Aliases for FAM153C Gene
Aliases for FAM153C Gene
External Ids for FAM153C Gene
- HGNC: 33936
- Entrez Gene: 653316
- Ensembl: ENSG00000204677
- UniProtKB: Q494X1
Previous GeneCards Identifiers for FAM153C Gene
- GC05P177369
- GC05P177435
- GC05P172169
- GC05P177437
- GC05P177440
- GC05P177445
- GC05P177448
- GC05P177451
Summaries for FAM153C Gene
GeneCards Summary for FAM153C Gene
FAM153C (Family With Sequence Similarity 153 Member C) is a Protein Coding gene. An important paralog of this gene is FAM153B.
Additional gene information for FAM153C Gene
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM153C Gene
Genomics for FAM153C Gene
GeneHancer (GH) Regulatory Elements for FAM153C Gene
Promoters and enhancers for FAM153C Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH05I178006 | Enhancer | 0.2 | Ensembl | 550.8 | +0.1 | 96 | 0.2 | FAM153C LOC100288656 PIR57455 | ||
| GH05I177591 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE | 17.2 | -414.0 | -413975 | 1.8 | SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 ZNF207 ZNF143 | TMED9 FAM153C B4GALT7 | |
| GH05I177606 | Enhancer | 0.8 | ENCODE | 18.6 | -398.9 | -398944 | 1.9 | RB1 ARID4B KLF17 SIN3A ZNF2 ZNF48 RAD21 ZNF335 SCRT2 ZNF143 | B4GALT7 FAM153C LOC202181 FAM153A TMED9 ENSG00000247679 | |
| GH05I178077 | Enhancer | 1 | Ensembl ENCODE | 10.1 | +72.0 | 72002 | 1.2 | HDGF PKNOX1 CLOCK NFIB NEUROD1 SIN3A ZBTB7B EGR1 E2F8 FOS | FAM193B ZNF354B RMND5B N4BP3 NSD1 LOC202181 HNRNPAB RPL21P60 ENSG00000247679 FAM153C | |
| GH05I178086 | Enhancer | 1 | ENCODE dbSUPER | 7.8 | +80.1 | 80109 | 0.7 | HDGF PKNOX1 NFIB SIN3A ZBTB7B RFX5 ELK1 EGR1 HSF1 FOS | N4BP3 RMND5B FAM153C RPL19P9 LOC105377754 PIR41367 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around FAM153C on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for FAM153C Gene
Genomic Locations for FAM153C Gene
- chr5:178,006,405-178,055,559
- (GRCh38/hg38)
- Size:
- 49,155 bases
- Orientation:
- Plus strand
- chr5:177,433,406-177,482,560
- (GRCh37/hg19)
Genomic View for FAM153C Gene
Genes around FAM153C on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q35.3 by Ensembl
- 5q35.3 by Entrez Gene
- 5q35.3 by HGNC
FAM153C Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FAM153C Gene
Proteins for FAM153C Gene
-
Protein details for FAM153C Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q494X1-F153C_HUMAN
- Recommended name:
- Protein FAM153C
- Protein Accession:
- Q494X1
- A4IF33
- B2RUV5
- B7ZW12
Protein attributes for FAM153C Gene
- Size:
- 144 amino acids
- Molecular mass:
- 16640 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for FAM153C Gene
No Post-translational modifications
Other Protein References for FAM153C Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for FAM153C
- Invitrogen Antibodies for FAM153C
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Protein Products
-
OriGene Purified Proteins for FAM153C
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Assay Products
No data available for DME Specific Peptides for FAM153C Gene
Domains & Families for FAM153C Gene
Gene Families for FAM153C Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for FAM153C Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q494X1- Family:
-
- Belongs to the FAM153 family.
