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FAM150B Gene

protein-coding   GIFtS: 42
GCID: GC02M000271

Family With Sequence Similarity 150, Member B

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disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 150, Member B1 2
PRO10972
RGPG5422
Protein FAM150B2

External Ids:    HGNC: 276831   Entrez Gene: 2850162   Ensembl: ENSG000001892927   UniProtKB: Q6UX463   

Export aliases for FAM150B gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM150B Gene:
FAM150B (family with sequence similarity 150, member B) is a protein-coding gene. An important paralog of this gene is FAM150A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005334.17  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAM150B gene promoter:
         Max1   AP-2gamma   GATA-1   RORalpha1   FOXJ2 (long isoform)   AP-2beta   TGIF   AP-2alpha   AP-2alphaA   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM150B promoter sequence
   Search Chromatin IP Primers for FAM150B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM150B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p25.3   Ensembl cytogenetic band:  2p25.3   HGNC cytogenetic band: 2p25.3

FAM150B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM150B gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M000271:  view genomic region     (about GC identifiers)

Start:
279,558 bp from pter      End:
288,851 bp from pter
Size:
9,294 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: F150B_HUMAN, Q6UX46 (See protein sequence)
Recommended Name: Protein FAM150B precursor  
Size: 152 amino acids; 16915 Da
Secondary accessions: B5MC76
Alternative splicing: 2 isoforms:  Q6UX46-1   Q6UX46-2   

Explore the universe of human proteins at neXtProt for FAM150B: NX_Q6UX46

Explore proteomics data for FAM150B at MOPED


See FAM150B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001002919.2  
ENSEMBL proteins: 
 ENSP00000384604   ENSP00000385537   ENSP00000385672   ENSP00000385214   ENSP00000339565  
 ENSP00000389939  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q6UX46

UniProtKB/Swiss-Prot: F150B_HUMAN, Q6UX46
Similarity: Belongs to the FAM150 family


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Phenotypes:
     2 GenomeRNAi human phenotypes for FAM150B:
 G0/1 arrest  Increased G1 DNA content 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAM150B
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miRNA
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miRTarBase miRNAs that target FAM150B:
hsa-mir-16-5p (MIRT051079)

Block miRNA regulation of human, mouse, rat FAM150B using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate FAM150B (see all 10):
hsa-miR-92a hsa-miR-367 hsa-miR-25 hsa-miR-32 hsa-miR-216b hsa-miR-1279 hsa-miR-124 hsa-miR-363
SwitchGear 3'UTR luciferase reporter plasmidFAM150B 3' UTR sequence
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
F150B_HUMAN, Q6UX46: Secreted (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular3

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--

Find genes that share ontologies with FAM150B           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM150B
Interactions:

    Search GeneGlobe Interaction Network for FAM150B

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for FAM150B (F150B)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for FAM150B gene: 
NM_001002919.2  

Unigene Cluster for FAM150B:

Family with sequence similarity 150, member B
Hs.355207  [show with all ESTs]
Unigene Representative Sequence: NM_001002919
7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000403610(uc010ewf.1 uc002qwi.4) ENST00000401503 ENST00000405290
ENST00000401489 ENST00000344414 ENST00000452023 ENST00000463919
miRNA
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Selected qRT-PCR Assays for microRNAs that regulate FAM150B (see all 10):
hsa-miR-92a hsa-miR-367 hsa-miR-25 hsa-miR-32 hsa-miR-216b hsa-miR-1279 hsa-miR-124 hsa-miR-363
SwitchGear 3'UTR luciferase reporter plasmidFAM150B 3' UTR sequence
Inhib. RNA
Products:
     
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Predesigned siRNA for gene silencing in human, mouse, rat FAM150B
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  QuantiFast Probe-based Assays in human, mouse, rat FAM150B

Additional mRNA sequence: 

AY358517.1 BC033490.1 

7 DOTS entries:

DT.101978251  DT.104150  DT.95368188  DT.100743786  DT.100641360  DT.75122219  DT.121013753 

Selected AceView cDNA sequences (see all 34):

BM129183 BX091090 BM128907 BC033490 AY358517 NM_001002919 CD105711 BM129405 
CK819507 BM129692 AA938980 BI831684 BF449053 AI300876 BE972686 AV702629 
AI917447 AI205786 BF195926 AI769402 AI983714 BU852925 AI024364 AW052022 

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for FAM150B    About this scheme

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP1:        -     -     -                 -                           
SP2:                                      -                           
SP3:                                      -                           
SP4:                                                                  


ECgene alternative splicing isoforms for FAM150B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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FAM150B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AAAAATTAAA
FAM150B Expression
About this image


FAM150B expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 5) fully expand
 
 Bone (Muscoskeletal System)    fully expand to see all 2 entries
         HyStem+BMP4-induced SK11 cells
 
 Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
         HyStem+BMP4-induced SM30 cells
 
 Neural Crest (Gastrulation Derivatives)
         PureStem SM30, NCr-fac & Meso-latp Progenitor
 
 Adipose (Muscoskeletal System)
         HyStem+BMP4-induced SM30 cells
 
 Lateral Plate Mesoderm (Gastrulation Derivatives)
         PureStem SM30, NCr-fac & Meso-latp Progenitor
FAM150B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

FAM150B Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.355207
    Custom PCR Arrays for FAM150B
Primer
Products:
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Pre-validated RT2 qPCR Primer Assay in human, mouse / rat FAM150B
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM150B

