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FAM153B Gene

protein-coding   GIFtS: 37
GCID: GC05P175511

Family With Sequence Similarity 153, Member B

  Search for FAM153B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 153, Member B1 2
Protein FAM153B2

External Ids:    HGNC: 273231   Entrez Gene: 2021342   Ensembl: ENSG000001822307   UniProtKB: P0C7A23   

Export aliases for FAM153B gene to outside databases

Previous GC identifers: GC05P175444 GC05P170477


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM153B Gene:
FAM153B (family with sequence similarity 153, member B) is a protein-coding gene. An important paralog of this gene is FAM153C.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NC_018916.2  NT_023133.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAM153B gene promoter:
         STAT1   NF-AT   E47   RORalpha1   NF-AT4   NF-AT2   HOXA5   c-Myb   NF-AT3   NF-AT1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for FAM153B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM153B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.2   Ensembl cytogenetic band:  5q35.2   HGNC cytogenetic band: 5q35.2

FAM153B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM153B gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P175511:  view genomic region     (about GC identifiers)

Start:
175,487,692 bp from pter      End:
175,559,261 bp from pter
Size:
71,570 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: F153B_HUMAN, P0C7A2 (See protein sequence)
Recommended Name: Protein FAM153B  
Size: 387 amino acids; 43591 Da
Sequence caution: Sequence=AAH28606.1; Type=Erroneous initiation;
Secondary accessions: A8MTI1
Alternative splicing: 2 isoforms:  P0C7A2-1   P0C7A2-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FAM153B: NX_P0C7A2

Explore proteomics data for FAM153B at MOPED


See FAM153B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001252544.1  
ENSEMBL proteins: 
 ENSP00000453424   ENSP00000453712   ENSP00000427684   ENSP00000424849   ENSP00000453011  
 ENSP00000253490  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR023249 FAM153

Graphical View of Domain Structure for InterPro Entry P0C7A2

ProtoNet protein and cluster: P0C7A2

UniProtKB/Swiss-Prot: F153B_HUMAN, P0C7A2
Similarity: Belongs to the FAM153 family


FAM153B for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAM153B
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus3
cytosol2

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM153B
Interactions:

    Search GeneGlobe Interaction Network for FAM153B

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

Selected Interacting proteins for FAM153B (ENSP000002534904) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
InteractantInteraction Details
GeneCardExternal ID(s)
PLOD3ENSP000002231274STRING: ENSP00000223127
ZNHIT1ENSP000003045934STRING: ENSP00000304593
ACTR5ENSP000002439034STRING: ENSP00000243903
ACTR8ENSP000003368424STRING: ENSP00000336842
VPS72ENSP000003578874STRING: ENSP00000357887
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for FAM153B (F153B)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for FAM153B gene (2 alternative transcripts): 
NM_001079529.2  NM_001265615.1  

Unigene Cluster for FAM153B:

Family with sequence similarity 153, member B
Hs.368516  [show with all ESTs]
Unigene Representative Sequence: AK055006
Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
ENST00000510151(uc010jjy.1) ENST00000514721 ENST00000511680 ENST00000512862
ENST00000513073 ENST00000515817 ENST00000507409 ENST00000508296 ENST00000393522
ENST00000503724 ENST00000513938 ENST00000514235 ENST00000503533 ENST00000502475
ENST00000507672 ENST00000513787(uc003mdl.2) ENST00000509747 ENST00000508356(uc003mdm.1)

miRNA
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Additional mRNA sequence: 

AK055006.1 AL117630.1 BC028606.1 BC128074.1 NR_038402.1 

Selected DOTS entries (see all 26):

DT.40212071  DT.99966427  DT.99932557  DT.65286666  DT.95204019  DT.120841341  DT.100644127  DT.120841354 
DT.120872247  DT.40301675  DT.434847  DT.95257498  DT.120841330  DT.120841347  DT.120841350  DT.120872241 
DT.120872242  DT.120888832  DT.456387  DT.87009802  DT.95201906  DT.100748401  DT.120888805  DT.40218035 

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for FAM153B    About this scheme

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6
SP1:                                -                           
SP2:                          -     -                           
SP3:                    -     -     -           -     -         
SP4:                                                            


ECgene alternative splicing isoforms for FAM153B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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FAM153B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
FAM153B Expression
About this image

FAM153B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

FAM153B Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.368516
    Custom PCR Arrays for FAM153B
Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM153B

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and chimp.

Orthologs for FAM153B gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chimpanzee
(Pan troglodytes)
Mammalia FAM153B1 family with sequence similarity 153, member B 97.63(n)
93.87(a)
  735361  XM_001134706.3  XP_001134706.2 


ENSEMBL Gene Tree for FAM153B (if available)
TreeFam Gene Tree for FAM153B (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for FAM153B gene
FAM153A1 2  FAM153C2  
2 SIMAP similar genes for FAM153B using alignment to 4 protein entries:     F153B_HUMAN (see all proteins):
FAM153A    FAM153C

FAM153B for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for FAM153B (see all 425)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 5 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1151233891,2
C--175492800(+) TTTTTG/TTTTCT 1 -- int10--------
rs2019417711,2
--175492800(+) TTTTT-/GTTTCT 1 -- int10--------
rs1860363591,2
--175497180(+) TGCAGA/GTAGAG 1 -- int10--------
rs2012775641,2
C--175497492(+) TCTCAC/TAGGGT 1 -- int10--------
rs1889316111,2
--175497659(+) GGTCCC/TGGTTA 1 -- int10--------
rs2019953751,2
C--175497683(+) ATGCTA/TTATAA 1 -- int10--------
rs1144277931,2
F--175497687(+) TTTATA/GACAAA 1 -- int11Minor allele frequency- G:0.11WA 118
rs44196181,2
--175497747(-) GACCAC/TGtttt 1 -- int10--------
rs1472124251,2
--175497749(+) AACATA/GGTCTG 1 -- int10--------
rs1397187151,2
--175498175(+) ATAGGC/TGACTG 1 -- int10--------

HapMap Linkage Disequilibrium report for FAM153B (175487692 - 175559261 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for FAM153B (see all 15):    About this table    
Variant IDTypeSubtypePubMed ID
esv2421778CNV Duplication20811451
nsv883137CNV Loss21882294
nsv10778CNV Loss18304495
nsv883122CNV Gain21882294
dgv6373n71CNV Gain21882294
esv34563CNV Gain17911159
dgv6371n71CNV Gain21882294
nsv883134CNV Gain21882294
dgv6374n71CNV Gain21882294
nsv883133CNV Gain21882294

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing FAM153B
DNA2.0 Custom Variant and Variant Library Synthesis for FAM153B

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for FAM153B gene integrated from 10 sources:
(articles sorted by number of sources associating them with FAM153B)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  2. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (Nature 2004)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  6. A method for global protein expression and antibody screening on high-density filters of an arrayed cDNA library. (PubMed id 9776767)1 BA1ssow K....Walter G. (Nucleic Acids Res. 1998)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 202134 HGNC: 27323 Ensembl:ENSG00000182230 euGenes: HUgn202134 ECgene: FAM153B
H-InvDB: FAM153B

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for FAM153B Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for FAM153B gene:
Search GeneIP for patents involving FAM153B

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 ThermoFisher Antibodies for FAM153B
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM153B
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAM153B
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FAM153B
 LSBio Antibodies in human, mouse, rat for FAM153B
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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