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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAM153B Gene

protein-coding   GIFtS: 37
GCID: GC05P175511

Family With Sequence Similarity 153, Member B

  Search for FAM153B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Family With Sequence Similarity 153, Member B1 2
Protein FAM153B2

External Ids:    HGNC: 273231   Entrez Gene: 2021342   Ensembl: ENSG000001822307   UniProtKB: P0C7A23   

Export aliases for FAM153B gene to outside databases

Previous GC identifers: GC05P175444 GC05P170477


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FAM153B Gene: 
FAM153B (family with sequence similarity 153, member B) is a protein-coding gene. An important paralog of this gene is FAM153C.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_023133.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FAM153B gene promoter:
         STAT1   NF-AT   E47   RORalpha1   NF-AT4   NF-AT2   HOXA5   c-Myb   NF-AT3   NF-AT1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for FAM153B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM153B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.2   Ensembl cytogenetic band:  5q35.2   HGNC cytogenetic band: 5q35.2

FAM153B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM153B gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P175511:  view genomic region     (about GC identifiers)

Start:
175,487,692 bp from pter      End:
175,559,261 bp from pter
Size:
71,570 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: F153B_HUMAN, P0C7A2 (See protein sequence)
Recommended Name: Protein FAM153B  
Size: 387 amino acids; 43591 Da
Sequence caution: Sequence=AAH28606.1; Type=Erroneous initiation;
Secondary accessions: A8MTI1
Alternative splicing: 2 isoforms:  P0C7A2-1   P0C7A2-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FAM153B: NX_P0C7A2

Explore proteomics data for FAM153B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P0C7A2

  • FAM153B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FAM153B Protein Expression
    REFSEQ proteins: NP_001252544.1  
    ENSEMBL proteins: 
     ENSP00000453424   ENSP00000453712   ENSP00000427684   ENSP00000424849   ENSP00000453011  
     ENSP00000253490  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR023249 FAM153

    Graphical View of Domain Structure for InterPro Entry P0C7A2

    ProtoNet protein and cluster: P0C7A2

    UniProtKB/Swiss-Prot: F153B_HUMAN, P0C7A2
    Similarity: Belongs to the FAM153 family


    FAM153B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FAM153B 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM153B

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for FAM153B (ENSP000002534904) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLOD3ENSP000002231274STRING: ENSP00000223127
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FAM153B (F153B)

    Search CenterWatch for drugs/clinical trials and news about FAM153B / F153B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FAM153B gene (2 alternative transcripts): 
    NM_001079529.2  NM_001265615.1  

    Unigene Cluster for FAM153B:

    Family with sequence similarity 153, member B
    Hs.368516  [show with all ESTs]
    Unigene Representative Sequence: AK055006
    18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000510151(uc010jjy.1) ENST00000514721 ENST00000511680 ENST00000512862
    ENST00000513073 ENST00000515817 ENST00000507409 ENST00000508296 ENST00000393522
    ENST00000503724 ENST00000513938 ENST00000514235 ENST00000503533 ENST00000502475
    ENST00000507672 ENST00000513787(uc003mdl.2) ENST00000509747 ENST00000508356(uc003mdm.1)

    miRNA
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    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM153B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM153B
    Sirion Biotech Customized lentivirus for stable overexpression of FAM153B 
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    Primer
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    Additional mRNA sequence: 

    AK055006.1 AL117630.1 BC028606.1 BC128074.1 NR_038402.1 

    24/26 DOTS entries (see all 26):

    DT.40212071  DT.99966427  DT.99932557  DT.65286666  DT.95204019  DT.120841341  DT.100644127  DT.120841354 
    DT.120872247  DT.40301675  DT.434847  DT.95257498  DT.120841330  DT.120841347  DT.120841350  DT.120872241 
    DT.120872242  DT.120888832  DT.456387  DT.87009802  DT.95201906  DT.100748401  DT.120888805  DT.40218035 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for FAM153B    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6
    SP1:                                -                           
    SP2:                          -     -                           
    SP3:                    -     -     -           -     -         
    SP4:                                                            


    ECgene alternative splicing isoforms for FAM153B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FAM153B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    FAM153B Expression
    About this image


    See FAM153B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FAM153B

    SOURCE GeneReport for Unigene cluster: Hs.368516
        SABiosciences Custom PCR Arrays for FAM153B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM153B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and chimp.

    Orthologs for FAM153B gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia LOC7353616
    --
    75(a)
    1 → many
    5(177153557-177195644)


    ENSEMBL Gene Tree for FAM153B (if available)
    TreeFam Gene Tree for FAM153B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FAM153B gene
    FAM153C2  FAM153A2  
    2 SIMAP similar genes for FAM153B using alignment to 4 protein entries:     F153B_HUMAN (see all proteins):
    FAM153A    FAM153C

    FAM153B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/425 SNPs in FAM153B are shown (see all 425)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1151233891,2
    C--175492800(+) TTTTTG/TTTTCT 1 -- int10--------
    rs2019417711,2
    --175492800(+) TTTTT-/GTTTCT 1 -- int10--------
    rs1860363591,2
    --175497180(+) TGCAGA/GTAGAG 1 -- int10--------
    rs2012775641,2
    C--175497492(+) TCTCAC/TAGGGT 1 -- int10--------
    rs1889316111,2
    --175497659(+) GGTCCC/TGGTTA 1 -- int10--------
    rs2019953751,2
    C--175497683(+) ATGCTA/TTATAA 1 -- int10--------
    rs1144277931,2
    F--175497687(+) TTTATA/GACAAA 1 -- int11Minor allele frequency- G:0.11WA 118
    rs44196181,2
    --175497747(-) GACCAC/TGtttt 1 -- int10--------
    rs1472124251,2
    --175497749(+) AACATA/GGTCTG 1 -- int10--------
    rs1397187151,2
    --175498175(+) ATAGGC/TGACTG 1 -- int10--------

    HapMap Linkage Disequilibrium report for FAM153B (175487692 - 175559261 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/15 variations for FAM153B (see all 15):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2421778CNV Duplication20811451
    nsv883137CNV Loss21882294
    nsv10778CNV Loss18304495
    nsv883122CNV Gain21882294
    dgv6373n71CNV Gain21882294
    esv34563CNV Gain17911159
    dgv6371n71CNV Gain21882294
    nsv883134CNV Gain21882294
    dgv6374n71CNV Gain21882294
    nsv883133CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FAM153B gene integrated from 9 sources:
    (articles sorted by number of sources associating them with FAM153B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    2. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    6. A method for global protein expression and antibody screening on high-density filters of an arrayed cDNA library. (PubMed id 9776767)1 Bussow K....Walter G. (1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 202134 HGNC: 27323 Ensembl:ENSG00000182230 euGenes: HUgn202134 ECgene: FAM153B
    H-InvDB: FAM153B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FAM153B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FAM153B gene:
    Search GeneIP for patents involving FAM153B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
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