneReport for Unigene cluster for FAM159A Gene Hs.424589

genes like me logo Genes that share expressions with FAM159A: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for FAM159A Gene

Orthologs for FAM159A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM159A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM159A 35
  • 84.22 (n)
  • 79.26 (a)
FAM159A 36
  • 79 (a)
(Canis familiaris)
Mammalia FAM159A 35
  • 84.39 (n)
  • 75.79 (a)
FAM159A 36
  • 76 (a)
(Mus musculus)
Mammalia Fam159a 35
  • 81.83 (n)
  • 75.13 (a)
Fam159a 16
Fam159a 36
  • 75 (a)
(Pan troglodytes)
Mammalia FAM159A 35
  • 99.3 (n)
  • 98.95 (a)
FAM159A 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Fam159a 35
  • 82.19 (n)
  • 77.78 (a)
(Gallus gallus)
Aves FAM159A 35
  • 71.2 (n)
  • 68 (a)
FAM159A 36
  • 70 (a)
(Anolis carolinensis)
Reptilia FAM159A 36
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam159a 35
  • 60.04 (n)
  • 58.43 (a)
(Danio rerio)
Actinopterygii LOC100536524 35
  • 59.8 (n)
  • 50.91 (a)
Species with no ortholog for FAM159A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM159A Gene

Gene Tree for FAM159A (if available)
Gene Tree for FAM159A (if available)

Paralogs for FAM159A Gene

Paralogs for FAM159A Gene

Selected SIMAP similar genes for FAM159A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM159A: view

Variants for FAM159A Gene

Sequence variations from dbSNP and Humsavar for FAM159A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs269320 -- 52,665,705(+) TCCCC(A/T)CCTCC intron-variant
rs269321 -- 52,663,473(-) ACATG(C/T)TCTGA intron-variant
rs269322 -- 52,663,447(-) AAGTT(A/G)AACTA intron-variant
rs269323 -- 52,660,843(-) GGGAT(C/T)GGGAC intron-variant
rs269324 -- 52,660,483(-) TCTGC(A/G)TATCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM159A Gene

Variant ID Type Subtype PubMed ID
esv2748129 CNV Deletion 23290073
esv1918082 CNV Deletion 18987734
esv2748141 CNV Deletion 23290073
esv2672204 CNV Deletion 23128226

Relevant External Links for FAM159A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM159A Gene

Disorders for FAM159A Gene

No disorders were found for FAM159A Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for FAM159A Gene

Publications for FAM159A Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4

Products for FAM159A Gene

Sources for FAM159A Gene

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