Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FAM149A Gene

Aliases for FAM149A Gene

  • Family With Sequence Similarity 149 Member A 2 3 5
  • Family With Sequence Similarity 149, Member A 2 3
  • MSTP119 3
  • MST119 3

External Ids for FAM149A Gene

Previous GeneCards Identifiers for FAM149A Gene

  • GC04P187304
  • GC04P187026
  • GC04P182817

Summaries for FAM149A Gene

GeneCards Summary for FAM149A Gene

FAM149A (Family With Sequence Similarity 149 Member A) is a Protein Coding gene. An important paralog of this gene is FAM149B1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM149A Gene

Genomics for FAM149A Gene

Regulatory Elements for FAM149A Gene

Enhancers for FAM149A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FAM149A on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM149A Gene

186,104,419 bp from pter
186,172,667 bp from pter
68,249 bases
Plus strand

Genomic View for FAM149A Gene

Genes around FAM149A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM149A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM149A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM149A Gene

Proteins for FAM149A Gene

  • Protein details for FAM149A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM149A
    Protein Accession:
    Secondary Accessions:
    • B5MDB8
    • Q2TAN6
    • Q7Z2S5
    • Q9Y4T9

    Protein attributes for FAM149A Gene

    773 amino acids
    Molecular mass:
    82698 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI10817.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAQ13641.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAQ13641.1; Type=Frameshift; Positions=635; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM149A Gene


neXtProt entry for FAM149A Gene

Proteomics data for FAM149A Gene at MOPED

Post-translational modifications for FAM149A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM149A Gene

Domains & Families for FAM149A Gene

Protein Domains for FAM149A Gene


Suggested Antigen Peptide Sequences for FAM149A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM149 family.
  • Belongs to the FAM149 family.
genes like me logo Genes that share domains with FAM149A: view

No data available for Gene Families for FAM149A Gene

Function for FAM149A Gene

Phenotypes for FAM149A Gene

GenomeRNAi human phenotypes for FAM149A:
genes like me logo Genes that share phenotypes with FAM149A: view

Animal Model Products

CRISPR Products

miRNA for FAM149A Gene

miRTarBase miRNAs that target FAM149A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM149A Gene

Localization for FAM149A Gene

Subcellular locations from

Jensen Localization Image for FAM149A Gene COMPARTMENTS Subcellular localization image for FAM149A gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM149A Gene

Pathways & Interactions for FAM149A Gene

SuperPathways for FAM149A Gene

No Data Available

Interacting Proteins for FAM149A Gene

Selected Interacting proteins: A5PLN7-F149A_HUMAN for FAM149A Gene via I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for FAM149A Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM149A Gene

Drugs & Compounds for FAM149A Gene

No Compound Related Data Available

Transcripts for FAM149A Gene

Unigene Clusters for FAM149A Gene

Family with sequence similarity 149, member A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM149A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c
SP2: -
SP3: -

Relevant External Links for FAM149A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM149A Gene

mRNA expression in normal human tissues for FAM149A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAM149A Gene

This gene is overexpressed in Testis (52.5) and Adipocyte (13.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM149A Gene

SOURCE GeneReport for Unigene cluster for FAM149A Gene Hs.744961

genes like me logo Genes that share expression patterns with FAM149A: view

Protein tissue co-expression partners for FAM149A Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM149A Gene

Orthologs for FAM149A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM149A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM149A 35
  • 77.8 (n)
  • 69.94 (a)
FAM149A 36
  • 41 (a)
(Canis familiaris)
Mammalia FAM149A 35
  • 79.9 (n)
  • 71.93 (a)
FAM149A 36
  • 59 (a)
(Mus musculus)
Mammalia Fam149a 35
  • 73.7 (n)
  • 68.48 (a)
Fam149a 16
Fam149a 36
  • 41 (a)
(Pan troglodytes)
Mammalia FAM149A 35
  • 98.5 (n)
  • 95.76 (a)
(Rattus norvegicus)
Mammalia Fam149a 35
  • 73.88 (n)
  • 68.07 (a)
(Monodelphis domestica)
Mammalia FAM149A 36
  • 38 (a)
(Ornithorhynchus anatinus)
Mammalia FAM149A 36
  • 35 (a)
(Gallus gallus)
Aves FAM149A 35
  • 59.96 (n)
  • 50.31 (a)
FAM149A 36
  • 38 (a)
(Anolis carolinensis)
Reptilia FAM149A 36
  • 37 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam149a 35
  • 59.27 (n)
  • 51.8 (a)
(Danio rerio)
Actinopterygii si:ch211-51g4.5 35
  • 48.61 (n)
  • 37.04 (a)
FAM149A 36
  • 23 (a)
Species with no ortholog for FAM149A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM149A Gene

Gene Tree for FAM149A (if available)
Gene Tree for FAM149A (if available)

Paralogs for FAM149A Gene

Paralogs for FAM149A Gene

genes like me logo Genes that share paralogs with FAM149A: view

Variants for FAM149A Gene

Sequence variations from dbSNP and Humsavar for FAM149A Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs4862650 - 186,153,679(+) CTGAC(A/G)AAGGC reference, missense
rs4862653 - 186,156,052(+) GGCGC(A/G)AACTC reference, missense
VAR_039052 -
VAR_039053 -
rs9991339 - 186,167,094(+) CGTTC(C/T)GGGTG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for FAM149A Gene

Variant ID Type Subtype PubMed ID
dgv683n27 CNV Gain 19166990
dgv5851n71 CNV Gain 21882294
nsv470097 CNV Gain 18288195
dgv5852n71 CNV Gain 21882294
nsv461864 CNV Gain 19166990
nsv830172 CNV Loss 17160897
dgv5853n71 CNV Loss 21882294
nsv508340 CNV Loss 20534489
esv2728928 CNV Deletion 23290073
nsv524972 CNV Loss 19592680
nsv4642 CNV Loss 18451855
esv33576 CNV Gain 17666407
esv991339 CNV Deletion 20482838
dgv47n50 CNV Loss 21212237
dgv99n16 CNV Deletion 17901297
esv2568129 CNV Deletion 19546169
dgv996e199 CNV Deletion 23128226
nsv820150 CNV Gain 19587683
dgv916n67 CNV Loss 20364138
nsv820551 CNV Deletion 20802225
esv270972 CNV Insertion 20981092
esv274663 CNV Insertion 20981092
dgv135e180 CNV Gain 20482838
esv27795 CNV Gain 19812545
esv32667 CNV Gain 17666407
nsv514284 CNV Loss 21397061

Variation tolerance for FAM149A Gene

Residual Variation Intolerance Score: 99.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.96; 87.29% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FAM149A Gene

Disorders for FAM149A Gene

Relevant External Links for FAM149A

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM149A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM149A Gene

Publications for FAM149A Gene

  1. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. (PMID: 19460752) Yeung M.L. … Jeang K.T. (J. Biol. Chem. 2009) 3 67
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3

Products for FAM149A Gene

Sources for FAM149A Gene