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Aliases for FAM153B Gene

Aliases for FAM153B Gene

  • Family With Sequence Similarity 153 Member B 2 3 5
  • Family With Sequence Similarity 153, Member B 2

External Ids for FAM153B Gene

Previous GeneCards Identifiers for FAM153B Gene

  • GC05P175444
  • GC05P175511
  • GC05P170477

Summaries for FAM153B Gene

GeneCards Summary for FAM153B Gene

FAM153B (Family With Sequence Similarity 153 Member B) is a Protein Coding gene. An important paralog of this gene is FAM153A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM153B Gene

Genomics for FAM153B Gene

Regulatory Elements for FAM153B Gene

Enhancers for FAM153B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around FAM153B on UCSC Golden Path with GeneCards custom track

Promoters for FAM153B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for FAM153B Gene

176,060,689 bp from pter
176,132,258 bp from pter
71,570 bases
Plus strand

Genomic View for FAM153B Gene

Genes around FAM153B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM153B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM153B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM153B Gene

Proteins for FAM153B Gene

  • Protein details for FAM153B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM153B
    Protein Accession:
    Secondary Accessions:
    • A8MTI1

    Protein attributes for FAM153B Gene

    387 amino acids
    Molecular mass:
    43591 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH28606.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM153B Gene


neXtProt entry for FAM153B Gene

Post-translational modifications for FAM153B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM153B Gene

No data available for DME Specific Peptides for FAM153B Gene

Domains & Families for FAM153B Gene

Protein Domains for FAM153B Gene


Suggested Antigen Peptide Sequences for FAM153B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM153 family.
  • Belongs to the FAM153 family.
genes like me logo Genes that share domains with FAM153B: view

No data available for Gene Families for FAM153B Gene

Function for FAM153B Gene

Phenotypes for FAM153B Gene

GenomeRNAi human phenotypes for FAM153B:
genes like me logo Genes that share phenotypes with FAM153B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM153B Gene

Localization for FAM153B Gene

Subcellular locations from

Jensen Localization Image for FAM153B Gene COMPARTMENTS Subcellular localization image for FAM153B gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM153B Gene

Pathways & Interactions for FAM153B Gene

SuperPathways for FAM153B Gene

No Data Available

Interacting Proteins for FAM153B Gene

Selected Interacting proteins: P0C7A2-F153B_HUMAN for FAM153B Gene via IID

Gene Ontology (GO) - Biological Process for FAM153B Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM153B Gene

Drugs & Compounds for FAM153B Gene

No Compound Related Data Available

Transcripts for FAM153B Gene

mRNA/cDNA for FAM153B Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(21) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM153B Gene

Family with sequence similarity 153, member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM153B Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6
SP1: -
SP2: - -
SP3: - - - - -

Relevant External Links for FAM153B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM153B Gene

mRNA expression in normal human tissues for FAM153B Gene

mRNA differential expression in normal tissues according to GTEx for FAM153B Gene

This gene is overexpressed in Brain - Cerebellum (x5.7), Brain - Cerebellar Hemisphere (x5.2), and Ovary (x4.6).

NURSA nuclear receptor signaling pathways regulating expression of FAM153B Gene:


SOURCE GeneReport for Unigene cluster for FAM153B Gene:

genes like me logo Genes that share expression patterns with FAM153B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for FAM153B Gene

Orthologs for FAM153B Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for FAM153B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM153B 34
  • 97.63 (n)
  • 93.87 (a)
-- 35
  • 75 (a)
-- 35
  • 97 (a)
Species where no ortholog for FAM153B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM153B Gene

Gene Tree for FAM153B (if available)
Gene Tree for FAM153B (if available)

Paralogs for FAM153B Gene

Paralogs for FAM153B Gene

(2) SIMAP similar genes for FAM153B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FAM153B: view

Variants for FAM153B Gene

Sequence variations from dbSNP and Humsavar for FAM153B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs3926603 -- 176,107,447(-) TCATG(C/G)CATTA intron-variant
rs4242196 -- 176,107,175(-) ATCCA(C/T)AATCA intron-variant
rs4242197 -- 176,107,445(+) GTTAA(C/T)GGCAT intron-variant
rs4248455 -- 176,067,327(+) ATGCA(C/T)GGCCT intron-variant
rs4269301 -- 176,086,397(+) TTGTC(C/G)CAGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM153B Gene

Variant ID Type Subtype PubMed ID
dgv5832n100 CNV gain 25217958
dgv5833n100 CNV gain 25217958
dgv5834n100 CNV gain 25217958
dgv5835n100 CNV gain+loss 25217958
dgv5836n100 CNV loss 25217958
dgv5837n100 CNV loss 25217958
dgv5838n100 CNV gain 25217958
esv2421778 CNV duplication 20811451
esv2658103 CNV deletion 23128226
esv2759395 CNV gain 17122850
esv2760985 CNV gain+loss 21179565
esv3428875 CNV duplication 20981092
esv34563 CNV gain 17911159
esv3570567 CNV loss 25503493
esv3575900 CNV gain 25503493
esv3607661 CNV loss 21293372
esv3607662 CNV gain 21293372
esv3607663 CNV loss 21293372
esv3607664 CNV loss 21293372
esv3607665 CNV gain 21293372
nsv1017719 CNV gain 25217958
nsv1023853 CNV gain 25217958
nsv10778 CNV loss 18304495
nsv1078562 CNV duplication 25765185
nsv1078563 CNV duplication 25765185
nsv1124928 CNV duplication 24896259
nsv1128920 CNV duplication 24896259
nsv1132616 CNV duplication 24896259
nsv1149049 CNV duplication 26484159
nsv1149555 CNV duplication 26484159
nsv428131 CNV gain 18775914
nsv441977 CNV gain 18776908
nsv950716 CNV deletion 24416366
nsv950718 CNV duplication 24416366
nsv964973 CNV duplication 23825009
nsv964974 CNV duplication 23825009
nsv964975 CNV duplication 23825009
nsv968274 CNV duplication 23825009
nsv968275 CNV duplication 23825009
nsv968347 CNV duplication 23825009
nsv968348 CNV duplication 23825009
nsv969018 CNV duplication 23825009
nsv980756 CNV duplication 23825009
nsv980757 CNV duplication 23825009
nsv980828 CNV duplication 23825009

Variation tolerance for FAM153B Gene

Residual Variation Intolerance Score: 60.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.70; 14.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM153B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM153B Gene

Disorders for FAM153B Gene

Relevant External Links for FAM153B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM153B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM153B Gene

Publications for FAM153B Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 65
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 65
  4. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 4 65
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 65

Products for FAM153B Gene

Sources for FAM153B Gene

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