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FAM156A Gene

protein-coding   GIFtS: 45
GCID: GC0XM052995

Family With Sequence Similarity 156, Member A

(Previous name: transmembrane protein 29)
(Previous symbol: TMEM29)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Family With Sequence Similarity 156, Member A1 2     PRO06592
TMEM291 2 3     Protein FAM156A2
Transmembrane Protein 291 2     Protein FAM156A/FAM156B2
Transmembrane Protein 29/29B2 3     TMEM29B3

External Ids:    HGNC: 301141   Entrez Gene: 290572   Ensembl: ENSG000001826467   UniProtKB: Q8NDB63   
ORGUL members:         

Export aliases for FAM156A gene to outside databases

Previous GC identifer: GC0XM050038


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM156A Gene:
FAM156A (family with sequence similarity 156, member A) is a protein-coding gene. Diseases associated with FAM156A include intrahepatic cholangiocarcinoma, and cholangiocarcinoma. An important paralog of this gene is FAM156B.

Gene Wiki entry for FAM156A (TMEM29) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NT_011630.15  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAM156A gene promoter:
         GCNF   NRSF form 1   NRSF form 2   POU2F1   POU2F1a   FOXJ2 (long isoform)   GCNF-1   FOXJ2   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FAM156A promoter sequence
   Search Chromatin IP Primers for FAM156A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM156A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.22   Ensembl cytogenetic band:  Xp11.22   HGNC cytogenetic band: Xp11.23

FAM156A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM156A gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM052995:  view genomic region     (about GC identifiers)

Start:
52,976,462 bp from pter      End:
53,024,651 bp from pter
Size:
48,190 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: FA156_HUMAN, Q8NDB6 (See protein sequence)
Recommended Name: Protein FAM156A/FAM156B  
Size: 213 amino acids; 24412 Da
Sequence caution: Sequence=AAF24055.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH00867.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B3KQ92 Q5JPL2 Q5JPL3 Q5JPL4 Q5JPL5 Q5JPL6 Q68D17 Q6NVY3 Q9UI49

Explore the universe of human proteins at neXtProt for FAM156A: NX_Q8NDB6

Explore proteomics data for FAM156A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FAM156A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (10 alternative transcripts): 
    NP_001229418.1  NP_001229419.1  NP_001229420.1  NP_001229421.1  NP_001229422.1  NP_001229423.1  NP_001229424.1  NP_001229425.1  
    NP_001229426.1  NP_054857.2  

    ENSEMBL proteins: 
     ENSP00000348687   ENSP00000318182   ENSP00000328443   ENSP00000426868   ENSP00000405771  
     ENSP00000398565   ENSP00000427693   ENSP00000421939   ENSP00000364622   ENSP00000412585  
     ENSP00000414701   ENSP00000425216   ENSP00000412234   ENSP00000424378  

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    Cloud-Clone Corp. CLIAs for FAM156A


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q8NDB6


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAM156A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FAM156A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FAM156A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FAM156A

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    2 qRT-PCR Assays for microRNAs that regulate FAM156A:
    hsa-miR-188-3p hsa-miR-512-3p
    SwitchGear 3'UTR luciferase reporter plasmidFAM156A 3' UTR sequence
    Inhib. RNA
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM156A

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM156A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FA156_HUMAN, Q8NDB6: Membrane; Single-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635nuclear envelope ----
    GO:0016021integral component of membrane ----

    FAM156A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM156A
    Interactions:

        Search GeneGlobe Interaction Network for FAM156A

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for FAM156A (Q8NDB62, 3 ENSP000003181824) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAGEA11P433642, 3, ENSP000003473584MINT-67583 I2D: score=5 STRING: ENSP00000347358
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM156A (FA156)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FAM156A gene (10 alternative transcripts): 
    NM_001242489.1  NM_001242490.1  NM_001242491.1  NM_001242492.1  NM_001242493.1  NM_001242494.1  NM_001242495.1  NM_001242496.1  
    NM_001242497.1  NM_014138.4  

    Unigene Clusters for FAM156A:

    Family with sequence similarity 156, member A
    Hs.6451  [show with all ESTs], Hs.653131  [show with all ESTs]
    Unigene Representative Sequences: BX649013, NM_014138
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000356333(uc004drn.3 uc022bwu.1 uc022bww.1 uc022bwx.1 uc022bxa.1)
    ENST00000316310(uc022bwt.1) ENST00000330025(uc004drq.3 uc022bwz.1)
    ENST00000512364(uc022bwv.1 uc004drs.3 uc022bwy.1 uc004drr.3)
    ENST00000414076 ENST00000438003 ENST00000411516 ENST00000503775 ENST00000375473
    ENST00000451084 ENST00000447562 ENST00000510517 ENST00000416923 ENST00000505988
    ENST00000475552 ENST00000493931 ENST00000511863 ENST00000510893
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FAM156A using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate FAM156A:
    hsa-miR-188-3p hsa-miR-512-3p
    SwitchGear 3'UTR luciferase reporter plasmidFAM156A 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FAM156A
    Predesigned siRNA for gene silencing in human, mouse, rat FAM156A
    Clone
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    OriGene clones in human, mouse for FAM156A (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FAM156A (NM_014138)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM156A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM156A
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FAM156A
    OriGene qSTAR qPCR primer pairs in human, mouse for FAM156A
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat FAM156A
      QuantiTect SYBR Green Assays in human, mouse, rat FAM156A
      QuantiFast Probe-based Assays in human, mouse, rat FAM156A

    Additional mRNA sequence: 

    AK057692.1 BC067819.1 

    21 DOTS entries:

    DT.314057  DT.95080000  DT.40211410  DT.100650036  DT.100650039  DT.100773012  DT.100871831  DT.100029755 
    DT.95082947  DT.97814117  DT.102829416  DT.91762993  DT.91762995  DT.97806949  DT.100029758  DT.100851354 
    DT.121311443  DT.121311461  DT.75146915  DT.102844711  DT.121311438 

    Selected AceView cDNA sequences (see all 214):

    AF090943 BX380824 AA554026 CR602587 AK092365 CR603409 BQ708350 BF969012 
    BQ899004 BX106839 BX365011 BF514303 AA961400 BQ056262 BI910806 AL834135 
    BQ008125 BQ717007 CR609149 BC000867 BU166122 CA449002 BQ710085 AK057692 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM156A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATGTAAATG
    FAM156A Expression
    About this image

    FAM156A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM156A Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.6451 Hs.653131
        Custom PCR Arrays for FAM156A
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM156A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    ENSEMBL Gene Tree for FAM156A (if available)
    TreeFam Gene Tree for FAM156A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM156A gene
    FAM156B1 2  
    1 SIMAP similar gene for FAM156A using alignment to 5 protein entries:     FA156_HUMAN (see all proteins):
    FAM156B

    FAM156A for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for FAM156A
    PGOHUM00000241331 PGOHUM00000241763


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM156A (see all 253)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2012301951,2
    --52977330(+) CCAGCA/GTCTCC 20 T M mis10--------
    rs3732235681,2
    C--52978175(+) AATTCC/TTGCTG 10 -- int10--------
    rs1893269441,2
    C--52987295(+) GGCATC/TCTCTT 10 -- int10--------
    rs2004416881,2
    --52992880(+) CCAGT-/AATGTT 9 -- int10--------
    rs1458919441,2
    C--53002420(+) AAATT-/AAAAAA 9 -- int10--------
    rs128351301,2
    F,H--53002484(+) AGCAAA/CAACAC 9 -- int14Minor allele frequency- C:0.04NS EA 418
    rs1915114591,2
    --53002507(+) GTTCAA/GCTACT 9 -- int10--------
    rs1845906661,2
    --53002544(+) CAATGC/TTCTGG 9 -- int10--------
    rs126899631,2
    C,F,A,H--53002657(+) acaatT/Cttttt 9 -- int16Minor allele frequency- C:0.30NS EA WA CSA 421
    rs1503569961,2
    --53002854(+) AAGTAA/CAAGAT 9 -- int10--------

    HapMap Linkage Disequilibrium report for FAM156A (52976462 - 53024651 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for FAM156A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2740175CNV Deletion23290073
    nsv435891CNV Deletion17901297
    nsv499358OTHER Inversion21111241
    nsv7447OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FAM156A
    DNA2.0 Custom Variant and Variant Library Synthesis for FAM156A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for FAM156A:    
    About MalaCards
    intrahepatic cholangiocarcinoma    cholangiocarcinoma


    FAM156A for disorders           About GeneDecksing


    Export disorders for FAM156A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM156A gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with FAM156A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    6. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    8. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (Biochem. Biophys. Res. Commun. 2006)
    9. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (Nucleic Acids Res. 2006)
    10. Identification of a new cancer/testis gene family, CT47, among expressed multicopy genes on the human X chromosome. (PubMed id 16382448)2 Chen Y.-T....Jongeneel C.V. (Genes Chromosomes Cancer 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 29057 HGNC: 30114 AceView: TMEM29.1 Ensembl:ENSG00000182646 euGenes: HUgn29057
    ECgene: FAM156A H-InvDB: FAM156A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM156A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM156A gene:
    Search GeneIP for patents involving FAM156A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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