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Aliases for FAM149A Gene

Aliases for FAM149A Gene

  • Family With Sequence Similarity 149 Member A 2 3 5
  • Family With Sequence Similarity 149, Member A 2
  • Protein FAM149A 3
  • MSTP119 3
  • MST119 3

External Ids for FAM149A Gene

Previous GeneCards Identifiers for FAM149A Gene

  • GC04P187304
  • GC04P187026
  • GC04P182817

Summaries for FAM149A Gene

GeneCards Summary for FAM149A Gene

FAM149A (Family With Sequence Similarity 149 Member A) is a Protein Coding gene. Diseases associated with FAM149A include Acute Mountain Sickness. An important paralog of this gene is FAM149B1.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM149A Gene

Genomics for FAM149A Gene

Regulatory Elements for FAM149A Gene

Enhancers for FAM149A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G186189 1.4 ENCODE dbSUPER 30.4 +86.9 86909 4.4 HNRNPUL1 CREB3L1 ARID4B SIN3A ZNF2 YY1 ZNF143 ZNF207 KLF13 MXD4 CYP4V2 FAM149A KLKB1 ORAOV1P1
GH04G186143 0.8 ENCODE 37.2 +40.5 40502 1.9 CTCF SUZ12 ZNF76 MAX UBTF ZIC2 ZNF2 YY1 ZFHX2 GATA2 FAM149A CYP4V2 TLR3 RPSAP70 ENSG00000253013
GH04G186104 1.1 FANTOM5 ENCODE 9.9 +1.1 1140 2.6 CTCF ATF1 ZBTB21 MAX GLI4 ZIC2 GLIS2 POLR2A ZBTB48 ZNF366 FAM149A SORBS2 PIR33423
GH04G186150 0.5 ENCODE 17.2 +45.8 45763 0.2 CTCF ZNF512 ZNF143 RAD21 NR2F2 FAM149A ENSG00000253013 CYP4V2 TLR3 RPSAP70
GH04G186764 1.5 Ensembl ENCODE dbSUPER 4.8 +661.3 661287 2.7 PKNOX1 FOXA2 ATF1 ARID4B FEZF1 DMAP1 ZNF48 YY1 ZHX2 MXD4 FAM149A FAT1 LOC102723906
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM149A on UCSC Golden Path with GeneCards custom track

Promoters for FAM149A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000177130 681 1001 CTCF MAZ SP3 L3MBTL2 MAX ZBTB8A ZNF398 ZIC2 GLIS2 HSF1

Genomic Location for FAM149A Gene

Chromosome:
4
Start:
186,104,419 bp from pter
End:
186,172,667 bp from pter
Size:
68,249 bases
Orientation:
Plus strand

Genomic View for FAM149A Gene

Genes around FAM149A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM149A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM149A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM149A Gene

Proteins for FAM149A Gene

  • Protein details for FAM149A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A5PLN7-F149A_HUMAN
    Recommended name:
    Protein FAM149A
    Protein Accession:
    A5PLN7
    Secondary Accessions:
    • B5MDB8
    • Q2TAN6
    • Q7Z2S5
    • Q9Y4T9

    Protein attributes for FAM149A Gene

    Size:
    773 amino acids
    Molecular mass:
    82698 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI10817.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAQ13641.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAQ13641.1; Type=Frameshift; Positions=635; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM149A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM149A Gene

Post-translational modifications for FAM149A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM149A Gene

Domains & Families for FAM149A Gene

Protein Domains for FAM149A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM149A Gene

Graphical View of Domain Structure for InterPro Entry

A5PLN7

UniProtKB/Swiss-Prot:

F149A_HUMAN :
  • Belongs to the FAM149 family.
Family:
  • Belongs to the FAM149 family.
genes like me logo Genes that share domains with FAM149A: view

No data available for Gene Families for FAM149A Gene

Function for FAM149A Gene

Phenotypes for FAM149A Gene

genes like me logo Genes that share phenotypes with FAM149A: view

Animal Model Products

CRISPR Products

miRNA for FAM149A Gene

miRTarBase miRNAs that target FAM149A

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM149A Gene

Localization for FAM149A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM149A gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM149A Gene

Pathways & Interactions for FAM149A Gene

SuperPathways for FAM149A Gene

No Data Available

Interacting Proteins for FAM149A Gene

Selected Interacting proteins: A5PLN7-F149A_HUMAN for FAM149A Gene via IID

Symbol External ID(s) Details
C2CD4A
DYNLT3

Gene Ontology (GO) - Biological Process for FAM149A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM149A Gene

Drugs & Compounds for FAM149A Gene

No Compound Related Data Available

Transcripts for FAM149A Gene

Unigene Clusters for FAM149A Gene

Family with sequence similarity 149, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM149A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c
SP1:
SP2: -
SP3: -

Relevant External Links for FAM149A Gene

GeneLoc Exon Structure for
FAM149A
ECgene alternative splicing isoforms for
FAM149A

