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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAM149B1 Gene

protein-coding   GIFtS: 38
GCID: GC10P074927

Family With Sequence Similarity 149, Member B1

(Previous name: KIAA0974)
(Previous symbol: KIAA0974)
  Search for FAM149B1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Family With Sequence Similarity 149, Member B11 2
KIAA09741 2 3
Protein FAM149B12

External Ids:    HGNC: 291621   Entrez Gene: 3176622   Ensembl: ENSG000001382867   UniProtKB: Q96BN63   

Export aliases for FAM149B1 gene to outside databases

Previous GC identifers: GC10U900852 GC10P074597 GC10P068921


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FAM149B1 Gene: 
FAM149B1 (family with sequence similarity 149, member B1) is a protein-coding gene. An important paralog of this gene is FAM149A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FAM149B1 gene promoter:
         ER-alpha   ATF-2   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   GATA-1   Pax-4a   ATF   ATF6   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for FAM149B1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM149B1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q22.2   Ensembl cytogenetic band:  10q22.2   HGNC cytogenetic band: 10q22.2

FAM149B1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM149B1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P074927:  view genomic region     (about GC identifiers)

Start:
74,927,877 bp from pter      End:
75,004,262 bp from pter
Size:
76,386 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: F149B_HUMAN, Q96BN6 (See protein sequence)
Recommended Name: Protein FAM149B1  
Size: 582 amino acids; 64618 Da
Sequence caution: Sequence=AAH15394.1; Type=Erroneous initiation;
Secondary accessions: Q9Y2I0
Alternative splicing: 2 isoforms:  Q96BN6-1   Q96BN6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FAM149B1: NX_Q96BN6

Explore proteomics data for FAM149B1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96BN6

  • FAM149B1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FAM149B1 Protein Expression
    REFSEQ proteins: NP_775483.1  
    ENSEMBL proteins: 
     ENSP00000242505   ENSP00000362046   ENSP00000402293  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR022194 DUF3719

    Graphical View of Domain Structure for InterPro Entry Q96BN6

    ProtoNet protein and cluster: Q96BN6

    UniProtKB/Swiss-Prot: F149B_HUMAN, Q96BN6
    Similarity: Belongs to the FAM149 family


    FAM149B1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM149B1

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FAM149B1 (F149B)

    Search CenterWatch for drugs/clinical trials and news about FAM149B1 / F149B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FAM149B1 gene: 
    NM_173348.1  

    Unigene Cluster for FAM149B1:

    Family with sequence similarity 149, member B1
    Hs.408577  [show with all ESTs]
    Unigene Representative Sequence: AB023191
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000242505(uc009xqz.3 uc010qkf.2 uc009xra.3) ENST00000372955(uc001jtq.3)
    ENST00000445951 ENST00000475829 ENST00000470798 ENST00000466261 ENST00000468462

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                         Customized lentivirus expression plasmids for stable overexpression of FAM149B1 
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    Additional mRNA sequence: 

    AB023191.1 AK023439.1 AK303436.1 BC015394.1 

    14 DOTS entries:

    DT.451865  DT.100650604  DT.86846823  DT.92433420  DT.95172105  DT.100752091  DT.75136646  DT.100033058 
    DT.100739881  DT.121301359  DT.95344151  DT.99972991  DT.75141170  DT.95172102 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for FAM149B1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b
    SP1:                                            -     -           -     -     -                     
    SP2:                                            -     -                       -                     
    SP3:                                                  -                                             
    SP4:                                            -     -                                             
    SP5:                                                                          -                     


    ECgene alternative splicing isoforms for FAM149B1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FAM149B1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAGTTTTAG
    FAM149B1 Expression
    About this image


    See FAM149B1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FAM149B1

    SOURCE GeneReport for Unigene cluster: Hs.408577
        SABiosciences Custom PCR Arrays for FAM149B1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM149B1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FAM149B1 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam149b1 , 5 family with sequence similarity 149, member B1, 5 83.8(n)1
    80.9(a)1
      14 (11.52 cM)5
    1054281  NM_001024512.21  NP_001019683.11 
     203481625 
    chicken
    (Gallus gallus)
    Aves FAM149B11 family with sequence similarity 149, member B1 63.97(n)
    54.58(a)
      423639  XM_421523.3  XP_421523.2 
    lizard
    (Anolis carolinensis)
    Reptilia FAM149B16
    family with sequence similarity 149, member B1
    47(a)
    1 ↔ 1
    GL343378.1(7567-30567)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1586511 zgc:158651 53.38(n)
    43.69(a)
      791183  NM_001080665.1  NP_001074134.1 


    ENSEMBL Gene Tree for FAM149B1 (if available)
    TreeFam Gene Tree for FAM149B1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FAM149B1 gene
    FAM149A2  

    FAM149B1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for FAM149B1
    PGOHUM00000257996


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1327 SNPs in FAM149B1 are shown (see all 1327)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1928808011,2
    --74929865(+) CATTCC/TTGGGT 1 -- int10--------
    rs1854681561,2
    --74929993(+) GTGGAC/TCCCCA 1 -- int10--------
    rs1892712431,2
    --74930047(+) CCTGAA/GCTCAG 1 -- int10--------
    rs1817799301,2
    --74930169(+) AGGCAC/TGAGAA 1 -- int10--------
    rs1402435801,2
    C--74930189(+) CCTGGA/GAGGCG 1 -- int10--------
    rs1847887691,2
    --74930210(+) TGAGCC/TGAGAT 1 -- int10--------
    rs37637241,2
    C--74930276(+) AATAAA/GTAAAT 1 -- int10--------
    rs1388119361,2
    C--74930282(+) AAATA-/AAAAT 
            
    AAAAT
    1 -- int10--------
    rs38349061,2
    C--74930284(+) AATAA-/AATAA 
            
    GAATA
    1 -- int10--------
    rs1175067691,2
    F--74930358(+) CCTTCG/ACACTT 1 -- int11Minor allele frequency- A:0.01NA 120

    HapMap Linkage Disequilibrium report for FAM149B1 (74927877 - 75004262 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FAM149B1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv7132CNV Loss18451855

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    FAM149B1 for disorders           About MalaCards

    FAM149B1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FAM149B1

    Export disorders for FAM149B1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FAM149B1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with FAM149B1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2, 3 Nagase T.... Ohara O. (1999)
    2. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    6. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 317662 HGNC: 29162 Ensembl:ENSG00000138286 euGenes: HUgn317662 ECgene: FAM149B1
    H-InvDB: FAM149B1

    (According to HUGE)
    About This Section
    HUGE: KIAA0974

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FAM149B1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FAM149B1 gene:
    Search GeneIP for patents involving FAM149B1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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