FAM149A Gene
protein-coding GIFtS : 38
GCID: GC04 P187026
family with sequence similarity 149, member A
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Aliasesfor FAM149A gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Family With Sequence Similarity 149, Member A 1 2 MSTP1191 2 DKFZP564J1021 MST1191 Protein FAM149A2
Export aliases for FAM149A gene to outside databases Previous GC identifers: GC04P187304 GC04P182817
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Summariesfor FAM149A gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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Genomic Viewsfor FAM149A gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000004.11 NC_018915.1 NT_016354.19 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the FAM149A gene promoter: GR ATF-2 Sox9 Cart-1 GR-alpha Zic3 En-1 Other transcription factors Search SABiosciences Chromatin IP Primers for FAM149A Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat FAM149A
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 4q35.1 Ensembl cytogenetic band: 4q35.1 HGNC cytogenetic band: 4q35.1 FAM149A Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 4 GeneLoc Exon Structure
GeneLoc location for GC04P187026: view genomic region
(about GC identifiers )
Start:
187,025,573 bp from pter
End:
187,093,821 bp from pter
Size:
68,249 bases
Orientation:
plus strand
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Proteinsfor FAM149A gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: F149A_HUMAN, A5PLN7 (See
protein sequence )Recommended Name: Protein FAM149A Size : 773 amino acids; 82698 Da
Sequence caution : Sequence=AAI10817.1; Type=Erroneous initiation; Sequence=AAQ13641.1; Type=Erroneous initiation;Note=Translation N-terminally extended; Sequence=AAQ13641.1; Type=Frameshift; Positions=635;
Secondary accessions : B5MDB8 Q2TAN6 Q7Z2S5 Q9Y4T9Alternative splicing : 4 isoforms : A5PLN7-1 A5PLN7-2 A5PLN7-3 A5PLN7-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for FAM149A: NX_A5PLN7 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_A5PLN7 FAM149A Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (2 alternative transcripts):
NP_001006656.1 NP_056213.1 ENSEMBL proteins: ENSP00000426835 ENSP00000422330 ENSP00000421713 ENSP00000421136 ENSP00000227065 ENSP00000427155 ENSP00000424380 ENSP00000423143 ENSP00000422722 ENSP00000422584 ENSP00000348732 ENSP00000374005 Human Recombinant Protein Products: FAM149A Antibody Products: Assay Products for FAM149A:
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Protein
Domains / Familiesfor FAM149A gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
FAM149A for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry A5PLN7 ProtoNet protein and cluster: A5PLN7
UniProtKB/Swiss-Prot: F149A_HUMAN, A5PLN7 Similarity : Belongs to the FAM149 family
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Functionfor FAM149A gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FAM149A (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FAM149A (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): FAM149A (NM_015398 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM149A Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FAM149A
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM149A
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Pathways & Interactionsfor FAM149A gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM149A 1 Interacting protein for FAM149A (A5PLN7 3 ) via UniProtKB, MINT, STRING, and/or I2D About this table
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Drugs & Compoundsfor FAM149A gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for FAM149A Search CenterWatch for drugs/clinical trials and news about FAM149A / F149A
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Transcriptsfor FAM149A gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
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GenScript ,
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Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for FAM149A gene (2 alternative transcripts): NM_001006655.2 NM_015398.2 Unigene Cluster for FAM149A:
Family with sequence similarity 149, member A Hs.357025 [show with all ESTs ] Unigene Representative Sequence: NM_015398 18 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000503432 ENST00000508379 ENST00000515078 (uc011cla.1 ) ENST00000504330 ENST00000510790 ENST00000513212 ENST00000514829 (uc010isj.2 uc010isk.2 )ENST00000509574 ENST00000513030 ENST00000227065 (uc003iyt.4 uc010isl.3 uc011clb.2 )ENST00000502970 ENST00000514153 ENST00000510843 ENST00000512271 ENST00000514956 ENST00000502894 ENST00000356371 ENST00000389354 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FAM149A (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FAM149A (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): FAM149A (NM_015398 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM149A Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FAM149A
Additional cDNA sequence: AF173894.1 AK057166.1 AK295340.1 AK297679.1 AK309233.1 AK311462.1 AL080065.1 BC110816.1 BC136792.1 BC142992.1 BC144411.1
13 DOTS entries : DT.100014747 DT.206140
