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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FAM154A Gene

protein-coding GIFtS: 46
GCID: GC09M018920

family with sequence similarity 154, member A

(Previous name: chromosome 9 open reading frame 138 )
(Previous symbol: C9orf138)

Explore 1 disease affiliated with
FAM154A via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Family With Sequence Similarity 154, Member A¹ ²
C9orf138¹ ² ³
MGC35182¹
Chromosome 9 Open Reading Frame 138¹
4930500O09Rik²
Protein FAM154A²

External Ids:	HGNC: 28566¹	Entrez Gene: 158297²	Ensembl: ENSG00000155875⁷	UniProtKB: Q8IYX7³

Export aliases for FAM154A gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008413.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FAM154A gene promoter:
AML1a Egr-1 FOXO3 CUTL1 Arnt FOXO3a Cart-1 Pax-4a Zic3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FAM154A promoter sequence

Search SABiosciences Chromatin IP Primers for FAM154A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM154A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p22.1 Ensembl cytogenetic band: 9p22.1 HGNC cytogenetic band: 9p22.1

FAM154A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM154A gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M018920: view genomic region (about GC identifiers)

Start:	18,927,656 bp from pter	End:	19,033,256 bp from pter
Size:	105,601 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: F154A_HUMAN, Q8IYX7 (See protein sequence)

Recommended Name: Protein FAM154A

Size: 474 amino acids; 54621 Da

Secondary accessions: Q5VY58

Explore the universe of human proteins at neXtProt for FAM154A: NX_Q8IYX7

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8IYX7

FAM154A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_714918.2

ENSEMBL proteins:

ENSP00000369907 ENSP00000369902 ENSP00000438823

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FAM154A for domains About GeneDecksing

1 InterPro domain/family:

IPR024963 STOP/FAM154

Graphical View of Domain Structure for InterPro Entry Q8IYX7

ProtoNet protein and cluster: Q8IYX7

UniProtKB/Swiss-Prot: F154A_HUMAN, Q8IYX7

Similarity: Belongs to the FAM154 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--

FAM154A for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for FAM154A:

Increased HPV18 LCR reporter a

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for FAM154A

1 Interacting protein for FAM154A (Q8IYX7¹) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
Hoxa1	P09022¹	EBI-3957636,EBI-3957603

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FAM154A
Search CenterWatch for drugs/clinical trials and news about FAM154A / F154A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FAM154A gene:

NM_153707.2

Unigene Cluster for FAM154A:

Family with sequence similarity 154, member A

Hs.731593 [show with all ESTs]

Unigene Representative Sequence: NM_153707

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000380534(uc003zni.2) ENST00000380530 ENST00000583128 ENST00000542071(uc010mip.2)

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Additional cDNA sequence:

AK057474.1 AK292245.1 BC033489.1

10 DOTS entries:

DT.100011962 DT.75142641 DT.441369 DT.100868161 DT.121185923 DT.95245194 DT.95245189 DT.100703083

DT.100705909 DT.100868150

24/25 AceView cDNA sequences (see all 25):

AW274676 AA442292 AK057474 BM563230 AA992255 AA868582 AA629329 NM_153707

BC033489 AA774548 BX119445 BI831917 AI014701 AW079914 BI826610 AA907910

BI462463 AA758280 AI183957 AI208210 AA634496 AA437228 AI192031 AI808568

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for FAM154A About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4a	·	4b	^	5	^	6	^	7
SP1:							-		-						-
SP2:
SP3:							-		-						-		-
SP4:							-		-

ECgene alternative splicing isoforms for FAM154A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FAM154A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CGCACAGAGC

About this image

FAM154A expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Antral Follicle

Secondary Oocyte

Female Gametocytes, Germ Cells

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See FAM154A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM154A

SOURCE GeneReport for Unigene cluster: Hs.731593

SABiosciences Custom PCR Arrays for FAM154A

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM154A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for FAM154A gene from 2/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
fruit fly (Drosophila melanogaster)	Insecta	CG7131⁶	--	16(a)	possible ortholog	3R(14112342-14114499)
worm (Caenorhabditis elegans)	Secernentea	T08G11.3⁶	Protein T08G11.3	18(a)	1 → many	I(8921183-8925320)

ENSEMBL Gene Tree for FAM154A (if available)
TreeFam Gene Tree for FAM154A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FAM154A gene

