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FAM151A Gene

protein-coding   GIFtS: 45
GCID: GC01M055074

Family With Sequence Similarity 151, Member A

(Previous name: chromosome 1 open reading frame 179)
(Previous symbol: C1orf179)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 151, Member A1 2
C1orf1791 2 3
Chromosome 1 Open Reading Frame 1791
Hyporthetical Protein MGC271692
Protein FAM151A2

External Ids:    HGNC: 250321   Entrez Gene: 3380942   Ensembl: ENSG000001623917   UniProtKB: Q8WW523   

Export aliases for FAM151A gene to outside databases

Previous GC identifers: GC01M054847 GC01M053189


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM151A Gene:
FAM151A (family with sequence similarity 151, member A) is a protein-coding gene. An important paralog of this gene is FAM151B.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAM151A gene promoter:
         ATF-2   AP-4   CBF-C   CRE-BP1   PPAR-gamma1   CBF-B   CBF-A   CP1A   PPAR-gamma2   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM151A promoter sequence
   Search Chromatin IP Primers for FAM151A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM151A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Ensembl cytogenetic band:  1p32.3   HGNC cytogenetic band: 1p32.3

FAM151A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM151A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M055074:  view genomic region     (about GC identifiers)

Start:
55,074,850 bp from pter      End:
55,089,229 bp from pter
Size:
14,380 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: F151A_HUMAN, Q8WW52 (See protein sequence)
Recommended Name: Protein FAM151A  
Size: 585 amino acids; 64028 Da
Secondary accessions: Q5VUG5 Q6DKH5 Q6UWV0 Q8NAX9 Q96KY5
Alternative splicing: 2 isoforms:  Q8WW52-1   Q8WW52-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FAM151A: NX_Q8WW52

Explore proteomics data for FAM151A at MOPED


See FAM151A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_788954.2  
ENSEMBL proteins: 
 ENSP00000306888   ENSP00000360353  

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antibodies-online peptides for FAM151A

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antibodies-online antibodies for FAM151A (19 products) 

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR019356 DUF2181

Graphical View of Domain Structure for InterPro Entry Q8WW52

ProtoNet protein and cluster: Q8WW52

UniProtKB/Swiss-Prot: F151A_HUMAN, Q8WW52
Similarity: Belongs to the FAM151 family


Find genes that share domains with FAM151A           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003674molecular_function ND--
     
Find genes that share ontologies with FAM151A           About GenesLikeMe


Phenotypes:
     1 MGI phenotypic allele for Fam151a (no phenotypes)

Find genes that share phenotypes with FAM151A           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Fam151atm1Lex for FAM151A

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAM151A
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   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FAM151A
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FAM151A

miRNA
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miRTarBase miRNAs that target FAM151A:
hsa-mir-335-5p (MIRT017107)

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
F151A_HUMAN, Q8WW52: Membrane; Single-pass membrane protein (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane2
endoplasmic reticulum1
extracellular1
golgi apparatus1
lysosome1
nucleus1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016020membrane NAS12975309
GO:0016021integral component of membrane IEA--
GO:0070062extracellular vesicular exosome IDA19056867

Find genes that share ontologies with FAM151A           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM151A
Interactions:

    Search GeneGlobe Interaction Network for FAM151A

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5 Interacting proteins for FAM151A (ENSP000003068884) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
ACOT11ENSP000003603664STRING: ENSP00000360366
DHCR24ENSP000003603164STRING: ENSP00000360316
MROH7ENSP000003966224STRING: ENSP00000396622
SSBP3ENSP000003603714STRING: ENSP00000360371
TTC22ENSP000003603234STRING: ENSP00000360323
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Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008150biological_process ND--

Find genes that share ontologies with FAM151A           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
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  Browse compounds at ApexBio 

Browse Tocris compounds for FAM151A (F151A)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for FAM151A gene: 
NM_176782.2  

Unigene Cluster for FAM151A:

Family with sequence similarity 151, member A
Hs.234786  [show with all ESTs]
Unigene Representative Sequence: AY358629
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000302250(uc001cxn.3) ENST00000371304
miRNA
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Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for FAM151A
Predesigned siRNA for gene silencing in human, mouse, rat FAM151A
Clone
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OriGene clones in human, mouse for FAM151A (see all 7)
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GenScript: all cDNA clones in your preferred vector: FAM151A (NM_176782)
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Primer
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OriGene qPCR primer pairs and template standards for FAM151A
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Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FAM151A
  QuantiTect SYBR Green Assays in human, mouse, rat FAM151A
  QuantiFast Probe-based Assays in human, mouse, rat FAM151A

Additional mRNA sequence: 