DT.97777596 DT.204674 DT.202789 DT.91864338 DT.121240379 DT.121240402 DT.75117000 DT.95155816 DT.40112106 DT.97791380 DT.97858384 24/63 AceView cDNA sequences (see all 63 ):
AI478795 CA312761 AI701607 AA886370 CR621440 AF173894 CD516421 BQ581487 AI017666 BM543645 T89347 BQ884007 BU609191 AW000935 BU786562 BX106165 BM978726 AL536668 CA445679 BM924922 AK057166 BQ270405 BX348436 AI434877 GeneLoc Exon Structure 3 Alternative Splicing Database (ASD) splice patterns (SP) for FAM149A About this scheme ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c SP1 :                                     SP2 :                         -             SP3 :                               -      
ECgene alternative splicing isoforms for FAM149A
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Expression for FAM149A gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section FAM149A expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: --
About this image FAM149A expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See FAM149A Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for FAM149A SOURCE GeneReport for Unigene cluster: Hs.357025 SABiosciences Custom PCR Arrays for FAM149A Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for FAM149ABrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat FAM149A QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat FAM149A QIAGEN QuantiFast Probe-based Assays in human , mouse , rat FAM149A In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM149A
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Orthologsfor FAM149A gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for FAM149A gene from 3/11 species (see all 11 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
FAM149A1
family with sequence similarity 149, member A
59.89(n) 50.31(a)
 
422721 XM_420676.3 XP_420676.3
lizard (Anolis carolinensis)
Reptilia
FAM149A6
--
41(a)
1 ↔ 1
5(112253072-112269892)
zebrafish (Danio rerio)
Actinopterygii
si:ch211-51g4.56
si:ch211-51g4.5
24(a)
1 ↔ 1
14(30810959-30843463)
ENSEMBL Gene Tree for FAM149A (if available)TreeFam Gene Tree for FAM149A (if available)
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Paralogsfor FAM149A gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for FAM149A gene FAM149B1 2
FAM149A for paralogs About GeneDecksing
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Genomic Variantsfor FAM149A gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 11 variations for FAM149A 10 CNVs : 23016 53588 92622 59197 7436 98996 36241 22588 64060 92623 1 Indel : 11230 SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing FAM149A
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Disorders
/ Diseasesfor FAM149A gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
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Publicationsfor FAM149A gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for FAM149A gene integrated from 9 sources : (articles sorted by number of sources associating them with FAM149A) Utopia : connect your pdf to the dynamic world of online information
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005) 2 Bechtel S.... Schupp I. (2007) Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621) 2 Hillier L.W....Wilson R.K. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 Ota T.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548) 1 Bonaldo M.F.... Soares M.B. (1996)
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External Searches for FAM149A gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing FAM149A gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing FAM149A gene
(According to HUGE )
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Specialized Databases showing FAM149A gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for FAM149A Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for FAM149A gene: Search GeneIP for patents involving FAM149A GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor FAM149A gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for FAM149A OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for FAM149A OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for FAM149A OriGene Protein Over-expression Lysate for FAM149A Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for FAM149A OriGene 3'-UTR Clone for FAM149A OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FAM149A OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FAM149A Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for FAM149A OriGene Custom Protein Services for FAM149A OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM149A QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing FAM149A QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat FAM149A QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat FAM149A QIAGEN QuantiFast Probe-based Assays in human , mouse , rat FAM149A QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat FAM149A
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FAM149A Proteins, Antibodies, CLIAs, and ELISAs
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FAM149A
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