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FAM153A Gene

protein-coding   GIFtS: 40
GCID: GC05M177134

Family With Sequence Similarity 153, Member A

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 153, Member A1 2
NY REN 7 Antigen1 2
Renal Carcinoma Antigen NY-REN-72 3
NY-REN-72
Protein FAM153A2
KIAA07523

External Ids:    HGNC: 299401   Entrez Gene: 2855962   Ensembl: ENSG000001700747   UniProtKB: Q9UHL33   

Export aliases for FAM153A gene to outside databases

Previous GC identifers: GC05M177071 GC05P172197


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM153A Gene:
FAM153A (family with sequence similarity 153, member A) is a protein-coding gene. An important paralog of this gene is FAM153B.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_023133.14  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAM153A gene promoter:
         TBP   RORalpha1   ISGF-3   IRF-7A   GATA-1   RORalpha2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM153A promoter sequence
   Search Chromatin IP Primers for FAM153A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM153A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.3   Ensembl cytogenetic band:  5q35.3   HGNC cytogenetic band: 5q35.3

FAM153A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM153A gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M177134:  view genomic region     (about GC identifiers)

Start:
177,134,982 bp from pter      End:
177,210,399 bp from pter
Size:
75,418 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: F153A_HUMAN, Q9UHL3 (See protein sequence)
Recommended Name: Protein FAM153A  
Size: 310 amino acids; 34712 Da
Sequence caution: Sequence=BAA34472.1; Type=Erroneous initiation;
Secondary accessions: A8K0F3 O94852

Explore the universe of human proteins at neXtProt for FAM153A: NX_Q9UHL3

Explore proteomics data for FAM153A at MOPED


See FAM153A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_775934.3  
ENSEMBL proteins: 
 ENSP00000353887   ENSP00000422174   ENSP00000411506   ENSP00000426689   ENSP00000421623  
 ENSP00000425931   ENSP00000424904   ENSP00000423766   ENSP00000425021   ENSP00000377153  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR023249 FAM153

Graphical View of Domain Structure for InterPro Entry Q9UHL3

ProtoNet protein and cluster: Q9UHL3

UniProtKB/Swiss-Prot: F153A_HUMAN, Q9UHL3
Similarity: Belongs to the FAM153 family


Find genes that share domains with FAM153A           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Phenotypes:
     1 GenomeRNAi human phenotype for FAM153A:
 Increased G1 DNA content 

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for FAM153A

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus3
cytosol2
mitochondrion1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for FAM153A About    
See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1Influenza Viral RNA Transcription and Replication
Viral mRNA Translation0.94
Eukaryotic Translation Initiation0.89
Peptide chain elongation0.94
Cap-dependent Translation Initiation0.89
Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.89
Formation of a pool of free 40S subunits0.94
Nonsense-Mediated Decay0.89
2Gene Expression
Gene Expression0.40
3Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Metabolism of proteins0.30
4Disease
Disease



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Interactions:

    Search GeneGlobe Interaction Network for FAM153A

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

Selected Interacting proteins for FAM153A (Q9UHL33 ENSP000003538874) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
InteractantInteraction Details
GeneCardExternal ID(s)
PLOD3O605683, ENSP000002231274I2D: score=2 STRING: ENSP00000223127
ZNHIT1ENSP000003045934STRING: ENSP00000304593
ACTR5ENSP000002439034STRING: ENSP00000243903
ACTR8ENSP000003368424STRING: ENSP00000336842
VPS72ENSP000003578874STRING: ENSP00000357887
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for FAM153A (F153A)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for FAM153A gene: 
NM_173663.3  

Unigene Cluster for FAM153A:

Family with sequence similarity 153, member A
Hs.652754  [show with all ESTs]
Unigene Representative Sequence: AF155097
Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
ENST00000506011 ENST00000360669(uc003mib.1 uc021yix.1 uc010jkp.1)
ENST00000509607 ENST00000514899 ENST00000510276 ENST00000512544 ENST00000440605(uc003mic.3)
ENST00000513554 ENST00000505531 ENST00000512612 ENST00000515787 ENST00000503845
ENST00000504518 ENST00000505683 ENST00000503909 ENST00000507615 ENST00000506354
ENST00000503567
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GenScript: all cDNA clones in your preferred vector: FAM153A (NM_173663)
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM153A
Primer
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  QuantiFast Probe-based Assays in human, mouse, rat FAM153A

Additional mRNA sequence: 

AF155097.1 AK289518.1 

4 DOTS entries:

DT.91669153  DT.120872254  DT.120872242  DT.87009802 

12 AceView cDNA sequences:

AI684503 AA353592 AL046089 AW665256 BQ428949 BQ711500 CB998646 AL042189 
BV189207 AW269432 BE763409 AI480077 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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FAM153A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
FAM153A Expression
About this image

FAM153A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

FAM153A Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.652754
    Custom PCR Arrays for FAM153A
Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM153A

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and chimp.

