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Aliases for FAM149B1 Gene

Aliases for FAM149B1 Gene

  • Family With Sequence Similarity 149 Member B1 2 3 5
  • KIAA0974 2 3 4
  • Family With Sequence Similarity 149, Member B1 2 3

External Ids for FAM149B1 Gene

Previous HGNC Symbols for FAM149B1 Gene

  • KIAA0974

Previous GeneCards Identifiers for FAM149B1 Gene

  • GC10U900852
  • GC10P074597
  • GC10P074927
  • GC10P068921

Summaries for FAM149B1 Gene

GeneCards Summary for FAM149B1 Gene

FAM149B1 (Family With Sequence Similarity 149 Member B1) is a Protein Coding gene. An important paralog of this gene is FAM149A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM149B1 Gene

Genomics for FAM149B1 Gene

Regulatory Elements for FAM149B1 Gene

Enhancers for FAM149B1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FAM149B1 on UCSC Golden Path with GeneCards custom track

Promoters for FAM149B1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAM149B1 on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM149B1 Gene

73,168,095 bp from pter
73,244,504 bp from pter
76,410 bases
Plus strand

Genomic View for FAM149B1 Gene

Genes around FAM149B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM149B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM149B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM149B1 Gene

Proteins for FAM149B1 Gene

  • Protein details for FAM149B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM149B1
    Protein Accession:
    Secondary Accessions:
    • Q9Y2I0

    Protein attributes for FAM149B1 Gene

    582 amino acids
    Molecular mass:
    64618 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH15394.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM149B1 Gene


neXtProt entry for FAM149B1 Gene

Proteomics data for FAM149B1 Gene at MOPED

Post-translational modifications for FAM149B1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM149B1 Gene

No data available for DME Specific Peptides for FAM149B1 Gene

Domains & Families for FAM149B1 Gene

Protein Domains for FAM149B1 Gene


Suggested Antigen Peptide Sequences for FAM149B1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM149 family.
  • Belongs to the FAM149 family.
genes like me logo Genes that share domains with FAM149B1: view

No data available for Gene Families for FAM149B1 Gene

Function for FAM149B1 Gene

Phenotypes for FAM149B1 Gene

genes like me logo Genes that share phenotypes with FAM149B1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM149B1 Gene

Localization for FAM149B1 Gene

Subcellular locations from

Jensen Localization Image for FAM149B1 Gene COMPARTMENTS Subcellular localization image for FAM149B1 gene
Compartment Confidence
nucleus 3
cytosol 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM149B1 Gene

Pathways & Interactions for FAM149B1 Gene

SuperPathways for FAM149B1 Gene

No Data Available

Interacting Proteins for FAM149B1 Gene

Gene Ontology (GO) - Biological Process for FAM149B1 Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM149B1 Gene

Drugs & Compounds for FAM149B1 Gene

No Compound Related Data Available

Transcripts for FAM149B1 Gene

mRNA/cDNA for FAM149B1 Gene

(10) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM149B1 Gene

Family with sequence similarity 149, member B1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM149B1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b
SP1: - - - - -
SP2: - - -
SP3: -
SP4: - -
SP5: -

Relevant External Links for FAM149B1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM149B1 Gene

mRNA expression in normal human tissues for FAM149B1 Gene

Protein differential expression in normal tissues from HIPED for FAM149B1 Gene

This gene is overexpressed in Breast (51.1) and Placenta (15.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM149B1 Gene

SOURCE GeneReport for Unigene cluster for FAM149B1 Gene Hs.408577

genes like me logo Genes that share expression patterns with FAM149B1: view

Protein tissue co-expression partners for FAM149B1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM149B1 Gene

Orthologs for FAM149B1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM149B1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM149B1 35
  • 88.3 (n)
  • 87.06 (a)
FAM149B1 36
  • 83 (a)
(Canis familiaris)
Mammalia FAM149B1 35
  • 88.47 (n)
  • 85.89 (a)
FAM149B1 36
  • 85 (a)
(Mus musculus)
Mammalia Fam149b 35
  • 83.8 (n)
  • 80.9 (a)
Fam149b 16
Fam149b 36
  • 80 (a)
(Pan troglodytes)
Mammalia FAM149B1 35
  • 99.43 (n)
  • 98.63 (a)
FAM149B1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Fam149b1 35
  • 82.33 (n)
  • 79.42 (a)
(Monodelphis domestica)
Mammalia FAM149B1 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 60 (a)
-- 36
  • 58 (a)
(Gallus gallus)
Aves FAM149B1 35
  • 63.03 (n)
  • 53.35 (a)
FAM149B1 36
  • 52 (a)
(Anolis carolinensis)
Reptilia FAM149B1 36
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam149b1 35
  • 54.07 (n)
  • 44.26 (a)
(Danio rerio)
Actinopterygii fam149b1 35
  • 54.04 (n)
  • 44.3 (a)
fam149b1 36
  • 34 (a)
Species with no ortholog for FAM149B1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM149B1 Gene

Gene Tree for FAM149B1 (if available)
Gene Tree for FAM149B1 (if available)

Paralogs for FAM149B1 Gene

Paralogs for FAM149B1 Gene Pseudogenes for FAM149B1 Gene

genes like me logo Genes that share paralogs with FAM149B1: view

Variants for FAM149B1 Gene

Sequence variations from dbSNP and Humsavar for FAM149B1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs12573841 - 73,240,981(+) AAAGC(A/G)GAGGC reference, missense
rs3750735 -- 73,177,748(+) ATGTT(A/T)ATCAC intron-variant
rs3763724 -- 73,170,518(+) AATAA(A/G)TAAAT intron-variant
rs3763725 -- 73,241,179(+) ATAGC(A/G)GCCAA utr-variant-3-prime
rs3834906 -- 73,170,531(+) AATAA(-/AATAA)GAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM149B1 Gene

Variant ID Type Subtype PubMed ID
nsv7132 CNV Loss 18451855

Variation tolerance for FAM149B1 Gene

Gene Damage Index Score: 13.21; 95.23% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FAM149B1 Gene

Disorders for FAM149B1 Gene

Relevant External Links for FAM149B1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM149B1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM149B1 Gene

Publications for FAM149B1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3

Products for FAM149B1 Gene

Sources for FAM149B1 Gene