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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FAM150B Gene

protein-coding GIFtS: 40
GCID: GC02M000271

family with sequence similarity 150, member B

Search for FAM150B
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Family With Sequence Similarity 150, Member B¹ ²
PRO1097²
RGPG542²
Protein FAM150B²

External Ids:	HGNC: 27683¹	Entrez Gene: 285016²	Ensembl: ENSG00000189292⁷	UniProtKB: Q6UX46³

Export aliases for FAM150B gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022221.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FAM150B gene promoter:
Max1 AP-2gamma GATA-1 RORalpha1 FOXJ2 (long isoform) AP-2beta TGIF AP-2alpha AP-2alphaA c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FAM150B promoter sequence

Search SABiosciences Chromatin IP Primers for FAM150B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM150B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p25.3 Ensembl cytogenetic band: 2p25.3 HGNC cytogenetic band: 2p25.3

FAM150B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM150B gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M000271: view genomic region (about GC identifiers)

Start:	279,561 bp from pter	End:	288,851 bp from pter
Size:	9,291 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: F150B_HUMAN, Q6UX46 (See protein sequence)

Recommended Name: Protein FAM150B precursor

Size: 152 amino acids; 16915 Da

Subcellular location: Secreted (Potential)

Secondary accessions: B5MC76

Alternative splicing: 2 isoforms: Q6UX46-1 Q6UX46-2

Explore the universe of human proteins at neXtProt for FAM150B: NX_Q6UX46

FAM150B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001002919.2

ENSEMBL proteins:

ENSP00000384604 ENSP00000385537 ENSP00000385672 ENSP00000385214 ENSP00000339565

ENSP00000389939

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--

FAM150B for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q6UX46

UniProtKB/Swiss-Prot: F150B_HUMAN, Q6UX46

Similarity: Belongs to the FAM150 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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2 GenomeRNAi human phenotypes for FAM150B:

G0/1 arrest

Increased G1 DNA content

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for FAM150B

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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Search CenterWatch for drugs/clinical trials and news about FAM150B / F150B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for FAM150B gene:

NM_001002919.2

Unigene Cluster for FAM150B:

Family with sequence similarity 150, member B

Hs.355207 [show with all ESTs]

Unigene Representative Sequence: NM_001002919

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000403610(uc010ewf.1 uc002qwi.4) ENST00000401503 ENST00000405290

ENST00000401489 ENST00000344414 ENST00000452023 ENST00000463919

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Additional cDNA sequence:

AY358517.1 BC033490.1

7 DOTS entries:

DT.101978251 DT.104150 DT.95368188 DT.100743786 DT.100641360 DT.75122219 DT.121013753

24/34 AceView cDNA sequences (see all 34):

CD105711 BC033490 AY358517 CK819507 BM128907 BM129405 BM129692 NM_001002919

BM129183 BX091090 BF195926 BE972686 BF449053 AA938980 AI205786 BF446898

AW052022 AI024364 AI983714 AI917447 AI769402 AW449590 BI831684 BM129744

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for FAM150B About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3	^	4a	·	4b	^	5	^	6a	·	6b	·	6c
SP1:			-		-		-						-
SP2:													-
SP3:													-
SP4:

ECgene alternative splicing isoforms for FAM150B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FAM150B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAAATTAAA

About this image

FAM150B expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 7 LifeMap Cells

Name

Category

PureStem™ progenitor T42 (Embryonic Progenitor Cell)

PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor T36 (Embryonic Progenitor Cell)

PureStem™ progenitor Z1 (Embryonic Progenitor Cell)

HyStem+BMP4-induced SK11 cells (HyStem+BMP4 inductio...)

Bone, Cartilage

HyStem+BMP4-induced SM30 cells (HyStem+BMP4 inductio...)

