Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FAM149B1 Gene

Aliases for FAM149B1 Gene

  • Family With Sequence Similarity 149 Member B1 2 3 5
  • KIAA0974 2 3 4
  • Family With Sequence Similarity 149, Member B1 2
  • Protein FAM149B1 3

External Ids for FAM149B1 Gene

Previous HGNC Symbols for FAM149B1 Gene

  • KIAA0974

Previous GeneCards Identifiers for FAM149B1 Gene

  • GC10U900852
  • GC10P074597
  • GC10P074927
  • GC10P068921

Summaries for FAM149B1 Gene

GeneCards Summary for FAM149B1 Gene

FAM149B1 (Family With Sequence Similarity 149 Member B1) is a Protein Coding gene. An important paralog of this gene is FAM149A.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM149B1 Gene

Genomics for FAM149B1 Gene

Regulatory Elements for FAM149B1 Gene

Enhancers for FAM149B1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G072212 1.7 Ensembl ENCODE dbSUPER 4.2 -951.6 -951579 7.1 MLX CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 TBX21 SSRP1 ECD ANAPC16 RPL15P14 DNAJB12 ASCC1 NUDT13 FAM149B1
GH10G072229 1.4 Ensembl ENCODE dbSUPER 4 -937.6 -937630 2.3 HDGF HDAC1 YBX3 PKNOX1 FEZF1 RAD21 YY1 TCF12 ZNF766 GATA2 ECD ENSG00000200294 ASCC1 FAM149B1 ENSG00000272630 ENSG00000200170 GC10M072248
GH10G072227 1.2 ENCODE dbSUPER 4.2 -939.6 -939614 1.1 PKNOX1 ARNT FEZF1 ZNF2 KLF7 ZNF263 TSHZ1 ZNF488 ZNF623 ZNF518A ENSG00000200294 DNAJB12 ASCC1 FAM149B1 ENSG00000272630 ENSG00000200170 GC10M072248
GH10G073166 1.1 ENCODE 0.7 -0.1 -93 2.4 PKNOX1 MLX CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 NUDT13 ECD AP3M1 ZSWIM8 FAM149B1 ENSG00000221164
GH10G073165 0.4 FANTOM5 0.7 -2.8 -2800 0.0 ATF3 ECD ANXA7 FAM149B1 ENSG00000221164
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM149B1 on UCSC Golden Path with GeneCards custom track

Promoters for FAM149B1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000029804 105 2001 PKNOX1 MLX CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for FAM149B1 Gene

Chromosome:
10
Start:
73,168,095 bp from pter
End:
73,244,504 bp from pter
Size:
76,410 bases
Orientation:
Plus strand

Genomic View for FAM149B1 Gene

Genes around FAM149B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM149B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM149B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM149B1 Gene

Proteins for FAM149B1 Gene

  • Protein details for FAM149B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BN6-F149B_HUMAN
    Recommended name:
    Protein FAM149B1
    Protein Accession:
    Q96BN6
    Secondary Accessions:
    • Q9Y2I0

    Protein attributes for FAM149B1 Gene

    Size:
    582 amino acids
    Molecular mass:
    64618 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH15394.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM149B1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM149B1 Gene

Post-translational modifications for FAM149B1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM149B1 Gene

Domains & Families for FAM149B1 Gene

Protein Domains for FAM149B1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM149B1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96BN6

UniProtKB/Swiss-Prot:

F149B_HUMAN :
  • Belongs to the FAM149 family.
Family:
  • Belongs to the FAM149 family.
genes like me logo Genes that share domains with FAM149B1: view

No data available for Gene Families for FAM149B1 Gene

Function for FAM149B1 Gene

Phenotypes for FAM149B1 Gene

genes like me logo Genes that share phenotypes with FAM149B1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM149B1 Gene

Localization for FAM149B1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM149B1 gene
Compartment Confidence
nucleus 3
mitochondrion 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM149B1 Gene

