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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAM153A Gene

protein-coding   GIFtS: 40
GCID: GC05M177134

Family With Sequence Similarity 153, Member A

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Family With Sequence Similarity 153, Member A1 2
NY REN 7 Antigen1 2
Renal Carcinoma Antigen NY-REN-72 3
NY-REN-72
Protein FAM153A2
KIAA07523

External Ids:    HGNC: 299401   Entrez Gene: 2855962   Ensembl: ENSG000001700747   UniProtKB: Q9UHL33   

Export aliases for FAM153A gene to outside databases

Previous GC identifers: GC05M177071 GC05P172197


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FAM153A Gene: 
FAM153A (family with sequence similarity 153, member A) is a protein-coding gene. Diseases associated with FAM153A include renal cell carcinoma. An important paralog of this gene is FAM153B.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_023133.13  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FAM153A gene promoter:
         TBP   RORalpha1   ISGF-3   IRF-7A   GATA-1   RORalpha2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM153A promoter sequence
   Search SABiosciences Chromatin IP Primers for FAM153A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM153A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.3   Ensembl cytogenetic band:  5q35.3   HGNC cytogenetic band: 5q35.3

FAM153A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM153A gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M177134:  view genomic region     (about GC identifiers)

Start:
177,134,982 bp from pter      End:
177,210,399 bp from pter
Size:
75,418 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: F153A_HUMAN, Q9UHL3 (See protein sequence)
Recommended Name: Protein FAM153A  
Size: 310 amino acids; 34712 Da
Sequence caution: Sequence=BAA34472.1; Type=Erroneous initiation;
Secondary accessions: A8K0F3 O94852

Explore the universe of human proteins at neXtProt for FAM153A: NX_Q9UHL3

Explore proteomics data for FAM153A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UHL3

  • FAM153A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FAM153A Protein Expression
    REFSEQ proteins: NP_775934.3  
    ENSEMBL proteins: 
     ENSP00000353887   ENSP00000422174   ENSP00000411506   ENSP00000426689   ENSP00000421623  
     ENSP00000425931   ENSP00000424904   ENSP00000423766   ENSP00000425021   ENSP00000377153  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR023249 FAM153

    Graphical View of Domain Structure for InterPro Entry Q9UHL3

    ProtoNet protein and cluster: Q9UHL3

    UniProtKB/Swiss-Prot: F153A_HUMAN, Q9UHL3
    Similarity: Belongs to the FAM153 family


    FAM153A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         1 GenomeRNAi human phenotype for FAM153A:
     Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FAM153A 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FAM153A

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM153A

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for FAM153A (Q9UHL33 ENSP000003538874) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLOD3O605683, ENSP000002231274I2D: score=2 STRING: ENSP00000223127
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FAM153A (F153A)

    Search CenterWatch for drugs/clinical trials and news about FAM153A / F153A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FAM153A gene: 
    NM_173663.3  

    Unigene Cluster for FAM153A:

    Family with sequence similarity 153, member A
    Hs.652754  [show with all ESTs]
    Unigene Representative Sequence: AF155097
    18/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000506011 ENST00000360669(uc003mib.1 uc021yix.1 uc010jkp.1)
    ENST00000509607 ENST00000514899 ENST00000510276 ENST00000512544 ENST00000440605(uc003mic.3)
    ENST00000513554 ENST00000505531 ENST00000512612 ENST00000515787 ENST00000503845
    ENST00000504518 ENST00000505683 ENST00000503909 ENST00000507615 ENST00000506354
    ENST00000503567
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidFAM153A 3' UTR sequence
    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM153A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM153A
    Sirion Biotech Customized lentivirus for stable overexpression of FAM153A 
                         Customized lentivirus expression plasmids for stable overexpression of FAM153A 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for FAM153A
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM153A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM153A

    Additional mRNA sequence: 

    AF155097.1 AK289518.1 

    4 DOTS entries:

    DT.91669153  DT.120872254  DT.120872242  DT.87009802 

    12 AceView cDNA sequences:

    AI684503 AA353592 CB998646 BQ428949 BQ711500 AW665256 BV189207 AL046089 
    AL042189 AW269432 BE763409 AI480077 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FAM153A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    FAM153A Expression
    About this image


    See FAM153A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FAM153A

    SOURCE GeneReport for Unigene cluster: Hs.652754
        SABiosciences Custom PCR Arrays for FAM153A
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM153A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and chimp.

    Orthologs for FAM153A gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia FAM153B1 family with sequence similarity 153, member B 97.31(n)
    93.23(a)
      735361  XM_001134706.3  XP_001134706.2 


    ENSEMBL Gene Tree for FAM153A (if available)
    TreeFam Gene Tree for FAM153A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FAM153A gene
    FAM153B2  FAM153C2  
    2 SIMAP similar genes for FAM153A using alignment to 8 protein entries:     F153A_HUMAN (see all proteins):
    FAM153C    FAM153B

    FAM153A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/563 SNPs in FAM153A are shown (see all 563)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1437335941,2
    Cuntested1177163583(+) ACATTC/TGGCCA 2 K E mis11Minor allele frequency- T:0.00NA 4408
    rs2000437271,2
    --177149878(+) GAAAC-/GGGGGAAT 1 -- cds10--------
    rs2018083861,2
    C--177150067(+) TTGAAC/TATGCA 1 -- int10--------
    rs2005473291,2
    C--177150235(+) TTTTAA/GAATTA 1 -- int10--------
    rs1831883681,2
    --177150529(+) CCTCAC/TCTTGA 1 -- ut310--------
    rs2007918491,2
    C--177151281(+) TCTGCC/GCACTG 1 -- int11Minor allele frequency- G:0.00EU 1079
    rs1416642261,2
    C,F--177151329(+) TTGCTT/GCTTCT 2 /E /A mis11Minor allele frequency- G:0.10EU 1262
    rs22708031,2
    C--177151456(+) GATGTC/TACTGG 1 -- int10--------
    rs1489724861,2
    C--177152038(+) TCCCAC/TGTACT 1 -- int10--------
    rs2012930611,2
    C--177152115(+) GGCAG-/CCGCCC 1 -- int10--------

    HapMap Linkage Disequilibrium report for FAM153A (177134982 - 177210399 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for FAM153A:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv5150CNV Loss18451855
    nsv519647CNV Loss19592680
    nsv508389CNV Loss20534489
    esv33718CNV Gain17666407
    nsv883182CNV Gain21882294
    esv25576CNV Gain+Loss19812545
    nsv442969CNV CNV18776908

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for FAM153A:    About MalaCards
    renal cell carcinoma    


    FAM153A for disorders           About GeneDecksing


    Export disorders for FAM153A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FAM153A gene integrated from 9 sources:
    (articles sorted by number of sources associating them with FAM153A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)1, 2, 3 Scanlan M.J....Old L.J. (1999)
    2. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2, 3 Nagase T.... Ohara O. (1998)
    3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    4. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    5. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 285596 HGNC: 29940 AceView: NY-REN-7 Ensembl:ENSG00000170074 euGenes: HUgn285596
    ECgene: FAM153A H-InvDB: FAM153A

    (According to HUGE)
    About This Section
    HUGE: KIAA0752

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FAM153A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FAM153A gene:
    Search GeneIP for patents involving FAM153A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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