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FAM156B Gene

protein-coding   GIFtS: 31
GCID: GC0XP052921

Family With Sequence Similarity 156, Member B

(Previous name: transmembrane protein 29B)
(Previous symbol: TMEM29B)
  Search for FAM156B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 156, Member B1 2     Protein FAM156A2
TMEM29B1 2 3     Protein FAM156A/FAM156B2
Transmembrane Protein 29B1 2     Transmembrane Protein 292
Transmembrane Protein 29/29B2 3     TMEM293

External Ids:    HGNC: 319621   Entrez Gene: 7278662   Ensembl: ENSG000001793047   UniProtKB: Q8NDB63   

Export aliases for FAM156B gene to outside databases

Previous GC identifer: GC0XP052940


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM156B Gene:
FAM156B (family with sequence similarity 156, member B) is a protein-coding gene. An important paralog of this gene is FAM156A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the FAM156B gene promoter:
         GCNF   NRSF form 1   NRSF form 2   POU2F1   POU2F1a   FOXJ2 (long isoform)   GCNF-1   FOXJ2   GCNF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for FAM156B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM156B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.22   Ensembl cytogenetic band:  Xp11.22   HGNC cytogenetic band: Xp11.22

FAM156B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM156B gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP052921:  view genomic region     (about GC identifiers)

Start:
52,920,336 bp from pter      End:
52,937,587 bp from pter
Size:
17,252 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FA156_HUMAN, Q8NDB6 (See protein sequence)
Recommended Name: Protein FAM156A/FAM156B  
Size: 213 amino acids; 24412 Da
Sequence caution: Sequence=AAF24055.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH00867.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B3KQ92 Q5JPL2 Q5JPL3 Q5JPL4 Q5JPL5 Q5JPL6 Q68D17 Q6NVY3 Q9UI49

Explore the universe of human proteins at neXtProt for FAM156B: NX_Q8NDB6

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • REFSEQ proteins: NP_001093154.1  
    ENSEMBL proteins: 
     ENSP00000420954   ENSP00000425174   ENSP00000426113   ENSP00000422884   ENSP00000424864  
     ENSP00000422411  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q8NDB6


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         3 GenomeRNAi human phenotypes for FAM156B:
     Decreased cell number  Decreased viability of wild-ty  Increased number of mitotic ce 

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FA156_HUMAN, Q8NDB6: Membrane; Single-pass membrane protein (Potential)

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635nuclear envelope IDA--
    GO:0016021integral component of membrane IEA--

    FAM156B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM156B
    Interactions:

        Search GeneGlobe Interaction Network for FAM156B

    1 Interacting protein for FAM156B (Q8NDB62, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAGEA11P433642, 3MINT-67583 I2D: score=5 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM156B (FA156)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FAM156B gene: 
    NM_001099684.1  

    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000452154 ENST00000414788 ENST00000458697 ENST00000430150(uc004dri.3)
    ENST00000452021 ENST00000412319(uc004drj.3) ENST00000416841(uc004drl.3)
    ENST00000509613
    miRNA
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    hsa-miR-188-3p hsa-miR-512-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FAM156B (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d
    SP1:        -     -     -     -     -                                       
    SP2:                          -     -                                       
    SP3:                                                                        
    SP4:                                                                        
    SP5:              -     -     -     -                                       


    ECgene alternative splicing isoforms for FAM156B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM156B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    FAM156B Expression
    About this image

    FAM156B Protein expression data from MOPED1, PaxDb2 and MaxQB3 --
        Custom PCR Arrays for FAM156B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM156B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for FAM156B gene from Selected species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem295 transmembrane protein 29   --   X (68.46 cM) 150397773 


    ENSEMBL Gene Tree for FAM156B (if available)
    TreeFam Gene Tree for FAM156B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM156B gene
    FAM156A1 2  
    1 SIMAP similar gene for FAM156B using alignment to 1 protein entry:     FA156_HUMAN:
    FAM156A

    FAM156B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM156B (see all 15)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2008640511,2
    --52926915(+) TATTG-/AAAC  
            
    AAACC
    1 -- us2k10--------
    rs796660721,2
    C--52933260(+) CGTATA/TGTATC 1 -- int10--------
    rs1832242711,2
    --52933357(+) GGGCTC/TGCTAT 1 -- int10--------
    rs1497417051,2
    --52933365(+) TATGTC/TGCCCA 1 -- int10--------
    rs3687042741,2
    C--52935874(+) AGCAGA/GGAATT 1 -- int10--------
    rs3703711181,2
    ----52933877(+) TATCCC/TTTCTC 1 -- int10--------
    rs3737462261,2
    ----52931066(+) TTTTTC/TTTTTT 1 -- int10--------
    rs3726899021,2
    ----52927790(+) GGGTGA/TCAATA 1 -- us2k10--------
    rs3740212651,2
    ----52933918(+) ACTCAC/TTGGAC 1 -- int10--------
    rs3757338501,2
    ----52932357(+) CGGGCA/GTACAT 1 -- int10--------

    HapMap Linkage Disequilibrium report for FAM156B (52920336 - 52937587 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for FAM156B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2740175CNV Deletion23290073
    nsv435891CNV Deletion17901297
    nsv499358OTHER Inversion21111241
    nsv7447OTHER Inversion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM156B gene integrated from 10 sources:
    (articles sorted by number of sources associating them with FAM156B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a new cancer/testis gene family, CT47, among expressed multicopy genes on the human X chromosome. (PubMed id 16382448)1, 2, 3 Chen Y.-T....Jongeneel C.V. (Genes Chromosomes Cancer 2006)
    2. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    6. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    7. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614)1 Simpson J.C.... Wiemann S. (EMBO Rep. 2000)
    8. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 727866 HGNC: 31962 Ensembl:ENSG00000179304 euGenes: HUgn727866 ECgene: FAM156B
    H-InvDB: FAM156B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM156B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM156B gene:
    Search GeneIP for patents involving FAM156B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse ESI BIO Cell Lines and PureStem Progenitors for FAM156B
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     Browse SwitchGear 3'UTR luciferase reporter plasmids for FAM156B
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     Search ThermoFisher Antibodies for FAM156B
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     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAM156B
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FAM156B
     LSBio Antibodies in human, mouse, rat for FAM156B
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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