Orthologs for FAM153A gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chimpanzee
(Pan troglodytes)
Mammalia FAM153B1 family with sequence similarity 153, member B 97.31(n)
93.23(a)
  735361  XM_001134706.3  XP_001134706.2 


ENSEMBL Gene Tree for FAM153A (if available)
TreeFam Gene Tree for FAM153A (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for FAM153A gene
FAM153B1 2  FAM153C2  
2 SIMAP similar genes for FAM153A using alignment to 8 protein entries:     F153A_HUMAN (see all proteins):
FAM153C    FAM153B

Find genes that share paralogs with FAM153A           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for FAM153A (see all 563)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 5 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1437335941,2
Cuntested1177163583(+) ACATTC/TGGCCA 2 K E mis11Minor allele frequency- T:0.00NA 4408
rs2000437271,2
--177149878(+) GAAAC-/GGGGGAAT 1 -- cds10--------
rs2018083861,2
C--177150067(+) TTGAAC/TATGCA 1 -- int10--------
rs2005473291,2
C--177150235(+) TTTTAA/GAATTA 1 -- int10--------
rs1831883681,2
--177150529(+) CCTCAC/TCTTGA 1 -- ut310--------
rs2007918491,2
C--177151281(+) TCTGCC/GCACTG 1 -- int11Minor allele frequency- G:0.00EU 1079
rs1416642261,2
C,F--177151329(+) TTGCTT/GCTTCT 2 /E /A mis11Minor allele frequency- G:0.10EU 1262
rs22708031,2
C--177151456(+) GATGTC/TACTGG 1 -- int10--------
rs1489724861,2
C--177152038(+) TCCCAC/TGTACT 1 -- int10--------
rs2012930611,2
C--177152115(+) GGCAG-/CCGCCC 1 -- int10--------

HapMap Linkage Disequilibrium report for FAM153A (177134982 - 177210399 bp)

Structural Variations
     Database of Genomic Variants (DGV) 7 variations for FAM153A:    About this table    
Variant IDTypeSubtypePubMed ID
nsv5150CNV Loss18451855
nsv519647CNV Loss19592680
nsv508389CNV Loss20534489
esv33718CNV Gain17666407
nsv883182CNV Gain21882294
esv25576CNV Gain+Loss19812545
nsv442969CNV CNV18776908

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for FAM153A gene integrated from 10 sources:
(articles sorted by number of sources associating them with FAM153A)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)1, 2, 3 Scanlan M.J....Old L.J. (Int. J. Cancer 1999)
  2. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1998)
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  4. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
  5. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (Nature 2004)
  6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 285596 HGNC: 29940 AceView: NY-REN-7 Ensembl:ENSG00000170074 euGenes: HUgn285596
ECgene: FAM153A H-InvDB: FAM153A

(According to HUGE)
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HUGE: KIAA0752

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for FAM153A Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for FAM153A gene:
Search GeneIP for patents involving FAM153A

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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 ELISAs for FAM153A
 CLIAs for FAM153A



 Browse ESI BIO Cell Lines and PureStem Progenitors for FAM153A
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM153A
 SwitchGear 3'UTR luciferase reporter plasmids for FAM153A
 SwitchGear Promoter luciferase reporter plasmids for FAM153A
 Search ThermoFisher Antibodies for FAM153A
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM153A
 Browse compounds at ApexBio
 Search Addgene for plasmids for FAM153A
  Search eBioscience for proteins for FAM153A
  Search eBioscience for elisas for FAM153A
  eBioscience FlowRNA Probe Sets
 genOway: Develop your customized and physiologically relevant rodent model for FAM153A
  Search antibodies-online for antibodies for FAM153A
 antibodies-online kits for FAM153A (2 products)
  Search antibodies-online for peptides for FAM153A
  Search antibodies-online for proteins for FAM153A
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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