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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FAM151A Gene

protein-coding GIFtS: 41
GCID: GC01M055074

family with sequence similarity 151, member A

(Previous name: chromosome 1 open reading frame 179 )
(Previous symbol: C1orf179)

Search for FAM151A
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Family With Sequence Similarity 151, Member A¹ ²
C1orf179¹ ² ³
MGC27169¹
Chromosome 1 Open Reading Frame 179¹
Hyporthetical Protein MGC27169²
Protein FAM151A²

External Ids:	HGNC: 25032¹	Entrez Gene: 338094²	Ensembl: ENSG00000162391⁷	UniProtKB: Q8WW52³

Export aliases for FAM151A gene to outside databases

Previous GC identifers: GC01M054847 GC01M053189

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FAM151A gene promoter:
ATF-2 AP-4 CBF-C CRE-BP1 PPAR-gamma1 CBF-B CBF-A CP1A PPAR-gamma2 CBF(2)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FAM151A promoter sequence

Search SABiosciences Chromatin IP Primers for FAM151A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM151A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Ensembl cytogenetic band: 1p32.3 HGNC cytogenetic band: 1p32.3

FAM151A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM151A gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M055074: view genomic region (about GC identifiers)

Start:	55,074,850 bp from pter	End:	55,089,229 bp from pter
Size:	14,380 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: F151A_HUMAN, Q8WW52 (See protein sequence)

Recommended Name: Protein FAM151A

Size: 585 amino acids; 64028 Da

Subcellular location: Membrane; Single-pass membrane protein (Potential)

Secondary accessions: Q5VUG5 Q6DKH5 Q6UWV0 Q8NAX9 Q96KY5

Alternative splicing: 2 isoforms: Q8WW52-1 Q8WW52-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FAM151A: NX_Q8WW52

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8WW52

FAM151A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_788954.2

ENSEMBL proteins:

ENSP00000306888 ENSP00000360353

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	NAS	12975309
GO:0016021	integral to membrane	IEA	--

FAM151A for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for FAM151A

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FAM151A for domains About GeneDecksing

1 InterPro domain/family:

IPR019356 DUF2181

Graphical View of Domain Structure for InterPro Entry Q8WW52

ProtoNet protein and cluster: Q8WW52

UniProtKB/Swiss-Prot: F151A_HUMAN, Q8WW52

Similarity: Belongs to the FAM151 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--

FAM151A for ontologies About GeneDecksing

Phenotypes:
1 MGI phenotypic allele

for Fam151a (no phenotypes)

FAM151A for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Fam151a^tm1Lex for FAM151A

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for FAM151A

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM151A

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for FAM151A

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5 Interacting proteins for FAM151A (ENSP00000306888⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ACOT11	ENSP00000360366⁴	STRING: ENSP00000360366
DHCR24	ENSP00000360316⁴	STRING: ENSP00000360316
MROH7	ENSP00000396622⁴	STRING: ENSP00000396622
SSBP3	ENSP00000360371⁴	STRING: ENSP00000360371
TTC22	ENSP00000360323⁴	STRING: ENSP00000360323

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008150	biological_process	ND	--

FAM151A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FAM151A
Search CenterWatch for drugs/clinical trials and news about FAM151A / F151A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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About This Section

REFSEQ mRNAs for FAM151A gene:

NM_176782.2

Unigene Cluster for FAM151A:

Family with sequence similarity 151, member A

Hs.741434 [show with all ESTs]

Unigene Representative Sequence: AY358629

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000302250(uc001cxn.3) ENST00000371304

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Additional cDNA sequence:

AK091901.1 AY358629.1 BC015993.1 BC020874.1 BC073921.1

6 DOTS entries:

DT.97835864 DT.121396912 DT.100743506 DT.121396795 DT.407361 DT.91679570

24 AceView cDNA sequences:

BM924478 BI765371 AY358629 BC015993 AX747244 BQ440014 BG429805 NM_176782

AK091901 BG433641 AW884213 BG428492 BC020874 BC073921 AW025605 BE041287

AI033275 AW750816 AW025604 BI760940 H78941 R92398 AA862436 T97673

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FAM151A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

