Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FAM150A Gene

Aliases for FAM150A Gene

  • Family With Sequence Similarity 150 Member A 2 3 5
  • Augmentor Beta 3 4
  • AUG-Beta 3 4
  • Family With Sequence Similarity 150, Member A 2
  • Protein FAM150A 3
  • RPLK9433 3
  • UNQ9433 3

External Ids for FAM150A Gene

Previous GeneCards Identifiers for FAM150A Gene

  • GC08M053611
  • GC08M053446
  • GC08M048914

Summaries for FAM150A Gene

GeneCards Summary for FAM150A Gene

FAM150A (Family With Sequence Similarity 150 Member A) is a Protein Coding gene. An important paralog of this gene is FAM150B.

UniProtKB/Swiss-Prot for FAM150A Gene

  • Ligand for receptor tyrosine kinase LTK and perhaps receptor tyrosine kinase ALK; activation of ALK is reported conflictingly.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM150A Gene

Genomics for FAM150A Gene

Regulatory Elements for FAM150A Gene

Enhancers for FAM150A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around FAM150A on UCSC Golden Path with GeneCards custom track

Promoters for FAM150A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for FAM150A Gene

Chromosome:
8
Start:
52,534,037 bp from pter
End:
52,565,507 bp from pter
Size:
31,471 bases
Orientation:
Minus strand

Genomic View for FAM150A Gene

Genes around FAM150A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM150A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM150A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM150A Gene

Proteins for FAM150A Gene

  • Protein details for FAM150A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXT8-F150A_HUMAN
    Recommended name:
    Protein FAM150A
    Protein Accession:
    Q6UXT8
    Secondary Accessions:
    • B7ZMG9

    Protein attributes for FAM150A Gene

    Size:
    129 amino acids
    Molecular mass:
    14269 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM150A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM150A Gene

Post-translational modifications for FAM150A Gene

  • Glycosylation at Thr 85
  • Modification sites at PhosphoSitePlus

Other Protein References for FAM150A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM150A Gene

Domains & Families for FAM150A Gene

Protein Domains for FAM150A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM150A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UXT8

UniProtKB/Swiss-Prot:

F150A_HUMAN :
  • Belongs to the FAM150 family.
Family:
  • Belongs to the FAM150 family.
genes like me logo Genes that share domains with FAM150A: view

No data available for Gene Families for FAM150A Gene

Function for FAM150A Gene

Molecular function for FAM150A Gene

UniProtKB/Swiss-Prot Function:
Ligand for receptor tyrosine kinase LTK and perhaps receptor tyrosine kinase ALK; activation of ALK is reported conflictingly.

Gene Ontology (GO) - Molecular Function for FAM150A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 26418745
GO:0030298 receptor signaling protein tyrosine kinase activator activity IDA 26418745
GO:0030971 receptor tyrosine kinase binding IDA 26418745
genes like me logo Genes that share ontologies with FAM150A: view

Phenotypes for FAM150A Gene

GenomeRNAi human phenotypes for FAM150A:
genes like me logo Genes that share phenotypes with FAM150A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for FAM150A

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM150A Gene

Localization for FAM150A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM150A Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM150A Gene COMPARTMENTS Subcellular localization image for FAM150A gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for FAM150A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with FAM150A: view

Pathways & Interactions for FAM150A Gene

SuperPathways for FAM150A Gene

No Data Available

Interacting Proteins for FAM150A Gene

Selected Interacting proteins: Q6UXT8-F150A_HUMAN for FAM150A Gene via UniProtKB

Gene Ontology (GO) - Biological Process for FAM150A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010976 positive regulation of neuron projection development IDA 26418745
GO:0061098 positive regulation of protein tyrosine kinase activity IEA --
GO:0070374 positive regulation of ERK1 and ERK2 cascade IDA 26418745
GO:0070378 positive regulation of ERK5 cascade IDA 26418745
genes like me logo Genes that share ontologies with FAM150A: view

No data available for Pathways by source and SIGNOR curated interactions for FAM150A Gene

Drugs & Compounds for FAM150A Gene

No Compound Related Data Available

Transcripts for FAM150A Gene

mRNA/cDNA for FAM150A Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM150A Gene

Family with sequence similarity 150, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM150A Gene

No ASD Table

Relevant External Links for FAM150A Gene

GeneLoc Exon Structure for
FAM150A
ECgene alternative splicing isoforms for
FAM150A

Expression for FAM150A Gene

mRNA expression in normal human tissues for FAM150A Gene

mRNA differential expression in normal tissues according to GTEx for FAM150A Gene

This gene is overexpressed in Thyroid (x7.5), Esophagus - Muscularis (x7.3), and Bladder (x6.0).

