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FAM155B Gene

protein-coding   GIFtS: 44
GCID: GC0XP068725

Family With Sequence Similarity 155, Member B

(Previous names: transmembrane protein 28, chromosome X open reading frame...)
(Previous symbols: TMEM28, CXorf63)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 155, Member B1 2     Chromosome X Open Reading Frame 631
Transmembrane Protein 281 2 3     bB57D9.12
TMEM281 2 3     BB57D9.1 (TED Protein)2
CXorf631 2     Transmembrane Protein FAM155B2
TED2 3     Protein TED3

External Ids:    HGNC: 307011   Entrez Gene: 271122   Ensembl: ENSG000001300547   UniProtKB: O759493   

Export aliases for FAM155B gene to outside databases

Previous GC identifers: GC0XP068643 GC0XP062546


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FAM155B Gene:
This gene encodes a product belonging to a family of proteins with unknown function. The presence of two
transmembrane domains suggests that this protein is a multi-pass membrane protein. (provided by RefSeq, Sep 2011)

GeneCards Summary for FAM155B Gene:
FAM155B (family with sequence similarity 155, member B) is a protein-coding gene. Diseases associated with FAM155B include marantic endocarditis, and enterobiasis. An important paralog of this gene is FAM155A.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NC_018934.2  NT_011651.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAM155B gene promoter:
         Spz1   Tal-1   Brachyury   NRSF form 1   NRSF form 2   c-Ets-1   E47   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM155B promoter sequence
   Search Chromatin IP Primers for FAM155B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM155B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq13.1   Ensembl cytogenetic band:  Xq13.1   HGNC cytogenetic band: Xq13.1

FAM155B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM155B gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP068725:  view genomic region     (about GC identifiers)

Start:
68,725,078 bp from pter      End:
68,752,351 bp from pter
Size:
27,274 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: F155B_HUMAN, O75949 (See protein sequence)
Recommended Name: Transmembrane protein FAM155B  
Size: 473 amino acids; 52605 Da
Secondary accessions: B1ALV6 B9EGK1 D3DVU1
Alternative splicing: 2 isoforms:  O75949-1   O75949-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FAM155B: NX_O75949

Explore proteomics data for FAM155B at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn120, Asn193

  • See FAM155B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056501.2  
    ENSEMBL proteins: 
     ENSP00000252338  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: O75949

    UniProtKB/Swiss-Prot: F155B_HUMAN, O75949
    Similarity: Belongs to the FAM155 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAM155B
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    hsa-mir-16-5p (MIRT051218)

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    Selected qRT-PCR Assays for microRNAs that regulate FAM155B (see all 112):
    hsa-miR-549 hsa-miR-520e hsa-miR-3607-3p hsa-miR-3938 hsa-miR-1224-3p hsa-miR-128 hsa-miR-632 hsa-miR-550a*
    SwitchGear 3'UTR luciferase reporter plasmidFAM155B 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM155B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    F155B_HUMAN, O75949: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular2
    cytosol1
    endoplasmic reticulum1
    golgi apparatus1
    lysosome1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    FAM155B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM155B
    Interactions:

        Search GeneGlobe Interaction Network for FAM155B

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM155B (F155B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FAM155B gene: 
    NM_015686.2  

    Unigene Cluster for FAM155B:

    Family with sequence similarity 155, member B
    Hs.87619  [show with all ESTs]
    Unigene Representative Sequence: NM_015686
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000252338(uc004dxk.3)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate FAM155B (see all 112):
    hsa-miR-549 hsa-miR-520e hsa-miR-3607-3p hsa-miR-3938 hsa-miR-1224-3p hsa-miR-128 hsa-miR-632 hsa-miR-550a*
    SwitchGear 3'UTR luciferase reporter plasmidFAM155B 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FAM155B
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat FAM155B
      QuantiFast Probe-based Assays in human, mouse, rat FAM155B

    Additional mRNA sequence: 

    AF087142.1 BC136518.1 BC136519.1 

    2 DOTS entries:

    DT.208808  DT.101969121 

    22 AceView cDNA sequences:

    AW451829 BX104103 AI829015 AA243172 AA954967 AF087142 AW296882 BV186063 
    NM_015686 BV186064 BE797226 AA357428 BE783832 AA918896 AA243234 CB956644 
    BF311520 AI933332 CF141548 AA885411 BG959246 CF121161 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM155B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTAGGACTT
    FAM155B Expression
    About this image

    FAM155B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM155B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.87619
        Custom PCR Arrays for FAM155B
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM155B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FAM155B gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem281 , 5 transmembrane protein 281, 5 93.56(n)1
    94.06(a)1
      X (43.59 cM)5
    6205921  NM_001081283.11  NP_001074752.11 
     998210215 
    chicken
    (Gallus gallus)
    Aves FAM155B1 family with sequence similarity 155, member B 67.9(n)
    58.46(a)
      769051  XM_001232239.3  XP_001232240.3 
    African clawed frog
    (Xenopus laevis)
    Amphibia BG486935.12   -- 77.07(n)    BG486935.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fam155b1 family with sequence similarity 155, member B 54.89(n)
    44.86(a)
      791161  NM_001080643.2  NP_001074112.2 


    ENSEMBL Gene Tree for FAM155B (if available)
    TreeFam Gene Tree for FAM155B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM155B gene
    FAM155A2  

    FAM155B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM155B (see all 376)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1815477081,2
    --68730689(+) CCGGCA/GACGGT 1 -- us2k10--------
    rs559718141,2
    C--68730723(+) CCAGT-/CAAG  
            
    GACAA
    1 -- int11Minor allele frequency- CAAG:0.50CSA 2
    rs128351281,2
    C--68730977(+) TGCTGG/CAAATA 1 -- us2k12Minor allele frequency- C:0.00NA 4
    rs128370081,2
    C--68731032(+) CACCGC/TCTTGC 1 -- us2k12Minor allele frequency- T:0.00NA 4
    rs1868909741,2
    --68731040(+) TGCCCC/TCTCCA 1 -- us2k10--------
    rs38113771,2
    C,F,H--68731041(-) CTGGAG/CGGGGC 1 -- us2k15Minor allele frequency- C:0.15NS EA NA 417
    rs1922881321,2
    --68731120(+) TTGTCC/TTCGGG 1 -- us2k10--------
    rs1840743521,2
    --68731208(+) ACGGGA/GACGGC 1 -- us2k10--------
    rs38113761,2
    C--68731411(-) ATCCGC/TCCGCT 1 -- us2k10--------
    rs38113751,2
    C,H--68731598(-) TTGGCG/CGGGAG 1 -- us2k1 tfbs32Minor allele frequency- C:0.00NS NA 120

    HapMap Linkage Disequilibrium report for FAM155B (68725078 - 68752351 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for FAM155B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv25466CNV Loss19812545
    esv23322CNV Gain19812545
    esv1584074OTHER Inversion17803354

    Locus Specific Mutation Databases (LSDB): FAM155B

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    5 diseases for FAM155B:    
    About MalaCards
    marantic endocarditis    enterobiasis    thrombophlebitis    endocarditis
    pulmonary embolism

    2 diseases from the University of Copenhagen DISEASES database for FAM155B:
    Pulmonary embolism     Enterobiasis

    FAM155B for disorders           About GeneDecksing

    Genetic Association Database (GAD): FAM155B

    Export disorders for FAM155B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM155B gene integrated from 10 sources:
    (articles sorted by number of sources associating them with FAM155B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association study reveals multiple loci associated with primary tooth development during infancy. (PubMed id 20195514)4 Pillas D....Jarvelin M.R. (PLoS Genet. 2010)
    2. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PubMed id 17903296)4 Kiel D.P....Karasik D. (BMC Med. Genet. 2007)
    3. The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (Nature 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    6. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27112 HGNC: 30701 AceView: TMEM28 Ensembl:ENSG00000130054 euGenes: HUgn27112
    ECgene: FAM155B H-InvDB: FAM155B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM155B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM155B gene:
    Search GeneIP for patents involving FAM155B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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