FAM154B²

2 SIMAP similar genes for FAM154A using alignment to 3 protein entries: F154A_HUMAN (see all proteins):

C9orf138 FAM154B

FAM154A for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs755168^1,2	C,F,O,A,H,	--	18927464(+)	`TTGCTC/G/TGTATG`	1	--	int¹		16		NA EA NS CSA WA	1038
rs184561710^1,2		--	18927583(+)	`CAATGC/GGGGTG`	1	--	int¹		0	--	--	--	--
rs115290897^1,2	F,	--	18927641(+)	`GCATAG/ACCAGC`	1	--	int¹		1		WA	118
rs945442^1,2	C,F,O,A,H,	--	18927768(+)	`AGAAAA/CCCTCA`	1	--	int¹ ese³		31		MN NA NS EA WA CSA	3100
rs945443^1,2	C,F,O,A,H,	--	18927818(+)	`TGAAAC/TGGGGT`	1	--	int¹ ese³		11		MN NS EA NA	1566
rs1052462^1,2	C,F,	--	18927821(-)	`CCCACC/ACCGTT`	1	--	int¹ ese³		5		MN NA CSA WA	427
rs188177138^1,2		--	18927864(+)	`TTAGCA/CGGTGA`	1	--	int¹		0	--	--	--	--
rs3839881^1,2	C,	--	18927886(-)	`GACTC-/AGGGAAA`	1	--	int¹		0	--	--	--	--
rs1052448^1,2	C,F,O,A,H,	--	18928039(-)	`AAAAAT/CAGTAA`	1	--	ut3¹		26		MN NA NS EA EU	4005
rs35562117^1,2	C,F,	--	18928083(-)	`GAAAAC/ACCCAA`	2	/K /N	mis¹		5		NA CSA WA EA	4848

HapMap Linkage Disequilibrium report for FAM154A (18927656 - 19033256 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for FAM154A
2 CNVs: 52767 52762
Human Gene Mutation Database (HGMD): FAM154A

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FAM154A for disorders About GeneDecksing

1 disease for FAM154A: About MalaCards

malaria

Human Genome Epidemiology (HuGE) Navigator: FAM154A (1 document)

Export disorders for FAM154A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FAM154A gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM154A)

Utopia: connect your pdf to the dynamic
world of online information

DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{1, 2} Humphray S.J.... Dunham I. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 158297	HGNC: 28566	AceView: C9orf138	Ensembl:ENSG00000155875	euGenes: HUgn158297
ECgene: FAM154A	H-InvDB: FAM154A

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FAM154A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FAM154A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for FAM154A gene:
Search GeneIP for patents involving FAM154A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
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About This Section


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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM154A

	SwitchGear 3'UTR luciferase reporter plasmids for FAM154A
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM154A

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes FAM154A gene at Home site.

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FAM154A Gene

family with sequence similarity 154, member A

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FAM154A Gene

family with sequence similarity 154, member A

Aliasesfor FAM154A gene

Summariesfor FAM154A gene

Genomic Viewsfor FAM154A gene

Proteinsfor FAM154A gene

Protein Domains /Familiesfor FAM154A gene

Functionfor FAM154A gene

Pathways & Interactionsfor FAM154A gene

Drugs & Compoundsfor FAM154A gene

Transcriptsfor FAM154A gene

Expression for FAM154A gene

Orthologsfor FAM154A gene

Paralogsfor FAM154A gene

Genomic Variantsfor FAM154A gene

Disorders / Diseasesfor FAM154A gene

Publicationsfor FAM154A gene

External Searches for FAM154A gene

Genome Databases showing FAM154A gene

Other Databases showing FAM154A gene

Specialized Databases showing FAM154A gene

Intellectual Propertyfor FAM154A gene

Productsfor FAM154A gene

View Random Gene

Aliases
for FAM154A gene

Summaries
for FAM154A gene

Genomic Views
for FAM154A gene

Proteins
for FAM154A gene

Protein Domains /
Families
for FAM154A gene

Function
for FAM154A gene

Pathways & Interactions
for FAM154A gene

Drugs & Compounds
for FAM154A gene

Transcripts
for FAM154A gene

Expression
for FAM154A gene

Orthologs
for FAM154A gene

Paralogs
for FAM154A gene

Genomic Variants
for FAM154A gene

Disorders / Diseases
for FAM154A gene

Publications
for FAM154A gene

Intellectual Property
for FAM154A gene

Products
for FAM154A gene