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for FAM150B gene from Selected species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Fam150b1 , 5 family with sequence similarity 150, member B1, 5 78.59(n)1
81.3(a)1
  12 (13.00 cM)5
1002945831  NM_001159743.11  NP_001153215.11 
 308843245 
chicken
(Gallus gallus)
Aves FAM150B1 family with sequence similarity 150, member B 69.52(n)
72.65(a)
  421910  XM_419928.3  XP_419928.1 
lizard
(Anolis carolinensis)
Reptilia FAM150B6
family with sequence similarity 150, member B
51(a)
1 ↔ 1
1(160107123-160122533)
tropical clawed frog
(Xenopus tropicalis)
Amphibia fam150b1 family with sequence similarity 150, member B 63.96(n)
59.46(a)
  100379943  XM_002936296.2  XP_002936342.2 
zebrafish
(Danio rerio)
Actinopterygii LOC1003292541 protein FAM150B-like 57.65(n)
54.1(a)
  100329254  XM_002665204.2  XP_002665250.2 


ENSEMBL Gene Tree for FAM150B (if available)
TreeFam Gene Tree for FAM150B (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for FAM150B gene
FAM150A2  
1 SIMAP similar gene for FAM150B using alignment to 4 protein entries:     F150B_HUMAN (see all proteins):
FAM150A

Find genes that share paralogs with FAM150B           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for FAM150B (see all 216)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 2 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1119203571,2
C--279189(+) TCCAAC/TTAGAT 1 -- int11Minor allele frequency- T:0.50WA 2
rs102037221,2
C,F,A,H--279266(+) AAGCAT/ATTTCA 1 -- int116Minor allele frequency- A:0.39NA NS EA CSA WA 922
rs1909605541,2
C--279348(+) TCTTAA/GGAAAT 1 -- int10--------
rs1817922271,2
--279352(+) AGGAAA/GTTATG 1 -- int10--------
rs578507591,2
C,F--279371(+) ATATAG/ATAGCC 1 -- int11Minor allele frequency- A:0.50WA 2
rs1429945031,2
--279481(+) TCATGA/CTCTCT 1 -- int10--------
rs1916663811,2
--279502(+) GAAGTC/GACGAA 1 -- int10--------
rs38283291,2
C,F,A,H--279705(+) CATGAC/TCGAAA 1 -- ut3124Minor allele frequency- T:0.35NS EA NA CSA WA 2766
rs1831727831,2
--279707(+) TGACCA/GAAATT 1 -- ut310--------
rs1882453761,2
--279739(+) AATAAC/TACTCT 1 -- ut310--------

HapMap Linkage Disequilibrium report for FAM150B (279558 - 288851 bp)

Structural Variations
     Database of Genomic Variants (DGV) 8 variations for FAM150B:    About this table    
Variant IDTypeSubtypePubMed ID
nsv833159CNV Loss17160897
nsv833170CNV Loss17160897
nsv873529CNV Gain21882294
nsv873530CNV Gain21882294
nsv873531CNV Gain21882294
essv3569CNV CNV17122850
essv2780CNV CNV17122850
dgv1137e1CNV Complex17122850

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing FAM150B
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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Find genes that share disorders with FAM150B           About GenesLikeMe

Genetic Association Database (GAD): FAM150B

Export disorders for FAM150B gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for FAM150B gene integrated from 10 sources:
(articles sorted by number of sources associating them with FAM150B)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
  2. Genome-wide association of serum uric acid concentration: replication of sequence variants in an island population of the Adriatic coast of Croatia. (PubMed id 22229870)4 Karns R....Deka R. (Ann. Hum. Genet. 2012)
  3. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PubMed id 20935630)4 Speliotes E.K....Loos R.J. (Nat. Genet. 2010)
  4. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. (PubMed id 21102462)4 Elks C.E....Murray A. (Nat. Genet. 2010)
  5. A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose. (PubMed id 19875614)4 Paterson A.D....Bull S.B. (Diabetes 2010)
  6. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. (PubMed id 19079261)4 Willer C.J....Hirschhorn J.N. (Nat. Genet. 2009)
  7. Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. (PubMed id 19079260)4 Thorleifsson G....Stefansson K. (Nat. Genet. 2009)
  8. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)
  9. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (Science 2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 285016 HGNC: 27683 AceView: LOC285016 Ensembl:ENSG00000189292 euGenes: HUgn285016
ECgene: FAM150B H-InvDB: FAM150B

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for FAM150B Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for FAM150B gene:
Search GeneIP for patents involving FAM150B

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 Block miRNA regulation of human, mouse, rat FAM150B using miScript Target Protectors SeqTarget long-range PCR primers for resequencing FAM150B
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 Custom PCR Arrays for FAM150B Search Chromatin IP Primers for FAM150B
 Pre-validated RT2 qPCR Primer Assay in human, mouse / rat FAM150B  Search GeneGlobe Interaction Network for FAM150B
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 Search Tocris compounds for FAM150B (F150B)
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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 Browse ESI BIO Cell Lines and PureStem Progenitors for FAM150B
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 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM150B
 SwitchGear 3'UTR luciferase reporter plasmids for FAM150B
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 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM150B
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAM150B
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 Search Addgene for plasmids for FAM150B
  Search eBioscience for proteins for FAM150B
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  eBioscience FlowRNA Probe Sets
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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