Adipose, Bone, Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See FAM150B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM150B

SOURCE GeneReport for Unigene cluster: Hs.355207

SABiosciences Custom PCR Arrays for FAM150B

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for FAM150B gene from 3/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	FAM150B¹	family with sequence similarity 150, member B	66.67(n) 63.76(a)		421910 XM_419928.2 XP_419928.1
lizard (Anolis carolinensis)	Reptilia	FAM150B⁶	--	86(a)	1 ↔ 1	1(160107130-160110177)
zebrafish (Danio rerio)	Actinopterygii	LOC100535009¹	protein FAM150-like	53.57(n) 43.57(a)		100535009 XM_003199060.1 XP_003199108.1

ENSEMBL Gene Tree for FAM150B (if available)
TreeFam Gene Tree for FAM150B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FAM150B gene

FAM150A²

1 SIMAP similar gene for FAM150B using alignment to 4 protein entries: F150B_HUMAN (see all proteins):

FAM150A

FAM150B for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs111920357^1,2	C,	--	279189(+)	`TCCAAC/TTAGAT`	1	--	int¹		1		WA	2
rs10203722^1,2	C,F,A,H,	--	279266(+)	`AAGCAT/ATTTCA`	1	--	int¹		16		NA NS EA CSA WA	922
rs190960554^1,2		--	279348(+)	`TCTTAA/GGAAAT`	1	--	int¹		0	--	--	--	--
rs181792227^1,2		--	279352(+)	`AGGAAA/GTTATG`	1	--	int¹		0	--	--	--	--
rs57850759^1,2	C,	--	279371(+)	`ATATAG/ATAGCC`	1	--	int¹		1		WA	2
rs142994503^1,2		--	279481(+)	`TCATGA/CTCTCT`	1	--	int¹		0	--	--	--	--
rs191666381^1,2		--	279502(+)	`GAAGTC/GACGAA`	1	--	int¹		0	--	--	--	--
rs3828329^1,2	C,F,A,H,	--	279705(+)	`CATGAC/TCGAAA`	1	--	ut3¹		24		NS EA NA CSA WA	2766
rs183172783^1,2		--	279707(+)	`TGACCA/GAAATT`	1	--	ut3¹		0	--	--	--	--
rs188245376^1,2		--	279739(+)	`AATAAC/TACTCT`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for FAM150B (279561 - 288851 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for FAM150B
2 CNVs: 2360 3341

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FAM150B gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM150B)

Utopia: connect your pdf to the dynamic
world of online information

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)² Hillier L.W....Wilson R.K. (2005)
The sequence of the human genome. (PubMed id 11181995)¹ Venter J.C.... Zhu X. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 285016	HGNC: 27683	AceView: LOC285016	Ensembl:ENSG00000189292	euGenes: HUgn285016
ECgene: FAM150B	H-InvDB: FAM150B

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FAM150B	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FAM150B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for FAM150B gene:
Search GeneIP for patents involving FAM150B

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM150B

	SwitchGear 3'UTR luciferase reporter plasmids for FAM150B
	SwitchGear Promoter luciferase reporter plasmids for FAM150B

Search ThermoFisher Antibodies for FAM150B

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM150B

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes FAM150B gene at Home site.

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FAM150B Gene

family with sequence similarity 150, member B

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for FAM150B gene

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for FAM150B gene

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Export list of displayed genes

FAM150B Gene

family with sequence similarity 150, member B

Aliasesfor FAM150B gene

Summariesfor FAM150B gene

Genomic Viewsfor FAM150B gene

Proteinsfor FAM150B gene

Protein Domains /Familiesfor FAM150B gene

Functionfor FAM150B gene

Pathways & Interactionsfor FAM150B gene

Drugs & Compoundsfor FAM150B gene

Transcriptsfor FAM150B gene

Expression for FAM150B gene

Orthologsfor FAM150B gene

Paralogsfor FAM150B gene

Genomic Variantsfor FAM150B gene

Disorders / Diseasesfor FAM150B gene

Publicationsfor FAM150B gene

External Searches for FAM150B gene

Genome Databases showing FAM150B gene

Other Databases showing FAM150B gene

Specialized Databases showing FAM150B gene

Intellectual Propertyfor FAM150B gene

Productsfor FAM150B gene

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Aliases
for FAM150B gene

Summaries
for FAM150B gene

Genomic Views
for FAM150B gene

Proteins
for FAM150B gene

Protein Domains /
Families
for FAM150B gene

Function
for FAM150B gene

Pathways & Interactions
for FAM150B gene

Drugs & Compounds
for FAM150B gene

Transcripts
for FAM150B gene

Expression
for FAM150B gene

Orthologs
for FAM150B gene

Paralogs
for FAM150B gene

Genomic Variants
for FAM150B gene

Disorders / Diseases
for FAM150B gene

Publications
for FAM150B gene

Intellectual Property
for FAM150B gene

Products
for FAM150B gene