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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAM154B Gene

protein-coding   GIFtS: 37
GCID: GC15P082555          (predicted)

Family With Sequence Similarity 154, Member B

  Search for FAM154B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Family With Sequence Similarity 154, Member B1 2
Protein FAM154B2

External Ids:    HGNC: 337271   Entrez Gene: 2837262   Ensembl: ENSG000001886597   UniProtKB: Q658L13   

Export aliases for FAM154B gene to outside databases

Previous GC identifers: GC15P080345 GC15P059313


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FAM154B Gene: 
FAM154B (family with sequence similarity 154, member B) is a protein-coding gene. An important paralog of this gene is FAM154A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FAM154B gene promoter:
         Bach1   Bach2   CUTL1   POU6F1 (c2)   E47   FAC1   POU2F1   POU2F1b   POU2F1a   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM154B promoter sequence
   Search SABiosciences Chromatin IP Primers for FAM154B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM154B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q25.2   Ensembl cytogenetic band:  15q25.2   HGNC cytogenetic band: 15q25.2

FAM154B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM154B gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P082555:  view genomic region     (about GC identifiers)

Start:
82,555,151 bp from pter      End:
82,577,271 bp from pter
Size:
22,121 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: F154B_HUMAN, Q658L1 (See protein sequence)
Recommended Name: Protein FAM154B  
Size: 398 amino acids; 45933 Da
Caution: It is uncertain whether Met-1 or Met-6 is the initiator

Explore the universe of human proteins at neXtProt for FAM154B: NX_Q658L1

Explore proteomics data for FAM154B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q658L1

  • FAM154B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FAM154B Protein Expression
    REFSEQ proteins: NP_001008227.1  
    ENSEMBL proteins: 
     ENSP00000454320   ENSP00000340445   ENSP00000455158   ENSP00000455957   ENSP00000458067  
     ENSP00000403743  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR024963 STOP/FAM154

    Graphical View of Domain Structure for InterPro Entry Q658L1

    ProtoNet protein and cluster: Q658L1

    UniProtKB/Swiss-Prot: F154B_HUMAN, Q658L1
    Similarity: Belongs to the FAM154 family


    FAM154B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FAM154B 
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    SwitchGear 3'UTR luciferase reporter plasmidFAM154B 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM154B

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FAM154B (F154B)

    Search CenterWatch for drugs/clinical trials and news about FAM154B / F154B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FAM154B gene: 
    NM_001008226.1  

    Unigene Cluster for FAM154B:

    Family with sequence similarity 154, member B
    Hs.459117  [show with all ESTs]
    Unigene Representative Sequence: AL833762
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000566205 ENST00000339465(uc002bgv.3 uc010unr.2 uc010uns.2)
    ENST00000569120 ENST00000566861 ENST00000562097 ENST00000565432 ENST00000565501
    ENST00000565006 ENST00000427381
    miRNA
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    hsa-miR-154 hsa-miR-186 hsa-miR-330-3p hsa-miR-548v hsa-miR-3133
    SwitchGear 3'UTR luciferase reporter plasmidFAM154B 3' UTR sequence
    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of FAM154B 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM154B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM154B

    Additional mRNA sequence: 

    AK304339.1 AL833762.1 BC144647.1 

    8 DOTS entries:

    DT.40308732  DT.121016311  DT.304000  DT.92026519  DT.95103894  DT.92416121  DT.99971544  DT.121016325 

    20 AceView cDNA sequences:

    CB215774 AL833762 AA995196 AA649001 BU689608 BF942184 BX090922 BF942406 
    AA835037 AI916879 BU634076 BM979289 BM931241 BF942237 BU743090 AI761990 
    BU607937 AW665398 AI867815 AI634060 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for FAM154B    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7
    SP1:              -     -     -                           
    SP2:                    -     -                           
    SP3:              -                                       
    SP4:                    -     -                           


    ECgene alternative splicing isoforms for FAM154B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FAM154B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAACATAATA
    FAM154B Expression
    About this image


    See FAM154B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FAM154B

    SOURCE GeneReport for Unigene cluster: Hs.459117
        SABiosciences Custom PCR Arrays for FAM154B
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM154B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FAM154B gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam154b1 , 5 family with sequence similarity 154, member B1, 5 86.68(n)1
    83.97(a)1
      7 (47.25 cM)5
    3305771  NM_177894.41  NP_808562.31 
     826329605 
    chicken
    (Gallus gallus)
    Aves FAM154B1 family with sequence similarity 154, member B 67.7(n)
    58.91(a)
      427505  XM_425077.3  XP_425077.3 
    lizard
    (Anolis carolinensis)
    Reptilia FAM154B6
    family with sequence similarity 154, member B
    44(a)
    1 ↔ 1
    GL343740.1(52156-64188)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.154682 Transcribed sequences 82.09(n)    BM316330.1 


    ENSEMBL Gene Tree for FAM154B (if available)
    TreeFam Gene Tree for FAM154B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FAM154B gene
    FAM154A2  
    2 SIMAP similar genes for FAM154B using alignment to 6 protein entries:     F154B_HUMAN (see all proteins):
    FAM154A    C9orf138

    FAM154B for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for FAM154B
    PGOHUM00000246897 PGOHUM00000262230 PGOHUM00000262231


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/380 SNPs in FAM154B are shown (see all 380)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1496030651,2
    Cuntested182575038(+) ATTTTC/G/TCTTTC 2 P S mis11NA 4498
    VAR_0393594
    ----see VAR_0393592 S G mis40--------
    rs1837539851,2
    --82557143(+) AATCAA/GGATGC 1 -- int10--------
    rs1866796791,2
    --82557198(+) TTCCAC/TGCAAG 1 -- int10--------
    rs1476812301,2
    --82557270(+) TGTGAA/CTACAC 1 -- int10--------
    rs1928256871,2
    --82557354(+) CTTCTA/GTAGTG 1 -- int10--------
    rs1848744451,2
    --82557473(+) GTTTTG/TGGGGG 1 -- int10--------
    rs1901129561,2
    --82557478(+) TGGGGG/TTTTTT 1 -- int10--------
    rs19660261,2
    F,A--82557543(+) gtggcA/Cggatc 1 -- int12Minor allele frequency- C:0.00NA 4
    rs19660271,2
    F,A--82557544(+) tggcaG/Cgatct 1 -- int12Minor allele frequency- C:0.00NA 4

    HapMap Linkage Disequilibrium report for FAM154B (82555151 - 82577271 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for FAM154B:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2663603CNV Deletion23128226
    nsv904442CNV Loss21882294
    nsv904443CNV Loss21882294
    dgv321n27CNV Gain19166990
    dgv2427n71CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed article for FAM154B gene integrated from 9 sources:
    (articles sorted by number of sources associating them with FAM154B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 283726 HGNC: 33727 AceView: LOC283726 Ensembl:ENSG00000188659 euGenes: HUgn283726
    ECgene: FAM154B H-InvDB: FAM154B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FAM154B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FAM154B gene:
    Search GeneIP for patents involving FAM154B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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     Regulatory tfbs in FAM154B promoter
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     Proteins for FAM154B
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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