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Aliases for FAM153C Gene

Aliases for FAM153C Gene

  • Family With Sequence Similarity 153 Member C 2 5
  • Family With Sequence Similarity 153, Member C, Pseudogene 3
  • Family With Sequence Similarity 153, Member C 2
  • NY-REN-7-Like 3

External Ids for FAM153C Gene

Previous GeneCards Identifiers for FAM153C Gene

  • GC05P177369
  • GC05P177435
  • GC05P172169
  • GC05P177437
  • GC05P177440
  • GC05P177445
  • GC05P177448
  • GC05P177451

Summaries for FAM153C Gene

GeneCards Summary for FAM153C Gene

FAM153C (Family With Sequence Similarity 153 Member C) is a Pseudogene. An important paralog of this gene is FAM153B.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM153C Gene

Genomics for FAM153C Gene

Regulatory Elements for FAM153C Gene

Enhancers for FAM153C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G177591 1.1 ENCODE 17.2 -414.0 -413975 1.8 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF207 ZNF143 ZNF263 FAM153C TMED9 B4GALT7
GH05G177606 0.9 ENCODE 18.5 -398.9 -398944 1.9 RB1 ARID4B SIN3A KLF17 ZNF2 ZNF48 RAD21 SCRT2 ZNF143 MIXL1 B4GALT7 FAM153C LOC202181 FAM153A TMED9 ENSG00000247679
GH05G178077 1.1 Ensembl ENCODE 10.1 +72.0 72002 1.2 HDGF PKNOX1 NFIB AGO1 SIN3A ZBTB7B EGR1 FOS RCOR1 HCFC1 RMND5B N4BP3 FAM153C RPL19P9 CLK4 LOC105377754 PIR41367
GH05G178086 1.1 ENCODE dbSUPER 7.8 +80.1 80109 0.7 HDGF PKNOX1 NFIB SIN3A ZBTB7B ELK1 EGR1 HSF1 FOS RCOR1 N4BP3 RMND5B FAM153C RPL19P9 LOC105377754 PIR41367
GH05G177615 0.4 FANTOM5 19.4 -390.5 -390514 0.6 FAM153C ENSG00000247679 B4GALT7 TMED9 NSD1 FAM193B PIR49975
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM153C on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM153C Gene

Chromosome:
5
Start:
178,006,405 bp from pter
End:
178,055,559 bp from pter
Size:
49,155 bases
Orientation:
Plus strand

Genomic View for FAM153C Gene

Genes around FAM153C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM153C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM153C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM153C Gene

Proteins for FAM153C Gene

  • Protein details for FAM153C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q494X1-F153C_HUMAN
    Recommended name:
    Protein FAM153C
    Protein Accession:
    Q494X1
    Secondary Accessions:
    • A4IF33
    • B2RUV5
    • B7ZW12

    Protein attributes for FAM153C Gene

    Size:
    144 amino acids
    Molecular mass:
    16640 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM153C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM153C Gene

Post-translational modifications for FAM153C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM153C Gene

No data available for DME Specific Peptides for FAM153C Gene

Domains & Families for FAM153C Gene

Protein Domains for FAM153C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM153C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q494X1

UniProtKB/Swiss-Prot:

F153C_HUMAN :
  • Belongs to the FAM153 family.
Family:
  • Belongs to the FAM153 family.
genes like me logo Genes that share domains with FAM153C: view

No data available for Gene Families for FAM153C Gene

Function for FAM153C Gene

Gene Ontology (GO) - Molecular Function for FAM153C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM153C: view

Phenotypes for FAM153C Gene

GenomeRNAi human phenotypes for FAM153C:
genes like me logo Genes that share phenotypes with FAM153C: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM153C Gene

Localization for FAM153C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM153C gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM153C Gene

Pathways & Interactions for FAM153C Gene

SuperPathways for FAM153C Gene

No Data Available

Interacting Proteins for FAM153C Gene

Selected Interacting proteins: Q494X1-F153C_HUMAN for FAM153C Gene via UniProtKB IID

Gene Ontology (GO) - Biological Process for FAM153C Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM153C Gene

Drugs & Compounds for FAM153C Gene

No Compound Related Data Available

Transcripts for FAM153C Gene

mRNA/cDNA for FAM153C Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM153C Gene

Family with sequence similarity 153, member C, pseudogene:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM153C Gene

No ASD Table

Relevant External Links for FAM153C Gene

GeneLoc Exon Structure for
FAM153C
ECgene alternative splicing isoforms for
FAM153C

Expression for FAM153C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM153C Gene

mRNA differential expression in normal tissues according to GTEx for FAM153C Gene

This gene is overexpressed in Brain - Cerebellum (x8.7), Brain - Cerebellar Hemisphere (x8.0), Testis (x5.2), and Pituitary (x5.0).

NURSA nuclear receptor signaling pathways regulating expression of FAM153C Gene:

FAM153C

SOURCE GeneReport for Unigene cluster for FAM153C Gene:

Hs.652193
genes like me logo Genes that share expression patterns with FAM153C: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM153C Gene

Orthologs for FAM153C Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for FAM153C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 97 (a)
ManyToMany
-- 35
  • 35 (a)
ManyToMany
Species where no ortholog for FAM153C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM153C Gene

ENSEMBL:
Gene Tree for FAM153C (if available)
TreeFam:
Gene Tree for FAM153C (if available)

Paralogs for FAM153C Gene

Paralogs for FAM153C Gene

(2) SIMAP similar genes for FAM153C Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FAM153C: view

Variants for FAM153C Gene

Sequence variations from dbSNP and Humsavar for FAM153C Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000040781 -- 178,024,758(+) TTGCC(G/T)GTTCA intron-variant
rs1000300940 -- 178,044,264(+) GCCAA(A/G)AGTCT intron-variant, downstream-variant-500B
rs1000339723 -- 178,005,583(+) ATGAA(A/G)TGCTG upstream-variant-2KB
rs1000481726 -- 178,016,005(+) ACTGT(A/G)TACTC intron-variant
rs1000496265 -- 178,015,820(+) GAGAA(C/T)TGACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM153C Gene

Variant ID Type Subtype PubMed ID
dgv5844n100 CNV gain 25217958
nsv1115711 CNV duplication 24896259
nsv1120062 OTHER inversion 24896259
nsv509105 CNV insertion 20534489
nsv950729 CNV deletion 24416366
nsv968283 CNV duplication 23825009
nsv968284 CNV duplication 23825009
nsv969026 CNV duplication 23825009
nsv969092 CNV duplication 23825009
nsv980768 CNV duplication 23825009

Variation tolerance for FAM153C Gene

Gene Damage Index Score: 0.07; 1.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM153C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM153C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM153C Gene

Disorders for FAM153C Gene

Relevant External Links for FAM153C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM153C

No disorders were found for FAM153C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM153C Gene

Publications for FAM153C Gene

  1. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for FAM153C Gene

Sources for FAM153C Gene

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