Pathways & Interactions for FAM149B1 Gene

SuperPathways for FAM149B1 Gene

No Data Available

Interacting Proteins for FAM149B1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000242505%0d%0a9606.ENSP00000381270%0d%0a
Selected Interacting proteins: ENSP00000242505 Q96BN6-F149B_HUMAN for FAM149B1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for FAM149B1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM149B1 Gene

Drugs & Compounds for FAM149B1 Gene

No Compound Related Data Available

Transcripts for FAM149B1 Gene

mRNA/cDNA for FAM149B1 Gene

(10) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM149B1 Gene

Family with sequence similarity 149, member B1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM149B1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b
SP1: - - - - -
SP2: - - -
SP3: -
SP4: - -
SP5: -

Relevant External Links for FAM149B1 Gene

GeneLoc Exon Structure for
FAM149B1
ECgene alternative splicing isoforms for
FAM149B1

Expression for FAM149B1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM149B1 Gene

Protein differential expression in normal tissues from HIPED for FAM149B1 Gene

This gene is overexpressed in Breast (51.1) and Placenta (15.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM149B1 Gene



Protein tissue co-expression partners for FAM149B1 Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM149B1 Gene:

FAM149B1

SOURCE GeneReport for Unigene cluster for FAM149B1 Gene:

Hs.408577
genes like me logo Genes that share expression patterns with FAM149B1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM149B1 Gene

Orthologs for FAM149B1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM149B1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM149B1 34 35
  • 99.43 (n)
dog
(Canis familiaris)
Mammalia FAM149B1 34 35
  • 88.47 (n)
cow
(Bos Taurus)
Mammalia FAM149B1 34 35
  • 88.3 (n)
mouse
(Mus musculus)
Mammalia Fam149b 34 16 35
  • 83.8 (n)
rat
(Rattus norvegicus)
Mammalia Fam149b1 34
  • 82.33 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM149B1 35
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 60 (a)
OneToMany
-- 35
  • 58 (a)
OneToMany
chicken
(Gallus gallus)
Aves FAM149B1 34 35
  • 63.03 (n)
lizard
(Anolis carolinensis)
Reptilia FAM149B1 35
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam149b1 34
  • 54.07 (n)
zebrafish
(Danio rerio)
Actinopterygii fam149b1 34 35
  • 54.04 (n)
Species where no ortholog for FAM149B1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM149B1 Gene

ENSEMBL:
Gene Tree for FAM149B1 (if available)
TreeFam:
Gene Tree for FAM149B1 (if available)

Paralogs for FAM149B1 Gene

Paralogs for FAM149B1 Gene

Pseudogenes.org Pseudogenes for FAM149B1 Gene

genes like me logo Genes that share paralogs with FAM149B1: view

Variants for FAM149B1 Gene

Sequence variations from dbSNP and Humsavar for FAM149B1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000063595 -- 73,237,556(+) CTGGG(A/G)CTACA intron-variant
rs1000066286 -- 73,240,814(+) CTACA(A/T)AACTA intron-variant
rs1000070960 -- 73,199,583(+) CCAGG(A/C)TGTCC intron-variant
rs1000073724 -- 73,193,123(+) TTCAC(A/G)TTTTT intron-variant
rs1000124413 -- 73,232,622(+) GGAGT(A/C)GGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM149B1 Gene

Variant ID Type Subtype PubMed ID
nsv7132 CNV deletion 18451855
nsv948065 CNV duplication 23825009

Variation tolerance for FAM149B1 Gene

Gene Damage Index Score: 13.21; 95.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM149B1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM149B1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM149B1 Gene

Disorders for FAM149B1 Gene

Relevant External Links for FAM149B1

Genetic Association Database (GAD)
FAM149B1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM149B1

No disorders were found for FAM149B1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM149B1 Gene

Publications for FAM149B1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64
  4. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for FAM149B1 Gene

Sources for FAM149B1 Gene

Content
Loading form....