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Aliases for FAM157A Gene

Subcategory (RNA class) for FAM157A Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for FAM157A Gene

  • Family With Sequence Similarity 157 Member A (Non-Protein Coding) 2 3 5
  • General Transcription Factor IIi Pseudogene 18 2 3
  • Family With Sequence Similarity 157, Member A 2 3
  • Family With Sequence Similarity 157 Member A 2
  • Putative Protein FAM157A 3
  • GTF2IP18 3

External Ids for FAM157A Gene

Previous HGNC Symbols for FAM157A Gene

  • GTF2IP18

Previous GeneCards Identifiers for FAM157A Gene

  • GC03P199364
  • GC03P197879

Summaries for FAM157A Gene

GeneCards Summary for FAM157A Gene

FAM157A (Family With Sequence Similarity 157 Member A (Non-Protein Coding)) is an RNA Gene, and is affiliated with the non-coding RNA class. An important paralog of this gene is FAM157B.

Additional gene information for FAM157A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM157A Gene

Genomics for FAM157A Gene

GeneHancer (GH) Regulatory Elements for FAM157A Gene

Promoters and enhancers for FAM157A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I198149 Enhancer 0.2 Ensembl 550.8 +0.6 627 7.2 FAM157A GC03M198153
GH03I197351 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.3 -798.2 -798243 4.1 HDGF PKNOX1 CLOCK FOXA2 SIN3A ZNF48 RCOR1 RUNX3 SMARCA5 HMG20B FAM157A MELTF-AS1 PAK2 LOC101926923 GC03M197355
GH03I198167 Enhancer 0.6 ENCODE 0.4 +15.8 15841 0.2 CTCF ZNF654 RB1 L3MBTL2 TRIM22 REST RAD21 ZNF592 ZNF143 SMC3 GC03M198153 FAM157A GC03P198186
GH03I198173 Enhancer 0.7 ENCODE 0.3 +21.4 21391 0.2 ESRRA ZNF195 BCL11B NCOA2 CC2D1A POLR2B POLR2A ZBTB48 ZIK1 ZNF662 LOC220729 ENSG00000234742 LRCH3 RPL35A GC03P198186 FAM157A GC03M198153
GH03I198146 Enhancer 0.2 Ensembl 0.8 -4.9 -4873 0.6 FAM157A ENSG00000236246
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM157A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM157A gene promoter:

Genomic Locations for FAM157A Gene

Genomic Locations for FAM157A Gene
chr3:198,151,974-198,222,513
(GRCh38/hg38)
Size:
70,540 bases
Orientation:
Plus strand
chr3:197,879,237-197,925,886
(GRCh37/hg19)

Genomic View for FAM157A Gene

Genes around FAM157A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM157A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM157A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM157A Gene

Proteins for FAM157A Gene

  • Protein details for FAM157A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    C9JC47-F157A_HUMAN
    Recommended name:
    Putative protein FAM157A
    Protein Accession:
    C9JC47

    Protein attributes for FAM157A Gene

    Size:
    383 amino acids
    Molecular mass:
    42896 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM157A Gene

Post-translational modifications for FAM157A Gene

No Post-translational modifications

Other Protein References for FAM157A Gene

REFSEQ proteins:

No data available for DME Specific Peptides for FAM157A Gene

Domains & Families for FAM157A Gene

Protein Domains for FAM157A Gene

Suggested Antigen Peptide Sequences for FAM157A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

C9JC47

UniProtKB/Swiss-Prot:

F157A_HUMAN :
  • Belongs to the FAM157 family.
Family:
  • Belongs to the FAM157 family.
genes like me logo Genes that share domains with FAM157A: view

No data available for Gene Families for FAM157A Gene

Function for FAM157A Gene

Phenotypes From GWAS Catalog for FAM157A Gene

Phenotypes for FAM157A Gene

GenomeRNAi human phenotypes for FAM157A:
genes like me logo Genes that share phenotypes with FAM157A: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM157A Gene

Localization for FAM157A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM157A gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for FAM157A Gene

Pathways & Interactions for FAM157A Gene

SuperPathways for FAM157A Gene

No Data Available

Interacting Proteins for FAM157A Gene

Gene Ontology (GO) - Biological Process for FAM157A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM157A Gene

Drugs & Compounds for FAM157A Gene

No Compound Related Data Available

Transcripts for FAM157A Gene

mRNA/cDNA for FAM157A Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM157A Gene

Family with sequence similarity 157, member A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM157A Gene

No ASD Table

Relevant External Links for FAM157A Gene

GeneLoc Exon Structure for
FAM157A
ECgene alternative splicing isoforms for
FAM157A

Expression for FAM157A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM157A Gene

mRNA differential expression in normal tissues according to GTEx for FAM157A Gene

This gene is overexpressed in Whole Blood (x25.1).

Protein differential expression in normal tissues from HIPED for FAM157A Gene

This gene is overexpressed in Urine (57.2) and Adipocyte (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM157A Gene



Protein tissue co-expression partners for FAM157A Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM157A Gene:

FAM157A

SOURCE GeneReport for Unigene cluster for FAM157A Gene:

Hs.744675

Evidence on tissue expression from TISSUES for FAM157A Gene

  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with FAM157A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM157A Gene

Orthologs for FAM157A Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for FAM157A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100615675 33
  • 96.4 (n)
Species where no ortholog for FAM157A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM157A Gene

ENSEMBL:
Gene Tree for FAM157A (if available)
TreeFam:
Gene Tree for FAM157A (if available)

Paralogs for FAM157A Gene

Paralogs for FAM157A Gene

(2) SIMAP similar genes for FAM157A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM157A: view

Variants for FAM157A Gene

Sequence variations from dbSNP and Humsavar for FAM157A Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000553092 -- 198,162,822(+) G/A intron_variant
rs1000686257 -- 198,178,518(+) C/T intron_variant
rs1000903135 -- 198,160,911(+) A/G intron_variant
rs1001669821 -- 198,157,762(+) A/G intron_variant
rs1001723855 -- 198,160,237(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM157A Gene

Variant ID Type Subtype PubMed ID
dgv2907e59 CNV duplication 20981092
dgv5046n100 CNV gain 25217958
dgv5048n100 CNV gain 25217958
dgv5049n100 CNV loss 25217958
esv26652 CNV gain+loss 19812545
esv2759215 CNV gain 17122850
esv2760756 CNV gain+loss 21179565
esv2763718 CNV gain+loss 21179565
esv3379603 CNV duplication 20981092
esv33797 CNV gain+loss 17666407
esv3406484 CNV duplication 20981092
esv3432549 CNV duplication 20981092
esv3449725 CNV duplication 20981092
esv6783 CNV loss 19470904
nsv1011094 CNV gain 25217958
nsv10407 CNV gain 18304495
nsv10408 CNV gain+loss 18304495
nsv1115657 CNV duplication 24896259
nsv1115658 CNV duplication 24896259
nsv1132581 CNV duplication 24896259
nsv1146285 CNV duplication 26484159
nsv471429 CNV gain 19718026
nsv482085 CNV gain 20164927
nsv593177 CNV loss 21841781
nsv593178 CNV loss 21841781
nsv820948 CNV duplication 20802225
nsv950317 CNV deletion 24416366
nsv965252 CNV duplication 23825009
nsv979918 CNV duplication 23825009

Additional Variant Information for FAM157A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM157A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for FAM157A Gene

Disorders for FAM157A Gene

Additional Disease Information for FAM157A

No disorders were found for FAM157A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM157A Gene

Publications for FAM157A Gene

  1. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 4 58

Products for FAM157A Gene

Sources for FAM157A Gene

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