Function for FAM153C Gene
Phenotypes From GWAS Catalog for FAM153C Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 25416956 |
Phenotypes for FAM153C Gene
- GenomeRNAi human phenotypes for FAM153C:
Animal Model Products
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-
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CRISPR Products
-
OriGene CRISPR knockouts for FAM153C
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- Overview of 21 available FAM153C gene related products
- Applied Biological Materials CRISPR for FAM153C
-
Vectors and viruses for KO, Activation, Repression, and more
miRNA Products
- Search ViGene Biosciences for FAM153C
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for FAM153C
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- genomics-online: shRNA clones - Search results for 21 available FAM153C gene related products
- Overview of 21 available FAM153C gene related products
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for FAM153C
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM153C Gene
Localization for FAM153C Gene
| Compartment | Confidence |
|---|---|
| nucleus | 2 |
| cytosol | 2 |
| extracellular | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for FAM153C Gene
Transcripts for FAM153C Gene
mRNA/cDNA for FAM153C Gene
- (2) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (13) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FAM153C Gene
CRISPR Products
-
OriGene CRISPR knockouts for FAM153C
- genomics-online: gRNA clones - Search results for 21 available FAM153C gene related products
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-
Vectors and viruses for KO, Activation, Repression, and more
miRNA Products
- Search ViGene Biosciences for FAM153C
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for FAM153C
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- genomics-online: shRNA clones - Search results for 21 available FAM153C gene related products
- Overview of 21 available FAM153C gene related products
- Search ViGene Biosciences for FAM153C
Clone Products
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- VectorBuilder custom plasmid, inducible vectors for FAM153C
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FAM153C
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for FAM153C
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for FAM153C Gene
mRNA differential expression in normal tissues according to GTEx for FAM153C Gene
This gene is overexpressed in Brain - Cerebellum (x8.7), Brain - Cerebellar Hemisphere (x8.0), Testis (x5.2), and Pituitary (x5.0).
NURSA nuclear receptor signaling pathways regulating expression of FAM153C Gene:
FAM153CSOURCE GeneReport for Unigene cluster for FAM153C Gene:
Hs.652193Primer Products
-
OriGene qPCR primer pairs for FAM153C
- genomics-online: primer clones - Search results for 21 available FAM153C gene related products
- Overview of 21 available FAM153C gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM153C Gene
Orthologs for FAM153C Gene
This gene was present in the common ancestor of human and chimp.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany |
- Species where no ortholog for FAM153C was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for FAM153C Gene
(2) SIMAP similar genes for FAM153C Gene using alignment to 4 proteins:
Variants for FAM153C Gene
| SNP ID | Clin | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000040781 | -- | 178,024,758(+) | T/G | intron_variant | |
| rs1000300940 | -- | 178,044,264(+) | A/G | intron_variant | |
| rs1000339723 | -- | 178,005,583(+) | A/G | upstream_transcript_variant | |
| rs1000481726 | -- | 178,016,005(+) | A/G | intron_variant | |
| rs1000496265 | -- | 178,015,820(+) | T/C | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv5844n100 | CNV | gain | 25217958 |
| nsv1115711 | CNV | duplication | 24896259 |
| nsv1120062 | OTHER | inversion | 24896259 |
| nsv509105 | CNV | insertion | 20534489 |
| nsv950729 | CNV | deletion | 24416366 |
| nsv968283 | CNV | duplication | 23825009 |
| nsv968284 | CNV | duplication | 23825009 |
| nsv969026 | CNV | duplication | 23825009 |
| nsv969092 | CNV | duplication | 23825009 |
| nsv980768 | CNV | duplication | 23825009 |
Gene Damage Index Score:
0.07;
1.61% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FAM153C Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FAM153C
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM153C Gene
Disorders for FAM153C Gene
Additional Disease Information for FAM153C
No disorders were found for FAM153C Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM153C Gene
Publications for FAM153C Gene
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
- A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
Products for FAM153C Gene
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- VectorBuilder custom plasmid, inducible vectors for FAM153C
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FAM153C
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneTex for Antibodies for FAM153C
- Search GeneTex for Proteins for FAM153C
- genomics-online: cdna clones - Search results for 21 available FAM153C gene related products
- Overview of 21 available FAM153C gene related products
- orf clones - Search results for 21 available FAM153C gene related products
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- genomics-online: gRNA clones - Search results for 21 available FAM153C gene related products
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- genomics-online: primer clones - Search results for 21 available FAM153C gene related products
- Overview of 21 available FAM153C gene related products
- genomics-online: shRNA clones - Search results for 21 available FAM153C gene related products
- Overview of 21 available FAM153C gene related products
Sources for FAM153C Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew