FAM153C Gene
protein-coding GIFtS: 31
GCID: GC05P177451
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Family With Sequence Similarity 153, Member C
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Aliases
for FAM153C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
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| Aliases |
|---|
| Family With Sequence Similarity 153, Member C1 | | NY-REN-7-like2 | | Family With Sequence Similarity 153, Member C, Pseudogene2 |
Export aliases for FAM153C gene to outside databasesPrevious GC identifers: GC05P177369 GC05P177435 GC05P172169 GC05P177437 GC05P177440 GC05P177445 GC05P177448 |
Summaries
for FAM153C gene(According to Entrez Gene,
GeneCards,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
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GeneCards Summary for FAM153C Gene:
FAM153C (family with sequence similarity 153, member C) is a protein-coding gene. An important paralog of this gene is FAM153B.
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Genomic Views
for FAM153C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 75),
Regulatory elements and Epigenetics data according to
QIAGEN, and/or
SwitchGear Genomics)
About This Section
TryGeneCards Plus | RefSeq DNA sequence:- NC_000005.10 NC_018916.2 NT_023133.14
Regulatory elements:
 Regulatory transcription factor binding sites in the FAM153C gene promoter:
Pax-5 Tal-1 p53 SREBP-1c STAT5A YY1 Gfi-1 SREBP-1b E47 SREBP-1a
Other transcription factors
Search Chromatin IP Primers for FAM153C
Epigenetics:
| | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM153C |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q35.3 Ensembl cytogenetic band: 5q35.3 HGNC cytogenetic band: 5q35.3FAM153C Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P177451: view genomic region
(about GC identifiers)
Start:
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177,433,406 bp from pter |
End:
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177,482,560 bp from pter |
Size:
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49,155 bases |
Orientation:
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plus strand |
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Proteins
for FAM153C gene
(According to
1UniProtKB,
HORDE,
2neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Antibodies by
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
About This Section
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UniProtKB/Swiss-Prot: F153C_HUMAN, Q494X1 (See
protein sequence)Recommended Name: Protein FAM153C Size: 144 amino acids; 16640 Da
Secondary accessions: A4IF33 B2RUV5 B7ZW12Alternative splicing: 2 isoforms: Q494X1-1 Q494X1-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for FAM153C: NX_Q494X1
Explore proteomics data for FAM153C at MOPED
See FAM153C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB
ENSEMBL proteins: ENSP00000423403 ENSP00000424623 ENSP00000381177 ENSP00000422293 ENSP00000426621
FAM153C Human Recombinant
Protein Products:FAM153C Antibody
Products:FAM153C Assay Products: |
Domains /
Families
for FAM153C gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
TryGeneCards Plus | 1 InterPro protein domain:Graphical View of Domain Structure for InterPro Entry Q494X1 ProtoNet protein and cluster: Q494X1 UniProtKB/Swiss-Prot: F153C_HUMAN, Q494X1Similarity: Belongs to the FAM153 family
FAM153C for domains About GeneDecksing
|
Function
for FAM153C gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
genOway,
transcription factor targeting from QIAGEN
and/or HOMER,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
SwitchGear Genomics,
Gene Editing from DNA2.0,
Clones from OriGene,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
ESI BIO,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
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Animal Models:
Inhib. RNA
Products: |  | OriGene RNAi products in human, mouse, rat for FAM153C
| | | Predesigned siRNA for gene silencing in human, mouse, rat FAM153C |
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for FAM153C | |  | Browse ESI BIO Cell Lines and PureStem Progenitors for FAM153C  | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM153C |
Localization
for FAM153C gene
(According to UniProtKB, COMPARTMENTS Subcellular localization database,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
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Subcellular locations from COMPARTMENTS:
| Compartment | Confidence |
|---|
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| cytosol | 2 | | nucleus | 2 | | extracellular | 1 |
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Pathways & Interactions
for FAM153C gene
(SuperPaths according to PathCards,
Pathways according to
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
QIAGEN,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene).