FAM151A expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Embryoid bodies (Two-step protocol fo...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See FAM151A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM151A

SOURCE GeneReport for Unigene cluster: Hs.741434

SABiosciences Custom PCR Arrays for FAM151A

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for FAM151A gene from 4/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	FAM151A⁶	--	63(a)	1 ↔ 1	4(104535196-104544860)
zebrafish (Danio rerio)	Actinopterygii	fam151a¹	protein FAM151A	54.06(n) 46.68(a)		100005645 NM_001100095.1 NP_001093565.1
fruit fly (Drosophila melanogaster)	Insecta	CG7231⁶	--	27(a)	1 → many	2L(7983946-7986785)
worm (Caenorhabditis elegans)	Secernentea	W01F3.1⁶	Protein W01F3.1, isoform a	18(a)	1 → many	V(20654621-20659688)

ENSEMBL Gene Tree for FAM151A (if available)
TreeFam Gene Tree for FAM151A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FAM151A gene

FAM151B²

1 SIMAP similar gene for FAM151A using alignment to 2 protein entries: F151A_HUMAN (see all proteins):

FAM151B

FAM151A for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for FAM151A
PGOHUM00000238307

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FAM151A
1 CNV: 6827

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FAM151A for disorders About MalaCards

FAM151A for disorders About GeneDecksing

Human Genome Epidemiology (HuGE) Navigator: FAM151A (4 documents)

Export disorders for FAM151A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FAM151A gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with FAM151A)

Utopia: connect your pdf to the dynamic
world of online information

Localization of a gene for nonsyndromic renal hypodysplasia to chromosome 1p32-33. (PubMed id 17273976)^{1, 3} Sanna-Cherchi S....Gharavi A.G. (2007)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)¹ Bailey S.D....Anand S. (2010)
Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)¹ Talmud P.J.... . (2009)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)² Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 338094	HGNC: 25032	AceView: MGC27169	Ensembl:ENSG00000162391	euGenes: HUgn338094
ECgene: FAM151A	H-InvDB: FAM151A

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FAM151A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FAM151A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for FAM151A gene:
Search GeneIP for patents involving FAM151A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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ThermoFisher Antibodies for FAM151A

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM151A

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for FAM151A

Sirion Biotech Customized:

	stable knockdown cell line services for FAM151A
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	design and validation of potent shRNA sequences against FAM151A
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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes FAM151A gene at Home site.

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FAM151A Gene

family with sequence similarity 151, member A

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for FAM151A gene

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Export list of displayed genes

FAM151A Gene

family with sequence similarity 151, member A

Aliasesfor FAM151A gene

Summariesfor FAM151A gene

Genomic Viewsfor FAM151A gene

Proteinsfor FAM151A gene

Protein Domains /Familiesfor FAM151A gene

Functionfor FAM151A gene

Pathways & Interactionsfor FAM151A gene

Drugs & Compoundsfor FAM151A gene

Transcriptsfor FAM151A gene

Expression for FAM151A gene

Orthologsfor FAM151A gene

Paralogsfor FAM151A gene

Genomic Variantsfor FAM151A gene

Disorders / Diseasesfor FAM151A gene

Publicationsfor FAM151A gene

External Searches for FAM151A gene

Genome Databases showing FAM151A gene

Other Databases showing FAM151A gene

Specialized Databases showing FAM151A gene

Intellectual Propertyfor FAM151A gene

Productsfor FAM151A gene

View Random Gene

Aliases
for FAM151A gene

Summaries
for FAM151A gene

Genomic Views
for FAM151A gene

Proteins
for FAM151A gene

Protein Domains /
Families
for FAM151A gene

Function
for FAM151A gene

Pathways & Interactions
for FAM151A gene

Drugs & Compounds
for FAM151A gene

Transcripts
for FAM151A gene

Expression
for FAM151A gene

Orthologs
for FAM151A gene

Paralogs
for FAM151A gene

Genomic Variants
for FAM151A gene

Disorders / Diseases
for FAM151A gene

Publications
for FAM151A gene

Intellectual Property
for FAM151A gene

Products
for FAM151A gene