Expression for FAM149A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM149A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAM149A Gene

This gene is overexpressed in Testis (52.5) and Adipocyte (13.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM149A Gene



Protein tissue co-expression partners for FAM149A Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM149A Gene:

FAM149A

SOURCE GeneReport for Unigene cluster for FAM149A Gene:

Hs.744961

Evidence on tissue expression from TISSUES for FAM149A Gene

  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with FAM149A: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM149A Gene

Orthologs for FAM149A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM149A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM149A 34
  • 98.5 (n)
dog
(Canis familiaris)
Mammalia FAM149A 34 35
  • 79.9 (n)
cow
(Bos Taurus)
Mammalia FAM149A 34 35
  • 77.8 (n)
rat
(Rattus norvegicus)
Mammalia Fam149a 34
  • 73.88 (n)
mouse
(Mus musculus)
Mammalia Fam149a 34 16 35
  • 73.7 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM149A 35
  • 38 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM149A 35
  • 35 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM149A 34 35
  • 59.96 (n)
lizard
(Anolis carolinensis)
Reptilia FAM149A 35
  • 37 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam149a 34
  • 59.27 (n)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-51g4.5 34
  • 48.61 (n)
FAM149A 35
  • 23 (a)
OneToOne
Species where no ortholog for FAM149A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM149A Gene

ENSEMBL:
Gene Tree for FAM149A (if available)
TreeFam:
Gene Tree for FAM149A (if available)

Paralogs for FAM149A Gene

Paralogs for FAM149A Gene

genes like me logo Genes that share paralogs with FAM149A: view

Variants for FAM149A Gene

Sequence variations from dbSNP and Humsavar for FAM149A Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000009613 -- 186,142,692(+) AGAGA(A/G)GGCTC intron-variant, upstream-variant-2KB
rs1000034332 -- 186,134,393(+) TGTAC(G/T)AGGTG intron-variant
rs1000059101 -- 186,148,513(+) TTAAG(C/T)GGTTC intron-variant, upstream-variant-2KB
rs1000124193 -- 186,150,009(+) TGGCC(A/G)GAAAT intron-variant
rs1000174645 -- 186,103,622(+) CAAAA(C/G)ATTCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FAM149A Gene

Variant ID Type Subtype PubMed ID
dgv1052e214 CNV gain 21293372
dgv135e180 CNV gain 20482838
dgv1555e212 CNV loss 25503493
dgv1556e212 CNV loss 25503493
dgv3152e59 CNV duplication 20981092
dgv47n50 CNV loss 21212237
dgv683n27 CNV gain 19166990
dgv916n67 CNV loss 20364138
dgv9426n54 CNV gain 21841781
dgv9430n54 CNV loss 21841781
dgv9431n54 CNV gain 21841781
dgv996e199 CNV deletion 23128226
dgv99n16 CNV deletion 17901297
esv2568129 CNV deletion 19546169
esv2728928 CNV deletion 23290073
esv27795 CNV gain 19812545
esv32667 CNV gain 17666407
esv33576 CNV gain 17666407
esv3565194 CNV deletion 23714750
esv3603517 CNV gain 21293372
esv3603522 CNV loss 21293372
esv3894090 CNV gain 25118596
esv991339 CNV deletion 20482838
nsv1016120 CNV gain 25217958
nsv1028146 CNV gain 25217958
nsv1074252 CNV deletion 25765185
nsv461864 CNV gain 19166990
nsv4642 CNV deletion 18451855
nsv470097 CNV gain 18288195
nsv508340 CNV deletion 20534489
nsv514284 CNV loss 21397061
nsv524972 CNV loss 19592680
nsv596392 CNV gain 21841781
nsv596400 CNV loss 21841781
nsv596401 CNV loss 21841781
nsv596403 CNV gain+loss 21841781
nsv820150 CNV gain 19587683
nsv820551 CNV deletion 20802225
nsv830172 CNV loss 17160897

Variation tolerance for FAM149A Gene

Residual Variation Intolerance Score: 99.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.96; 87.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM149A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM149A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM149A Gene

Disorders for FAM149A Gene

MalaCards: The human disease database

(1) MalaCards diseases for FAM149A Gene - From: GeneCards

Disorder Aliases PubMed IDs
acute mountain sickness
  • altitude anoxia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for FAM149A

Genetic Association Database (GAD)
FAM149A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM149A
genes like me logo Genes that share disorders with FAM149A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAM149A Gene

Publications for FAM149A Gene

  1. A Preliminary Genome-Wide Association Study of Acute Mountain Sickness Susceptibility in a Group of Nepalese Pilgrims Ascending to 4380a88m. (PMID: 26600424) MacInnis M.J. … Koehle M.S. (High Alt. Med. Biol. 2015) 3 64
  2. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. (PMID: 19460752) Yeung M.L. … Jeang K.T. (J. Biol. Chem. 2009) 3 64
  3. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4 64

Products for FAM149A Gene

Sources for FAM149A Gene

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