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Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM153C
Interactions:
Search GeneGlobe Interaction Network for FAM153C
STRING Interaction
Network Preview (showing 5 interactants - click image to see 13)
Selected Interacting proteins for FAM153C (ENSP000003811774) via UniProtKB, MINT, STRING, and/or I2D (see all 13)About this table
|
Drugs & Compounds
for FAM153C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience,
ApexBio,
HMDB,
BitterDB, and/or
Novoseek,
Ligands according to IUPHAR,
and Drugs according to DrugBank,
Enzo Life Sciences, and/or
PharmGKB)
About This Section
TryGeneCards Plus |  Browse compounds at ApexBio
 Browse Tocris compounds for FAM153C (F153C)
|
Transcripts
for FAM153C gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
SwitchGear Genomics,
Tagged/untagged cDNA clones from
OriGene,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene, and/or
QIAGEN
)
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REFSEQ mRNAs for FAM153C gene: NM_001079527.1 Unigene Cluster for FAM153C: Family with sequence similarity 153, member C, pseudogene Hs.652193 [show with all ESTs]Unigene Representative Sequence: BC10133912 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000504530 ENST00000505582 ENST00000507848(uc011dge.2) ENST00000508839
ENST00000505394 ENST00000398106 ENST00000511856 ENST00000511189 ENST00000511511
ENST00000511819 ENST00000506096 ENST00000515878
Inhib. RNA
Products: | | OriGene RNAi products in human, mouse, rat for FAM153C
| |
| | Predesigned siRNA for gene silencing in human, mouse, rat FAM153C |
Primer
Products: | | OriGene qSTAR qPCR primer pairs in human, mouse for FAM153C
| | | Pre-validated RT2 qPCR Primer Assay in human, mouse / rat FAM153C | | | QuantiTect SYBR Green Assays in human, mouse, rat FAM153C | | | QuantiFast Probe-based Assays in human, mouse, rat FAM153C |
Additional mRNA sequence: AK294762.1 BC101339.2 BC101340.2 BC131737.1 BC171810.1 NR_038353.1 7 DOTS entries: DT.120888808 DT.87009802 DT.92015534 DT.99966427 DT.95257498 DT.100748401 DT.120888805
GeneLoc Exon Structure
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Expression
for FAM153C gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MaxQB,
plus additional links to
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
QIAGEN,
Primers from
OriGene, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
TryGeneCards Plus | FAM153C expression in normal human tissues
(normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AATCCCCCTG
About this image FAM153C Protein expression data from MOPED1, PaxDb2 and
MaxQB3:  About this image
SOURCE GeneReport for Unigene cluster: Hs.652193
Custom PCR Arrays for FAM153C
Primer
Products: | | OriGene qSTAR qPCR primer pairs in human, mouse for FAM153C
| | | Pre-validated RT2 qPCR Primer Assay in human, mouse / rat FAM153C | | | QuantiTect SYBR Green Assays in human, mouse, rat FAM153C | | | QuantiFast Probe-based Assays in human, mouse, rat FAM153C | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM153C |
Orthologs
for FAM153C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
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This gene was present in the common ancestor of human and chimp.
Orthologs for FAM153C gene from 1 species (see representative species ) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chimpanzee
(Pan troglodytes) |
Mammalia |
---- |
Uncharacterized protein |
97(a)35(a) |
many ↔ manymany ↔ many |
5(179106609-179161675) 5(177153557-177195644) |
ENSEMBL Gene Tree for FAM153C (if available)
TreeFam Gene Tree for FAM153C (if available) |
Paralogs
for FAM153C gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
TryGeneCards Plus | Paralogs for FAM153C gene
- FAM153B2 FAM153A2
2 SIMAP similar genes for FAM153C using alignment to 4 protein entries: F153C_HUMAN (see all proteins):FAM153A FAM153B
FAM153C for paralogs About GeneDecksing
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Genomic Variants
for FAM153C gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD), the Human Cytochrome P450 Allele
Nomenclature Database, and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM153C (177433406 - 177482560 bp)
Structural Variations
Database of Genomic Variants (DGV) 4 variations for FAM153C: About this table
| | Site Specific Mutation Identification with PCR Assays |
|
Disorders
/ Diseases
for FAM153C gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
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TryGeneCards Plus | -- |
Publications
for FAM153C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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PubMed articles for FAM153C gene integrated from 10 sources:
(articles sorted by number of sources associating them with FAM153C) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
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External Searches for FAM153C gene (in PubMed,
OMIM, and NCBI Bookshelf)
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|
Genome Databases showing FAM153C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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|
Other Databases showing FAM153C gene
(According to HUGE)
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Specialized Databases showing FAM153C gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for FAM153C | Pharmacogenomics, SNPs, Pathways |
|
| | |
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TryGeneCards Plus | Patent Information for FAM153C gene:
Search GeneIP for patents involving FAM153C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM153C gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or
ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory,
genOway)
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|  | Block miRNA regulation of human, mouse, rat FAM153C using miScript Target Protectors | | SeqTarget long-range PCR primers for resequencing FAM153C | | | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM153C | | Predesigned siRNA for gene silencing in human, mouse, rat FAM153C | | | QuantiFast Probe-based Assays in human, mouse, rat FAM153C | | QuantiTect SYBR Green Assays in human, mouse, rat FAM153C | | | Custom PCR Arrays for FAM153C | | Search Chromatin IP Primers for FAM153C | | | Pre-validated RT2 qPCR Primer Assay in human, mouse / rat FAM153C | | Search GeneGlobe Interaction Network for FAM153C | | | Regulatory tfbs in FAM153C promoter |
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 |  | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM153C |
| |  |  |  |  | | | Search ThermoFisher Antibodies for FAM153C |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM153C |
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