FAM154B Gene
protein-coding GIFtS: 39
GCID: GC15P082555 (predicted)
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family with sequence similarity 154, member B
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Aliases
for FAM154B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Family With Sequence Similarity 154, Member B1 2 | | DKFZp666G0571 | | Protein FAM154B2 |
Export aliases for FAM154B gene to outside databasesPrevious GC identifers: GC15P080345 GC15P059313 |
Summaries
for FAM154B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FAM154B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FAM154B gene promoter:
Bach1 Bach2 CUTL1 POU6F1 (c2) E47 FAC1 POU2F1 POU2F1b POU2F1a Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM154B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM154B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q25.2 Ensembl cytogenetic band: 15q25.2 HGNC cytogenetic band: 15q25.2FAM154B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15P082555: view genomic region
(about GC identifiers)
Start:
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82,555,151 bp from pter |
End:
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82,577,271 bp from pter |
Size:
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22,121 bases |
Orientation:
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plus strand |
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Proteins
for FAM154B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: F154B_HUMAN, Q658L1 (See
protein sequence)Recommended Name: Protein FAM154B Size: 398 amino acids; 45933 Da
Caution: It is uncertain whether Met-1 or Met-6 is the initiatorExplore the universe of human proteins at neXtProt for FAM154B: NX_Q658L1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q658L1
FAM154B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001008227.1
ENSEMBL proteins: ENSP00000454320 ENSP00000340445 ENSP00000455158 ENSP00000455957 ENSP00000458067 ENSP00000403743
Human Recombinant Protein Products:
FAM154B Antibody Products:
Assay Products for FAM154B: |
Protein
Domains /
Families
for FAM154B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FAM154B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q658L1ProtoNet protein and cluster: Q658L1 UniProtKB/Swiss-Prot: F154B_HUMAN, Q658L1Similarity: Belongs to the FAM154 family |
Function
for FAM154B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM154B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM154B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FAM154B (NM_001008226) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM154B | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FAM154B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM154B |
|
Pathways & Interactions
for FAM154B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM154B
|
Drugs & Compounds
for FAM154B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM154B
Search CenterWatch for drugs/clinical trials and news about FAM154B / F154B
|
Transcripts
for FAM154B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAM154B gene: NM_001008226.1 Unigene Cluster for FAM154B: Family with sequence similarity 154, member B Hs.459117 [show with all ESTs]Unigene Representative Sequence: AL8337629 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000566205 ENST00000339465(uc002bgv.3 uc010unr.2 uc010uns.2)
ENST00000569120 ENST00000566861 ENST00000562097 ENST00000565432 ENST00000565501
ENST00000565006 ENST00000427381
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM154B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM154B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FAM154B (NM_001008226) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM154B | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FAM154B |
Additional cDNA sequence: AK304339.1 AL833762.1 BC144647.1 8 DOTS entries: DT.40308732 DT.121016311 DT.304000 DT.92026519 DT.95103894 DT.92416121 DT.99971544 DT.121016325 20 AceView cDNA sequences: BU689608 BF942406 AL833762 AA649001 AA995196 BX090922 BF942184 CB215774 AA835037 BU607937 BM979289 BU634076 AI916879 BF942237 BM931241 AI761990 BU743090 AW665398 AI634060 AI867815
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for FAM154B About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 |
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| SP1: | | | | | - | | - | | - | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | | | | | | | | | |
| SP3: | | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | | | | | | | | |
ECgene alternative splicing isoforms for FAM154B
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Expression
for FAM154B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAM154B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAACATAATA
About this image
See FAM154B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM154B
SOURCE GeneReport for Unigene cluster: Hs.459117
SABiosciences Custom PCR Arrays for FAM154B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM154B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FAM154B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM154B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM154B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM154B |
Orthologs
for FAM154B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FAM154B gene from 6/20 species (see all 20) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Fam154b1 , 5 |
family with sequence similarity 154, member B1, 5 |
86.68(n)1
83.97(a)1 |
|
7 (47.25 cM)5
3305771 NM_177894.41 NP_808562.31
826329605 |
chicken
(Gallus gallus) |
Aves |
FAM154B1 |
family with sequence similarity 154, member B |
67.7(n)
58.91(a) |
|
427505 XM_425077.3 XP_425077.3 |
lizard
(Anolis carolinensis) |
Reptilia |
FAM154B6 |
-- |
45(a) |
1 ↔ 1 |
GL343740.1(57161-60458) |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.154682 |
Transcribed sequences |
82.09(n) |
|
BM316330.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG71316 |
-- |
15(a) |
possible ortholog |
3R(14112342-14114499) |
worm
(Caenorhabditis elegans) |
Secernentea |
T08G11.36 |
Protein T08G11.3 |
15(a) |
1 → many |
I(8921183-8925320) |
ENSEMBL Gene Tree for FAM154B (if available)
TreeFam Gene Tree for FAM154B (if available) |
Paralogs
for FAM154B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAM154B gene
- FAM154A2
2 SIMAP similar genes for FAM154B using alignment to 6 protein entries: F154B_HUMAN (see all proteins):FAM154A C9orf138
FAM154B for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for FAM154B
PGOHUM00000246897 PGOHUM00000262230 PGOHUM00000262231
|
Genomic Variants
for FAM154B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM154B (82555151 - 82577271 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FAM154B
1 CNV: 53109 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM154B |
|
Disorders
/ Diseases
for FAM154B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FAM154B for disorders About GeneDecksing
1  disease for FAM154B: About MalaCardsmalaria
Export disorders for FAM154B gene to outside databases
|
Publications
for FAM154B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed article for FAM154B gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM154B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
|
External Searches for FAM154B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FAM154B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM154B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FAM154B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAM154B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FAM154B gene:
Search GeneIP for patents involving FAM154B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM154B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FAM154B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM154B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM154B | | | OriGene Protein Over-expression Lysate for FAM154B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FAM154B | | OriGene 3'-UTR Clone for FAM154B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM154B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM154B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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 |
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| |
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| | | | Search Tocris compounds for FAM154B |
| |  |  |  |  | | | | |
 |
 |
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 | | | FAM154B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM154B |
|  |  |  | | | | Search ThermoFisher Antibodies for FAM154B |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FAM154B |
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