NURSA nuclear receptor signaling pathways regulating expression of FAM150A Gene:

FAM150A

SOURCE GeneReport for Unigene cluster for FAM150A Gene:

Hs.527111

mRNA Expression by UniProt/SwissProt for FAM150A Gene:

Q6UXT8-F150A_HUMAN
Tissue specificity: Widely expressed with highest levels in thyroid and moderate levels in stomach, trachea, small intestine, prostate and brain.
genes like me logo Genes that share expression patterns with FAM150A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for FAM150A Gene

Orthologs for FAM150A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM150A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAM150A 34
  • 81.51 (n)
  • 79.83 (a)
dog
(Canis familiaris)
Mammalia LOC608857 34
  • 87.15 (n)
  • 83.33 (a)
FAM150A 35
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam150a 34
  • 85.39 (n)
  • 80.9 (a)
Fam150a 16
Fam150a 35
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM150A 34
  • 99.74 (n)
  • 99.22 (a)
FAM150A 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100910984 34
  • 84.27 (n)
  • 79.78 (a)
oppossum
(Monodelphis domestica)
Mammalia FAM150A 35
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM150A 35
  • 77 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii FAM150A 35
  • 38 (a)
OneToOne
Species where no ortholog for FAM150A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM150A Gene

ENSEMBL:
Gene Tree for FAM150A (if available)
TreeFam:
Gene Tree for FAM150A (if available)

Paralogs for FAM150A Gene

Paralogs for FAM150A Gene

(1) SIMAP similar genes for FAM150A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FAM150A: view

Variants for FAM150A Gene

Sequence variations from dbSNP and Humsavar for FAM150A Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1440797 -- 52,535,383(-) tttgg(G/T)ggcaa intron-variant
rs1440798 -- 52,534,696(-) ACAGA(G/T)TCTTT intron-variant
rs1992361 -- 52,567,366(+) TAGTT(A/C)TGAAG upstream-variant-2KB
rs2033934 -- 52,552,089(-) gacat(A/G)atgac intron-variant
rs2033935 -- 52,539,006(-) gagac(A/C)agcct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM150A Gene

Variant ID Type Subtype PubMed ID
dgv7218n100 CNV gain 25217958
dgv7219n100 CNV gain 25217958
esv2761192 CNV gain 21179565
esv2764065 CNV gain 21179565
esv3576572 CNV gain 25503493
esv3617214 CNV gain 21293372
esv3617216 CNV gain 21293372
esv3891394 CNV gain 25118596
esv3891395 CNV gain 25118596
nsv465680 CNV gain 19166990
nsv470213 CNV gain 18288195
nsv611355 CNV gain 21841781
nsv611356 CNV gain 21841781
nsv611357 CNV gain 21841781

Variation tolerance for FAM150A Gene

Residual Variation Intolerance Score: 47.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.54; 11.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM150A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM150A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM150A Gene

Disorders for FAM150A Gene

Relevant External Links for FAM150A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM150A

No disorders were found for FAM150A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM150A Gene

Publications for FAM150A Gene

  1. FAM150A and FAM150B are activating ligands for anaplastic lymphoma kinase. (PMID: 26418745) Guan J. … Palmer R.H. (Elife 2015) 3 4 65
  2. Augmentor alpha and beta (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand- receptor interactions. (PMID: 26630010) Reshetnyak A.V. … Schlessinger J. (Proc. Natl. Acad. Sci. U.S.A. 2015) 3 4 65
  3. Deorphanization of the human leukocyte tyrosine kinase (LTK) receptor by a signaling screen of the extracellular proteome. (PMID: 25331893) Zhang H. … Williams L.T. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3 4 65
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 65
  5. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C. … Lander E.S. (Nature 2006) 4 65

Products for FAM150A Gene

Sources for FAM150A Gene

Content
Loading form....