AK091901.1 AY358629.1 BC015993.1 BC020874.1 BC073921.1 

7 DOTS entries:

DT.97835864  DT.121396912  DT.100743506  DT.407361  DT.121396795  DT.102826042  DT.91679570 

24 AceView cDNA sequences:

BI765371 BC015993 BM924478 AY358629 BG429805 BG433641 BC073921 AW884213 
BG428492 AX747244 NM_176782 BC020874 AK091901 BQ440014 AI033275 BE041287 
AW750816 AW025605 R92398 BI760940 AW025604 AA862436 H78941 T97673 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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FAM151A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
FAM151A Expression
About this image


FAM151A expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 3) fully expand
 
 Liver (Hepatobiliary System)
         Hepatocyte-like cells
 
 NULL (Uncategorized)
         Vascular endothelial growth factor-induced embryoid bodies
 
 Kidney (Urinary System)
FAM151A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

FAM151A Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.234786
    Custom PCR Arrays for FAM151A
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QuantiFast Probe-based Assays in human, mouse, rat FAM151A
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM151A

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for FAM151A gene from Selected species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Fam151a1 , 5 family with sequence simliarity 151, member A1, 5 77.61(n)1
71.28(a)1
  4 (49.74 cM)5
2305791  NM_146149.11  NP_666261.11 
 1067338895 
lizard
(Anolis carolinensis)
Reptilia FAM151A6
family with sequence similarity 151, member A
60(a)
1 ↔ 1
4(104535196-104547396)
tropical clawed frog
(Xenopus tropicalis)
Amphibia fam151a1 family with sequence similarity 151, member A 53.86(n)
47.33(a)
  100145765  XM_002931462.2  XP_002931508.2 
zebrafish
(Danio rerio)
Actinopterygii fam151a1 family with sequence similarity 151, member A 54.03(n)
46.86(a)
  100005645  NM_001100095.1  NP_001093565.1 
fruit fly
(Drosophila melanogaster)
Insecta CG72316
--
26(a)
1 → many
2L(7983946-7986785)
worm
(Caenorhabditis elegans)
Secernentea mnr-16
Protein W01F3.1, isoform a (W01F3.1) mRNA, complet...
15(a)
1 → many
V(20654652-20659719) WBGene00012184


ENSEMBL Gene Tree for FAM151A (if available)
TreeFam Gene Tree for FAM151A (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for FAM151A gene
FAM151B2  
1 SIMAP similar gene for FAM151A using alignment to 2 protein entries:     F151A_HUMAN (see all proteins):
FAM151B

Find genes that share paralogs with FAM151A           About GenesLikeMe


1 Pseudogenes.org Pseudogene for FAM151A
PGOHUM00000238307


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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6 SNPs for FAM151A    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs13688831,2,4
----see VAR_0371122 mis40--------
rs178518431,2,4
----see VAR_0371112 mis40--------
rs22890151,2,4
----see VAR_0371142 mis40--------
rs178566201,2,4
----see VAR_0371102 mis40--------
rs112063941,2,4
----see VAR_0371132 mis40--------
rs173992971,2,4
----see VAR_0371092 mis40--------

HapMap Linkage Disequilibrium report for FAM151A (55074850 - 55089229 bp)

Structural Variations
     Database of Genomic Variants (DGV) 9 variations for FAM151A:    About this table    
Variant IDTypeSubtypePubMed ID
esv2748330CNV Deletion23290073
nsv516654CNV Loss19592680
nsv829904CNV Loss17160897
nsv910CNV Loss18451855
nsv461561CNV Gain19166990
nsv817614CNV Gain22305530
nsv461594CNV Gain19166990
dgv229n71CNV Gain21882294
esv33550CNV Gain+Loss17666407

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing FAM151A
DNA2.0 Custom Variant and Variant Library Synthesis for FAM151A

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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Find genes that share disorders with FAM151A           About GenesLikeMe

Genetic Association Database (GAD): FAM151A
Human Genome Epidemiology (HuGE) Navigator: FAM151A (4 documents)

Export disorders for FAM151A gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for FAM151A gene, integrated from 10 sources (see all 12):
(articles sorted by number of sources associating them with FAM151A)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
  3. Localization of a gene for nonsyndromic renal hypodysplasia to chromosome 1p32-33. (PubMed id 17273976)1, 3 Sanna-Cherchi S....Gharavi A.G. (Am. J. Hum. Genet. 2007)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
  6. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
  7. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
  8. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PubMed id 19056867)1 Gonzales P.A....Knepper M.A. (J. Am. Soc. Nephrol. 2009)
  9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  10. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 338094 HGNC: 25032 AceView: MGC27169 Ensembl:ENSG00000162391 euGenes: HUgn338094
ECgene: FAM151A H-InvDB: FAM151A

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for FAM151A Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for FAM151A gene:
Search GeneIP for patents involving FAM151A

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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