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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAM156A Gene

protein-coding   GIFtS: 44
GCID: GC0XM052995

family with sequence similarity 156, member A

(Previous name: transmembrane protein 29 )
(Previous symbol: TMEM29)
 Explore 2 diseases affiliated with
FAM156A via our new
 Human Malady Compendium 
Biological research products
for FAM156A
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Family With Sequence Similarity 156, Member A1 2     Transmembrane Protein 29/29B2 3
TMEM291 2 3     Protein FAM156A2
PRO06591 2     Protein FAM156A/FAM156B2
Transmembrane Protein 291 2     TMEM29B3

External Ids:    HGNC: 301141   Entrez Gene: 290572   Ensembl: ENSG000001826467   UniProtKB: Q8NDB63   

Export aliases for FAM156A gene to outside databases

Previous GC identifer: GC0XM050038


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Gene Wiki entry for FAM156A (TMEM29)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_011630.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FAM156A gene promoter:
         GCNF   NRSF form 1   NRSF form 2   POU2F1   POU2F1a   FOXJ2 (long isoform)   GCNF-1   FOXJ2   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FAM156A promoter sequence
   Search SABiosciences Chromatin IP Primers for FAM156A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM156A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.22   Ensembl cytogenetic band:  Xp11.22   HGNC cytogenetic band: Xp11.23

FAM156A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM156A gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM052995:  view genomic region     (about GC identifiers)

Start:
52,976,462 bp from pter      End:
53,024,651 bp from pter
Size:
48,190 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FA156_HUMAN, Q8NDB6 (See protein sequence)
Recommended Name: Protein FAM156A/FAM156B  
Size: 213 amino acids; 24412 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Sequence caution: Sequence=AAF24055.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH00867.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B3KQ92 Q5JPL2 Q5JPL3 Q5JPL4 Q5JPL5 Q5JPL6 Q68D17 Q6NVY3 Q9UI49

Explore the universe of human proteins at neXtProt for FAM156A: NX_Q8NDB6

FAM156A Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins (10 alternative transcripts): 
NP_001229418.1  NP_001229419.1  NP_001229420.1  NP_001229421.1  NP_001229422.1  NP_001229423.1  NP_001229424.1  NP_001229425.1  
NP_001229426.1  NP_054857.2  

ENSEMBL proteins: 
 ENSP00000328443   ENSP00000318182   ENSP00000348687   ENSP00000426868   ENSP00000405771  
 ENSP00000398565   ENSP00000427693   ENSP00000421939   ENSP00000364622   ENSP00000412585  
 ENSP00000414701   ENSP00000425216   ENSP00000412234   ENSP00000424378  

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Uscn Proteins for FAM156A

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005635nuclear envelope ----
GO:0016021integral to membrane ----


FAM156A for ontologies           About GeneDecksing



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Uscn ELISAs and CLIAs for FAM156A


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q8NDB6


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

miRNA
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Browse MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FAM156A
2 QIAGEN miScript miRNA Assays for microRNAs that regulate FAM156A:
hsa-miR-188-3p hsa-miR-512-3p
SwitchGear 3'UTR luciferase reporter plasmidFAM156A 3' UTR sequence
Inhib. RNA
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM156A


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM156A

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for FAM156A (Q8NDB62, 3 ENSP000003181824) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
MAGEA11P433642, 3, ENSP000003473584MINT-67583 I2D: score=5 STRING: ENSP00000347358
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FAM156A
Search CenterWatch for drugs/clinical trials and news about FAM156A / FA156 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FAM156A gene (10 alternative transcripts): 
NM_001242489.1  NM_001242490.1  NM_001242491.1  NM_001242492.1  NM_001242493.1  NM_001242494.1  NM_001242495.1  NM_001242496.1  
NM_001242497.1  NM_014138.4  

Unigene Clusters for FAM156A:

Family with sequence similarity 156, member A
Hs.6451  [show with all ESTs], Hs.653131  [show with all ESTs]
Unigene Representative Sequences: BX649013, NM_014138
18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
ENST00000330025(uc004drq.3 uc022bwz.1) ENST00000316310(uc022bwt.1)
ENST00000356333(uc004drn.3 uc022bwu.1 uc022bww.1 uc022bwx.1 uc022bxa.1)
ENST00000512364(uc022bwv.1 uc004drs.3 uc022bwy.1 uc004drr.3)
ENST00000414076 ENST00000438003 ENST00000411516 ENST00000503775 ENST00000375473
ENST00000451084 ENST00000447562 ENST00000510517 ENST00000416923 ENST00000505988
ENST00000475552 ENST00000493931 ENST00000511863 ENST00000510893

miRNA
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OriGene 3'-UTR Clone: FAM156A
Browse OriGene MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FAM156A
2 QIAGEN miScript miRNA Assays for microRNAs that regulate FAM156A:
hsa-miR-188-3p hsa-miR-512-3p
SwitchGear 3'UTR luciferase reporter plasmidFAM156A 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM156A
OriGene shRNA RFP: FAM156A
OriGene siRNA: FAM156A
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM156A
Clone
Products:
     
OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM156A
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM156A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector: FAM156A (NM_014138)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM156A
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM156A 
Primer
Products:
    
OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM156A
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse / rat FAM156A
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM156A
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM156A

Additional cDNA sequence: 

AK057692.1 BC067819.1 

21 DOTS entries:

DT.314057  DT.95080000  DT.40211410  DT.100650036  DT.100650039  DT.100773012  DT.100871831  DT.100029755 
DT.95082947  DT.97814117  DT.102829416  DT.91762993  DT.91762995  DT.97806949  DT.100029758  DT.100851354 
DT.121311443  DT.121311461  DT.75146915  DT.102844711  DT.121311438 

24/214 AceView cDNA sequences (see all 214):

BQ899004 AA961400 AK092365 BI910806 BX365011 BF514303 AA595505 BX106839 
BG055733 AX747504 AA421638 CB107661 BQ712577 BU633199 AL834135 BQ708350 
BQ069477 BF969012 AI313115 AI332760 AF090943 BX380824 CR602587 AA554026 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FAM156A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATGTAAATG

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)

About this image
See FAM156A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM156A

SOURCE GeneReport for Unigene clusters: Hs.6451 Hs.653131
    SABiosciences Custom PCR Arrays for FAM156A
Primer
Products:
OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM156A
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse / rat FAM156A
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM156A
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM156A
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM156A

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
  --

ENSEMBL Gene Tree for FAM156A (if available)
TreeFam Gene Tree for FAM156A (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for FAM156A gene
FAM156B1 2  
1 SIMAP similar gene for FAM156A using alignment to 5 protein entries:     FA156_HUMAN (see all proteins):
FAM156B

FAM156A for paralogs           About GeneDecksing


2 Pseudogenes.org Pseudogenes for FAM156A
PGOHUM00000241331 PGOHUM00000241763


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/216 NCBI SNPs in FAM156A are shown (see all 216    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr X posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs2012301951,2
--52977330(+) CCAGCA/GTCTCC 20 T M mis10--------
rs1893269441,2
--52987295(+) GGCATC/TCTCTT 10 -- int10--------
rs2004416881,2
--52992880(+) CCAGT-/AATGTT 9 -- int10--------
rs1458919441,2
C--53002420(+) AAATT-/AAAAAA 9 -- int10--------
rs128351301,2
F,H--53002484(+) AGCAAA/CAACAC 9 -- int14Minor allele frequency- C:0.04NS EA 418
rs1915114591,2
--53002507(+) GTTCAA/GCTACT 9 -- int10--------
rs1845906661,2
--53002544(+) CAATGC/TTCTGG 9 -- int10--------
rs126899631,2
C,F,A,H--53002657(+) ACAATT/CTTTTT 9 -- int16Minor allele frequency- C:0.30NS EA WA CSA 421
rs1503569961,2
--53002854(+) AAGTAA/CAAGAT 9 -- int10--------
rs70516641,2
C,--53003418(+) CAGAAG/AGCTGG 9 -- int15Minor allele frequency- A:0.00WA NA 9

HapMap Linkage Disequilibrium report for FAM156A (52976462 - 53024651 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for FAM156A
     2 CNVs: 23256 96692
     1 Inversion: 37383

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FAM156A for disorders           About GeneDecksing

2 diseases for FAM156A:    About MalaCards
intrahepatic cholangiocarcinoma    cholangiocarcinoma


Export disorders for FAM156A gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for FAM156A gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with FAM156A)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
  5. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
  6. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (2006)
  7. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
  8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
  9. Identification of a new cancer/testis gene family, CT47, among expressed multicopy genes on the human X chromosome. (PubMed id 16382448)2 Chen Y.T....Jongeneel C.V. (2006)
  10. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 29057 HGNC: 30114 AceView: TMEM29.1 Ensembl:ENSG00000182646 euGenes: HUgn29057
ECgene: FAM156A H-InvDB: FAM156A

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for FAM156A Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for FAM156A gene:
Search GeneIP for patents involving FAM156A

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

 
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 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM156A
 QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM156A
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